Pubmed – tDCS and Cognition

  • Direct current stimulation of endothelial monolayers induces a transient and reversible increase in transport due to the electroosmotic effect.
    Related ArticlesDirect current stimulation of endothelial monolayers induces a transient and reversible increase in transport due to the electroosmotic effect. Sci Rep. 2018 Jun 18;8(1):9265 Authors: Cancel LM, Arias K, Bikson M, Tarbell JM Abstract We investigated the effects of direct current stimulation (DCS) on fluid and solute transport across endothelial cell (EC) monolayers in vitro. Our motivation was transcranial direct current stimulation (tDCS) that has been investigated for treatment of neuropsychiatric disorders, to enhance neurorehabilitation, and to change cognition in healthy subjects. The mechanisms underlying this diversity of applications remain under investigation. To address the possible role of blood-brain ... read more
    Pubmed – tDCS and Cognition
  • Cognitive Rehabilitation in Parkinson’s Disease: Is it Feasible?
    Related ArticlesCognitive Rehabilitation in Parkinson's Disease: Is it Feasible? Arch Clin Neuropsychol. 2017 Nov 01;32(7):840-860 Authors: Biundo R, Weis L, Fiorenzato E, Antonini A Abstract Parkinson's disease (PD) is a common neurodegenerative disorder, characterized by motor and non-motor symptoms. Dementia is one of the most relevant non-motor symptoms considering its functional affect on PD patients' activities of daily living and family members' wellbeing. Cognitive abnormalities in PD are heterogeneous and reliable biomarkers to detect patients at risk for dementia early on remain to be identified. Pharmacological treatments specifically for PD dementia and mild cognitive impairment are lacking, and alternative ... read more
    Pubmed – tDCS and Cognition
  • Transcranial Direct Current Stimulation, Symptomatology, and Cognition in Psychosis: A Qualitative Review.
    Related ArticlesTranscranial Direct Current Stimulation, Symptomatology, and Cognition in Psychosis: A Qualitative Review. Front Behav Neurosci. 2018;12:94 Authors: Gupta T, Kelley NJ, Pelletier-Baldelli A, Mittal VA Abstract Schizophrenia is a chronic, debilitating condition that affects approximately 1% of the population. Individuals diagnosed with schizophrenia typically exhibit positive (e.g., hallucinations) and negative symptoms (e.g., anhedonia) and impairments in cognitive function. Given the limitations of antipsychotic medication and psychotherapy in fully treating psychosis symptomatology, there has been increasing interest in other interventions such as transcranial direct current stimulation (tDCS). tDCS is a non-invasive neuromodulation technique, that is safe, cost-effective, and widely accessible. ... read more
    Pubmed – tDCS and Cognition
  • Role of the Prefrontal Cortex in Pain Processing.
    Related ArticlesRole of the Prefrontal Cortex in Pain Processing. Mol Neurobiol. 2018 Jun 06;: Authors: Ong WY, Stohler CS, Herr DR Abstract The prefrontal cortex (PFC) is not only important in executive functions, but also pain processing. The latter is dependent on its connections to other areas of the cerebral neocortex, hippocampus, periaqueductal gray (PAG), thalamus, amygdala, and basal nuclei. Changes in neurotransmitters, gene expression, glial cells, and neuroinflammation occur in the PFC during acute and chronic pain, that result in alterations to its structure, activity, and connectivity. The medial PFC (mPFC) could serve dual, opposing roles in pain: ... read more
    Pubmed – tDCS and Cognition
  • Neuronal and behavioral effects of multi-day brain stimulation and memory training.
    Related ArticlesNeuronal and behavioral effects of multi-day brain stimulation and memory training. Neurobiol Aging. 2018 Jan;61:245-254 Authors: Antonenko D, Külzow N, Sousa A, Prehn K, Grittner U, Flöel A Abstract Strategies for memory enhancement, especially for the older population, are of great scientific and public interest. Here, we aimed at investigating neuronal and behavioral effects of transcranial direct current stimulation (tDCS) paired with memory training. Young and older adults were trained on an object-location-memory task on 3 consecutive days with either anodal or sham tDCS. Recall performance was assessed immediately after training, 1 day and 1 month later, as well as ... read more
    Pubmed – tDCS and Cognition
  • Anodal tDCS over Primary Motor Cortex Provides No Advantage to Learning Motor Sequences via Observation.
    Related ArticlesAnodal tDCS over Primary Motor Cortex Provides No Advantage to Learning Motor Sequences via Observation. Neural Plast. 2018;2018:1237962 Authors: Apšvalka D, Ramsey R, Cross ES Abstract When learning a new motor skill, we benefit from watching others. It has been suggested that observation of others' actions can build a motor representation in the observer, and as such, physical and observational learning might share a similar neural basis. If physical and observational learning share a similar neural basis, then motor cortex stimulation during observational practice should similarly enhance learning by observation as it does through physical practice. Here, we ... read more
    Pubmed – tDCS and Cognition
  • Improvements in Attention and Decision-Making Following Combined Behavioral Training and Brain Stimulation.
    Related ArticlesImprovements in Attention and Decision-Making Following Combined Behavioral Training and Brain Stimulation. Cereb Cortex. 2017 Jul 01;27(7):3675-3682 Authors: Filmer HL, Varghese E, Hawkins GE, Mattingley JB, Dux PE Abstract In recent years there has been a significant commercial interest in 'brain training' - massed or spaced practice on a small set of tasks to boost cognitive performance. Recently, researchers have combined cognitive training regimes with brain stimulation to try and maximize training benefits, leading to task-specific cognitive enhancement. It remains unclear, however, whether the performance gains afforded by such regimes can transfer to untrained tasks, or how training ... read more
    Pubmed – tDCS and Cognition
  • Individual differences in learning correlate with modulation of brain activity induced by transcranial direct current stimulation.
    Related ArticlesIndividual differences in learning correlate with modulation of brain activity induced by transcranial direct current stimulation. PLoS One. 2018;13(5):e0197192 Authors: Falcone B, Wada A, Parasuraman R, Callan DE Abstract Transcranial direct current stimulation (tDCS) has been shown to enhance cognitive performance on a variety of tasks. It is hypothesized that tDCS enhances performance by affecting task related cortical excitability changes in networks underlying or connected to the site of stimulation facilitating long term potentiation. However, many recent studies have called into question the reliability and efficacy of tDCS to induce modulatory changes in brain activity. In this study, ... read more
    Pubmed – tDCS and Cognition
  • Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation.
    Related ArticlesEffects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation. J Vis Exp. 2017 Sep 23;(127): Authors: Shpektor A, Nazarova M, Feurra M Abstract Transcranial Alternating Current Stimulation (tACS) is a neuromodulatory technique able to act through sinusoidal electrical waveforms in a specific frequency and in turn modulate ongoing cortical oscillatory activity. This neurotool allows the establishment of a causal link between endogenous oscillatory activity and behavior. Most of the tACS studies have shown online effects of tACS. However, little is known about the underlying action mechanisms of this ... read more
    Pubmed – tDCS and Cognition
  • Anodal transcranial direct current stimulation over the right hemisphere improves auditory comprehension in a case of dementia.
    Related ArticlesAnodal transcranial direct current stimulation over the right hemisphere improves auditory comprehension in a case of dementia. NeuroRehabilitation. 2017;41(2):567-575 Authors: Costa V, Brighina F, Piccoli T, Realmuto S, Fierro B Abstract BACKGROUND: Noninvasive transcranial stimulation methods have been increasingly employed in order to improve cognitive performance in neurological patients. In previous studies with both stroke patients and healthy subjects, noninvasive stimulation of temporal-parietal regions and their homologue produced an improvement in linguistic tasks. OBJECTIVE: The aim of the current study was to evaluate if anodal transcranial direct current stimulation (tDCS) over Brodmann areas 39/40 (angular and supramarginal gyri) ... read more
    Pubmed – tDCS and Cognition
  • Single transcranial direct current stimulation in schizophrenia: Randomized, cross-over study of neurocognition, social cognition, ERPs, and side effects.
    Related ArticlesSingle transcranial direct current stimulation in schizophrenia: Randomized, cross-over study of neurocognition, social cognition, ERPs, and side effects. PLoS One. 2018;13(5):e0197023 Authors: Rassovsky Y, Dunn W, Wynn JK, Wu AD, Iacoboni M, Hellemann G, Green MF Abstract Over the last decades, the treatment of schizophrenia has shifted fundamentally from a focus on symptom reduction to a focus on recovery and improving aspects of functioning. In this study, we examined the effect of transcranial direct current stimulation (tDCS) on social cognitive and nonsocial neurocognitive functions, as well as on electroencephalogram (EEG) measures, in individuals with schizophrenia. Thirty-seven individuals with schizophrenia ... read more
    Pubmed – tDCS and Cognition
  • Transcranial Direct Current Stimulation (tDCS): A Promising Treatment for Major Depressive Disorder?
    Related ArticlesTranscranial Direct Current Stimulation (tDCS): A Promising Treatment for Major Depressive Disorder? Brain Sci. 2018 May 06;8(5): Authors: Bennabi D, Haffen E Abstract Background: Transcranial direct current stimulation (tDCS) opens new perspectives in the treatment of major depressive disorder (MDD), because of its ability to modulate cortical excitability and induce long-lasting effects. The aim of this review is to summarize the current status of knowledge regarding tDCS application in MDD. Methods: In this review, we searched for articles published in PubMed/MEDLINE from the earliest available date to February 2018 that explored clinical and cognitive effects of tDCS in MDD. ... read more
    Pubmed – tDCS and Cognition
  • No Change in Social Decision-Making Following Transcranial Direct Current Stimulation of the Right Temporoparietal Junction.
    Related ArticlesNo Change in Social Decision-Making Following Transcranial Direct Current Stimulation of the Right Temporoparietal Junction. Front Neurosci. 2018;12:258 Authors: Blair-West LF, Hoy KE, Hall PJ, Fitzgerald PB, Fitzgibbon BM Abstract The right temporoparietal junction (rTPJ) is thought to play an important role in social cognition and pro-social decision-making. One way to explore this link is through the use of transcranial direct current stimulation (tDCS), a non-invasive brain stimulation method that is able to modulate cortical activity. The aim of this research was therefore to determine whether anodal tDCS to the rTPJ altered response to a social decision-making task. In ... read more
    Pubmed – tDCS and Cognition
  • Driving working memory with frequency-tuned noninvasive brain stimulation.
    Related ArticlesDriving working memory with frequency-tuned noninvasive brain stimulation. Ann N Y Acad Sci. 2018 Apr 29;: Authors: Albouy P, Baillet S, Zatorre RJ Abstract Frequency-tuned noninvasive brain stimulation is a recent approach in cognitive neuroscience that involves matching the frequency of transcranially applied electromagnetic fields to that of specific oscillatory components of the underlying neurophysiology. The objective of this method is to modulate ongoing/intrinsic brain oscillations, which correspond to rhythmic fluctuations of neural excitability, to causally change behavior. We review the impact of frequency-tuned noninvasive brain stimulation on the research field of human working memory. We argue that this ... read more
    Pubmed – tDCS and Cognition
  • Eyes wide shut: Transcranial alternating current stimulation drives alpha rhythm in a state dependent manner.
    Related ArticlesEyes wide shut: Transcranial alternating current stimulation drives alpha rhythm in a state dependent manner. Sci Rep. 2016 06 02;6:27138 Authors: Ruhnau P, Neuling T, Fuscá M, Herrmann CS, Demarchi G, Weisz N Abstract Transcranial alternating current stimulation (tACS) is used to modulate brain oscillations to measure changes in cognitive function. It is only since recently that brain activity in human subjects during tACS can be investigated. The present study aims to investigate the phase relationship between the external tACS signal and concurrent brain activity. Subjects were stimulated with tACS at individual alpha frequency during eyes open ... read more
    Pubmed – tDCS and Cognition
  • The Effects of Anodal Transcranial Direct Current Stimulation on Working Memory.
    Related ArticlesThe Effects of Anodal Transcranial Direct Current Stimulation on Working Memory. Adv Exp Med Biol. 2017;987:283-289 Authors: Katsoulaki M, Kastrinis A, Tsekoura M Abstract The aim of this paper was to review the effects of anodal transcranial direct current stimulation (tdcs) on working memory in healthy population. Ten studies were identified involving 319 subjects. Working memory performance was measured using cognitive tasks such as the n-back task, digit span forward or digit span backwards test, Sternberg WM task, the Pacet Auditory Serial Addition Task (PASAT) and the Pacet Auditory Serial Subtraction Task (PASST), verbal and visuospatial tasks and ... read more
    Pubmed – tDCS and Cognition
  • The critical role of cognitive-based trait differences in transcranial direct current stimulation (tDCS) suppression of food craving and eating in frank obesity.
    Related ArticlesThe critical role of cognitive-based trait differences in transcranial direct current stimulation (tDCS) suppression of food craving and eating in frank obesity. Appetite. 2017 Sep 01;116:568-574 Authors: Ray MK, Sylvester MD, Osborn L, Helms J, Turan B, Burgess EE, Boggiano MM Abstract Obesity remains a major public health concern and novel treatments are needed. Transcranial direct current stimulation (tDCS) is a neuromodulation technique shown to reduce food craving and consumption, especially when targeting the dorsolateral prefrontal cortex (DLPFC) with a right anode/left cathode electrode montage. Despite the implications to treat frank (non-bingeeating) obesity, no study has tested the ... read more
    Pubmed – tDCS and Cognition
  • tDCS over left M1 or DLPFC does not improve learning of a bimanual coordination task.
    Related ArticlestDCS over left M1 or DLPFC does not improve learning of a bimanual coordination task. Sci Rep. 2016 10 25;6:35739 Authors: Vancleef K, Meesen R, Swinnen SP, Fujiyama H Abstract Previously, transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has resulted in improved performance in simple motor tasks. For a complex bimanual movement, studies using functional magnetic resonance imaging and transcranial magnetic stimulation indicated the involvement of the left dorsolateral prefrontal cortex (DLPFC) as well as left M1. Here we investigated the relative effect of up-regulating the cortical function in left DLPFC and left ... read more
    Pubmed – tDCS and Cognition
  • Low to No Effect: Application of tRNS During Two-Digit Addition.
    Related ArticlesLow to No Effect: Application of tRNS During Two-Digit Addition. Front Neurosci. 2018;12:176 Authors: Bieck SM, Artemenko C, Moeller K, Klein E Abstract Transcranial electric stimulation such as transcranial random noise stimulation (tRNS) and transcranial direct current stimulation (tDCS) have been used to investigate structure-function relationships in numerical cognition. Recently, tRNS was suggested to be more effective than tDCS. However, so far there is no evidence on the differential impact of tDCS and tRNS on numerical cognition using the same experimental paradigm. In the present study, we used a two-digit addition paradigm for which significant-albeit small-effects of tDCS were ... read more
    Pubmed – tDCS and Cognition
  • Roadblocks to driving cognitive gains through transcranial electrical stimulation.
    Related ArticlesRoadblocks to driving cognitive gains through transcranial electrical stimulation. Schizophr Res. 2018 Apr 15;: Authors: Mehta UM PMID: 29669695 [PubMed - as supplied by publisher] ... read more
    Pubmed – tDCS and Cognition
  • Individual Differences and Long-term Consequences of tDCS-augmented Cognitive Training.
    Related ArticlesIndividual Differences and Long-term Consequences of tDCS-augmented Cognitive Training. J Cogn Neurosci. 2017 Sep;29(9):1498-1508 Authors: Katz B, Au J, Buschkuehl M, Abagis T, Zabel C, Jaeggi SM, Jonides J Abstract A great deal of interest surrounds the use of transcranial direct current stimulation (tDCS) to augment cognitive training. However, effects are inconsistent across studies, and meta-analytic evidence is mixed, especially for healthy, young adults. One major source of this inconsistency is individual differences among the participants, but these differences are rarely examined in the context of combined training/stimulation studies. In addition, it is unclear how long the effects of ... read more
    Pubmed – tDCS and Cognition
  • Auditory System Target Engagement During Plasticity-Based Interventions in Schizophrenia: A Focus on Modulation of N-Methyl-D-Aspartate-Type Glutamate Receptor Function.
    Related ArticlesAuditory System Target Engagement During Plasticity-Based Interventions in Schizophrenia: A Focus on Modulation of N-Methyl-D-Aspartate-Type Glutamate Receptor Function. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Feb 22;: Authors: Kantrowitz JT, Swerdlow NR, Dunn W, Vinogradov S Abstract Cognitive deficits are predictive of long-term social and occupational functional deficits in schizophrenia but are currently without gold-standard treatments. In particular, augmentation of auditory cortical neuroplasticity may represent a rate-limiting first step before addressing higher-order cognitive deficits. We review the rationale for N-methyl-d-aspartate-type glutamate receptor (NMDAR) modulators as treatments for auditory plasticity deficits in schizophrenia, along with potential serum and electroencephalographic target engagement ... read more
    Pubmed – tDCS and Cognition
  • Cognitive effects of transcranial direct current stimulation treatment in patients with major depressive disorder: an individual patient data meta-analysis of randomised, sham-controlled trials.
    Related ArticlesCognitive effects of transcranial direct current stimulation treatment in patients with major depressive disorder: an individual patient data meta-analysis of randomised, sham-controlled trials. Neurosci Biobehav Rev. 2018 Apr 13;: Authors: Martin DM, Moffa A, Nikolin S, Bennabi D, Brunoni AR, Flannery W, Haffen E, McClintock SM, Moreno ML, Padberg F, Palm U, Loo CK Abstract Transcranial direct current stimulation (tDCS) has emerged as a promising new treatment for major depression. While recent randomised, sham-controlled studies found tDCS to have antidepressant effects, it remains to be determined whether a tDCS treatment course may also enhance cognitive function independent of mood ... read more
    Pubmed – tDCS and Cognition
  • Frontotemporal stimulation modulates semantically-guided visual search during confrontation naming: A combined tDCS and eye tracking investigation.
    Frontotemporal stimulation modulates semantically-guided visual search during confrontation naming: A combined tDCS and eye tracking investigation. Brain Lang. 2018 Apr 11;180-182:14-23 Authors: Binney RJ, Ashaie SA, Zuckerman BM, Hung J, Reilly J Abstract Transcranial direct current stimulation (tDCS) was paired with eye tracking to elucidate contributions of frontal, temporoparietal and anterior temporal cortex to early visual search patterns during picture naming (e.g., rapid visual scanning to diagnostic semantic features). Neurotypical adults named line drawings of objects prior to and following tDCS in three separate sessions, each employing a unique electrode montage. The gaze data revealed montage by stimulation (pre/post) interaction ... read more
    Pubmed – tDCS and Cognition
  • Can 8 months of daily tDCS application slow the cognitive decline in Alzheimer’s disease? A case study.
    Related ArticlesCan 8 months of daily tDCS application slow the cognitive decline in Alzheimer's disease? A case study. Neurocase. 2017 Apr;23(2):146-148 Authors: Bystad M, Rasmussen ID, Grønli O, Aslaksen PM Abstract This case study presents a patient with early-onset Alzheimer`s disease, who applied transcranial direct current stimulation (tDCS) daily for 8 consecutive months. This was a much higher frequency than previous tDCS studies. Neuropsychological assessments were conducted before the first tDCS session, after 5 months and after 8 months. After 8 months, the patient's immediate recall improved with 39%, whereas delayed recall improved 23%. Overall, the results revealed that patient's cognitive functions were ... read more
    Pubmed – tDCS and Cognition