Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation

Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation
Nat Neurosci. 2022 Sep;25(9):1237-1246. doi: 10.1038/s41593-022-01132-3. Epub 2022 Aug 22.ABSTRACTThe development of technologies to protect or enhance memory in older people is an enduring goal of translational medicine. Here we describe repetitive (4-day) transcranial alternating current stimulation (tACS) protocols for the selective, sustainable enhancement of auditory-verbal working memory and long-term memory in 65-88-year-old people. Modulation of synchronous low-frequency, but not high-frequency, activity in parietal cortex preferentially improved working memory on day 3 and day 4 and 1 month after intervention, whereas modulation of synchronous high-frequency, but not low-frequency, activity in prefrontal cortex preferentially improved long-term memory on days 2-4 and ... read more
Pubmed – tDCS and CognitionBy Shrey Grover