Scientific Studies on tDCS and Learning

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Scientific Studies Related to tDCS and Learning

This collection of articles was sourced from PubMed.gov

As of Dec. 29th, we found 548 articles focusing on tDCS and Learning

  • Effects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study.
    Related ArticlesEffects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study. PLoS One. 2020;15(1):e0222620 Authors: Nwaroh C, Giuffre A, Cole L, Bell T, Carlson HL, MacMaster FP, Kirton A, Harris AD Abstract Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation that safely modulates brain excitability and has therapeutic potential for many conditions. Several studies have shown that anodal tDCS of the primary motor cortex (M1) facilitates motor learning and plasticity, but there is little information about the underlying mechanisms. Using magnetic resonance spectroscopy (MRS), it has been shown that ... read more
    3 days ago
  • Multi-session Transcranial Direct Current Stimulation Over Primary Motor Cortex Facilitates Sequence Learning, Chunking, and One Year Retention.
    Related ArticlesMulti-session Transcranial Direct Current Stimulation Over Primary Motor Cortex Facilitates Sequence Learning, Chunking, and One Year Retention. Front Hum Neurosci. 2020;14:75 Authors: Greeley B, Barnhoorn JS, Verwey WB, Seidler RD Abstract Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can facilitate motor learning, but it has not been established how stimulation to other brain regions impacts online and offline motor sequence learning, as well as long-term retention. Here, we completed three experiments comparing the effects of tDCS and sham stimulation to the prefrontal cortex (PFC), M1, and the supplementary motor area complex to understand the ... read more
    4 days ago
  • Effects of different transcranial direct current stimulation protocols on visuo-spatial contextual learning formation: evidence of homeostatic regulatory mechanisms.
    Related ArticlesEffects of different transcranial direct current stimulation protocols on visuo-spatial contextual learning formation: evidence of homeostatic regulatory mechanisms. Sci Rep. 2020 Mar 12;10(1):4622 Authors: Grasso PA, Tonolli E, Miniussi C Abstract In the present study we tested the effects of different transcranial direct current stimulation (tDCS) protocols in the formation of visuo-spatial contextual learning (VSCL). The study comprised three experiments designed to evaluate tDCS-induced changes in VSCL measures collected during the execution of a visual search task widely used to examine statistical learning in the visuo-spatial domain. In Experiment 1, we probed for the effects of left-posterior parietal ... read more
    3 weeks ago
  • The effect of cathodal tDCS on fear extinction: A cross-measures study.
    Related ArticlesThe effect of cathodal tDCS on fear extinction: A cross-measures study. PLoS One. 2019;14(9):e0221282 Authors: Ganho-Ávila A, Gonçalves ÓF, Guiomar R, Boggio PS, Asthana MK, Krypotos AM, Almeida J Abstract BACKGROUND: Extinction-based procedures are often used to inhibit maladaptive fear responses. However, because extinction procedures show efficacy limitations, transcranial direct current stimulation (tDCS) has been suggested as a promising add-on enhancer. OBJECTIVE: In this study, we tested how cathodal tDCS over the right dorsolateral prefrontal cortex affects extinction and tried to unveil the processes at play that boost the effectiveness of extinction procedures and its translational potential ... read more
    4 weeks ago
  • Combining reward and M1 transcranial direct current stimulation enhances the retention of newly learnt sensorimotor mappings.
    Related ArticlesCombining reward and M1 transcranial direct current stimulation enhances the retention of newly learnt sensorimotor mappings. Brain Stimul. 2019 Sep - Oct;12(5):1205-1212 Authors: Spampinato DA, Satar Z, Rothwell JC Abstract BACKGROUND: Reward-based feedback given during motor learning has been shown to improve the retention of the behaviour being acquired. Interestingly, applying transcranial direct current stimulation (tDCS) during learning over the primary motor cortex (M1), an area associated with motor retention, also results in enhanced retention of the newly formed motor memories. However, it remains unknown whether combining these distinct interventions result in an additive benefit of ... read more
    3 months ago
  • Interhemispheric control of sensory cue integration and self-motion perception.
    Related ArticlesInterhemispheric control of sensory cue integration and self-motion perception. Neuroscience. 2019 06 01;408:378-387 Authors: Arshad Q, Ortega MC, Goga U, Lobo R, Siddiqui S, Mediratta S, Bednarczuk NF, Kaski D, Bronstein AM Abstract Spatial orientation necessitates the integration of visual and vestibular sensory cues, in-turn facilitating self-motion perception. However, the neural mechanisms underpinning sensory integration remain unknown. Recently we have illustrated that spatial orientation and vestibular thresholds are influenced by interhemispheric asymmetries associated with the posterior parietal cortices (PPC) that predominantly house the vestibulo-cortical network. Given that sensory integration is a prerequisite to both spatial orientation and ... read more
    3 months ago
  • Clinical Implications of the Perception of Time in Attention Deficit Hyperactivity Disorder (ADHD): A Review.
    Related ArticlesClinical Implications of the Perception of Time in Attention Deficit Hyperactivity Disorder (ADHD): A Review. Med Sci Monit. 2019 May 26;25:3918-3924 Authors: Ptacek R, Weissenberger S, Braaten E, Klicperova-Baker M, Goetz M, Raboch J, Vnukova M, Stefano GB Abstract Attention deficit hyperactivity disorder (ADHD) is a lifelong neurodevelopmental disorder that can affect many areas of the daily life of individuals and is associated with poor health outcomes and with debilitating deficits in executive function. Recently, increasing numbers of research studies have begun to investigate the associations between neural and behavioral manifestations of ADHD. This review summarizes recent research ... read more
    4 months ago
  • The effect of transcranial direct current stimulation combined with functional task training on motor recovery in stroke patients.
    Related ArticlesThe effect of transcranial direct current stimulation combined with functional task training on motor recovery in stroke patients. Eur Rev Med Pharmacol Sci. 2018 11;22(21):7385-7392 Authors: Alsharidah M, Al-Hussain F, Iqbal M, Hamza A, Yoo WK, Bashir S Abstract The field of neuromodulation encompasses a wide spectrum of interventional technologies that modify pathological activity within the nervous system to achieve a therapeutic effect. Therapy including transcranial direct current stimulation (tDCS) has all shown promising results across a range of neurological and neuropsychiatric disorders. This article reviews the state-of-the-art of neuromodulation for stroke and discusses the opportunities and challenges ... read more
    5 months ago
  • Nicotine modulates human brain plasticity via calcium-dependent mechanisms.
    Related ArticlesNicotine modulates human brain plasticity via calcium-dependent mechanisms. J Physiol. 2018 11;596(22):5429-5441 Authors: Grundey J, Barlay J, Batsikadze G, Kuo MF, Paulus W, Nitsche M Abstract KEY POINTS: Nicotine (NIC) modulates cognition and memory function by targeting the nicotinic ACh receptor and releasing different transmitter systems postsynaptically. With both NIC-generated mechanisms, calcium influx and calcium permeability can be regulated, which is a key requirement for the induction of long-term potentiation, comprising the physiological basis of learning and memory function. We attempt to unmask the underlying mechanism of nicotinic effects on anodal transcranial direct current stimulation (tDCS)-induced ... read more
    5 months ago
  • Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial.
    Related ArticlesCognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial. Sci Rep. 2018 08 20;8(1):12477 Authors: Santos VSDSD, Zortea M, Alves RL, Naziazeno CCDS, Saldanha JS, Carvalho SDCR, Leite AJDC, Torres ILDS, Souza A, Calvetti PÜ, Fregni F, Caumo W Abstract Cognitive dysfunction in fibromyalgia has been reported, especially memory. Anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in enhancing this function. We tested the effects of eight sessions of tDCS and cognitive training on immediate and delayed memory, verbal fluency and ... read more
    5 months ago
  • Combining cognitive bias modification training (CBM) and transcranial direct current stimulation (tDCS) to treat binge eating disorder: study protocol of a randomised controlled feasibility trial.
    Related ArticlesCombining cognitive bias modification training (CBM) and transcranial direct current stimulation (tDCS) to treat binge eating disorder: study protocol of a randomised controlled feasibility trial. BMJ Open. 2019 Oct 22;9(10):e030023 Authors: Gordon G, Brockmeyer T, Schmidt U, Campbell IC Abstract INTRODUCTION: Binge eating disorder (BED) is a common mental disorder, closely associated with obesity. Existing treatments are only moderately effective with high relapse rates, necessitating novel interventions. This paper describes the rationale for, and protocol of, a feasibility randomised controlled trial (RCT), evaluating the combination of transcranial direct current stimulation (tDCS) and a computerised cognitive training, namely approach ... read more
    5 months ago
  • Electrical Stimulation Over Human Posterior Parietal Cortex Selectively Enhances the Capacity of Visual Short-Term Memory.
    Related ArticlesElectrical Stimulation Over Human Posterior Parietal Cortex Selectively Enhances the Capacity of Visual Short-Term Memory. J Neurosci. 2019 01 16;39(3):528-536 Authors: Wang S, Itthipuripat S, Ku Y Abstract Visual short-term memory (VSTM) provides an on-line mental space for incoming sensory information to be temporally maintained to carry out complex behavioral tasks. Despite its essential functions, the capacity at which VSTM could maintain sensory information is limited (i.e., VSTM can hold only about three to four visual items at once). Moreover, the quality of sensory representation (i.e., precision) degrades as more information has to be maintained in VSTM. ... read more
    6 months ago
  • Modulating Regional Motor Cortical Excitability with Noninvasive Brain Stimulation Results in Neurochemical Changes in Bilateral Motor Cortices.
    Related ArticlesModulating Regional Motor Cortical Excitability with Noninvasive Brain Stimulation Results in Neurochemical Changes in Bilateral Motor Cortices. J Neurosci. 2018 08 15;38(33):7327-7336 Authors: Bachtiar V, Johnstone A, Berrington A, Lemke C, Johansen-Berg H, Emir U, Stagg CJ Abstract Learning a novel motor skill is dependent both on regional changes within the primary motor cortex (M1) contralateral to the active hand and also on modulation between and within anatomically distant but functionally connected brain regions. Interregional changes are particularly important in functional recovery after stroke, when critical plastic changes underpinning behavioral improvements are observed in both ipsilesional and ... read more
    6 months ago
  • The Hippocampus and Neocortical Inhibitory Engrams Protect against Memory Interference.
    Related ArticlesThe Hippocampus and Neocortical Inhibitory Engrams Protect against Memory Interference. Neuron. 2019 02 06;101(3):528-541.e6 Authors: Koolschijn RS, Emir UE, Pantelides AC, Nili H, Behrens TEJ, Barron HC Abstract Our experiences often overlap with each other, yet we are able to selectively recall individual memories to guide decisions and future actions. The neural mechanisms that support such precise memory recall remain unclear. Here, using ultra-high field 7T MRI we reveal two distinct mechanisms that protect memories from interference. The first mechanism involves the hippocampus, where the blood-oxygen-level-dependent (BOLD) signal predicts behavioral measures of memory interference, and representations ... read more
    7 months ago
  • Craving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum.
    Related ArticlesCraving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum. Addict Biol. 2018 01;23(1):337-346 Authors: Zhang JT, Ma SS, Li CR, Liu L, Xia CC, Lan J, Wang LJ, Liu B, Yao YW, Fang XY Abstract Psychobehavioral intervention is an effective treatment of Internet addiction, including Internet gaming disorder (IGD). However, the neural mechanisms underlying its efficacy remain unclear. Cortical-ventral striatum (VS) circuitry is a common target of psychobehavioral interventions in drug addiction, and cortical-VS dysfunction has been reported in IGD; hence, the primary aim of the study was to investigate how ... read more
    7 months ago
  • High-definition tDCS of the temporo-parietal cortex enhances access to newly learned words.
    Related ArticlesHigh-definition tDCS of the temporo-parietal cortex enhances access to newly learned words. Sci Rep. 2017 12 05;7(1):17023 Authors: Perceval G, Martin AK, Copland DA, Laine M, Meinzer M Abstract Learning associations between words and their referents is crucial for language learning in the developing and adult brain and for language re-learning after neurological injury. Non-invasive transcranial direct current stimulation (tDCS) to the posterior temporo-parietal cortex has been suggested to enhance this process. However, previous studies employed standard tDCS set-ups that induce diffuse current flow in the brain, preventing the attribution of stimulation effects to the target region. ... read more
    8 months ago
  • Recruitment challenges in stroke neurorecovery clinical trials.
    Related ArticlesRecruitment challenges in stroke neurorecovery clinical trials. Contemp Clin Trials Commun. 2019 Sep;15:100404 Authors: Ferreira IS, Pinto CB, Saleh Velez FG, Leffa DT, Vulcano de Toledo Piza P, Fregni F Abstract There are multiple available treatments to enhance stroke rehabilitation, although few interventions have confirmed significant clinical improvements on motor function in pivotal Randomized Clinical Trials. Development of large Randomized Clinical Trials is limited by several barriers and low enrollment rate is considered an important factor. Consequently, most of the evidence comes from small sample size studies, often leading to limited conclusions. According to the National Institute of ... read more
    8 months ago
  • Dose response of somatosensory cortex repeated anodal transcranial direct current stimulation on vibrotactile detection: a randomized sham-controlled trial.
    Related ArticlesDose response of somatosensory cortex repeated anodal transcranial direct current stimulation on vibrotactile detection: a randomized sham-controlled trial. J Neurophysiol. 2018 08 01;120(2):610-616 Authors: Folmli B, Turman B, Johnson P, Abbott A Abstract This randomized sham-controlled trial investigated anodal transcranial direct current stimulation (tDCS) over the somatosensory cortex contralateral to hand dominance for dose-response (1 mA, 20 min × 5 days) effects on vibrotactile detection thresholds (VDT). VDT was measured before and after tDCS on days 1, 3, and 5 for low- (30 Hz) and high-frequency (200 Hz) vibrations on the dominant and nondominant hands in 29 healthy ... read more
    8 months ago
  • Interactive effects of music and prefrontal cortex stimulation in modulating response inhibition.
    Related ArticlesInteractive effects of music and prefrontal cortex stimulation in modulating response inhibition. Sci Rep. 2017 12 22;7(1):18096 Authors: Mansouri FA, Acevedo N, Illipparampil R, Fehring DJ, Fitzgerald PB, Jaberzadeh S Abstract Influential hypotheses propose that alterations in emotional state influence decision processes and executive control of behavior. Both music and transcranial direct current stimulation (tDCS) of prefrontal cortex affect emotional state, however interactive effects of music and tDCS on executive functions remain unknown. Learning to inhibit inappropriate responses is an important aspect of executive control which is guided by assessing the decision outcomes such as errors. We ... read more
    8 months ago
  • Randomized trial of iReadMore word reading training and brain stimulation in central alexia.
    Related ArticlesRandomized trial of iReadMore word reading training and brain stimulation in central alexia. Brain. 2018 07 01;141(7):2127-2141 Authors: Woodhead ZVJ, Kerry SJ, Aguilar OM, Ong YH, Hogan JS, Pappa K, Leff AP, Crinion JT Abstract Central alexia is an acquired reading disorder co-occurring with a generalized language deficit (aphasia). We tested the impact of a novel training app, 'iReadMore', and anodal transcranial direct current stimulation of the left inferior frontal gyrus, on word reading ability in central alexia. The trial was registered at www.clinicaltrials.gov (NCT02062619). Twenty-one chronic stroke patients with central alexia participated. A baseline-controlled, repeated-measures, crossover ... read more
    9 months ago
  • A review of transcranial electrical stimulation methods in stroke rehabilitation.
    Related ArticlesA review of transcranial electrical stimulation methods in stroke rehabilitation. Neurol India. 2019 Mar-Apr;67(2):417-423 Authors: Solomons CD, Shanmugasundaram V Abstract Transcranial electrical stimulation (TES) uses direct or alternating current to non-invasively stimulate the brain. Neuronal activity in the brain is modulated by the electrical field according to the polarity of the current being applied. TES includes transcranial direct current stimulation (tDCS), transcranial random noise stimulation, and transcranial alternating current stimulation (tACS). tDCS and tACS are the two non-invasive brain stimulation techniques that have been used alone or in combination with other rehabilitative therapies for the improvement of motor ... read more
    9 months ago
  • Direction of TDCS current flow in human sensorimotor cortex influences behavioural learning.
    Related ArticlesDirection of TDCS current flow in human sensorimotor cortex influences behavioural learning. Brain Stimul. 2019 May - Jun;12(3):684-692 Authors: Hannah R, Iacovou A, Rothwell JC Abstract BACKGROUND: Recent studies have shown that neurophysiological outcomes of transcranial direct current stimulation (TDCS) are influenced by current flow in brain regions between the electrodes, and in particular the orientation of current flow relative to the cortical surface. OBJECTIVE: We asked whether the directional effects of TDCS on physiological measures in the motor system would also be observed on motor behaviours. METHODS: We applied TDCS during the practice of a ... read more
    9 months ago
  • Task demands, tDCS intensity, and the COMT val158met polymorphism impact tDCS-linked working memory training gains.
    Related ArticlesTask demands, tDCS intensity, and the COMT val158met polymorphism impact tDCS-linked working memory training gains. Sci Rep. 2017 10 18;7(1):13463 Authors: Stephens JA, Jones KT, Berryhill ME Abstract Working memory (WM) training paired with transcranial direct current stimulation (tDCS) can improve executive function in older adults. The unclear mechanism of tDCS likely depends on tDCS intensity, and task relevant genetic factors (e.g., for WM: COMT val158met, DAT, BDNF val66met). Higher tDCS intensity does not always lead to greater cognitive gains, and genetic polymorphisms may modulate tDCS-linked WM improvements. To evaluate these factors, 137 healthy older adults provided ... read more
    9 months ago
  • Stimulating the Dorsolateral Prefrontal Cortex Decreases the Asset Bubble: A tDCS Study.
    Related ArticlesStimulating the Dorsolateral Prefrontal Cortex Decreases the Asset Bubble: A tDCS Study. Front Psychol. 2019;10:1031 Authors: Jin X, Chen C, Zhou X, Yang X Abstract Many studies have discussed the neural basis of asset bubbles. They found that the dorsolateral prefrontal cortex (DLPFC) played an important role in bubble formation, but whether a causal relationship exists and the mechanism of the effect of the DLPFC on bubbles remains unsettled. Using transcranial direct current stimulation (tDCS), we modulated the activity of the DLPFC and investigated the causal relationship between the DLPFC and the asset bubble in the classical ... read more
    10 months ago
  • Transcranial direct current stimulation effects on memory consolidation: timing matters.
    Related ArticlesTranscranial direct current stimulation effects on memory consolidation: timing matters. eNeuro. 2019 May 24;: Authors: Vorobiova AN, Pozdniakov I, Feurra M Abstract Transcranial direct current stimulation (tDCS) is a promising tool for modulation of learning and memory, allowing to transiently change cortical excitability of specific brain regions with physiological and behavioral outcomes. A detailed exploration of factors that can moderate tDCS effects on episodic long-term memory (LTM) is of high interest due to the clinical potential for patients with traumatic or pathological memory deficits and with cognitive impairments. This commentary discusses findings by Marián et al. (2018) recently published ... read more
    10 months ago