Pubmed – tDCS and Cognition

  • Evidence for modulation of planning and working memory capacities by transcranial direct current stimulation in a sample of adults with attention deficit hyperactivity disorder
    Neurosci Lett. 2022 Sep 21:136883. doi: 10.1016/j.neulet.2022.136883. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder that affects up to 2.8% of the adult population. Albeit pharmacological and behavioral therapies alleviate some core symptoms of ADHD, they do not avail cognitive dysfunction adequately. Executive dysfunction has been considered to have a principal role in ADHD and has previously been linked to activity alterations in the prefrontal cortex. Transcranial Direct Current Stimulation (tDCS) is a noninvasive brain stimulation technique that may modulate prefrontal cortex activity and induce neuroplasticity, with preliminary results in ADHD. The ... read more
    Pubmed – tDCS and CognitionBy Huzeyfe Barham
  • Does Executive Function Training Impact on Communication? A Randomized Controlled tDCS Study on Post-Stroke Aphasia
    Brain Sci. 2022 Sep 19;12(9):1265. doi: 10.3390/brainsci12091265.ABSTRACTNew approaches in aphasia rehabilitation have recently identified the crucial role of executive functions (EFs) in language recovery, especially for people with severe aphasia (PWSA). Indeed, EFs include high-order cognitive abilities such as planning and problem solving, which enable humans to adapt to novel situations and are essential for everyday functional communication. In a randomized double-blind crossover design, twenty chronic Italian PWSA underwent ten days of transcranial direct current stimulation (tDCS) (20 min, 2 mA) over the right dorsolateral prefrontal cortex (DLPFC). Two conditions were considered, i.e., anodal and sham, while performing four types ... read more
    Pubmed – tDCS and CognitionBy Francesca Pisano
  • Transcranial-Direct-Current-Stimulation Accelerates Motor Recovery After Cortical Infarction in Mice: The Interplay of Structural Cellular Responses and Functional Recovery
    Neurorehabil Neural Repair. 2022 Sep 20:15459683221124116. doi: 10.1177/15459683221124116. Online ahead of print.ABSTRACTBACKGROUND: Transcranial direct current stimulation (tDCS) promotes recovery after stroke in humans. The underlying mechanisms, however, remain to be elucidated. Animal models suggest tDCS effects on neuroinflammation, stem cell proliferation, neurogenesis, and neural plasticity.OBJECTIVE: In a longitudinal study, we employed tDCS in the subacute and chronic phase after experimental focal cerebral ischemia in mice to explore the relationship between functional recovery and cellular processes.METHODS: Mice received photothrombosis in the right motor cortex, verified by Magnetic Resonance Imaging. A composite neuroscore quantified subsequent functional deficits. Mice received tDCS daily: either ... read more
    Pubmed – tDCS and CognitionBy Helene Luise Walter
  • Non-pharmacological intervention effects on apathy caused by central nervous system organic diseases: A network meta-analysis
    Medicine (Baltimore). 2022 Sep 2;101(35):e30467. doi: 10.1097/MD.0000000000030467.ABSTRACTBACKGROUND: To evaluate the best non-pharmacological interventions on apathy in patients with central nervous system (CNS) organic diseases.METHODS: We searched PubMed, Web of Science, Embase, Cochrane Library electronic databases, China national knowledge infrastructure, Wanfang and Chinese biomedical literature database studies published from 2011 to May 29, 2021. A combination of subject words and free words were used for searching. Randomized controlled trials (RCTs) of non-pharmacological interventions for apathy in patients with central nervous organic disease were included. Two researchers independently identified the eligible RCTs and extracted information. The risk of bias within each individual ... read more
    Pubmed – tDCS and CognitionBy Shaoying Tan
  • High-definition transcranial direct current stimulation modulates theta response during a Go-NoGo task in traumatic brain injury
    Clin Neurophysiol. 2022 Aug 30;143:36-47. doi: 10.1016/j.clinph.2022.08.015. Online ahead of print.ABSTRACTOBJECTIVE: High Definition transcranial Direct Current Stimulation (HD-tDCS) has been shown to improve cognitive performance in individuals with chronic traumatic brain injury (TBI), although electrophysiological mechanisms remain unclear.METHODS: Veterans with TBI underwent active anodal (N = 15) vs sham (N = 10) HD-tDCS targeting the pre-supplementary motor area (pre-SMA). A Go-NoGo task was conducted simultaneously with electroencephalography (EEG) at baseline and after intervention completion.RESULTS: We found increased theta event-related spectral perturbation (ERSP) and inter-trial phase coherence (ITPC) during Go in the frontal midline electrodes overlying the pre-SMA after active HD-tDCS ... read more
    Pubmed – tDCS and CognitionBy Hsueh-Sheng Chiang
  • Modulation of thalamic network connectivity using transcranial direct current stimulation based on resting-state functional magnetic resonance imaging to improve hypoxia-induced cognitive impairments
    Front Neurosci. 2022 Aug 25;16:955096. doi: 10.3389/fnins.2022.955096. eCollection 2022.ABSTRACTHypoxic conditions at high altitudes severely affect cognitive functions such as vigilance, attention, and memory and reduce cognitive ability. Hence, there is a critical need to investigate methods and associated mechanisms for improving the cognitive ability of workers at high altitudes. This study aimed to use transcranial direct current stimulation (tDCS) to modulate thalamic network functional connectivity to enhance cognitive ability. We recruited 20 healthy participants that underwent hypoxia exposure in a hypoxic chamber at atmospheric pressure to simulate a hypoxic environment at 4,000 m. Participants received both sham and real stimulation. ... read more
    Pubmed – tDCS and CognitionBy Guo Dalong
  • Association of Transcranial Direct Current Stimulation and Neurofeedback With Declarative Memory and Cerebral Arterial Flow in University Students: Protocol for a Double-blind Randomized Controlled Study
    JMIR Res Protoc. 2022 Aug 26;11(8):e36294. doi: 10.2196/36294.ABSTRACTBACKGROUND: The performance of a task depends on ongoing brain activity, which can be influenced by attention, excitement, or motivation. Scientific studies have confirmed that mindfulness leads to better performance, health, and well-being. However, these cognitive efficiency modulating factors are nonspecific, can be difficult to control, and are not suitable to specifically facilitate neural processing.OBJECTIVE: The aim of this study is to evaluate the effects of transcranial direct current stimulation associated with neurofeedback on declarative memory and cerebral blood flow in university students.METHODS: In this study, we will use transcranial direct current stimulation, ... read more
    Pubmed – tDCS and CognitionBy Leandro H Grecco
  • Does concurrent self-administered transcranial direct current stimulation and attention bias modification training improve symptoms of binge eating disorder? Protocol for the TANDEM feasibility randomized controlled trial
    Front Psychiatry. 2022 Aug 3;13:949246. doi: 10.3389/fpsyt.2022.949246. eCollection 2022.ABSTRACTBACKGROUND: Binge eating disorder (BED) is a common and disabling problem associated with impaired cognitive control. Preliminary studies show that brain-directed treatments, including transcranial direct current stimulation (tDCS) and attention bias modification training (ABMT), improve cognitive control and alleviate symptoms of BED. When combined, tDCS may enhance the effects of ABMT, and vice versa, thereby improving treatment outcomes.METHODS: This protocol describes a feasibility single-blind randomized sham-controlled trial of concurrent self-administered tDCS and ABMT in adults with BED (The TANDEM Trial). Eighty adults with BED will be randomly assigned to one of four ... read more
    Pubmed – tDCS and CognitionBy Michaela Flynn
  • Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation
    Nat Neurosci. 2022 Sep;25(9):1237-1246. doi: 10.1038/s41593-022-01132-3. Epub 2022 Aug 22.ABSTRACTThe development of technologies to protect or enhance memory in older people is an enduring goal of translational medicine. Here we describe repetitive (4-day) transcranial alternating current stimulation (tACS) protocols for the selective, sustainable enhancement of auditory-verbal working memory and long-term memory in 65-88-year-old people. Modulation of synchronous low-frequency, but not high-frequency, activity in parietal cortex preferentially improved working memory on day 3 and day 4 and 1 month after intervention, whereas modulation of synchronous high-frequency, but not low-frequency, activity in prefrontal cortex preferentially improved long-term memory on days 2-4 and ... read more
    Pubmed – tDCS and CognitionBy Shrey Grover
  • Neuromodulating the performance monitoring network during conflict and error processing in healthy populations: Insights from transcranial electric stimulation studies
    Front Integr Neurosci. 2022 Jul 22;16:953928. doi: 10.3389/fnint.2022.953928. eCollection 2022.ABSTRACTThe performance monitoring system is fundamentally important for adapting one's own behavior in conflicting and error-prone, highly demanding circumstances. Flexible behavior requires that neuronal populations optimize information processing through efficient multi-scale communication. Non-invasive brain stimulation (NIBS) studies using transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES) fields to alter the cortical activity promise to illuminate the neurophysiological mechanisms that underpin neuro-cognitive and behavioral processing and their causal relationship. Here, we focus on the transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) that have been increasingly used in ... read more
    Pubmed – tDCS and CognitionBy Gabriele Fusco