NMDA receptor-related mechanisms of dopaminergic modulation of tDCS-induced neuroplasticity

NMDA receptor-related mechanisms of dopaminergic modulation of tDCS-induced neuroplasticity
Cereb Cortex. 2022 Feb 15:bhac028. doi: 10.1093/cercor/bhac028. Online ahead of print.ABSTRACTDopamine is a key neuromodulator of neuroplasticity and an important neuronal substrate of learning, and memory formation, which critically involves glutamatergic N-methyl-D-aspartate (NMDA) receptors. Dopamine modulates NMDA receptor activity via dopamine D1 and D2 receptor subtypes. It is hypothesized that dopamine focuses on long-term potentiation (LTP)-like plasticity, i.e. reduces diffuse widespread but enhances locally restricted plasticity via a D2 receptor-dependent NMDA receptor activity reduction. Here, we explored NMDA receptor-dependent mechanisms underlying dopaminergic modulation of LTP-like plasticity induced by transcranial direct current stimulation (tDCS). Eleven healthy, right-handed volunteers received anodal tDCS ... read more
PubMed Abstract – tDCS and memoryBy Elham Ghanavati