The Brain Stimulation Journal:
Basic, Translational, and Clinical Research in Neuromodulation Feed. This feed contains the latest published articles, both articles that have been published in an issue as well as articles that have been published as Articles in Press.
- Seizure threshold manipulation in electroconvulsive therapy via repetitive transcranial magnetic stimulation. A novel way of augmentation?A high seizure threshold (ST) is an impeding factor in certain patients, potentially preventing a successful electroconvulsive therapy (ECT) treatment. Several pharmacological and non-pharmacological methods have been put forward to augment ECT in such patients, however, to this date, only a handful of case reports existed about the potential role of repetitive transcranial magnetic stimulation (rTMS), as an augmentation method. ... read more4 days ago
- Age-related differences of motor cortex plasticity in adults: a transcranial direct current stimulation studyCognitive, and motor performance are reduced in aging, especially with respect to acquisition of new knowledge, which is associated with a neural plasticity decline. Animal models show a reduction of long-term potentiation, but not long-term depression, in higher age. Findings in humans are more heterogeneous, with some studies showing respective deficits, but others not, or mixed results, for plasticity induced by non-invasive brain stimulation. One reason for these heterogeneous results might be the inclusion of different age ranges in these studies. ... read more1 week ago
- Differential effects of vagus nerve stimulation paradigms guide clinical development for Parkinson’s diseaseVagus nerve stimulation (VNS) modifies brain rhythms in the locus coeruleus (LC) via the solitary nucleus. Degeneration of the LC in Parkinson’s disease (PD) is an early catalyst of the spreading neurodegenerative process, suggesting that stimulating LC output with VNS has the potential to modify disease progression. We previously showed in a lesion PD model that VNS delivered twice daily reduced neuroinflammation and motor deficits, and attenuated tyrosine hydroxylase (TH)-positive cell loss. ... read more3 months ago
- A case of non-affective psychosis followed by extended response to non-stimulation in deep brain stimulation for obsessive-compulsive disorderWe present a case of acute onset of psychotic symptoms, without signs of hypomania, following DBS for intractable OCD in a patient with no prior history of psychosis or delusional beliefs. The patient was a male in his early 20s with a history of intractable OCD, receiving DBS of the ventral capsule/ventral striatum (VC/VS) implanted as part of a randomized clinical trial of DBS for OCD (NCT00640133). The study sought to investigate effectiveness of DBS as a treatment for intractable OCD, as preliminary data had shown promising therapeutic effects [1,2]. ... read more3 months ago
- Corrigendum to “The effect of electroconvulsive therapy on cerebral monoamine oxidase a expression in treatment-resistant depression investigated using positron emission tomography” [Brain Stimul 12 (3) (2019) 714–723]An error occurred during decay correction of the radioactive metabolites of [11C]harmine using high-performance liquid chromatography. Consequently, the quantification of monoamine oxidase A volume of distribution and subsequent statistical analyses were incorrect. We reran the analyses based on the correct data which revealed that the numerical changes resulting from the latest computations have no consequences for the main results or the conclusions of this publication that are subsumed below. ... read more3 months ago
- Neural noise and cortical inhibition in schizophreniaNeural information processing is subject to noise and this leads to variability in neural firing and behavior. Schizophrenia has been associated with both more variable motor control and impaired cortical inhibition, which is crucial for excitatory/inhibitory balance in neural commands. ... read more3 months ago
- Decreased interhemispheric connectivity and increased cortical excitability in unmedicated schizophrenia: A prefrontal interleaved TMS fMRI studyPrefrontal abnormalities in schizophrenia have consistently emerged from resting state and cognitive neuroimaging studies. However, these correlative findings require causal verification via combined imaging/stimulation approaches. To date, no interleaved transcranial magnetic stimulation and functional magnetic resonance imaging study (TMS fMRI) has probed putative prefrontal cortex abnormalities in schizophrenia. ... read more3 months ago
- The role of low-frequency repetitive transcranial magnetic stimulation in major depression: A call to increase the evidence baseRepetitive transcranial magnetic stimulation (rTMS) is an effective intervention in major depressive disorder (MDD), with superior tolerability over medication [1]. Unfortunately, its widespread adoption has been impeded by high operational costs, decreasing accessibility. ... read more3 months ago