Scientific Studies on tDCS and Learning

PubMed Logo

Scientific Studies Related to tDCS and Learning

This collection of articles was sourced from PubMed.gov

As of Dec. 29th, we found 548 articles focusing on tDCS and Learning

  • Anodal Transcranial Direct Current Stimulation Can Improve Spatial Learning and Memory and Attenuate Aβ42 Burden at the Early Stage of Alzheimer’s Disease in APP/PS1 Transgenic Mice.
    Related ArticlesAnodal Transcranial Direct Current Stimulation Can Improve Spatial Learning and Memory and Attenuate Aβ42 Burden at the Early Stage of Alzheimer's Disease in APP/PS1 Transgenic Mice. Front Aging Neurosci. 2020;12:134 Authors: Luo Y, Yang W, Li N, Yang X, Zhu B, Wang C, Hou W, Wang X, Wen H, Tian X Abstract Alzheimer's disease (AD) is an irreversible progressive neurodegenerative disease. Intervention in the early stage of AD is a new path for AD treatment that is being explored. The behavioral and pathological effects of anodal transcranial direct current stimulation (AtDCS) at the early stage of AD ... read more
    2 days ago
  • Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes.
    Related ArticlesBeyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes. J Neuroeng Rehabil. 2019 11 15;16(1):141 Authors: Morya E, Monte-Silva K, Bikson M, Esmaeilpour Z, Biazoli CE, Fonseca A, Bocci T, Farzan F, Chatterjee R, Hausdorff JM, da Silva Machado DG, Brunoni AR, Mezger E, Moscaleski LA, Pegado R, Sato JR, Caetano MS, Sá KN, Tanaka C, Li LM, Baptista AF, Okano AH Abstract Transcranial Direct Current Stimulation (tDCS) is a non-invasive technique used to modulate neural tissue. Neuromodulation apparently improves cognitive functions in several neurologic diseases treatment and sports performance. ... read more
    3 weeks ago
  • Direct current stimulation-induced synaptic plasticity in the sensorimotor cortex: structure follows function.
    Related ArticlesDirect current stimulation-induced synaptic plasticity in the sensorimotor cortex: structure follows function. Brain Stimul. 2020 Jan - Feb;13(1):80-88 Authors: Gellner AK, Reis J, Holtick C, Schubert C, Fritsch B Abstract BACKGROUND: Non-invasive direct current stimulation (DCS) of the brain induces functional plasticity in vitro and facilitates motor learning across species. The effect of DCS on structural synaptic plasticity is currently unknown. OBJECTIVE: This study addresses the effects and the underlying mechanisms of anodal DCS on structural plasticity and morphology of dendritic spines in the sensorimotor cortex (M1/S1). METHODS: A DCS electrode setup was combined with a chronic cranial ... read more
    1 month ago
  • Anodal tDCS over the right parietal but not frontal cortex enhances the ability to overcome task set inhibition during task switching.
    Related ArticlesAnodal tDCS over the right parietal but not frontal cortex enhances the ability to overcome task set inhibition during task switching. PLoS One. 2020;15(2):e0228541 Authors: Sdoia S, Zivi P, Ferlazzo F Abstract Switching between tasks requires individuals to inhibit mental representations of the previous task demands and to activate representations of the new task demands. The inhibition of the executed task remains active for a while so that when the inhibited task set must be re-activated shortly after, the need to overcome residual task set inhibition leads to behavioral costs. In a sham-controlled balanced-order within-subjects experimental design ... read more
    2 months ago
  • Anodal transcranial direct current stimulation reduces collinear lateral inhibition in normal peripheral vision.
    Related ArticlesAnodal transcranial direct current stimulation reduces collinear lateral inhibition in normal peripheral vision. PLoS One. 2020;15(5):e0232276 Authors: Raveendran RN, Tsang K, Tiwana D, Chow A, Thompson B Abstract Collinear flanking stimuli can reduce the detectability of a Gabor target presented in peripheral vision. This phenomenon is called collinear lateral inhibition and it may contribute to crowding in peripheral vision. Perceptual learning can reduce collinear lateral inhibition in peripheral vision, however intensive training is required. Our aim was to assess whether modulation of collinear lateral inhibition can be achieved within a short time-frame using a single 20-minute session of ... read more
    2 months ago
  • Neurodiagnostics in Sports: Investigating the Athlete’s Brain to Augment Performance and Sport-Specific Skills.
    Related ArticlesNeurodiagnostics in Sports: Investigating the Athlete's Brain to Augment Performance and Sport-Specific Skills. Front Hum Neurosci. 2020;14:133 Authors: Seidel-Marzi O, Ragert P Abstract Enhancing performance levels of athletes during training and competition is a desired goal in sports. Quantifying training success is typically accompanied by performance diagnostics including the assessment of sports-relevant behavioral and physiological parameters. Even though optimal brain processing is a key factor for augmented motor performance and skill learning, neurodiagnostics is typically not implemented in performance diagnostics of athletes. We propose, that neurodiagnostics via non-invasive brain imaging techniques such as functional near-infrared spectroscopy (fNIRS) will ... read more
    2 months ago
  • Cerebellar Transcranial Direct Current Stimulation Improves Reactive Response Inhibition in Healthy Volunteers.
    Related ArticlesCerebellar Transcranial Direct Current Stimulation Improves Reactive Response Inhibition in Healthy Volunteers. Cerebellum. 2019 Dec;18(6):983-988 Authors: Wynn SC, Driessen JMA, Glennon JC, Brazil IA, Schutter DJLG Abstract Involvement of the cerebellum to non-motor related aspects of behavior is becoming increasingly clear. The aim of this study was to investigate the role of the cerebellum in reactive and proactive behavioral control and interference. In a double-blind controlled within-subject design, 26 healthy volunteers underwent real and sham cerebellar transcranial direct current stimulation (tDCS) while performing a go/no-go task and a delay discounting task. Results showed that the number of ... read more
    3 months ago
  • Eye contact enhances interpersonal motor resonance: comparing video stimuli to a live two-person action context.
    Related ArticlesEye contact enhances interpersonal motor resonance: comparing video stimuli to a live two-person action context. Soc Cogn Affect Neurosci. 2019 09 30;14(9):967-976 Authors: Prinsen J, Alaerts K Abstract Previous research has shown a link between eye contact and interpersonal motor resonance, indicating that the mirroring of observed movements is enhanced when accompanied with mutual eye contact between actor and observer. Here, we further explored the role of eye contact within a naturalistic two-person action context. Twenty-two participants observed simple hand movements combined with direct or averted gaze presented via a live model in a two-person setting or ... read more
    3 months ago
  • Effects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study.
    Related ArticlesEffects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study. PLoS One. 2020;15(1):e0222620 Authors: Nwaroh C, Giuffre A, Cole L, Bell T, Carlson HL, MacMaster FP, Kirton A, Harris AD Abstract Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation that safely modulates brain excitability and has therapeutic potential for many conditions. Several studies have shown that anodal tDCS of the primary motor cortex (M1) facilitates motor learning and plasticity, but there is little information about the underlying mechanisms. Using magnetic resonance spectroscopy (MRS), it has been shown that ... read more
    3 months ago
  • Multi-session Transcranial Direct Current Stimulation Over Primary Motor Cortex Facilitates Sequence Learning, Chunking, and One Year Retention.
    Related ArticlesMulti-session Transcranial Direct Current Stimulation Over Primary Motor Cortex Facilitates Sequence Learning, Chunking, and One Year Retention. Front Hum Neurosci. 2020;14:75 Authors: Greeley B, Barnhoorn JS, Verwey WB, Seidler RD Abstract Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can facilitate motor learning, but it has not been established how stimulation to other brain regions impacts online and offline motor sequence learning, as well as long-term retention. Here, we completed three experiments comparing the effects of tDCS and sham stimulation to the prefrontal cortex (PFC), M1, and the supplementary motor area complex to understand the ... read more
    3 months ago
  • Effects of different transcranial direct current stimulation protocols on visuo-spatial contextual learning formation: evidence of homeostatic regulatory mechanisms.
    Related ArticlesEffects of different transcranial direct current stimulation protocols on visuo-spatial contextual learning formation: evidence of homeostatic regulatory mechanisms. Sci Rep. 2020 Mar 12;10(1):4622 Authors: Grasso PA, Tonolli E, Miniussi C Abstract In the present study we tested the effects of different transcranial direct current stimulation (tDCS) protocols in the formation of visuo-spatial contextual learning (VSCL). The study comprised three experiments designed to evaluate tDCS-induced changes in VSCL measures collected during the execution of a visual search task widely used to examine statistical learning in the visuo-spatial domain. In Experiment 1, we probed for the effects of left-posterior parietal ... read more
    4 months ago
  • The effect of cathodal tDCS on fear extinction: A cross-measures study.
    Related ArticlesThe effect of cathodal tDCS on fear extinction: A cross-measures study. PLoS One. 2019;14(9):e0221282 Authors: Ganho-Ávila A, Gonçalves ÓF, Guiomar R, Boggio PS, Asthana MK, Krypotos AM, Almeida J Abstract BACKGROUND: Extinction-based procedures are often used to inhibit maladaptive fear responses. However, because extinction procedures show efficacy limitations, transcranial direct current stimulation (tDCS) has been suggested as a promising add-on enhancer. OBJECTIVE: In this study, we tested how cathodal tDCS over the right dorsolateral prefrontal cortex affects extinction and tried to unveil the processes at play that boost the effectiveness of extinction procedures and its translational potential ... read more
    4 months ago
  • Combining reward and M1 transcranial direct current stimulation enhances the retention of newly learnt sensorimotor mappings.
    Related ArticlesCombining reward and M1 transcranial direct current stimulation enhances the retention of newly learnt sensorimotor mappings. Brain Stimul. 2019 Sep - Oct;12(5):1205-1212 Authors: Spampinato DA, Satar Z, Rothwell JC Abstract BACKGROUND: Reward-based feedback given during motor learning has been shown to improve the retention of the behaviour being acquired. Interestingly, applying transcranial direct current stimulation (tDCS) during learning over the primary motor cortex (M1), an area associated with motor retention, also results in enhanced retention of the newly formed motor memories. However, it remains unknown whether combining these distinct interventions result in an additive benefit of ... read more
    6 months ago
  • Interhemispheric control of sensory cue integration and self-motion perception.
    Related ArticlesInterhemispheric control of sensory cue integration and self-motion perception. Neuroscience. 2019 06 01;408:378-387 Authors: Arshad Q, Ortega MC, Goga U, Lobo R, Siddiqui S, Mediratta S, Bednarczuk NF, Kaski D, Bronstein AM Abstract Spatial orientation necessitates the integration of visual and vestibular sensory cues, in-turn facilitating self-motion perception. However, the neural mechanisms underpinning sensory integration remain unknown. Recently we have illustrated that spatial orientation and vestibular thresholds are influenced by interhemispheric asymmetries associated with the posterior parietal cortices (PPC) that predominantly house the vestibulo-cortical network. Given that sensory integration is a prerequisite to both spatial orientation and ... read more
    6 months ago
  • Clinical Implications of the Perception of Time in Attention Deficit Hyperactivity Disorder (ADHD): A Review.
    Related ArticlesClinical Implications of the Perception of Time in Attention Deficit Hyperactivity Disorder (ADHD): A Review. Med Sci Monit. 2019 May 26;25:3918-3924 Authors: Ptacek R, Weissenberger S, Braaten E, Klicperova-Baker M, Goetz M, Raboch J, Vnukova M, Stefano GB Abstract Attention deficit hyperactivity disorder (ADHD) is a lifelong neurodevelopmental disorder that can affect many areas of the daily life of individuals and is associated with poor health outcomes and with debilitating deficits in executive function. Recently, increasing numbers of research studies have begun to investigate the associations between neural and behavioral manifestations of ADHD. This review summarizes recent research ... read more
    7 months ago
  • The effect of transcranial direct current stimulation combined with functional task training on motor recovery in stroke patients.
    Related ArticlesThe effect of transcranial direct current stimulation combined with functional task training on motor recovery in stroke patients. Eur Rev Med Pharmacol Sci. 2018 11;22(21):7385-7392 Authors: Alsharidah M, Al-Hussain F, Iqbal M, Hamza A, Yoo WK, Bashir S Abstract The field of neuromodulation encompasses a wide spectrum of interventional technologies that modify pathological activity within the nervous system to achieve a therapeutic effect. Therapy including transcranial direct current stimulation (tDCS) has all shown promising results across a range of neurological and neuropsychiatric disorders. This article reviews the state-of-the-art of neuromodulation for stroke and discusses the opportunities and challenges ... read more
    8 months ago
  • Nicotine modulates human brain plasticity via calcium-dependent mechanisms.
    Related ArticlesNicotine modulates human brain plasticity via calcium-dependent mechanisms. J Physiol. 2018 11;596(22):5429-5441 Authors: Grundey J, Barlay J, Batsikadze G, Kuo MF, Paulus W, Nitsche M Abstract KEY POINTS: Nicotine (NIC) modulates cognition and memory function by targeting the nicotinic ACh receptor and releasing different transmitter systems postsynaptically. With both NIC-generated mechanisms, calcium influx and calcium permeability can be regulated, which is a key requirement for the induction of long-term potentiation, comprising the physiological basis of learning and memory function. We attempt to unmask the underlying mechanism of nicotinic effects on anodal transcranial direct current stimulation (tDCS)-induced ... read more
    8 months ago
  • Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial.
    Related ArticlesCognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial. Sci Rep. 2018 08 20;8(1):12477 Authors: Santos VSDSD, Zortea M, Alves RL, Naziazeno CCDS, Saldanha JS, Carvalho SDCR, Leite AJDC, Torres ILDS, Souza A, Calvetti PÜ, Fregni F, Caumo W Abstract Cognitive dysfunction in fibromyalgia has been reported, especially memory. Anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in enhancing this function. We tested the effects of eight sessions of tDCS and cognitive training on immediate and delayed memory, verbal fluency and ... read more
    8 months ago
  • Combining cognitive bias modification training (CBM) and transcranial direct current stimulation (tDCS) to treat binge eating disorder: study protocol of a randomised controlled feasibility trial.
    Related ArticlesCombining cognitive bias modification training (CBM) and transcranial direct current stimulation (tDCS) to treat binge eating disorder: study protocol of a randomised controlled feasibility trial. BMJ Open. 2019 Oct 22;9(10):e030023 Authors: Gordon G, Brockmeyer T, Schmidt U, Campbell IC Abstract INTRODUCTION: Binge eating disorder (BED) is a common mental disorder, closely associated with obesity. Existing treatments are only moderately effective with high relapse rates, necessitating novel interventions. This paper describes the rationale for, and protocol of, a feasibility randomised controlled trial (RCT), evaluating the combination of transcranial direct current stimulation (tDCS) and a computerised cognitive training, namely approach ... read more
    8 months ago
  • Electrical Stimulation Over Human Posterior Parietal Cortex Selectively Enhances the Capacity of Visual Short-Term Memory.
    Related ArticlesElectrical Stimulation Over Human Posterior Parietal Cortex Selectively Enhances the Capacity of Visual Short-Term Memory. J Neurosci. 2019 01 16;39(3):528-536 Authors: Wang S, Itthipuripat S, Ku Y Abstract Visual short-term memory (VSTM) provides an on-line mental space for incoming sensory information to be temporally maintained to carry out complex behavioral tasks. Despite its essential functions, the capacity at which VSTM could maintain sensory information is limited (i.e., VSTM can hold only about three to four visual items at once). Moreover, the quality of sensory representation (i.e., precision) degrades as more information has to be maintained in VSTM. ... read more
    9 months ago
  • Modulating Regional Motor Cortical Excitability with Noninvasive Brain Stimulation Results in Neurochemical Changes in Bilateral Motor Cortices.
    Related ArticlesModulating Regional Motor Cortical Excitability with Noninvasive Brain Stimulation Results in Neurochemical Changes in Bilateral Motor Cortices. J Neurosci. 2018 08 15;38(33):7327-7336 Authors: Bachtiar V, Johnstone A, Berrington A, Lemke C, Johansen-Berg H, Emir U, Stagg CJ Abstract Learning a novel motor skill is dependent both on regional changes within the primary motor cortex (M1) contralateral to the active hand and also on modulation between and within anatomically distant but functionally connected brain regions. Interregional changes are particularly important in functional recovery after stroke, when critical plastic changes underpinning behavioral improvements are observed in both ipsilesional and ... read more
    9 months ago
  • The Hippocampus and Neocortical Inhibitory Engrams Protect against Memory Interference.
    Related ArticlesThe Hippocampus and Neocortical Inhibitory Engrams Protect against Memory Interference. Neuron. 2019 02 06;101(3):528-541.e6 Authors: Koolschijn RS, Emir UE, Pantelides AC, Nili H, Behrens TEJ, Barron HC Abstract Our experiences often overlap with each other, yet we are able to selectively recall individual memories to guide decisions and future actions. The neural mechanisms that support such precise memory recall remain unclear. Here, using ultra-high field 7T MRI we reveal two distinct mechanisms that protect memories from interference. The first mechanism involves the hippocampus, where the blood-oxygen-level-dependent (BOLD) signal predicts behavioral measures of memory interference, and representations ... read more
    10 months ago
  • Craving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum.
    Related ArticlesCraving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum. Addict Biol. 2018 01;23(1):337-346 Authors: Zhang JT, Ma SS, Li CR, Liu L, Xia CC, Lan J, Wang LJ, Liu B, Yao YW, Fang XY Abstract Psychobehavioral intervention is an effective treatment of Internet addiction, including Internet gaming disorder (IGD). However, the neural mechanisms underlying its efficacy remain unclear. Cortical-ventral striatum (VS) circuitry is a common target of psychobehavioral interventions in drug addiction, and cortical-VS dysfunction has been reported in IGD; hence, the primary aim of the study was to investigate how ... read more
    10 months ago
  • High-definition tDCS of the temporo-parietal cortex enhances access to newly learned words.
    Related ArticlesHigh-definition tDCS of the temporo-parietal cortex enhances access to newly learned words. Sci Rep. 2017 12 05;7(1):17023 Authors: Perceval G, Martin AK, Copland DA, Laine M, Meinzer M Abstract Learning associations between words and their referents is crucial for language learning in the developing and adult brain and for language re-learning after neurological injury. Non-invasive transcranial direct current stimulation (tDCS) to the posterior temporo-parietal cortex has been suggested to enhance this process. However, previous studies employed standard tDCS set-ups that induce diffuse current flow in the brain, preventing the attribution of stimulation effects to the target region. ... read more
    11 months ago
  • Recruitment challenges in stroke neurorecovery clinical trials.
    Related ArticlesRecruitment challenges in stroke neurorecovery clinical trials. Contemp Clin Trials Commun. 2019 Sep;15:100404 Authors: Ferreira IS, Pinto CB, Saleh Velez FG, Leffa DT, Vulcano de Toledo Piza P, Fregni F Abstract There are multiple available treatments to enhance stroke rehabilitation, although few interventions have confirmed significant clinical improvements on motor function in pivotal Randomized Clinical Trials. Development of large Randomized Clinical Trials is limited by several barriers and low enrollment rate is considered an important factor. Consequently, most of the evidence comes from small sample size studies, often leading to limited conclusions. According to the National Institute of ... read more
    11 months ago