Role of the Prefrontal Cortex in Pain Processing.

Role of the Prefrontal Cortex in Pain Processing.
Related ArticlesRole of the Prefrontal Cortex in Pain Processing. Mol Neurobiol. 2018 Jun 06;: Authors: Ong WY, Stohler CS, Herr DR Abstract The prefrontal cortex (PFC) is not only important in executive functions, but also pain processing. The latter is dependent on its connections to other areas of the cerebral neocortex, hippocampus, periaqueductal gray (PAG), thalamus, amygdala, and basal nuclei. Changes in neurotransmitters, gene expression, glial cells, and neuroinflammation occur in the PFC during acute and chronic pain, that result in alterations to its structure, activity, and connectivity. The medial PFC (mPFC) could serve dual, opposing roles in pain: ... read more
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