Magnetic-field-synchronized wireless modulation of neural activity by magnetoelectric nanoparticles

Magnetic-field-synchronized wireless modulation of neural activity by magnetoelectric nanoparticles
The in vitro study demonstrates wirelessly controlled modulation of neural activity using magnetoelectric nanoparticles (MENPs), synchronized to magnetic field application with a sub-25-msec temporal response. Herein, MENPs are sub-30-nm [email protected] core-shell nanostructures. MENPs were added to E18 rat hippocampal cell cultures (0.5 μg of MENPs per 100,000 neurons) tagged with fluorescent Ca2+ sensitive indicator cal520. MENPs were shown to wirelessly induce calcium transients which were synchronized with application of 1200-Oe bipolar 25-msec magnetic pulses at a rate of 20 pulses/sec. ... read more
Brain Stimulation Journal FeedBy E. Zhang, M. Abdel-Mottaleb, P. Liang, B. Navarrete, Y. Akin Yildirim, M. Alberteris Campos, I.T. Smith, P. Wang, B. Yildirim, L. Yang, S. Chen, I. Smith, G. Lur, B.T. Nguyen, X. Jin, B. Noga, P. Ganzer, S. Khizroev