Vagus nerve stimulation promotes generalization of conditioned fear extinction and reduces anxiety in rats

Vagus nerve stimulation promotes generalization of conditioned fear extinction and reduces anxiety in rats
Exposure-based therapies are used to treat a variety of trauma- and anxiety-related disorders by generating successful extinction following cue exposure during treatment. The development of adjuvant strategies that accelerate extinction learning, improve tolerability, and increase efficiency of treatment could increase the efficacy of exposure-based therapies. Vagus nerve stimulation (VNS) paired with exposure can enhance fear extinction, in rat models of psychiatric disorders, and chronic administration of VNS reduces anxiety in rats and humans. ... read more
Brain Stimulation Journal FeedBy Lindsey J. Noble, Venkat B. Meruva, Seth A. Hays, Robert L. Rennaker, Michael P. Kilgard, Christa K. McIntyre