Scientific Studies on tDCS and Learning

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Scientific Studies Related to tDCS and Learning

This collection of articles was sourced from PubMed.gov

As of Dec. 29th, we found 548 articles focusing on tDCS and Learning

  • No Impact of Cerebellar Anodal Transcranial Direct Current Stimulation at Three Different Timings on Motor Learning in a Sequential Finger-Tapping Task
    Front Hum Neurosci. 2021 Feb 5;15:631517. doi: 10.3389/fnhum.2021.631517. eCollection 2021.ABSTRACTBackground: Recently, attention has grown toward cerebellar neuromodulation in motor learning using transcranial direct current stimulation (tDCS). An important point of discussion regarding this modulation is the optimal timing of tDCS, as this parameter could significantly influence the outcome. Hence, this study aimed to investigate the effects of the timing of cerebellar anodal tDCS (ca-tDCS) on motor learning using a sequential finger-tapping task (FTT). Methods: One hundred and twenty two healthy young, right-handed subjects (96 females) were randomized into four groups (Duringsham, Before, Duringreal, After). They performed 2 days of FTT ... read more
    PubMed Abstract – tDCS and LearningPublished on 2021-02-22By Carine Nguemeni
    2 weeks ago
  • Functional Effects of Bilateral Dorsolateral Prefrontal Cortex Modulation During Sequential Decision-Making: A Functional Near-Infrared Spectroscopy Study With Offline Transcranial Direct Current Stimulation
    Front Hum Neurosci. 2021 Feb 3;14:605190. doi: 10.3389/fnhum.2020.605190. eCollection 2020.ABSTRACTThe ability to learn sequential contingencies of actions for predicting future outcomes is indispensable for flexible behavior in many daily decision-making contexts. It remains open whether such ability may be enhanced by transcranial direct current stimulation (tDCS). The present study combined tDCS with functional near-infrared spectroscopy (fNIRS) to investigate potential tDCS-induced effects on sequential decision-making and the neural mechanisms underlying such modulations. Offline tDCS and sham stimulation were applied over the left and right dorsolateral prefrontal cortex (dlPFC) in young male adults (N = 29, mean age = 23.4 years, SD ... read more
    PubMed Abstract – tDCS and LearningPublished on 2021-02-22By Iryna Schommartz
    2 weeks ago
  • Cathodal Transcranial Direct Current Stimulation (tDCS) Applied to the Left Premotor Cortex Interferes with Explicit Reproduction of a Motor Sequence.
    Related Articles Cathodal Transcranial Direct Current Stimulation (tDCS) Applied to the Left Premotor Cortex Interferes with Explicit Reproduction of a Motor Sequence. Brain Sci. 2021 Feb 09;11(2): Authors: Pollok B, Schmitz-Justen C, Krause V Abstract Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that allows the modulation of cortical excitability. TDCS effects can outlast the stimulation period presumably due to changes of GABA concentration which play a critical role in use-dependent plasticity. Consequently, tDCS and learning-related synaptic plasticity are assumed to share common mechanisms. Motor sequence learning has been related to activation changes within a cortico-subcortical ... read more
    3 weeks ago
  • Cathodal Transcranial Direct Current Stimulation (tDCS) Applied to the Left Premotor Cortex Interferes with Explicit Reproduction of a Motor Sequence
    Brain Sci. 2021 Feb 9;11(2):207. doi: 10.3390/brainsci11020207.ABSTRACTTranscranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that allows the modulation of cortical excitability. TDCS effects can outlast the stimulation period presumably due to changes of GABA concentration which play a critical role in use-dependent plasticity. Consequently, tDCS and learning-related synaptic plasticity are assumed to share common mechanisms. Motor sequence learning has been related to activation changes within a cortico-subcortical network and findings from a meta-analysis point towards a core network comprising the cerebellum as well as the primary motor (M1) and the dorsolateral premotor cortex (dPMC). The latter has ... read more
    PubMed Abstract – tDCS and LearningPublished on 2021-02-12By Bettina Pollok
    3 weeks ago
  • TDCS effects on pointing task learning in young and old adults
    Sci Rep. 2021 Feb 9;11(1):3421. doi: 10.1038/s41598-021-82275-4.ABSTRACTSkill increase in motor performance can be defined as explicitly measuring task success but also via more implicit measures of movement kinematics. Even though these measures are often related, there is evidence that they represent distinct concepts of learning. In the present study, the effect of multiple tDCS-sessions on both explicit and implicit measures of learning are investigated in a pointing task in 30 young adults (YA) between 27.07 ± 3.8 years and 30 old adults (OA) between 67.97 years ± 5.3 years. We hypothesized, that OA would show slower explicit skill learning indicated ... read more
    PubMed Abstract – tDCS and LearningPublished on 2021-02-10By E Kaminski
    3 weeks ago
  • Protocol for a cost-utility analysis of neurostimulation and intensive camp-based therapy for children with perinatal stroke and hemiparesis based on a multicentre clinical trial
    BMJ Open. 2021 Jan 19;11(1):e041444. doi: 10.1136/bmjopen-2020-041444.ABSTRACTINTRODUCTION: Perinatal stroke leads to cerebral palsy (CP) and lifelong disability for thousands of Canadian children. Hemiparesis, referring to impaired functionality in one side of the body, is a common complication of perinatal stroke. Standard long-term care for hemiparetic CP focuses on rehabilitation therapies. Early research suggests that patients with hemiparesis may benefit from adjunctive neuromodulation treatments such as transcranial direct current stimulation (tDCS). tDCS uses electric current to stimulate targeted areas of the brain non-invasively, potentially enhancing the effects of motor learning therapies. This protocol describes an economic evaluation to be conducted alongside ... read more
    PubMed Abstract – tDCS and LearningPublished on 2021-01-20By Patrick Berrigan
    1 month ago
  • Multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill
    Sci Rep. 2021 Jan 19;11(1):1756. doi: 10.1038/s41598-021-81154-2.ABSTRACTTranscranial direct current stimulation (tDCS)-based interventions for augmenting motor learning are gaining interest in systems neuroscience and clinical research. Current approaches focus largely on monofocal motorcortical stimulation. Innovative stimulation protocols, accounting for motor learning related brain network interactions also, may further enhance effect sizes. Here, we tested different stimulation approaches targeting the cerebro-cerebellar loop. Forty young, healthy participants trained a fine motor skill with concurrent tDCS in four sessions over two days, testing the following conditions: (1) monofocal motorcortical, (2) sham, (3) monofocal cerebellar, or (4) sequential multifocal motorcortico-cerebellar stimulation in a double-blind, parallel ... read more
    PubMed Abstract – tDCS and LearningPublished on 2021-01-20By Maximilian J Wessel
    1 month ago
  • Acquisition of concrete and abstract words is modulated by tDCS of Wernicke's area
    Sci Rep. 2021 Jan 15;11(1):1508. doi: 10.1038/s41598-020-79967-8.ABSTRACTPrevious behavioural and neuroimaging research suggested distinct cortical systems involved in processing abstract and concrete semantics; however, there is a dearth of causal evidence to support this. To address this, we applied anodal, cathodal, or sham (placebo) tDCS over Wernicke's area before a session of contextual learning of novel concrete and abstract words (n = 10 each), presented five times in short stories. Learning effects were assessed at lexical and semantic levels immediately after the training and, to attest any consolidation effects of overnight sleep, on the next day. We observed successful learning of ... read more
    PubMed Abstract – tDCS and LearningPublished on 2021-01-16By Diana Kurmakaeva
    2 months ago
  • Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence
    Nat Commun. 2021 Jan 13;12(1):363. doi: 10.1038/s41467-020-20581-7.ABSTRACTAberrant neural oscillations hallmark numerous brain disorders. Here, we first report a method to track the phase of neural oscillations in real-time via endpoint-corrected Hilbert transform (ecHT) that mitigates the characteristic Gibbs distortion. We then used ecHT to show that the aberrant neural oscillation that hallmarks essential tremor (ET) syndrome, the most common adult movement disorder, can be transiently suppressed via transcranial electrical stimulation of the cerebellum phase-locked to the tremor. The tremor suppression is sustained shortly after the end of the stimulation and can be phenomenologically predicted. Finally, we use feature-based statistical-learning and ... read more
    PubMed Abstract – tDCS and LearningPublished on 2021-01-14By Sebastian R Schreglmann
    2 months ago
  • Neuropsychological Subgroups of Emotion Processing in Youths With Conduct Disorder
    Front Psychiatry. 2020 Dec 22;11:585052. doi: 10.3389/fpsyt.2020.585052. eCollection 2020.ABSTRACTBackground: At the group level, youths with conduct disorder (CD) show deficient emotion processing across various tasks compared to typically developing controls (TDC). But little is known about neuropsychological subgroups within the CD population, the clinical correlates of emotion processing deficits [for instance, with regard to the presence or absence of the DSM-5 Limited Prosocial Emotions (LPE) specifier], and associated risk factors. Methods: 542 children and adolescents with CD (317 girls) and 710 TDCs (479 girls), aged 9-18 years, were included from the FemNAT-CD multisite study. All participants completed three neuropsychological tasks ... read more
    PubMed Abstract – tDCS and LearningPublished on 2021-01-08By Gregor Kohls
    2 months ago
  • Stimulation artifact source separation (SASS) for assessing electric brain oscillations during transcranial alternating current stimulation (tACS)
    Neuroimage. 2021 Mar;228:117571. doi: 10.1016/j.neuroimage.2020.117571. Epub 2021 Jan 4.ABSTRACTBrain oscillations, e.g. measured by electro- or magnetoencephalography (EEG/MEG), are causally linked to brain functions that are fundamental for perception, cognition and learning. Recent advances in neurotechnology provide means to non-invasively target these oscillations using frequency-tuned amplitude-modulated transcranial alternating current stimulation (AM-tACS). However, online adaptation of stimulation parameters to ongoing brain oscillations remains an unsolved problem due to stimulation artifacts that impede such adaptation, particularly at the target frequency. Here, we introduce a real-time compatible artifact rejection algorithm (Stimulation Artifact Source Separation, SASS) that overcomes this limitation. SASS is a spatial filter ... read more
    PubMed Abstract – tDCS and LearningPublished on 2021-01-07By David Haslacher
    2 months ago
  • Transcranial direct current stimulation modulates brain functional connectivity in autism
    Neuroimage Clin. 2020;28:102500. doi: 10.1016/j.nicl.2020.102500. Epub 2020 Nov 19.ABSTRACTAutism spectrum disorder (ASD) is characterized by deficits in social interactions, impairments in language and communication, and highly restricted behavioral interests. Transcranial direct current stimulation (tDCS) is a widely used form of noninvasive stimulation and may have therapeutic potential for ASD. So far, despite the widespread use of this technique in the neuroscience field, its effects on network-level neural activity and the underlying mechanisms of any effects are still unclear. In the present study, we used electroencephalography (EEG) to investigate tDCS induced brain network changes in children with ASD before and after ... read more
    PubMed Abstract – tDCS and LearningPublished on 2021-01-05By Tianyi Zhou
    2 months ago
  • Long-term effects of cerebellar anodal transcranial direct current stimulation (tDCS) on the acquisition and extinction of conditioned eyeblink responses
    Sci Rep. 2020 Dec 31;10(1):22434. doi: 10.1038/s41598-020-80023-8.ABSTRACTCerebellar transcranial direct current stimulation (tDCS) has been reported to enhance the acquisition of conditioned eyeblink responses (CR), a form of associative motor learning. The aim of the present study was to determine possible long-term effects of cerebellar tDCS on the acquisition and extinction of CRs. Delay eyeblink conditioning was performed in 40 young and healthy human participants. On day 1, 100 paired CS (conditioned stimulus)-US (unconditioned stimulus) trials were applied. During the first 50 paired CS-US trials, 20 participants received anodal cerebellar tDCS, and 20 participants received sham stimulation. On days 2, 8 ... read more
    PubMed Abstract – tDCS and LearningPublished on 2021-01-01By Otilia Kimpel
    2 months ago
  • Transcranial direct current stimulation and attention skills in burnout patients: a randomized blinded sham-controlled pilot study
    F1000Res. 2020 Feb 14;9:116. doi: 10.12688/f1000research.21831.2. eCollection 2020.ABSTRACTBackground: Burnout is characterized by deficiencies in attention and several components of the working memory. It has been shown that cognitive behavioral therapy can have a positive effect on burnout and depressive symptoms, however, the lingering effects of impaired attention and executive functions are the most frustrating. We hypothesized that anodal transcranial direct current stimulation (atDCS) over the left dorsolateral prefrontal cortex (DLPFC) can improve the executive control of attention and possibly several other components of working memory in patients with burnout. Methods: This was a randomized double-blind sham-controlled pilot study with two ... read more
    PubMed Abstract – tDCS and LearningPublished on 2020-12-29By Pia Van Noppen
    2 months ago
  • Effects of Transcranial Direct Current Stimulation on Motor Function in Children 8-12 Years With Developmental Coordination Disorder: A Randomized Controlled Trial
    Front Hum Neurosci. 2020 Dec 11;14:608131. doi: 10.3389/fnhum.2020.608131. eCollection 2020.ABSTRACTBackground and objectives: Developmental coordination disorder (DCD) is a neurodevelopmental motor disorder occurring in 5-6% of school-aged children. It is suggested that children with DCD show deficits in motor learning. Transcranial direct current stimulation (tDCS) enhances motor learning in adults and children but is unstudied in DCD. We aimed to investigate if tDCS, paired with motor skill training, facilitates motor learning in a pediatric sample with DCD. Methods: Twenty-eight children with diagnosed DCD (22 males, mean age: 10.62 ± 1.44 years) were randomized and placed into a treatment or sham group. ... read more
    PubMed Abstract – tDCS and LearningPublished on 2020-12-28By Melody N Grohs
    2 months ago
  • Cerebellar Transcranial Direct Current Stimulation for Motor Learning in People with Chronic Stroke: A Pilot Randomized Controlled Trial
    Brain Sci. 2020 Dec 14;10(12):982. doi: 10.3390/brainsci10120982.ABSTRACTCerebellar transcranial direct current stimulation (ctDCS) is a non-invasive brain stimulation technique that alters neural plasticity through weak, continuous, direct currents delivered to the cerebellum. This study aimed to evaluate the feasibility of conducting a randomized controlled trial (RCT) delivering three consecutive days of ctDCS during split-belt treadmill training (SBTT) in people with chronic stroke. Using a double-blinded, parallel-group RCT design, eligible participants were randomly allocated to receive either active anodal ctDCS or sham ctDCS combined with SBTT on three consecutive days. Outcomes were assessed at one-week follow-up, using step length symmetry as a ... read more
    PubMed Abstract – tDCS and LearningPublished on 2020-12-17By Nitika Kumari
    3 months ago
  • Preoperative Transcranial Direct Current Stimulation in Glioma Patients: A Proof of Concept Pilot Study
    Front Neurol. 2020 Nov 19;11:593950. doi: 10.3389/fneur.2020.593950. eCollection 2020.ABSTRACTBackground: Transcranial direct current stimulation (tDCS) has been used extensively in patient populations to facilitate motor network plasticity. However, it has not been studied in patients with brain tumors. We aimed to determine the feasibility of a preoperative motor training and tDCS intervention in patients with glioma. In an exploratory manner, we assessed changes in motor network connectivity following this intervention and related these changes to predicted electrical field strength from the stimulated motor cortex. Methods: Patients with left-sided glioma (n=8) were recruited in an open label proof of concept pilot trial ... read more
    PubMed Abstract – tDCS and LearningPublished on 2020-12-17By Stefan Lang
    3 months ago
  • Lack of cerebellar tDCS effects on learning of a complex whole body dynamic balance task in middle-aged (50-65 years) adults
    Neurol Res Pract. 2020 Sep 22;2:38. doi: 10.1186/s42466-020-00085-x. eCollection 2020.ABSTRACTBACKGROUND: Cerebellar transcranial direct current stimulation (tDCS) is widely considered as a promising non-invasive tool to foster motor performance and learning in health and disease. The results of previous studies, however, are inconsistent. Our group failed to provide evidence for an effect of cerebellar tDCS on learning of a complex whole body dynamic balance task in young and healthy participants. Ceiling effects in the young study population are one possible explanation for the negative findings.METHODS: In the present study, we therefore tested 40 middle-aged healthy participants between the ages of 50 ... read more
    PubMed Abstract – tDCS and LearningPublished on 2020-12-16By M Rauscher
    3 months ago
  • Effects of Multiple Sessions of Cathodal Priming and Anodal HD-tDCS on Visuo Motor Task Plateau Learning and Retention
    Brain Sci. 2020 Nov 19;10(11):875. doi: 10.3390/brainsci10110875.ABSTRACTA single session of priming cathodal transcranial direct current stimulation (tDCS) prior to anodal tDCS (c-a-tDCS) allows cumulative effects on motor learning and retention. However, the impact of multiple sessions of c-a-tDCS priming on learning and retention remains unclear. Here, we tested whether multiple sessions of c-a-tDCS (over 3 consecutive days) applied over the left sensorimotor cortex can further enhance motor learning and retention of an already learned visuo-motor task as compared to anodal tDCS (a-tDCS) or sham. In a between group and randomized double-blind sham-controlled study design, 25 participants separated in 3 independent ... read more
    PubMed Abstract – tDCS and LearningPublished on 2020-11-24By Pierre Besson
    3 months ago
  • Modulation of the human sensorimotor system by afferent somatosensory input: evidence from experimental pressure stimulation and physiotherapy
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020 Dec;164(4):371-379. doi: 10.5507/bp.2020.052. Epub 2020 Nov 13.ABSTRACTPeripheral afferent input is critical for human motor control and motor learning. Both skin and deep muscle mechanoreceptors can affect motor behaviour when stimulated. Whereas some modalities such as vibration have been employed for decades to alter cutaneous and proprioceptive input, both experimentally and therapeutically, the central effects of mechanical pressure stimulation have been studied less frequently. This discrepancy is especially striking when considering the limited knowledge of the neurobiological principles of frequently used physiotherapeutic techniques that utilise peripheral stimulation, such as reflex locomotion ... read more
    PubMed Abstract – tDCS and LearningPublished on 2020-11-18By Pavel Hok
    4 months ago
  • Effects of tDCS on Tactile Perception Depend on Tactile Expertise in Both Musicians and Non-Musicians
    Brain Sci. 2020 Nov 12;10(11):843. doi: 10.3390/brainsci10110843.ABSTRACTBrain plasticity in the somatosensory cortex and tactile performance can be facilitated by brain stimulation. Here, we investigated the effects of transcranial direct current stimulation (tDCS) on tactile perception in musicians and non-musicians to elucidate how tDCS-effects might depend on tactile expertise. On three separate days, 17 semi-professional musicians (e.g., piano or violin players) and 16 non-musicians aged 18-27 years received 15 min of 1 mA anodal (a-tDCS), cathodal (c-tDCS) or sham tDCS in a pseudorandomized design. Pre and post tDCS, tactile sensitivity (Touch Detection Task; TDT) and discrimination performance (Grating Orientation Task; GOT) ... read more
    PubMed Abstract – tDCS and LearningPublished on 2020-11-17By Ben Godde
    4 months ago
  • Age as a Mediator of tDCS Effects on Pain: An Integrative Systematic Review and Meta-Analysis
    Front Hum Neurosci. 2020 Oct 28;14:568306. doi: 10.3389/fnhum.2020.568306. eCollection 2020.ABSTRACTIntroduction: The transcranial direct current stimulation (tDCS) is a neuromodulatory technique with the potential to decrease pain scores and to improve chronic pain treatment. Although age is an essential factor that might impact the tDCS effect, most studies are solely conducted in adults. Therefore, the age limitation presents a critical research gap in this field and can be shown by only a handful of studies that have included other age groups. To examine the evidence upon the tDCS effect on pain scores on children, adolescents, or elderly, and indirectly, to infer ... read more
    PubMed Abstract – tDCS and LearningPublished on 2020-11-16By Júlia Schirmer Saldanha
    4 months ago
  • Sensation seeking and neuroticism in fear conditioning and extinction: The role of avoidance behaviour
    Behav Res Ther. 2020 Dec;135:103761. doi: 10.1016/j.brat.2020.103761. Epub 2020 Oct 27.ABSTRACTMaladaptive avoidance behaviour, a key symptom of anxiety-related disorders, prevents extinction learning and maintains anxiety. Individual personality traits likely influence avoidance propensity: high sensation-seeking may decrease avoidance, thereby increasing extinction, and neuroticism may have the reverse effect. However, research on this is scarce. Using a naturalistic conditioned avoidance paradigm, 163 women underwent differential fear acquisition to a conditioned stimulus (CSplus). Next, during extinction, participants could either choose a risky shortcut, anticipating shock signalled by CSplus, or a time-consuming avoidance option (lengthy detour). Across participants, increased skin conductance (SCR) acquisition learning ... read more
    PubMed Abstract – tDCS and LearningPublished on 2020-11-13By Julina A Rattel
    4 months ago
  • Efficacy of single-session transcranial direct current stimulation on addiction-related inhibitory control and craving: a randomized trial in males with Internet gaming disorder
    J Psychiatry Neurosci. 2021 Jan 4;46(1):E111-E118. doi: 10.1503/jpn.190137.ABSTRACTBACKGROUND: Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (dlPFC) may reduce substance use and other addictive behaviours. However, the cognitive mechanisms that underpin such effects remain unclear. Impaired inhibitory control linked to hypoactivation of the prefrontal cortex may allow craving-related motivations to lead to compulsive addictive behaviours. However, very few studies have examined whether increasing the activation of the dlPFC via anodal tDCS could enhance inhibitory control over addiction-related distractors. The current study aimed to enrich empirical evidence related to this issue.METHODS: Thirty-three males with Internet gaming disorder underwent active ... read more
    PubMed Abstract – tDCS and LearningPublished on 2020-10-29By Lu-Lu Wu
    4 months ago
  • Appraising the effectiveness of electrical and magnetic brain stimulation techniques in acute major depressive episodes: an umbrella review of meta-analyses of randomized controlled trials
    Braz J Psychiatry. 2020 Oct 23:S1516-44462020005035205. doi: 10.1590/1516-4446-2020-1169. Online ahead of print.ABSTRACTElectrical and magnetic brain stimulation techniques present distinct mechanisms and efficacy in the acute treatment of depression. This was an umbrella review of meta-analyses of randomized controlled trials of brain stimulation techniques for managing acute major depressive episodes. A systematic review was performed in the PubMed/MEDLINE databases from inception until March 2020. We included the English language meta-analysis with the most randomized controlled trials on the effects of any brain stimulation technique vs. control in adults with an acute depressive episode. Continuous and dichotomous outcomes were assessed. A Measurement ... read more
    PubMed Abstract – tDCS and LearningPublished on 2020-10-28By Laís B Razza
    4 months ago