The Brain Stimulation Journal:
Basic, Translational, and Clinical Research in Neuromodulation Feed. This feed contains the latest published articles, both articles that have been published in an issue as well as articles that have been published as Articles in Press.
- Preventing misestimation of transcranial magnetic stimulation motor threshold with MTAT 2.0We discovered situations in which the popular transcranial magnetic stimulation (TMS) motor threshold (MT) assessment software tool MTAT 2.0 [1] can produce a large misestimation of the MT. We describe the issue, study it computationally, and suggest ways to address it. ... read more
- Pre-frontal tDCS improves sustained attention and promotes artificial grammar learning in aphasia: An open-label studyTranscranial direct current stimulation (tDCS) is a potentially ground-breaking form of aphasia treatment, but questions remain related to stimulation targets and underlying cognitive benefits of tDCS. TDCS may be especially useful for increasing cost-effectiveness of aphasia therapy due to its relatively low cost and evidence that it may enhance certain types of therapy outcomes [1,2]. Many studies investigating tDCS in aphasia have used fMRI to locate active regions surrounding participants’ lesions [2,3] then targeted for tDCS stimulation. ... read more
- Cerebellar involvement in distributional semantic learning: Insights from a combined TMS-computational approachThe cerebellum has been suggested to contribute to higher-order cognitive functions, including linguistic processing [1]. Cerebellar involvement in linguistic functions may hark back to its predictive nature, as probabilistic predictions on linguistic contextual information are pivotal during language comprehension. Yet, the extent to which words can be probabilistically predicted from language can vary depending on the level at which these computations operate. Accordingly, simple lexical-prediction processes (i.e., lexical surprisal) are neurally dissociable from processes building on the overall distributional history of words in linguistic context [2]. ... read more
- Electroconvulsive therapy on the Roof of the World: The safety and efficacy of ECT in Tibetans living in high altitude climatesElectroconvulsive therapy (ECT) has been widely used in many countries and diverse patient populations [1,2]. However, there are no reports on the safety and efficacy of ECT in patients living above 2500 m (8250 feet) or high altitude (HA) areas where arterial oxygen saturation levels begin to fall compared to low altitude (LA) areas. Residents living in HA areas adapt to the decreased oxygen saturation through genetic and physiologic changes including ventilatory responsiveness [3,4] and increased hemoglobin (Hb) concentrations [5]. ... read more
- Local field potentials in patients with obsessive compulsive disorder: Acute effects of deep brain stimulation in the bed nucleus stria terminalis after symptom provocationObsessive-compulsive disorder is treatable with invasive neuromodulation. It is essential to measure the immediate effect of stimulation. We report for the first-time local field potentials directly from the bed nucleus during symptom provocation and electrical stimulation. ... read more
- Long-term directional deep brain stimulation: Monopolar review vs. local field potential guided programmingDirectional subthalamic stimulation in Parkinson's disease can increase stimulation threshold for adverse effects and widen the therapeutic window. However, selection of programming settings is time consuming, requiring a thorough monopolar clinical review. To overcome this, programming may be guided by intraoperatively recording local field potential beta oscillations (13–35 Hz). ... read more
- Directional stimulation improves stimulation-induced dysgeusia in DBS for essential tremorDeep brain stimulation (DBS) targeting the dentatorubrothalamic (DRT) tract is an effective treatment for medication-refractive tremor [1,2]. An altered perception of taste is a disabling and underreported side effect and is assumed to relate to the unintended stimulation of the gustatory pathway [3,4]. In some cases, DBS-induced dysgeusia can be reduced by conventional DBS programming techniques, whereas in others on demand or permanent stimulation discontinuation or surgical repositioning of the electrode(s) is required [3–5]. ... read more
- Age as a determinant of transcranial magnetic stimulation efficacy for major depressive disorder in a naturalistic clinic settingMajor depressive disorder (MDD) is a highly prevalent, debilitating public health issue that is a leading cause of disease burden throughout the world [1]. Pharmacotherapy is typically used as a first line treatment for MDD [2]. Treatment resistant depression (TRD) is commonly defined as failure to respond or achieve remission after two or more trials of antidepressant medication of adequate dose and duration. Each year, 30.9% of adults develop TRD [3] (see ). ... read more
- Complex negative emotions induced by electrical stimulation of the human hypothalamusStimulation of the ventromedial hypothalamic region in animals has been reported to cause attack behavior labeled as sham-rage without offering information about the internal affective state of the animal being stimulated. ... read more
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