Scientific Studies on tDCS and Learning

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Scientific Studies Related to tDCS and Learning

This collection of articles was sourced from PubMed.gov

As of Dec. 29th, we found 548 articles focusing on tDCS and Learning

  • Effects of anodal transcranial direct current stimulation on cognitive dysfunction in patients with progressive supranuclear palsy.
    Related ArticlesEffects of anodal transcranial direct current stimulation on cognitive dysfunction in patients with progressive supranuclear palsy. Psychiatriki. 2019 Oct-Dec;30(4):320-328 Authors: Alexoudi A, Patrikelis P, Deftereos S, Fasilis T, Karakalos D, Verentzioti A, Korfias S, Sakas D, Gatzonis S Abstract Progressive supranuclear palsy (PSP) is a tauopathy characterized by motor, neurobehavioral and disabling brainstem deficits. No disease-modifying therapeutic options exist. The therapeutic potential of transcranial direct current stimulation (tDCS) has been highlighted in studies on patients with other neurodegenerative diseases. Therefore, by drawing upon the limited tDCS literature on PSP, we conducted a pilot study in order to evaluate the ... read more
    4 days ago
  • Randomized controlled trial of TDCS on cognition in 201 seniors with mild neurocognitive disorder.
    Related ArticlesRandomized controlled trial of TDCS on cognition in 201 seniors with mild neurocognitive disorder. Ann Clin Transl Neurol. 2019 10;6(10):1938-1948 Authors: Lu H, Chan SSM, Chan WC, Lin C, Cheng CPW, Linda Chiu Wa L Abstract OBJECTIVE: To examine the efficacy and safety of combined transcranial direct current stimulation (tDCS) and working memory training (WMT) in enhancing the cognitive functions for individuals with mild neurocognitive disorder due to AD (NCD-AD). METHODS: In this double-blind, sham-controlled randomized clinical trial (RCT), 201 patients with NCD-AD were randomly assigned for a 4-week intervention of either a combination of tDCS and ... read more
    2 weeks ago
  • Precision non-implantable neuromodulation therapies: a perspective for the depressed brain.
    Related ArticlesPrecision non-implantable neuromodulation therapies: a perspective for the depressed brain. Braz J Psychiatry. 2020 08;42(4):403-419 Authors: Borrione L, Bellini H, Razza LB, Avila AG, Baeken C, Brem AK, Busatto G, Carvalho AF, Chekroud A, Daskalakis ZJ, Deng ZD, Downar J, Gattaz W, Loo C, Lotufo PA, Martin MDGM, McClintock SM, O'Shea J, Padberg F, Passos IC, Salum GA, Vanderhasselt MA, Fraguas R, Benseñor I, Valiengo L, Brunoni AR Abstract Current first-line treatments for major depressive disorder (MDD) include pharmacotherapy and cognitive-behavioral therapy. However, one-third of depressed patients do not achieve remission after multiple medication trials, and psychotherapy ... read more
    2 weeks ago
  • No effects of cerebellar transcranial direct current stimulation on force field and visuomotor reach adaptation in young and healthy subjects.
    Related ArticlesNo effects of cerebellar transcranial direct current stimulation on force field and visuomotor reach adaptation in young and healthy subjects. J Neurophysiol. 2019 06 01;121(6):2112-2125 Authors: Mamlins A, Hulst T, Donchin O, Timmann D, Claassen J Abstract Previous studies have shown that cerebellar transcranial direct current stimulation (tDCS) leads to faster adaptation of arm reaching movements to visuomotor rotation and force field perturbations in healthy subjects. The first aim of the present study was to confirm a stimulation-dependent effect on motor adaptation. Second, we investigated whether tDCS effects differ depending on onset, that is, before or at the ... read more
    4 weeks ago
  • Transcranial direct current stimulation facilitates category learning.
    Related ArticlesTranscranial direct current stimulation facilitates category learning. Brain Stimul. 2020 Mar - Apr;13(2):393-400 Authors: Gibson BC, Mullins TS, Heinrich MD, Witkiewitz K, Yu AB, Hansberger JT, Clark VP Abstract BACKGROUND: After two decades of transcranial direct current stimulation (tDCS) research, it is still unclear which applications benefit most from which tDCS protocols. One prospect is the acceleration of learning, where previous work has demonstrated that anodal tDCS applied to the right ventrolateral prefrontal cortex (rVLPFC) is capable of doubling the rate of learning in a visual camouflaged threat detection and category learning task. GOALS: Questions remain as ... read more
    4 weeks ago
  • Anodal Transcranial Direct Current Stimulation to the Left Rostrolateral Prefrontal Cortex Selectively Improves Source Memory Retrieval.
    Related ArticlesAnodal Transcranial Direct Current Stimulation to the Left Rostrolateral Prefrontal Cortex Selectively Improves Source Memory Retrieval. J Cogn Neurosci. 2019 09;31(9):1380-1391 Authors: Westphal AJ, Chow TE, Ngoy C, Zuo X, Liao V, Storozuk LA, Peters MAK, Wu AD, Rissman J Abstract Functional neuroimaging studies have consistently implicated the left rostrolateral prefrontal cortex (RLPFC) as playing a crucial role in the cognitive operations supporting episodic memory and analogical reasoning. However, the degree to which the left RLPFC causally contributes to these processes remains underspecified. We aimed to assess whether targeted anodal stimulation-thought to boost cortical excitability-of the left RLPFC with ... read more
    1 month ago
  • Direct current stimulation boosts hebbian plasticity in vitro.
    Related ArticlesDirect current stimulation boosts hebbian plasticity in vitro. Brain Stimul. 2020 Mar - Apr;13(2):287-301 Authors: Kronberg G, Rahman A, Sharma M, Bikson M, Parra LC Abstract BACKGROUND: There is evidence that transcranial direct current stimulation (tDCS) can improve learning performance. Arguably, this effect is related to long term potentiation (LTP), but the precise biophysical mechanisms remain unknown. HYPOTHESIS: We propose that direct current stimulation (DCS) causes small changes in postsynaptic membrane potential during ongoing endogenous synaptic activity. The altered voltage dynamics in the postsynaptic neuron then modify synaptic strength via the machinery of endogenous voltage-dependent Hebbian plasticity. This ... read more
    1 month ago
  • Anodal Transcranial Direct Current Stimulation Can Improve Spatial Learning and Memory and Attenuate Aβ42 Burden at the Early Stage of Alzheimer’s Disease in APP/PS1 Transgenic Mice.
    Related ArticlesAnodal Transcranial Direct Current Stimulation Can Improve Spatial Learning and Memory and Attenuate Aβ42 Burden at the Early Stage of Alzheimer's Disease in APP/PS1 Transgenic Mice. Front Aging Neurosci. 2020;12:134 Authors: Luo Y, Yang W, Li N, Yang X, Zhu B, Wang C, Hou W, Wang X, Wen H, Tian X Abstract Alzheimer's disease (AD) is an irreversible progressive neurodegenerative disease. Intervention in the early stage of AD is a new path for AD treatment that is being explored. The behavioral and pathological effects of anodal transcranial direct current stimulation (AtDCS) at the early stage of AD ... read more
    3 months ago
  • Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes.
    Related ArticlesBeyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes. J Neuroeng Rehabil. 2019 11 15;16(1):141 Authors: Morya E, Monte-Silva K, Bikson M, Esmaeilpour Z, Biazoli CE, Fonseca A, Bocci T, Farzan F, Chatterjee R, Hausdorff JM, da Silva Machado DG, Brunoni AR, Mezger E, Moscaleski LA, Pegado R, Sato JR, Caetano MS, Sá KN, Tanaka C, Li LM, Baptista AF, Okano AH Abstract Transcranial Direct Current Stimulation (tDCS) is a non-invasive technique used to modulate neural tissue. Neuromodulation apparently improves cognitive functions in several neurologic diseases treatment and sports performance. ... read more
    4 months ago
  • Direct current stimulation-induced synaptic plasticity in the sensorimotor cortex: structure follows function.
    Related ArticlesDirect current stimulation-induced synaptic plasticity in the sensorimotor cortex: structure follows function. Brain Stimul. 2020 Jan - Feb;13(1):80-88 Authors: Gellner AK, Reis J, Holtick C, Schubert C, Fritsch B Abstract BACKGROUND: Non-invasive direct current stimulation (DCS) of the brain induces functional plasticity in vitro and facilitates motor learning across species. The effect of DCS on structural synaptic plasticity is currently unknown. OBJECTIVE: This study addresses the effects and the underlying mechanisms of anodal DCS on structural plasticity and morphology of dendritic spines in the sensorimotor cortex (M1/S1). METHODS: A DCS electrode setup was combined with a chronic cranial ... read more
    4 months ago
  • Anodal tDCS over the right parietal but not frontal cortex enhances the ability to overcome task set inhibition during task switching.
    Related ArticlesAnodal tDCS over the right parietal but not frontal cortex enhances the ability to overcome task set inhibition during task switching. PLoS One. 2020;15(2):e0228541 Authors: Sdoia S, Zivi P, Ferlazzo F Abstract Switching between tasks requires individuals to inhibit mental representations of the previous task demands and to activate representations of the new task demands. The inhibition of the executed task remains active for a while so that when the inhibited task set must be re-activated shortly after, the need to overcome residual task set inhibition leads to behavioral costs. In a sham-controlled balanced-order within-subjects experimental design ... read more
    5 months ago
  • Anodal transcranial direct current stimulation reduces collinear lateral inhibition in normal peripheral vision.
    Related ArticlesAnodal transcranial direct current stimulation reduces collinear lateral inhibition in normal peripheral vision. PLoS One. 2020;15(5):e0232276 Authors: Raveendran RN, Tsang K, Tiwana D, Chow A, Thompson B Abstract Collinear flanking stimuli can reduce the detectability of a Gabor target presented in peripheral vision. This phenomenon is called collinear lateral inhibition and it may contribute to crowding in peripheral vision. Perceptual learning can reduce collinear lateral inhibition in peripheral vision, however intensive training is required. Our aim was to assess whether modulation of collinear lateral inhibition can be achieved within a short time-frame using a single 20-minute session of ... read more
    5 months ago
  • Neurodiagnostics in Sports: Investigating the Athlete’s Brain to Augment Performance and Sport-Specific Skills.
    Related ArticlesNeurodiagnostics in Sports: Investigating the Athlete's Brain to Augment Performance and Sport-Specific Skills. Front Hum Neurosci. 2020;14:133 Authors: Seidel-Marzi O, Ragert P Abstract Enhancing performance levels of athletes during training and competition is a desired goal in sports. Quantifying training success is typically accompanied by performance diagnostics including the assessment of sports-relevant behavioral and physiological parameters. Even though optimal brain processing is a key factor for augmented motor performance and skill learning, neurodiagnostics is typically not implemented in performance diagnostics of athletes. We propose, that neurodiagnostics via non-invasive brain imaging techniques such as functional near-infrared spectroscopy (fNIRS) will ... read more
    5 months ago
  • Cerebellar Transcranial Direct Current Stimulation Improves Reactive Response Inhibition in Healthy Volunteers.
    Related ArticlesCerebellar Transcranial Direct Current Stimulation Improves Reactive Response Inhibition in Healthy Volunteers. Cerebellum. 2019 Dec;18(6):983-988 Authors: Wynn SC, Driessen JMA, Glennon JC, Brazil IA, Schutter DJLG Abstract Involvement of the cerebellum to non-motor related aspects of behavior is becoming increasingly clear. The aim of this study was to investigate the role of the cerebellum in reactive and proactive behavioral control and interference. In a double-blind controlled within-subject design, 26 healthy volunteers underwent real and sham cerebellar transcranial direct current stimulation (tDCS) while performing a go/no-go task and a delay discounting task. Results showed that the number of ... read more
    6 months ago
  • Eye contact enhances interpersonal motor resonance: comparing video stimuli to a live two-person action context.
    Related ArticlesEye contact enhances interpersonal motor resonance: comparing video stimuli to a live two-person action context. Soc Cogn Affect Neurosci. 2019 09 30;14(9):967-976 Authors: Prinsen J, Alaerts K Abstract Previous research has shown a link between eye contact and interpersonal motor resonance, indicating that the mirroring of observed movements is enhanced when accompanied with mutual eye contact between actor and observer. Here, we further explored the role of eye contact within a naturalistic two-person action context. Twenty-two participants observed simple hand movements combined with direct or averted gaze presented via a live model in a two-person setting or ... read more
    6 months ago
  • Effects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study.
    Related ArticlesEffects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study. PLoS One. 2020;15(1):e0222620 Authors: Nwaroh C, Giuffre A, Cole L, Bell T, Carlson HL, MacMaster FP, Kirton A, Harris AD Abstract Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation that safely modulates brain excitability and has therapeutic potential for many conditions. Several studies have shown that anodal tDCS of the primary motor cortex (M1) facilitates motor learning and plasticity, but there is little information about the underlying mechanisms. Using magnetic resonance spectroscopy (MRS), it has been shown that ... read more
    6 months ago
  • Multi-session Transcranial Direct Current Stimulation Over Primary Motor Cortex Facilitates Sequence Learning, Chunking, and One Year Retention.
    Related ArticlesMulti-session Transcranial Direct Current Stimulation Over Primary Motor Cortex Facilitates Sequence Learning, Chunking, and One Year Retention. Front Hum Neurosci. 2020;14:75 Authors: Greeley B, Barnhoorn JS, Verwey WB, Seidler RD Abstract Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can facilitate motor learning, but it has not been established how stimulation to other brain regions impacts online and offline motor sequence learning, as well as long-term retention. Here, we completed three experiments comparing the effects of tDCS and sham stimulation to the prefrontal cortex (PFC), M1, and the supplementary motor area complex to understand the ... read more
    6 months ago
  • Effects of different transcranial direct current stimulation protocols on visuo-spatial contextual learning formation: evidence of homeostatic regulatory mechanisms.
    Related ArticlesEffects of different transcranial direct current stimulation protocols on visuo-spatial contextual learning formation: evidence of homeostatic regulatory mechanisms. Sci Rep. 2020 Mar 12;10(1):4622 Authors: Grasso PA, Tonolli E, Miniussi C Abstract In the present study we tested the effects of different transcranial direct current stimulation (tDCS) protocols in the formation of visuo-spatial contextual learning (VSCL). The study comprised three experiments designed to evaluate tDCS-induced changes in VSCL measures collected during the execution of a visual search task widely used to examine statistical learning in the visuo-spatial domain. In Experiment 1, we probed for the effects of left-posterior parietal ... read more
    6 months ago
  • The effect of cathodal tDCS on fear extinction: A cross-measures study.
    Related ArticlesThe effect of cathodal tDCS on fear extinction: A cross-measures study. PLoS One. 2019;14(9):e0221282 Authors: Ganho-Ávila A, Gonçalves ÓF, Guiomar R, Boggio PS, Asthana MK, Krypotos AM, Almeida J Abstract BACKGROUND: Extinction-based procedures are often used to inhibit maladaptive fear responses. However, because extinction procedures show efficacy limitations, transcranial direct current stimulation (tDCS) has been suggested as a promising add-on enhancer. OBJECTIVE: In this study, we tested how cathodal tDCS over the right dorsolateral prefrontal cortex affects extinction and tried to unveil the processes at play that boost the effectiveness of extinction procedures and its translational potential ... read more
    7 months ago
  • Combining reward and M1 transcranial direct current stimulation enhances the retention of newly learnt sensorimotor mappings.
    Related ArticlesCombining reward and M1 transcranial direct current stimulation enhances the retention of newly learnt sensorimotor mappings. Brain Stimul. 2019 Sep - Oct;12(5):1205-1212 Authors: Spampinato DA, Satar Z, Rothwell JC Abstract BACKGROUND: Reward-based feedback given during motor learning has been shown to improve the retention of the behaviour being acquired. Interestingly, applying transcranial direct current stimulation (tDCS) during learning over the primary motor cortex (M1), an area associated with motor retention, also results in enhanced retention of the newly formed motor memories. However, it remains unknown whether combining these distinct interventions result in an additive benefit of ... read more
    8 months ago
  • Interhemispheric control of sensory cue integration and self-motion perception.
    Related ArticlesInterhemispheric control of sensory cue integration and self-motion perception. Neuroscience. 2019 06 01;408:378-387 Authors: Arshad Q, Ortega MC, Goga U, Lobo R, Siddiqui S, Mediratta S, Bednarczuk NF, Kaski D, Bronstein AM Abstract Spatial orientation necessitates the integration of visual and vestibular sensory cues, in-turn facilitating self-motion perception. However, the neural mechanisms underpinning sensory integration remain unknown. Recently we have illustrated that spatial orientation and vestibular thresholds are influenced by interhemispheric asymmetries associated with the posterior parietal cortices (PPC) that predominantly house the vestibulo-cortical network. Given that sensory integration is a prerequisite to both spatial orientation and ... read more
    9 months ago
  • Clinical Implications of the Perception of Time in Attention Deficit Hyperactivity Disorder (ADHD): A Review.
    Related ArticlesClinical Implications of the Perception of Time in Attention Deficit Hyperactivity Disorder (ADHD): A Review. Med Sci Monit. 2019 May 26;25:3918-3924 Authors: Ptacek R, Weissenberger S, Braaten E, Klicperova-Baker M, Goetz M, Raboch J, Vnukova M, Stefano GB Abstract Attention deficit hyperactivity disorder (ADHD) is a lifelong neurodevelopmental disorder that can affect many areas of the daily life of individuals and is associated with poor health outcomes and with debilitating deficits in executive function. Recently, increasing numbers of research studies have begun to investigate the associations between neural and behavioral manifestations of ADHD. This review summarizes recent research ... read more
    9 months ago
  • The effect of transcranial direct current stimulation combined with functional task training on motor recovery in stroke patients.
    Related ArticlesThe effect of transcranial direct current stimulation combined with functional task training on motor recovery in stroke patients. Eur Rev Med Pharmacol Sci. 2018 11;22(21):7385-7392 Authors: Alsharidah M, Al-Hussain F, Iqbal M, Hamza A, Yoo WK, Bashir S Abstract The field of neuromodulation encompasses a wide spectrum of interventional technologies that modify pathological activity within the nervous system to achieve a therapeutic effect. Therapy including transcranial direct current stimulation (tDCS) has all shown promising results across a range of neurological and neuropsychiatric disorders. This article reviews the state-of-the-art of neuromodulation for stroke and discusses the opportunities and challenges ... read more
    10 months ago
  • Nicotine modulates human brain plasticity via calcium-dependent mechanisms.
    Related ArticlesNicotine modulates human brain plasticity via calcium-dependent mechanisms. J Physiol. 2018 11;596(22):5429-5441 Authors: Grundey J, Barlay J, Batsikadze G, Kuo MF, Paulus W, Nitsche M Abstract KEY POINTS: Nicotine (NIC) modulates cognition and memory function by targeting the nicotinic ACh receptor and releasing different transmitter systems postsynaptically. With both NIC-generated mechanisms, calcium influx and calcium permeability can be regulated, which is a key requirement for the induction of long-term potentiation, comprising the physiological basis of learning and memory function. We attempt to unmask the underlying mechanism of nicotinic effects on anodal transcranial direct current stimulation (tDCS)-induced ... read more
    10 months ago
  • Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial.
    Related ArticlesCognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial. Sci Rep. 2018 08 20;8(1):12477 Authors: Santos VSDSD, Zortea M, Alves RL, Naziazeno CCDS, Saldanha JS, Carvalho SDCR, Leite AJDC, Torres ILDS, Souza A, Calvetti PÜ, Fregni F, Caumo W Abstract Cognitive dysfunction in fibromyalgia has been reported, especially memory. Anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in enhancing this function. We tested the effects of eight sessions of tDCS and cognitive training on immediate and delayed memory, verbal fluency and ... read more
    11 months ago