Scientific Studies on tDCS and Learning

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Scientific Studies Related to tDCS and Learning

This collection of articles was sourced from PubMed.gov

As of Dec. 29th, we found 548 articles focusing on tDCS and Learning

  • High-definition tDCS of the temporo-parietal cortex enhances access to newly learned words.
    Related ArticlesHigh-definition tDCS of the temporo-parietal cortex enhances access to newly learned words. Sci Rep. 2017 12 05;7(1):17023 Authors: Perceval G, Martin AK, Copland DA, Laine M, Meinzer M Abstract Learning associations between words and their referents is crucial for language learning in the developing and adult brain and for language re-learning after neurological injury. Non-invasive transcranial direct current stimulation (tDCS) to the posterior temporo-parietal cortex has been suggested to enhance this process. However, previous studies employed standard tDCS set-ups that induce diffuse current flow in the brain, preventing the attribution of stimulation effects to the target region. ... read more
    2 weeks ago
  • Recruitment challenges in stroke neurorecovery clinical trials.
    Related ArticlesRecruitment challenges in stroke neurorecovery clinical trials. Contemp Clin Trials Commun. 2019 Sep;15:100404 Authors: Ferreira IS, Pinto CB, Saleh Velez FG, Leffa DT, Vulcano de Toledo Piza P, Fregni F Abstract There are multiple available treatments to enhance stroke rehabilitation, although few interventions have confirmed significant clinical improvements on motor function in pivotal Randomized Clinical Trials. Development of large Randomized Clinical Trials is limited by several barriers and low enrollment rate is considered an important factor. Consequently, most of the evidence comes from small sample size studies, often leading to limited conclusions. According to the National Institute of ... read more
    3 weeks ago
  • Dose response of somatosensory cortex repeated anodal transcranial direct current stimulation on vibrotactile detection: a randomized sham-controlled trial.
    Related ArticlesDose response of somatosensory cortex repeated anodal transcranial direct current stimulation on vibrotactile detection: a randomized sham-controlled trial. J Neurophysiol. 2018 08 01;120(2):610-616 Authors: Folmli B, Turman B, Johnson P, Abbott A Abstract This randomized sham-controlled trial investigated anodal transcranial direct current stimulation (tDCS) over the somatosensory cortex contralateral to hand dominance for dose-response (1 mA, 20 min × 5 days) effects on vibrotactile detection thresholds (VDT). VDT was measured before and after tDCS on days 1, 3, and 5 for low- (30 Hz) and high-frequency (200 Hz) vibrations on the dominant and nondominant hands in 29 healthy ... read more
    3 weeks ago
  • Interactive effects of music and prefrontal cortex stimulation in modulating response inhibition.
    Related ArticlesInteractive effects of music and prefrontal cortex stimulation in modulating response inhibition. Sci Rep. 2017 12 22;7(1):18096 Authors: Mansouri FA, Acevedo N, Illipparampil R, Fehring DJ, Fitzgerald PB, Jaberzadeh S Abstract Influential hypotheses propose that alterations in emotional state influence decision processes and executive control of behavior. Both music and transcranial direct current stimulation (tDCS) of prefrontal cortex affect emotional state, however interactive effects of music and tDCS on executive functions remain unknown. Learning to inhibit inappropriate responses is an important aspect of executive control which is guided by assessing the decision outcomes such as errors. We ... read more
    3 weeks ago
  • Randomized trial of iReadMore word reading training and brain stimulation in central alexia.
    Related ArticlesRandomized trial of iReadMore word reading training and brain stimulation in central alexia. Brain. 2018 07 01;141(7):2127-2141 Authors: Woodhead ZVJ, Kerry SJ, Aguilar OM, Ong YH, Hogan JS, Pappa K, Leff AP, Crinion JT Abstract Central alexia is an acquired reading disorder co-occurring with a generalized language deficit (aphasia). We tested the impact of a novel training app, 'iReadMore', and anodal transcranial direct current stimulation of the left inferior frontal gyrus, on word reading ability in central alexia. The trial was registered at www.clinicaltrials.gov (NCT02062619). Twenty-one chronic stroke patients with central alexia participated. A baseline-controlled, repeated-measures, crossover ... read more
    1 month ago
  • A review of transcranial electrical stimulation methods in stroke rehabilitation.
    Related ArticlesA review of transcranial electrical stimulation methods in stroke rehabilitation. Neurol India. 2019 Mar-Apr;67(2):417-423 Authors: Solomons CD, Shanmugasundaram V Abstract Transcranial electrical stimulation (TES) uses direct or alternating current to non-invasively stimulate the brain. Neuronal activity in the brain is modulated by the electrical field according to the polarity of the current being applied. TES includes transcranial direct current stimulation (tDCS), transcranial random noise stimulation, and transcranial alternating current stimulation (tACS). tDCS and tACS are the two non-invasive brain stimulation techniques that have been used alone or in combination with other rehabilitative therapies for the improvement of motor ... read more
    1 month ago
  • Direction of TDCS current flow in human sensorimotor cortex influences behavioural learning.
    Related ArticlesDirection of TDCS current flow in human sensorimotor cortex influences behavioural learning. Brain Stimul. 2019 May - Jun;12(3):684-692 Authors: Hannah R, Iacovou A, Rothwell JC Abstract BACKGROUND: Recent studies have shown that neurophysiological outcomes of transcranial direct current stimulation (TDCS) are influenced by current flow in brain regions between the electrodes, and in particular the orientation of current flow relative to the cortical surface. OBJECTIVE: We asked whether the directional effects of TDCS on physiological measures in the motor system would also be observed on motor behaviours. METHODS: We applied TDCS during the practice of a ... read more
    1 month ago
  • Task demands, tDCS intensity, and the COMT val158met polymorphism impact tDCS-linked working memory training gains.
    Related ArticlesTask demands, tDCS intensity, and the COMT val158met polymorphism impact tDCS-linked working memory training gains. Sci Rep. 2017 10 18;7(1):13463 Authors: Stephens JA, Jones KT, Berryhill ME Abstract Working memory (WM) training paired with transcranial direct current stimulation (tDCS) can improve executive function in older adults. The unclear mechanism of tDCS likely depends on tDCS intensity, and task relevant genetic factors (e.g., for WM: COMT val158met, DAT, BDNF val66met). Higher tDCS intensity does not always lead to greater cognitive gains, and genetic polymorphisms may modulate tDCS-linked WM improvements. To evaluate these factors, 137 healthy older adults provided ... read more
    2 months ago
  • Stimulating the Dorsolateral Prefrontal Cortex Decreases the Asset Bubble: A tDCS Study.
    Related ArticlesStimulating the Dorsolateral Prefrontal Cortex Decreases the Asset Bubble: A tDCS Study. Front Psychol. 2019;10:1031 Authors: Jin X, Chen C, Zhou X, Yang X Abstract Many studies have discussed the neural basis of asset bubbles. They found that the dorsolateral prefrontal cortex (DLPFC) played an important role in bubble formation, but whether a causal relationship exists and the mechanism of the effect of the DLPFC on bubbles remains unsettled. Using transcranial direct current stimulation (tDCS), we modulated the activity of the DLPFC and investigated the causal relationship between the DLPFC and the asset bubble in the classical ... read more
    3 months ago
  • Transcranial direct current stimulation effects on memory consolidation: timing matters.
    Related ArticlesTranscranial direct current stimulation effects on memory consolidation: timing matters. eNeuro. 2019 May 24;: Authors: Vorobiova AN, Pozdniakov I, Feurra M Abstract Transcranial direct current stimulation (tDCS) is a promising tool for modulation of learning and memory, allowing to transiently change cortical excitability of specific brain regions with physiological and behavioral outcomes. A detailed exploration of factors that can moderate tDCS effects on episodic long-term memory (LTM) is of high interest due to the clinical potential for patients with traumatic or pathological memory deficits and with cognitive impairments. This commentary discusses findings by Marián et al. (2018) recently published ... read more
    3 months ago
  • Augmenting cognitive training in older adults (The ACT Study): Design and Methods of a Phase III tDCS and cognitive training trial.
    Related ArticlesAugmenting cognitive training in older adults (The ACT Study): Design and Methods of a Phase III tDCS and cognitive training trial. Contemp Clin Trials. 2018 02;65:19-32 Authors: Woods AJ, Cohen R, Marsiske M, Alexander GE, Czaja SJ, Wu S Abstract BACKGROUND: Adults over age 65 represent the fastest growing population in the US. Decline in cognitive abilities is a hallmark of advanced age and is associated with loss of independence and dementia risk. There is a pressing need to develop effective interventions for slowing or reversing the cognitive aging process. While certain forms of cognitive training have ... read more
    3 months ago
  • Personalized upper limb training combined with anodal-tDCS for sensorimotor recovery in spastic hemiparesis: study protocol for a randomized controlled trial.
    Related ArticlesPersonalized upper limb training combined with anodal-tDCS for sensorimotor recovery in spastic hemiparesis: study protocol for a randomized controlled trial. Trials. 2018 Jan 04;19(1):7 Authors: Levin MF, Baniña MC, Frenkel-Toledo S, Berman S, Soroker N, Solomon JM, Liebermann DG Abstract BACKGROUND: Recovery of voluntary movement is a main rehabilitation goal. Efforts to identify effective upper limb (UL) interventions after stroke have been unsatisfactory. This study includes personalized impairment-based UL reaching training in virtual reality (VR) combined with non-invasive brain stimulation to enhance motor learning. The approach is guided by limiting reaching training to the angular zone in ... read more
    3 months ago
  • Altering alpha-frequency brain oscillations with rapid analog feedback-driven neurostimulation.
    Related ArticlesAltering alpha-frequency brain oscillations with rapid analog feedback-driven neurostimulation. PLoS One. 2018;13(12):e0207781 Authors: Widge AS, Boggess M, Rockhill AP, Mullen A, Sheopory S, Loonis R, Freeman DK, Miller EK Abstract Oscillations of the brain's local field potential (LFP) may coordinate neural ensembles and brain networks. It has been difficult to causally test this model or to translate its implications into treatments, because there are few reliable ways to alter LFP oscillations. We developed a closed-loop analog circuit to enhance brain oscillations by feeding them back into cortex through phase-locked transcranial electrical stimulation. We tested the system in ... read more
    3 months ago
  • No effects of transcranial DLPFC stimulation on implicit task sequence learning and consolidation.
    Related ArticlesNo effects of transcranial DLPFC stimulation on implicit task sequence learning and consolidation. Sci Rep. 2017 08 29;7(1):9649 Authors: Savic B, Cazzoli D, Müri R, Meier B Abstract Neurostimulation of the dorsolateral prefrontal cortex (DLPFC) can modulate performance in cognitive tasks. In a recent study, however, transcranial direct current stimulation (tDCS) of the DLPFC did not affect implicit task sequence learning and consolidation in a paradigm that involved bimanual responses. Because bimanual performance increases the coupling between homologous cortical areas of the hemispheres and left and right DLPFC were stimulated separately the null findings may have been ... read more
    4 months ago
  • Differential Effects of Unihemispheric Concurrent Dual-Site and Conventional tDCS on Motor Learning: A Randomized, Sham-Controlled Study.
    Related ArticlesDifferential Effects of Unihemispheric Concurrent Dual-Site and Conventional tDCS on Motor Learning: A Randomized, Sham-Controlled Study. Basic Clin Neurosci. 2019 Jan-Feb;10(1):59-72 Authors: Talimkhani A, Abdollahi I, Mohseni-Bandpei MA, Ehsani F, Khalili S, Jaberzadeh S Abstract Introduction: Based on the literature, unihemispheric concurrent dual-site anodal transcranial Direct Current Stimulation (a-tDCSUHCDS) of primary Motor cortex (M1) and Dorsolateral Prefrontal Cortex (DLPFC) would be more efficient than conventional a-tDCS of M1 to induce larger and longer-lasting M1 corticospinal excitability. The main objective of the present study was to compare the effects of a-tDCSUHCDS and conventional M1 a-tDCS on the extent and ... read more
    4 months ago
  • The Involvement of D1 and D2 Dopamine Receptors in the Restoration Effect of Left Frontal Anodal, but not Cathodal, tDCS on Streptozocin-Induced Amnesia.
    Related ArticlesThe Involvement of D1 and D2 Dopamine Receptors in the Restoration Effect of Left Frontal Anodal, but not Cathodal, tDCS on Streptozocin-Induced Amnesia. Arch Iran Med. 2019 Mar 01;22(3):144-154 Authors: Roostaei A, Vaezi G, Nasehi M, Haeri-Rohani A, Zarrindast MR Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive method that improves learning and memory. In this study, the effect of tDCS on streptozotocin (STZ) induced amnesia in the presence or absence of SCH23390 (D1 dopamine receptor antagonist) and sulpiride (dopamine D2 receptor antagonist) has been investigated in male Wistar rats. METHODS: Passive avoidance memory, locomotor activity ... read more
    4 months ago
  • Concurrent exergaming and transcranial direct current stimulation to improve balance in people with Parkinson’s disease: study protocol for a randomised controlled trial.
    Related ArticlesConcurrent exergaming and transcranial direct current stimulation to improve balance in people with Parkinson's disease: study protocol for a randomised controlled trial. Trials. 2018 Jul 16;19(1):387 Authors: Harris DM, Rantalainen T, Muthalib M, Johnson L, Duckham RL, Smith ST, Daly RM, Teo WP Abstract BACKGROUND: People with Parkinson's disease (PD) commonly experience postural instability, resulting in poor balance and an increased risk of falls. Exercise-based video gaming (exergaming) is a form of physical training that is delivered through virtual reality technology to facilitate motor learning and is efficacious in improving balance in aged populations. In addition, studies ... read more
    5 months ago
  • Frontal cortex electrophysiology in reward- and punishment-related feedback processing during advice-guided decision making: An interleaved EEG-DC stimulation study.
    Related ArticlesFrontal cortex electrophysiology in reward- and punishment-related feedback processing during advice-guided decision making: An interleaved EEG-DC stimulation study. Cogn Affect Behav Neurosci. 2018 04;18(2):249-262 Authors: Wischnewski M, Bekkering H, Schutter DJLG Abstract During decision making, individuals are prone to rely on external cues such as expert advice when the outcome is not known. However, the electrophysiological correlates associated with outcome uncertainty and the use of expert advice are not completely understood. The feedback-related negativity (FRN), P3a, and P3b are event-related brain potentials (ERPs) linked to dissociable stages of feedback and attentional processing during decision making. Even though ... read more
    5 months ago
  • Long term at-home treatment with transcranial direct current stimulation (tDCS) improves symptoms of cerebellar ataxia: a case report.
    Related ArticlesLong term at-home treatment with transcranial direct current stimulation (tDCS) improves symptoms of cerebellar ataxia: a case report. J Neuroeng Rehabil. 2019 Mar 19;16(1):41 Authors: Pilloni G, Shaw M, Feinberg C, Clayton A, Palmeri M, Datta A, Charvet LE Abstract BACKGROUND: Progressive cerebellar ataxia is a neurodegenerative disorder without effective treatment options that seriously hinders quality of life. Previously, transcranial direct current stimulation (tDCS) has been demonstrated to benefit cerebellar functions (including improved motor control, learning and emotional processing) in healthy individuals and patients with neurological disorders. While tDCS is an emerging therapy, multiple daily sessions are needed for ... read more
    5 months ago
  • Cerebellar transcranial direct current stimulation interacts with BDNF Val66Met in motor learning.
    Related ArticlesCerebellar transcranial direct current stimulation interacts with BDNF Val66Met in motor learning. Brain Stimul. 2018 Jul - Aug;11(4):759-771 Authors: van der Vliet R, Jonker ZD, Louwen SC, Heuvelman M, de Vreede L, Ribbers GM, De Zeeuw CI, Donchin O, Selles RW, van der Geest JN, Frens MA Abstract BACKGROUND: Cerebellar transcranial direct current stimulation has been reported to enhance motor associative learning and motor adaptation, holding promise for clinical application in patients with movement disorders. However, behavioral benefits from cerebellar tDCS have been inconsistent. OBJECTIVE: Identifying determinants of treatment success is necessary. BDNF Val66Met is a candidate ... read more
    5 months ago
  • Sensorimotor Robotic Measures of tDCS- and HD-tDCS-Enhanced Motor Learning in Children.
    Related ArticlesSensorimotor Robotic Measures of tDCS- and HD-tDCS-Enhanced Motor Learning in Children. Neural Plast. 2018;2018:5317405 Authors: Cole L, Dukelow SP, Giuffre A, Nettel-Aguirre A, Metzler MJ, Kirton A Abstract Transcranial direct-current stimulation (tDCS) enhances motor learning in adults. We have demonstrated that anodal tDCS and high-definition (HD) tDCS of the motor cortex can enhance motor skill acquisition in children, but behavioral mechanisms remain unknown. Robotics can objectively quantify complex sensorimotor functions to better understand mechanisms of motor learning. We aimed to characterize changes in sensorimotor function induced by tDCS and HD-tDCS paired motor learning in children within an ... read more
    5 months ago
  • Visual training in hemianopia alters neural activity in the absence of behavioural improvement: a pilot study.
    Related ArticlesVisual training in hemianopia alters neural activity in the absence of behavioural improvement: a pilot study. Ophthalmic Physiol Opt. 2018 09;38(5):538-549 Authors: Larcombe SJ, Kulyomina Y, Antonova N, Ajina S, Stagg CJ, Clatworthy PL, Bridge H Abstract BACKGROUND: Damage to the primary visual cortex (V1) due to stroke often results in permanent loss of sight affecting one side of the visual field (homonymous hemianopia). Some rehabilitation approaches have shown improvement in visual performance in the blind region, but require a significant time investment. METHODS: Seven patients with cortical damage performed 400 trials of a motion direction discrimination ... read more
    5 months ago
  • tDCS-induced episodic memory enhancement and its association with functional network coupling in older adults.
    Related ArticlestDCS-induced episodic memory enhancement and its association with functional network coupling in older adults. Sci Rep. 2019 Feb 19;9(1):2273 Authors: Antonenko D, Hayek D, Netzband J, Grittner U, Flöel A Abstract Transcranial direct current stimulation (tDCS) augments training-induced cognitive gains, an issue of particular relevance in the aging population. However, negative outcomes have been reported as well, and few studies so far have evaluated the impact of tDCS on episodic memory formation in elderly cohorts. The heterogeneity of previous findings highlights the importance of elucidating neuronal underpinnings of tDCS-induced modulations, and of determining individual predictors of a positive ... read more
    6 months ago
  • Investigating the roles of medial prefrontal and superior temporal cortex in source monitoring.
    Related ArticlesInvestigating the roles of medial prefrontal and superior temporal cortex in source monitoring. Neuropsychologia. 2018 11;120:113-123 Authors: Moseley P, Mitrenga KJ, Ellison A, Fernyhough C Abstract Source monitoring, or the ability to recall the origin of information, is a crucial aspect of remembering past experience. One facet of this, reality monitoring, refers to the ability to distinguish between internally generated and externally generated information, biases in which have previously been associated with auditory verbal hallucinations in schizophrenia. Neuroimaging evidence suggests that medial prefrontal and superior temporal (STG) regions may play a role in reality monitoring for ... read more
    6 months ago