Promising Scientific Studies on Transcranial Direct Current Stimulation

  • Randomized trial of transcranial alternating current stimulation for treatment of auditory hallucinations in schizophrenia.
    Related ArticlesRandomized trial of transcranial alternating current stimulation for treatment of auditory hallucinations in schizophrenia. Eur Psychiatry. 2018 06;51:25-33 Authors: Mellin JM, Alagapan S, Lustenberger C, Lugo CE, Alexander ML, Gilmore JH, Jarskog LF, Fröhlich F Abstract BACKGROUND: Approximately 30% of patients with schizophrenia experience auditory hallucinations that are refractory to antipsychotic medications. Here, we evaluated the feasibility and efficacy of transcranial alternating current stimulation (tACS) that we hypothesized would improve auditory hallucination symptoms by enhancing synchronization between the frontal and temporo-parietal areas of the left hemisphere. METHOD: 22 participants were randomized to one of three arms and received ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
  • Differential effects of high-frequency transcranial random noise stimulation (hf-tRNS) on contrast sensitivity and visual acuity when combined with a short perceptual training in adults with amblyopia.
    Related ArticlesDifferential effects of high-frequency transcranial random noise stimulation (hf-tRNS) on contrast sensitivity and visual acuity when combined with a short perceptual training in adults with amblyopia. Neuropsychologia. 2018 06;114:125-133 Authors: Moret B, Camilleri R, Pavan A, Lo Giudice G, Veronese A, Rizzo R, Campana G Abstract Amblyopia is a neuro-developmental disorder characterised by several functional impairments in spatial vision even with the best optical correction. There is evidence that extensive perceptual training can improve visual acuity (VA) and contrast sensitivity (CS) in adults with amblyopia. In the present study, we assessed the efficacy of a recently developed neuro-modulatory ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
  • Modulating the excitability of the visual cortex using a stimulation priming paradigm.
    Related ArticlesModulating the excitability of the visual cortex using a stimulation priming paradigm. Neuropsychologia. 2018 10;119:165-171 Authors: Herpich F, Contò F, van Koningsbruggen M, Battelli L Abstract BACKGROUND: Transcranial random noise stimulation (tRNS) can cause long term increase of corticospinal excitability when used to prime the motor cortex, before measuring the motor response in the hand muscles with TMS (Terney et al., 2008). In cognitive studies, tRNS has been used to improve visual attention and mathematical skills, an enhancement effect that might suggest sustained cortical plasticity changes (Cappelletti et al., 2013; Snowball et al., 2013). However, while the behavioral ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
  • Noninvasive brain stimulation combined with other therapies improves gait speed after stroke: a systematic review and meta-analysis.
    Related ArticlesNoninvasive brain stimulation combined with other therapies improves gait speed after stroke: a systematic review and meta-analysis. Top Stroke Rehabil. 2019 Feb 08;:1-13 Authors: Vaz PG, Salazar APDS, Stein C, Marchese RR, Lukrafka JL, Plentz RDM, Pagnussat AS Abstract BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are noninvasive brain stimulation (NIBS) techniques able to modulate cortical excitability. OBJECTIVE: To determine the effects of NIBS combined with other therapies on gait speed after stroke. METHODS: Electronic databases searched were PUBMED, EMBASE, COCHRANE, SCOPUS, SCIELO and PEDro. Eligibility criteria were randomized controlled trials that reported ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
  • Brain-state determines learning improvements after transcranial alternating-current stimulation to frontal cortex.
    Related ArticlesBrain-state determines learning improvements after transcranial alternating-current stimulation to frontal cortex. Brain Stimul. 2018 Jul - Aug;11(4):723-726 Authors: Nguyen J, Deng Y, Reinhart RMG Abstract BACKGROUND: Theories of executive control propose that communication between medial frontal cortex (MFC) and lateral prefrontal cortex (lPFC) is critical for learning. 6-Hz phase synchronization may be the mechanism by which neural activity between MFC and lPFC is coordinated into a functional network. Recent evidence suggests that switching from eyes closed to open may induce a change in brain-state reflected by enhanced executive control and related functional connectivity. OBJECTIVE/HYPOTHESIS: To examine whether causal ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
  • After-effects of repetitive anodal transcranial direct current stimulation on learning and memory in a rat model of Alzheimer’s disease.
    Related ArticlesAfter-effects of repetitive anodal transcranial direct current stimulation on learning and memory in a rat model of Alzheimer's disease. Neurobiol Learn Mem. 2019 Feb 05;: Authors: Yang WJ, Wen HZ, Zhou LX, Luo YP, Hou WS, Xing W, Tian XL Abstract Repetitive anodal transcranial direct current stimulation (tDCS) in a rat model of Alzheimer's disease (AD) has been shown to have distinct neuroprotective effects. Moreover, the effects of anodal tDCS not only occur during the stimulation but also persist after the stimulation has ended (after-effects). Here, the duration of the after-effects induced by repetitive anodal tDCS was investigated ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
  • On the importance of precise electrode placement for targeted transcranial electric stimulation.
    Related ArticlesOn the importance of precise electrode placement for targeted transcranial electric stimulation. Neuroimage. 2018 11 01;181:560-567 Authors: Opitz A, Yeagle E, Thielscher A, Schroeder C, Mehta AD, Milham MP Abstract Transcranial electric stimulation (TES) is an increasingly popular method for non-invasive modulation of brain activity and a potential treatment for neuropsychiatric disorders. However, there are concerns about the reliability of its application because of variability in TES-induced intracranial electric fields across individuals. While realistic computational models offer can help to alleviate these concerns, their direct empirical validation is sparse, and their practical implications are not always clear. In ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
  • Effects of alpha and gamma transcranial alternating current stimulation (tACS) on verbal creativity and intelligence test performance.
    Related ArticlesEffects of alpha and gamma transcranial alternating current stimulation (tACS) on verbal creativity and intelligence test performance. Neuropsychologia. 2018 09;118(Pt A):91-98 Authors: Grabner RH, Krenn J, Fink A, Arendasy M, Benedek M Abstract Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation method that allows to directly modulate brain oscillations of a given frequency. Using this method, it was recently shown that increasing alpha (10Hz) oscillations improved creative ideation with figural material and that increasing gamma (40Hz) oscillations speeded up performance in a figural matrices intelligence task. The aim of the present study was to examine whether ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
  • Frequency-dependent tACS modulation of BOLD signal during rhythmic visual stimulation.
    Related ArticlesFrequency-dependent tACS modulation of BOLD signal during rhythmic visual stimulation. Hum Brain Mapp. 2018 05;39(5):2111-2120 Authors: Chai Y, Sheng J, Bandettini PA, Gao JH Abstract Transcranial alternating current stimulation (tACS) has emerged as a promising tool for modulating cortical oscillations. In previous electroencephalogram (EEG) studies, tACS has been found to modulate brain oscillatory activity in a frequency-specific manner. However, the spatial distribution and hemodynamic response for this modulation remains poorly understood. Functional magnetic resonance imaging (fMRI) has the advantage of measuring neuronal activity in regions not only below the tACS electrodes but also across the whole brain ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
  • Targeting alpha-band oscillations in a cortical model with amplitude-modulated high-frequency transcranial electric stimulation.
    Related ArticlesTargeting alpha-band oscillations in a cortical model with amplitude-modulated high-frequency transcranial electric stimulation. Neuroimage. 2018 06;173:3-12 Authors: Negahbani E, Kasten FH, Herrmann CS, Fröhlich F Abstract Non-invasive brain stimulation to target specific network activity patterns, e.g. transcranial alternating current stimulation (tACS), has become an essential tool to understand the causal role of neuronal oscillations in cognition and behavior. However, conventional sinusoidal tACS limits the ability to record neuronal activity during stimulation and lacks spatial focality. One particularly promising new tACS stimulation paradigm uses amplitude-modulated (AM) high-frequency waveforms (AM-tACS) with a slow signal envelope that may overcome the limitations. ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
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