PubMed Title/Abstract/PubDate – tDCS & Learning

  • Bimanual Skill Learning after Transcranial Direct Current Stimulation in Children with Unilateral Cerebral Palsy: A Brief Report.
    Bimanual Skill Learning after Transcranial Direct Current Stimulation in Children with Unilateral Cerebral Palsy: A Brief Report. Dev Neurorehabil. 2019 Apr 03;:1-5 Authors: Nemanich ST, Rich TL, Gordon AM, Friel KM, Gillick BT Abstract Bimanual skills are important for goal-oriented activities. Children with unilateral cerebral palsy (UCP) have deficits in unimanual and bimanual motor control and learning. The application of non-invasive brain stimulation with existing motor training may further promote motor learning; however, the effects of stimulation on bimanual learning have not been examined. Here, we assessed the performance of a novel bimanual skill (modified Speed Stacks task) in eight ... read more
    2 weeks ago
  • Noninvasive brain stimulation over M1 and DLPFC cortex enhances the learning of bimanual isometric force control.
    Related ArticlesNoninvasive brain stimulation over M1 and DLPFC cortex enhances the learning of bimanual isometric force control. Hum Mov Sci. 2019 Mar 25;66:73-83 Authors: Jin Y, Lee J, Kim S, Yoon B Abstract Motor learning plays an important role in upper-limb function and the recovery of lost functionality. This study aimed to investigate the relative impact of transcranial direct current stimulation (tDCS) on learning in relation to the left primary motor cortex (M1) and left dorsolateral prefrontal cortex (DLPFC) during bimanual isometric force-control tasks performed with both hands under different task constraints. In a single-blind cross-over design, 20 right-handed participants ... read more
    3 weeks ago
  • Differential Effects of Left and Right Prefrontal Cortex Anodal Transcranial Direct Current Stimulation during Probabilistic Sequence Learning.
    Related ArticlesDifferential Effects of Left and Right Prefrontal Cortex Anodal Transcranial Direct Current Stimulation during Probabilistic Sequence Learning. J Neurophysiol. 2019 Mar 27;: Authors: Greeley B, Seidler RD Abstract Left and right prefrontal cortex and the primary motor cortex (M1) are activated during learning of motor sequences. Previous literature is mixed on whether prefrontal cortex aids or interferes with sequence learning. The present study investigated the roles of prefrontal cortices and M1 in sequence learning. Participants received anodal transcranial direct current stimulation (tDCS) to right or left prefrontal cortex or left M1 during a probabilistic sequence learning task. Relative to ... read more
    3 weeks ago
  • Neurostimulation Reveals Context-Dependent Arbitration Between Model-Based and Model-Free Reinforcement Learning.
    Related ArticlesNeurostimulation Reveals Context-Dependent Arbitration Between Model-Based and Model-Free Reinforcement Learning. Cereb Cortex. 2019 Mar 19;: Authors: Weissengruber S, Lee SW, O'Doherty JP, Ruff CC Abstract While it is established that humans use model-based (MB) and model-free (MF) reinforcement learning in a complementary fashion, much less is known about how the brain determines which of these systems should control behavior at any given moment. Here we provide causal evidence for a neural mechanism that acts as a context-dependent arbitrator between both systems. We applied excitatory and inhibitory transcranial direct current stimulation over a region of the left ventrolateral prefrontal cortex ... read more
    4 weeks ago
  • Increased perseverative errors following high-definition transcranial direct current stimulation over the ventrolateral cortex during probabilistic reversal learning.
    Related ArticlesIncreased perseverative errors following high-definition transcranial direct current stimulation over the ventrolateral cortex during probabilistic reversal learning. Brain Stimul. 2019 Feb 21;: Authors: Albein-Urios N, Chase H, Clark L, Kirkovski M, Davies C, Enticott PG Abstract BACKGROUND: The prefrontal cortex regulates behavioural adaptation in response to feedback. However, the causal role of different prefrontal regions remains unclear, based on indirect evidence derived from functional neuroimaging. Neuroimaging studies show dorsomedial prefrontal activation during feedback monitoring, whereas the ventrolateral prefrontal cortex engages during behavioural adaptation (shifting). OBJECTIVE: We used high-definition transcranial direct current stimulation (HD-tDCS) to elucidate the roles of the ... read more
    1 month ago
  • Differential effects of bihemispheric and unihemispheric transcranial direct current stimulation in young and elderly adults in verbal learning.
    Related ArticlesDifferential effects of bihemispheric and unihemispheric transcranial direct current stimulation in young and elderly adults in verbal learning. Behav Brain Res. 2017 03 15;321:170-175 Authors: Fiori V, Nitsche M, Iasevoli L, Cucuzza G, Caltagirone C, Marangolo P Abstract For the past few years, the potential of transcranial direct current stimulation (tDCS) for the treatment of several pathologies has been investigated. In the language domain, several studies, in healthy and brain-damaged populations, have already shown that tDCS is effective in enhancing naming, repetition and semantic word generation. In those studies, different tDCS electrode configurations have been tested, however, a ... read more
    2 months ago
  • Impact of transcranial direct current stimulation on somatosensory transfer learning: When the secondary somatosensory cortex comes into play.
    Related ArticlesImpact of transcranial direct current stimulation on somatosensory transfer learning: When the secondary somatosensory cortex comes into play. Brain Res. 2018 06 15;1689:98-108 Authors: Hirtz R, Weiss T, Huonker R, Witte OW Abstract Transfer learning is an immanent feature of perceptual learning. Yet, despite the increasingly widespread application of transcranial direct current stimulation (tDCS) to study learning, transfer effects in response to tDCS have not been studied. Therefore, the present study investigated the transfer of tactile acuity evoked by repeatedly applied anodal tDCS over the left primary somatosensory cortex (S1) over the course of five days from the ... read more
    2 months ago
  • Cerebellar transcranial direct current stimulation interacts with BDNF Val66Met in motor learning.
    Related ArticlesCerebellar transcranial direct current stimulation interacts with BDNF Val66Met in motor learning. Brain Stimul. 2018 Jul - Aug;11(4):759-771 Authors: van der Vliet R, Jonker ZD, Louwen SC, Heuvelman M, de Vreede L, Ribbers GM, De Zeeuw CI, Donchin O, Selles RW, van der Geest JN, Frens MA Abstract BACKGROUND: Cerebellar transcranial direct current stimulation has been reported to enhance motor associative learning and motor adaptation, holding promise for clinical application in patients with movement disorders. However, behavioral benefits from cerebellar tDCS have been inconsistent. OBJECTIVE: Identifying determinants of treatment success is necessary. BDNF Val66Met is a candidate ... read more
    2 months ago
  • Null tDCS Effects in a Sustained Attention Task: The Modulating Role of Learning.
    Related ArticlesNull tDCS Effects in a Sustained Attention Task: The Modulating Role of Learning. Front Psychol. 2018;9:476 Authors: Jacoby N, Lavidor M Abstract The purpose of this study was to investigate sustained attention through modulation of the fronto-cerebral network with transcranial direct current stimulation (tDCS) in adults with attention-deficit/hyperactivity disorder (ADHD) and control participants. Thirty-seven participants (21 with ADHD) underwent three separate sessions (baseline, active tDCS, and sham) and performed the MOXO Continuous Performance Test (CPT). We applied double anodal stimulation of 1.8 mA tDCS for 20 min over the left and right dorsolateral prefrontal cortex (DLPFC), with ... read more
    2 months ago
  • Transcranial Direct Current Stimulation Enhances Motor Skill Learning but Not Generalization in Chronic Stroke.
    Related ArticlesTranscranial Direct Current Stimulation Enhances Motor Skill Learning but Not Generalization in Chronic Stroke. Neurorehabil Neural Repair. 2018 Apr-May;32(4-5):295-308 Authors: Hamoudi M, Schambra HM, Fritsch B, Schoechlin-Marx A, Weiller C, Cohen LG, Reis J Abstract BACKGROUND: Motor training alone or combined with transcranial direct current stimulation (tDCS) positioned over the motor cortex (M1) improves motor function in chronic stroke. Currently, understanding of how tDCS influences the process of motor skill learning after stroke is lacking. OBJECTIVE: To assess the effects of tDCS on the stages of motor skill learning and on generalization to untrained motor function. METHODS: In ... read more
    2 months ago
  • A Preliminary Comparison of Motor Learning Across Different Non-invasive Brain Stimulation Paradigms Shows No Consistent Modulations.
    Related ArticlesA Preliminary Comparison of Motor Learning Across Different Non-invasive Brain Stimulation Paradigms Shows No Consistent Modulations. Front Neurosci. 2018;12:253 Authors: Lopez-Alonso V, Liew SL, Fernández Del Olmo M, Cheeran B, Sandrini M, Abe M, Cohen LG Abstract Non-invasive brain stimulation (NIBS) has been widely explored as a way to safely modulate brain activity and alter human performance for nearly three decades. Research using NIBS has grown exponentially within the last decade with promising results across a variety of clinical and healthy populations. However, recent work has shown high inter-individual variability and a lack of reproducibility of previous ... read more
    2 months ago
  • Individual differences in learning correlate with modulation of brain activity induced by transcranial direct current stimulation.
    Related ArticlesIndividual differences in learning correlate with modulation of brain activity induced by transcranial direct current stimulation. PLoS One. 2018;13(5):e0197192 Authors: Falcone B, Wada A, Parasuraman R, Callan DE Abstract Transcranial direct current stimulation (tDCS) has been shown to enhance cognitive performance on a variety of tasks. It is hypothesized that tDCS enhances performance by affecting task related cortical excitability changes in networks underlying or connected to the site of stimulation facilitating long term potentiation. However, many recent studies have called into question the reliability and efficacy of tDCS to induce modulatory changes in brain activity. In this ... read more
    2 months ago
  • Anodal tDCS over Primary Motor Cortex Provides No Advantage to Learning Motor Sequences via Observation.
    Related ArticlesAnodal tDCS over Primary Motor Cortex Provides No Advantage to Learning Motor Sequences via Observation. Neural Plast. 2018;2018:1237962 Authors: Apšvalka D, Ramsey R, Cross ES Abstract When learning a new motor skill, we benefit from watching others. It has been suggested that observation of others' actions can build a motor representation in the observer, and as such, physical and observational learning might share a similar neural basis. If physical and observational learning share a similar neural basis, then motor cortex stimulation during observational practice should similarly enhance learning by observation as it does through physical practice. Here, ... read more
    2 months ago
  • Transcranial direct current stimulation (tDCS) facilitates verb learning by altering effective connectivity in the healthy brain.
    Related ArticlesTranscranial direct current stimulation (tDCS) facilitates verb learning by altering effective connectivity in the healthy brain. Neuroimage. 2018 11 01;181:550-559 Authors: Fiori V, Kunz L, Kuhnke P, Marangolo P, Hartwigsen G Abstract Recent studies have shown that the left inferior frontal gyrus (IFG) plays a key role in language learning. Facilitatory stimulation over this region by means of anodal transcranial direct current stimulation (tDCS) can modulate linguistic abilities in healthy individuals and improve language performance in patients with post-stroke aphasia. Neuroimaging studies in healthy participants have suggested that anodal tDCS decreases task-related activity at the stimulated site when ... read more
    2 months ago
  • Anodal Transcranial Direct Current Stimulation (tDCS) Over the Right Primary Motor Cortex (M1) Impairs Implicit Motor Sequence Learning of the Ipsilateral Hand.
    Related ArticlesAnodal Transcranial Direct Current Stimulation (tDCS) Over the Right Primary Motor Cortex (M1) Impairs Implicit Motor Sequence Learning of the Ipsilateral Hand. Front Hum Neurosci. 2018;12:289 Authors: Keitel A, Øfsteng H, Krause V, Pollok B Abstract Motor sequence learning is associated with the activation of bilateral primary motor cortices (M1). While previous data support the hypothesis that the contralateral M1 is causally involved in the acquisition as well as early consolidation of a motor sequence, the functional significance of the ipsilateral M1 has yet to be solved. Transcranial direct current stimulation (tDCS) allows the non-invasive modulation of ... read more
    2 months ago
  • Effect of acute exposure to toluene on cortical excitability, neuroplasticity, and motor learning in healthy humans.
    Related ArticlesEffect of acute exposure to toluene on cortical excitability, neuroplasticity, and motor learning in healthy humans. Arch Toxicol. 2018 Oct;92(10):3149-3162 Authors: Yavari F, van Thriel C, Nitsche MA, Kuo MF Abstract Toluene is a well-known neurotoxic organic solvent and a major component of many industrial and commercial products such as adhesives, paint thinners and gasoline. Many workers are regularly exposed to toluene in their working environment and occupational exposure limits (OELs) have been set to avoid adverse health effects. These OELs or short-term exposure limits vary from 14 to 300 ppm across countries partly due to heterogeneity of the ... read more
    2 months ago
  • The role of experience-based perceptual learning in the face inversion effect.
    Related ArticlesThe role of experience-based perceptual learning in the face inversion effect. Vision Res. 2018 Apr 03;: Authors: Civile C, Obhi SS, McLaren IPL Abstract Perceptual learning of the type we consider here is a consequence of experience with a class of stimuli. It amounts to an enhanced ability to discriminate between stimuli. We argue that it contributes to the ability to distinguish between faces and recognize individuals, and in particular contributes to the face inversion effect (better recognition performance for upright vs inverted faces). Previously, we have shown that experience with a prototype defined category of checkerboards leads ... read more
    2 months ago
  • How we can change your mind: Anodal tDCS to Fp3 alters human stimulus representation and learning.
    Related ArticlesHow we can change your mind: Anodal tDCS to Fp3 alters human stimulus representation and learning. Neuropsychologia. 2018 10;119:241-246 Authors: Civile C, McLaren R, McLaren IPL Abstract The aim of the current work is to advance our understanding of both the mechanisms controlling perceptual learning and the face inversion effect. In the three double blind experiments reported here (total N = 144) we have shown that anodal tDCS stimulation (10 min at 1.5 mA) delivered over the left DLPFC at Fp3 affects perceptual learning and drastically reduces the, usually robust, face inversion effect. In Experiment 1, we found a significantly reduced inversion ... read more
    2 months ago
  • Variable Neural Contributions to Explicit and Implicit Learning During Visuomotor Adaptation.
    Related ArticlesVariable Neural Contributions to Explicit and Implicit Learning During Visuomotor Adaptation. Front Neurosci. 2018;12:610 Authors: Liew SL, Thompson T, Ramirez J, Butcher PA, Taylor JA, Celnik PA Abstract We routinely make fine motor adjustments to maintain optimal motor performance. These adaptations have been attributed to both implicit, error-based mechanisms, and explicit, strategy-based mechanisms. However, little is known about the neural basis of implicit vs. explicit learning. Here, we aimed to use anodal transcranial direct current stimulation (tDCS) to probe the relationship between different brain regions and learning mechanisms during a visuomotor adaptation task in humans. We hypothesized ... read more
    2 months ago
  • GABA, not BOLD, reveals dissociable learning-dependent plasticity mechanisms in the human brain.
    Related ArticlesGABA, not BOLD, reveals dissociable learning-dependent plasticity mechanisms in the human brain. Elife. 2018 10 25;7: Authors: Frangou P, Correia M, Kourtzi Z Abstract Experience and training have been shown to facilitate our ability to extract and discriminate meaningful patterns from cluttered environments. Yet, the human brain mechanisms that mediate our ability to learn by suppressing noisy and irrelevant signals remain largely unknown. To test the role of suppression in perceptual learning, we combine fMRI with MR Spectroscopy measurements of GABA, as fMRI alone does not allow us to discern inhibitory vs. excitatory mechanisms. Our results demonstrate ... read more
    2 months ago
  • Motor Learning Improvement Remains 3 Months After a Multisession Anodal tDCS Intervention in an Aging Population.
    Related ArticlesMotor Learning Improvement Remains 3 Months After a Multisession Anodal tDCS Intervention in an Aging Population. Front Aging Neurosci. 2018;10:335 Authors: Dumel G, Bourassa ME, Charlebois-Plante C, Desjardins M, Doyon J, Saint-Amour D, De Beaumont L Abstract Healthy aging is associated with decline of motor function that can generate serious consequences on the quality of life and safety. Our studies aim to explore the 3-month effects of a 5-day multisession anodal transcranial direct current stimulation (a-tDCS) protocol applied over the primary motor cortex (M1) during motor sequence learning in elderly. The present sham-controlled aging study investigated whether ... read more
    2 months ago
  • Effects of High-Definition and Conventional Transcranial Direct-Current Stimulation on Motor Learning in Children.
    Related ArticlesEffects of High-Definition and Conventional Transcranial Direct-Current Stimulation on Motor Learning in Children. Front Neurosci. 2018;12:787 Authors: Cole L, Giuffre A, Ciechanski P, Carlson HL, Zewdie E, Kuo HC, Kirton A Abstract Background: Transcranial direct current stimulation (tDCS) can improve motor learning in children. High-definition approaches (HD-tDCS) have not been examined in children. Objectives/Hypothesis: We hypothesized that primary motor cortex HD-tDCS would enhance motor learning but be inferior to tDCS in children. Methods: Twenty-four children were recruited for a randomized, sham-controlled, double-blinded interventional trial (NCT03193580, clinicaltrials.gov/ct2/show/NCT03193580) to receive (1) right hemisphere (contralateral) primary motor cortex (M1) 1 ... read more
    2 months ago
  • The Role of Frontostriatal Systems in Instructed Reinforcement Learning: Evidence From Genetic and Experimentally-Induced Variation.
    Related ArticlesThe Role of Frontostriatal Systems in Instructed Reinforcement Learning: Evidence From Genetic and Experimentally-Induced Variation. Front Hum Neurosci. 2018;12:472 Authors: Tardiff N, Graves KN, Thompson-Schill SL Abstract Instructions have a powerful effect on learning and decision-making, biasing choice even in the face of disconfirming feedback. Detrimental biasing effects have been reported in a number of studies in which instruction was given prior to trial-and-error learning. Previous work has attributed individual differences in instructional bias to variations in prefrontal and striatal dopaminergic genes, suggesting a role for prefrontally-mediated cognitive control processes in biasing learning. The current study replicates ... read more
    2 months ago
  • Using tDCS to facilitate motor learning in speech production: The role of timing.
    Related ArticlesUsing tDCS to facilitate motor learning in speech production: The role of timing. Cortex. 2019 Feb;111:274-285 Authors: Buchwald A, Calhoun H, Rimikis S, Lowe MS, Wellner R, Edwards DJ Abstract There exists debate regarding the extent to which transcranial direct current stimulation (tDCS) can affect or enhance human behavior. Here, we examined a previously unexplored domain: speech motor learning. We investigated whether speech motor learning in unimpaired participants can be enhanced using a single-session tDCS experiment, and investigated whether the timing of tDCS relative to a behavioral task affected performance. Participants (N = 80) performed a twenty minute learning task ... read more
    2 months ago
  • Non-linear effects of cathodal transcranial direct current stimulation (tDCS) of the primary motor cortex on implicit motor learning.
    Related ArticlesNon-linear effects of cathodal transcranial direct current stimulation (tDCS) of the primary motor cortex on implicit motor learning. Exp Brain Res. 2019 Jan 19;: Authors: Shilo G, Lavidor M Abstract Transcranial direct current stimulation (tDCS) of 1 mA for 13 min was reported to create a linear inter-dependency between the intensity and duration of the current and the effects of the stimulation. tDCS on the primary motor cortex (M1) has been shown to have an effect on both motor-evoked potential (MEP) and motor learning. However, recent findings have shown that the known linear effect is invalid in a 2 mA stimulation ... read more
    2 months ago
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