PubMed Transcranial Direct Current Stimulation

  • Higher success rate with transcranial electrical stimulation of motor-evoked potentials using constant-voltage stimulation compared with constant-current stimulation in patients undergoing spinal surgery.
    Related ArticlesHigher success rate with transcranial electrical stimulation of motor-evoked potentials using constant-voltage stimulation compared with constant-current stimulation in patients undergoing spinal surgery. Spine J. 2017 Oct;17(10):1472-1479 Authors: Shigematsu H, Kawaguchi M, Hayashi H, Takatani T, Iwata E, Tanaka M, Okuda A, Morimoto Y, Masuda K, Tanaka Y, Tanaka Y Abstract BACKGROUND CONTEXT: During spine surgery, the spinal cord is electrophysiologically monitored via transcranial electrical stimulation of motor-evoked potentials (TES-MEPs) to prevent injury. Transcranial electrical stimulation of motor-evoked potential involves the use of either constant-current or constant-voltage stimulation; however, there are few comparative data available regarding their ability to ... read more
    PubMed Transcranial Direct Current Stimulation
  • tDCS over left M1 or DLPFC does not improve learning of a bimanual coordination task.
    Related ArticlestDCS over left M1 or DLPFC does not improve learning of a bimanual coordination task. Sci Rep. 2016 10 25;6:35739 Authors: Vancleef K, Meesen R, Swinnen SP, Fujiyama H Abstract Previously, transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has resulted in improved performance in simple motor tasks. For a complex bimanual movement, studies using functional magnetic resonance imaging and transcranial magnetic stimulation indicated the involvement of the left dorsolateral prefrontal cortex (DLPFC) as well as left M1. Here we investigated the relative effect of up-regulating the cortical function in left DLPFC and left ... read more
    PubMed Transcranial Direct Current Stimulation
  • Direct-Current Stimulation Does Little to Improve the Outcome of Working Memory Training in Older Adults.
    Related ArticlesDirect-Current Stimulation Does Little to Improve the Outcome of Working Memory Training in Older Adults. Psychol Sci. 2017 Jul;28(7):907-920 Authors: Nilsson J, Lebedev AV, Rydström A, Lövdén M Abstract The promise of transcranial direct-current stimulation (tDCS) as a modulator of cognition has appealed to researchers, media, and the general public. Researchers have suggested that tDCS may increase effects of cognitive training. In this study of 123 older adults, we examined the interactive effects of 20 sessions of anodal tDCS over the left prefrontal cortex (vs. sham tDCS) and simultaneous working memory training (vs. control training) on change in ... read more
    PubMed Transcranial Direct Current Stimulation
  • tDCS does not enhance the effects of robot-assisted gait training in patients with subacute stroke.
    Related ArticlestDCS does not enhance the effects of robot-assisted gait training in patients with subacute stroke. Restor Neurol Neurosci. 2017;35(4):377-384 Authors: Leon D, Cortes M, Elder J, Kumru H, Laxe S, Edwards DJ, Tormos JM, Bernabeu M, Pascual-Leone A Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique, which can modulate cortical excitability and combined with rehabilitation therapies may improve motor recovery after stroke. OBJECTIVE: Our aim was to study the feasibility of a 4-week robotic gait training protocol combined with tDCS, and to study tDCS to the leg versus hand motor cortex or sham ... read more
    PubMed Transcranial Direct Current Stimulation
  • Balanced bifrontal transcranial direct current stimulation enhances working memory in adults with high-functioning autism: a sham-controlled crossover study.
    Related ArticlesBalanced bifrontal transcranial direct current stimulation enhances working memory in adults with high-functioning autism: a sham-controlled crossover study. Mol Autism. 2017;8:40 Authors: van Steenburgh JJ, Varvaris M, Schretlen DJ, Vannorsdall TD, Gordon B Abstract BACKGROUND: Working memory (WM) often is impaired in autism spectrum disorder (ASD). Such impairment may underlie core deficits in cognition and social functioning. Transcranial direct current stimulation (tDCS) has been shown to enhance WM in both healthy adults and clinical populations, but its efficacy in ASD is unknown. We predicted that bifrontal tDCS would improve WM performances of adults with high-functioning autism during ... read more
    PubMed Transcranial Direct Current Stimulation
  • Cerebellar transcranial direct current stimulation interacts with BDNF Val66Met in motor learning.
    Related ArticlesCerebellar transcranial direct current stimulation interacts with BDNF Val66Met in motor learning. Brain Stimul. 2018 Apr 11;: Authors: van der Vliet R, Jonker ZD, Louwen SC, Heuvelman M, de Vreede L, Ribbers GM, De Zeeuw CI, Donchin O, Selles RW, van der Geest JN, Frens MA Abstract BACKGROUND: Cerebellar transcranial direct current stimulation has been reported to enhance motor associative learning and motor adaptation, holding promise for clinical application in patients with movement disorders. However, behavioral benefits from cerebellar tDCS have been inconsistent. OBJECTIVE: Identifying determinants of treatment success is necessary. BDNF Val66Met is a candidate determinant, because the ... read more
    PubMed Transcranial Direct Current Stimulation
  • Transcranial Direct Current Stimulation Enhances Motor Skill Learning but Not Generalization in Chronic Stroke.
    Transcranial Direct Current Stimulation Enhances Motor Skill Learning but Not Generalization in Chronic Stroke. Neurorehabil Neural Repair. 2018 Apr 01;:1545968318769164 Authors: Hamoudi M, Schambra HM, Fritsch B, Schoechlin-Marx A, Weiller C, Cohen LG, Reis J Abstract BACKGROUND: Motor training alone or combined with transcranial direct current stimulation (tDCS) positioned over the motor cortex (M1) improves motor function in chronic stroke. Currently, understanding of how tDCS influences the process of motor skill learning after stroke is lacking. OBJECTIVE: To assess the effects of tDCS on the stages of motor skill learning and on generalization to untrained motor function. METHODS: In this ... read more
    PubMed Transcranial Direct Current Stimulation
  • Null tDCS Effects in a Sustained Attention Task: The Modulating Role of Learning.
    Related ArticlesNull tDCS Effects in a Sustained Attention Task: The Modulating Role of Learning. Front Psychol. 2018;9:476 Authors: Jacoby N, Lavidor M Abstract The purpose of this study was to investigate sustained attention through modulation of the fronto-cerebral network with transcranial direct current stimulation (tDCS) in adults with attention-deficit/hyperactivity disorder (ADHD) and control participants. Thirty-seven participants (21 with ADHD) underwent three separate sessions (baseline, active tDCS, and sham) and performed the MOXO Continuous Performance Test (CPT). We applied double anodal stimulation of 1.8 mA tDCS for 20 min over the left and right dorsolateral prefrontal cortex (DLPFC), with the cathode ... read more
    PubMed Transcranial Direct Current Stimulation
  • Evidence of the homeostatic regulation with the combination of transcranial direct current stimulation and physical activity.
    Evidence of the homeostatic regulation with the combination of transcranial direct current stimulation and physical activity. Am J Phys Med Rehabil. 2018 Apr 20;: Authors: Baltar A, Nogueira F, Marques D, Carneiro M, Monte-Silva K Abstract Transcranial direct current stimulation (tDCS) can optimize beneficial effects induced by motor practice in patients with neurological disorders. However, possibly due to homeostatic regulation, the conditioning effects of tDCS are often imprecise and variable, limiting its therapeutic application. OBJECTIVE: to explore the magnitude and direction of the after-effects induced by physical activity (PA) on tDCS-preconditioned cortical excitability (CE). DESIGN: First, a crossover experiment was ... read more
    PubMed Transcranial Direct Current Stimulation
  • Epilepsy and Neuromodulation-Randomized Controlled Trials.
    Related ArticlesEpilepsy and Neuromodulation-Randomized Controlled Trials. Brain Sci. 2018 Apr 18;8(4): Authors: Kwon CS, Ripa V, Al-Awar O, Panov F, Ghatan S, Jetté N Abstract Neuromodulation is a treatment strategy that is increasingly being utilized in those suffering from drug-resistant epilepsy who are not appropriate for resective surgery. The number of double-blinded RCTs demonstrating the efficacy of neurostimulation in persons with epilepsy is increasing. Although reductions in seizure frequency is common in these trials, obtaining seizure freedom is rare. Invasive neuromodulation procedures (DBS, VNS, and RNS) have been approved as therapeutic measures. However, further investigations are necessary to delineate effective ... read more
    PubMed Transcranial Direct Current Stimulation
  • Transcranial direct current stimulation (tDCS) for improving capacity in activities and arm function after stroke: a network meta-analysis of randomised controlled trials.
    Related ArticlesTranscranial direct current stimulation (tDCS) for improving capacity in activities and arm function after stroke: a network meta-analysis of randomised controlled trials. J Neuroeng Rehabil. 2017 Sep 13;14(1):95 Authors: Elsner B, Kwakkel G, Kugler J, Mehrholz J Abstract BACKGROUND: Transcranial Direct Current Stimulation (tDCS) is an emerging approach for improving capacity in activities of daily living (ADL) and upper limb function after stroke. However, it remains unclear what type of tDCS stimulation is most effective. Our aim was to give an overview of the evidence network regarding the efficacy and safety of tDCS and to estimate the ... read more
    PubMed Transcranial Direct Current Stimulation
  • Effects of tDCS on Bimanual Motor Skills: A Brief Review.
    Related ArticlesEffects of tDCS on Bimanual Motor Skills: A Brief Review. Front Behav Neurosci. 2018;12:63 Authors: Pixa NH, Pollok B Abstract Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that allows the modulation of cortical excitability as well as neuroplastic reorganization using a weak constant current applied through the skull on the cerebral cortex. TDCS has been found to improve motor performance in general and motor learning in particular. However, these effects have been reported almost exclusively for unimanual motor tasks such as serial reaction time tasks, adaptation tasks, or visuo-motor tracking. Despite the importance of bimanual ... read more
    PubMed Transcranial Direct Current Stimulation
  • Neurostimulation for Memory Enhancement in Epilepsy.
    Related ArticlesNeurostimulation for Memory Enhancement in Epilepsy. Curr Neurol Neurosci Rep. 2018 Apr 19;18(6):30 Authors: Meisenhelter S, Jobst BC Abstract PURPOSE OF REVIEW: Memory is one of the top concerns of epilepsy patients, but there are no known treatments to directly alleviate the memory deficits associated with epilepsy. Neurostimulation may provide new therapeutic tools to enhance memory in epilepsy patients. Here, we critically review recent investigations of memory enhancement using transcranial electrical stimulation (tES), transcranial magnetic stimulation (TMS), vagus nerve stimulation (VNS), chronic intracranial stimulation, and acute intracranial stimulation. RECENT FINDINGS: Existing literature suggests that transcranial direct current stimulation (tDCS) ... read more
    PubMed Transcranial Direct Current Stimulation
  • Modulating phonemic fluency performance in healthy subjects with transcranial magnetic stimulation over the left or right lateral frontal cortex.
    Related ArticlesModulating phonemic fluency performance in healthy subjects with transcranial magnetic stimulation over the left or right lateral frontal cortex. Neuropsychologia. 2017 Jul 28;102:109-115 Authors: Smirni D, Turriziani P, Mangano GR, Bracco M, Oliveri M, Cipolotti L Abstract A growing body of evidence have suggested that non-invasive brain stimulation techniques, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), can improve the performance of aphasic patients in language tasks. For example, application of inhibitory rTMS or tDCs over the right frontal lobe of dysphasic patients resulted in improved naming abilities. Several studies have also reported that ... read more
    PubMed Transcranial Direct Current Stimulation
  • Enhancing anger perception in older adults by stimulating inferior frontal cortex with high frequency transcranial random noise stimulation.
    Related ArticlesEnhancing anger perception in older adults by stimulating inferior frontal cortex with high frequency transcranial random noise stimulation. Neuropsychologia. 2017 Jul 28;102:163-169 Authors: Yang T, Banissy MJ Abstract Extensive behavioural evidence has shown that older people have declined ability in facial emotion perception. Recent work has begun to examine the neural mechanism that contribute to this, and potential tools to support emotion perception during aging. The aim of this study was to investigate whether high frequency tRNS applied to the inferior frontal cortex would enhance facial expression perception in older adults. Healthy aged adults (60+ years) were randomly ... read more
    PubMed Transcranial Direct Current Stimulation
  • TDCS modulates cortical excitability in patients with disorders of consciousness.
    Related ArticlesTDCS modulates cortical excitability in patients with disorders of consciousness. Neuroimage Clin. 2017;15:702-709 Authors: Bai Y, Xia X, Kang J, Yang Y, He J, Li X Abstract Transcranial direct current stimulation (tDCS) has been reported to be a promising technique for consciousness improvement for patients with disorders of consciousness (DOC). However, there has been no direct electrophysiological evidence to demonstrate the efficacy of tDCS on patients with DOC. Therefore, we aim to measure the cortical excitability changes induced by tDCS in patients with DOC, to find electrophysiological evidence supporting the therapeutic efficacy of tDCS on patients with ... read more
    PubMed Transcranial Direct Current Stimulation
  • Auditory System Target Engagement During Plasticity-Based Interventions in Schizophrenia: A Focus on Modulation of N-Methyl-D-Aspartate-Type Glutamate Receptor Function.
    Related ArticlesAuditory System Target Engagement During Plasticity-Based Interventions in Schizophrenia: A Focus on Modulation of N-Methyl-D-Aspartate-Type Glutamate Receptor Function. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Feb 22;: Authors: Kantrowitz JT, Swerdlow NR, Dunn W, Vinogradov S Abstract Cognitive deficits are predictive of long-term social and occupational functional deficits in schizophrenia but are currently without gold-standard treatments. In particular, augmentation of auditory cortical neuroplasticity may represent a rate-limiting first step before addressing higher-order cognitive deficits. We review the rationale for N-methyl-d-aspartate-type glutamate receptor (NMDAR) modulators as treatments for auditory plasticity deficits in schizophrenia, along with potential serum and electroencephalographic target engagement ... read more
    PubMed Transcranial Direct Current Stimulation
  • Transcranial direct current stimulation improves long-term memory deficits in an animal model of attention-deficit/hyperactivity disorder and modulates oxidative and inflammatory parameters.
    Related ArticlesTranscranial direct current stimulation improves long-term memory deficits in an animal model of attention-deficit/hyperactivity disorder and modulates oxidative and inflammatory parameters. Brain Stimul. 2018 Apr 05;: Authors: Leffa DT, Bellaver B, Salvi AA, de Oliveira C, Caumo W, Grevet EH, Fregni F, Quincozes-Santos A, Rohde LA, Torres ILS Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) is a technique that modulates neuronal activity and has been proposed as a potential therapeutic tool for attention-deficit/hyperactivity disorder (ADHD) symptoms. Although pilot studies have shown evidence of efficacy, its mechanism of action remains unclear. OBJECTIVE/HYPOTHESIS: We evaluated the effects of tDCS on behavioral ... read more
    PubMed Transcranial Direct Current Stimulation
  • Efficacy of transcranial direct current stimulation combined with cognitive training in the treatment of apathy in patients with Alzheimer’s disease: study protocol for a randomized trial.
    Related ArticlesEfficacy of transcranial direct current stimulation combined with cognitive training in the treatment of apathy in patients with Alzheimer's disease: study protocol for a randomized trial. Rev Recent Clin Trials. 2018 Apr 16;: Authors: Jean-Paul N, Boutoleau-Bretonniere C, Lefaucheur JP, Suarez A, Gaillard H, Chapelet G, Abad S, Van Langhenhove A, Nizard J, de Decke L Abstract BACKGROUND: Apathy, commonly defined as loss of motivation, is a symptom frequently encountered in Alzheimer's disease (AD). The treatment of apathy remains challenging in the absence of any truly effective medications. Transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) can ... read more
    PubMed Transcranial Direct Current Stimulation
  • Cognitive effects of transcranial direct current stimulation treatment in patients with major depressive disorder: an individual patient data meta-analysis of randomised, sham-controlled trials.
    Related ArticlesCognitive effects of transcranial direct current stimulation treatment in patients with major depressive disorder: an individual patient data meta-analysis of randomised, sham-controlled trials. Neurosci Biobehav Rev. 2018 Apr 13;: Authors: Martin DM, Moffa A, Nikolin S, Bennabi D, Brunoni AR, Flannery W, Haffen E, McClintock SM, Moreno ML, Padberg F, Palm U, Loo CK Abstract Transcranial direct current stimulation (tDCS) has emerged as a promising new treatment for major depression. While recent randomised, sham-controlled studies found tDCS to have antidepressant effects, it remains to be determined whether a tDCS treatment course may also enhance cognitive function independent of mood ... read more
    PubMed Transcranial Direct Current Stimulation