The Brain Stimulation Journal:
Basic, Translational, and Clinical Research in Neuromodulation Feed. This feed contains the latest published articles, both articles that have been published in an issue as well as articles that have been published as Articles in Press.
- Efficacy and safety of HD-tDCS and respiratory rehabilitation for critically ill patients with COVID-19 The HD-RECOVERY randomized clinical trialAcute Respiratory Distress Syndrome (ADRS) due to coronavirus disease 2019 (COVID-19) has been associated with muscle fatigue, corticospinal pathways dysfunction, and mortality. High-Definition transcranial Direct Current Stimulation (HD-tDCS) may be used to attenuate clinical impairment in these patients. The HD-RECOVERY randomized clinical trial was conducted to evaluate the efficacy and safety of HD-tDCS with respiratory rehabilitation in patients with moderate to severe ARDS due to COVID-19. ... read more
- Human Studies of Transcranial Ultrasound neuromodulation: A systematic review of effectiveness and safetyTranscranial ultrasound stimulation (TUS) is gaining traction as a safe and non-invasive technique in human studies. There has been a rapid increase in TUS human studies in recent years, with more than half of studies to date published after 2020. This rapid growth in the relevant body of literature necessitates comprehensive reviews to update clinicians and researchers. ... read more
- Long-term directional deep brain stimulation: Monopolar review vs. local field potential guided programmingDirectional subthalamic stimulation in Parkinson's disease can increase stimulation threshold for adverse effects and widen the therapeutic window. However, selection of programming settings is time consuming, requiring a thorough monopolar clinical review. To overcome this, programming may be guided by intraoperatively recording local field potential beta oscillations (13–35 Hz). ... read more
- Tolerability and feasibility of at-home remotely supervised transcranial direct current stimulation (RS-tDCS): Single-center evidence from 6,779 sessionsThe ability to deploy transcranial direct current stimulation (tDCS) at home is a key usability advantage to support scaling for pivotal clinical trials. We have established a home-based tDCS protocol for use in clinical trials termed remotely supervised (RS)-tDCS. ... read more
- Neurophysiological and behavioral effects of multisession prefrontal tDCS and concurrent cognitive remediation training in patients with autism spectrum disorder (ASD): A double-blind, randomized controlled fNIRS studyThe clinical effects and neurophysiological mechanisms of prefrontal tDCS and concurrent cognitive remediation training in individuals with autism spectrum disorder (ASD) remain unclear. ... read more
- Transcutaneous electrical cranial-auricular acupoints stimulation (TECAS) for treatment of the depressive disorder with insomnia as the complaint (DDI): A case seriesEpidemiologic studies have shown that above 80% of Major depressive disorder (MDD) patients have insomnia disorder (ID) [1], MDD and ID are highly comorbid, with insomnia symptoms amplifying the chronicity and severity of MDD. Meanwhile, ID is one of the primary manifestations and diagnostic criteria for MDD [2]. Furthermore, the depressive disorder with insomnia as the complaint(DDI) is associated with a poorer response to depression-focused psychological and pharmacological treatments, making it more difficult diagnostic and treatment decisions for clinicians [3]. ... read more
- Case evidence of repetitive transcranial magnetic stimulation in the management of refractory irritable bowel syndrome with comorbid depressionIrritable bowel syndrome (IBS) is a common functional gastrointestinal disease characterised by abdominal pain and in most cases comorbid mood symptoms. IBS can substantially reduce quality of life, especially in those with comorbid mood symptoms, while the treatments remain poor. Neuroimaging studies with IBS patients have demonstrated metabolic changes in brain regions involved in pain and emotions, such as the hippocampus, the medial prefrontal cortex (mPFC), and the insular cortex [1,2]. ... read more
- Transcranial focused ultrasound induces sustained synaptic plasticity in rat hippocampusTranscranial focused ultrasound (tFUS) neuromodulation provides a promising emerging non-invasive therapy for the treatment of neurological disorders. Many studies have demonstrated the ability of tFUS to elicit transient changes in neural responses. However, the ability of tFUS to induce sustained changes need to be carefully examined. In this study, we use the long-term potentiation/long term depression (LTP/LTD) model in the rat hippocampus, the medial perforant path (mPP) to dentate gyrus (DG) pathway, to explore whether tFUS is capable of encoding frequency specific information to induce plasticity. ... read more
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