Multimodal approach leads to seizure-freedom in a case of highly refractory drug-resistant focal epilepsy

Multimodal approach leads to seizure-freedom in a case of highly refractory drug-resistant focal epilepsy
Epilepsy Behav Rep. 2022 Nov 7;20:100570. doi: 10.1016/j.ebr.2022.100570. eCollection 2022.ABSTRACTDrug-resistant, nonlesional, extratemporal lobe focal epilepsy can be difficult to treat and may require a high degree of multidisciplinary teamwork to localize the seizure onset zone for resective surgery. Here, we describe a patient with longstanding drug-resistant, nonlesional, extratemporal focal epilepsy with a high seizure burden who became seizure-free after prolonged evaluation and eventual left frontal cortical resection. Prior evaluations included magnetoencephalography, invasive video-EEG monitoring, and implantation of a responsive neurostimulation (RNS) device for ongoing intracranial stimulation. Highly sophisticated techniques were utilized including stereotactic localization of prior evaluations to guide repeat ... read more
Pubmed – tDCS and CognitionBy Kelsey M Smith