Deep brain stimulation electrode insertion and depression: Patterns of activity and modulation by analgesics

Deep brain stimulation electrode insertion and depression: Patterns of activity and modulation by analgesics
An initial antidepressant effect when using deep brain stimulation (DBS) of the subcallosal area of the cingulate cortex (Cg25) to treat resistant depression that could be the result of electrode insertion has been described. We previously showed that electrode insertion into the infralimbic cortex (ILC; the Cg25 rodent correlate) provokes a temporally limited antidepressant-like effect that is counteracted by non-steroidal anti-inflammatory drugs, such as those routinely used for pain relief. ... read more
Brain Stimulation Journal FeedBy L. Perez-Caballero, M.L. Soto-Montenegro, M. Hidalgo-Figueroa, J.A. Mico, M. Desco, E. Berrocoso