Tag Archives: Scientific Publications

The Impact of Transcranial Direct Current Stimulation (tDCS) on Bipolar Depression, Mania, and Euthymia: a Systematic Review of Preliminary Data

The Impact of Transcranial Direct Current Stimulation (tDCS) on Bipolar Depression, Mania, and Euthymia: a Systematic Review of Preliminary Data

Article Date: (Revised: 2019-01-03)
Authors: Dondé C, Neufeld NH, Geoffroy PA
PMID Link: 29785673


Journal Information
Title: The Psychiatric quarterly
Abbreviation: Psychiatr Q
Volume: 89
Issue: 4
Date: 2018-12-01
Citation: Psychiatr Q 2018 12;89(4):855-867

Abstract

The neurobiological basis of bipolar disorders (BD) has received increased attention and several brain regions and brain circuits have been correlated with clinical symptoms. These brain regions and circuits may represent targets for neuromodulation techniques such as transcranial Direct Current Stimulation (tDCS). We systematically reviewed the literature to explore the risks and benefits of tDCS in BD and examined all mood states. Following the PRISMA guidelines, a systematic literature search using several databases was performed from April 2002 to June 2017. From the 135 eligible studies, we retained 19 relevant articles for the systematic review, including 170 patients with BD treated by tDCS. Data from 10 studies suggest that tDCS improves depressive symptoms in BD. One case report of add-on-tDCS reported a significant positive response on manic symptoms. In 4 studies, tDCS impacted specific neurocognitive functions in euthymic patients. There is also preliminary evidence that tDCS improves neurological soft signs and sleep quality in euthymia. Side effects were predominantly transient and low-intensity, although 6 cases of hypomanic/manic affective switches have been reported. The majority of studies have been open trials with few patients. More sufficiently powered randomized controlled trials are needed to clarify the effectiveness of tDCS. Preliminary data suggests that tDCS holds promise as a treatment for BD, especially during depressive episodes. Perhaps most promising are emerging data suggesting tDCS may impact neurocognition and sleep quality in euthymia and be useful for relapse prevention.

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Transcranial Direct Current Stimulation on Opium Craving, Depression, and Anxiety: A Preliminary Study

Transcranial Direct Current Stimulation on Opium Craving, Depression, and Anxiety: A Preliminary Study

Article Date: 2019-01-16 (Revised: 2019-01-21)
Authors: Taremian F, Nazari S, Moradveisi L, Moloodi R
PMID Link: 30664050


Journal Information
Title: The journal of ECT
Abbreviation: J ECT
Volume:
Issue:
Date: 2019-01-16
Citation: J ECT 2019 Jan;

Abstract

OBJECTIVES: Transcranial direct current stimulation can be effective in reducing the craving for food, alcohol, and methamphetamine. Because its effects have not been tested on patients with opium use disorder, we investigated its efficacy when it is combined with a standard methadone maintenance therapy protocol.

METHODS: We carried out a pretest-posttest control group method to evaluate the effect of transcranial direct current stimulation at the dorsolateral prefrontal cortex (right anodal/left cathodal) on opium craving, depression, and anxiety symptoms. We considered opium craving as a primary outcome as well as depression and anxiety symptoms as secondary outcomes. Sixty participants with opium use disorder were randomly assigned into 3 groups (n = 20 for each group): (1) an active transcranial direct current stimulation with methadone maintenance treatment (active tDCS group), (2) sham transcranial direct current stimulation with methadone maintenance treatment (sham tDCS group), and (3) only methadone maintenance treatment (methadone maintenance treatment group). All participants completed the Desire for Drug Questionnaire, Obsessive-Compulsive Drug Use Scale, Beck Depression Inventory II, and Beck Anxiety Inventory a week before and a week after the treatment. The outcomes were assessed by independent assessors who were blind to the treatment conditions.

RESULTS: The active tDCS group had a significant reduction in opium craving, depression, and anxiety symptoms compared with the other 2 groups.

CONCLUSIONS: Our results provide a preliminary support for using the transcranial direct current stimulation along with methadone maintenance therapy in the treatment of patients with opium use disorder.

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Commentary: Efficacy and Safety of Transcranial Direct Current Stimulation as an Add-on Treatment for Bipolar Depression: A Randomized Clinical Trial

Commentary: Efficacy and Safety of Transcranial Direct Current Stimulation as an Add-on Treatment for Bipolar Depression: A Randomized Clinical Trial

Article Date: 2018-12-03 (Revised: 2018-12-25)
Authors: Hu ZY, Liu X, Zheng H, Zhou DS
PMID Link: 30574077


Journal Information
Title: Frontiers in human neuroscience
Abbreviation: Front Hum Neurosci
Volume: 12
Issue:
Date: 2018-01-01
Citation: Front Hum Neurosci 2018;12:480

Abstract

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Hospital production cost of transcranial direct current stimulation (tDCS) in the treatment of depression

Hospital production cost of transcranial direct current stimulation (tDCS) in the treatment of depression

Article Date: 2018-11-27 (Revised: 2019-02-01)
Authors: Sauvaget A, Tostivint A, Etcheverrigaray F, Pichot A, Dert C, Schirr-Bonnais S, Clouet J, Sellal O, Mauduit N, Leux C, Cabelguen C, Bulteau S, Riche VP
PMID Link: 30502122


Journal Information
Title: Neurophysiologie clinique = Clinical neurophysiology
Abbreviation: Neurophysiol Clin
Volume: 49
Issue: 1
Date: 2019-02-01
Citation: Neurophysiol Clin 2019 Feb;49(1):11-18

Abstract

OBJECTIVES: Due to its ease of use, tolerance, and cost of acquisition, transcranial direct current stimulation (tDCS) could constitute a credible therapeutic option for non-resistant depression in primary care, when combined with drug management. This indication has yet to receive official recognition in France. The objective of this study is to evaluate the production cost of tDCS for the treatment of depression in hospitals, under realistic conditions.

METHODS: The methodology adopted is based on cost accounting and was validated by a multidisciplinary working group. It includes equipment, staff, and structural costs to obtain the most realistic estimate possible. We first estimated the cost of producing a tDCS session, based on our annual activity objective, and then estimated the cost of a 15-session treatment program. This was followed up with a sensitivity analysis applying appropriate parameters.

RESULTS: The hospital production cost of a tDCS depression treatment program for a single patient was estimated at €1555.60 euros: €99 in equipment costs, €1076.95 in staff costs, and €379.65 in structural costs.

CONCLUSION: This cost analysis should make it possible to draw up pricing proposals in compliance with regulations and health policy choices and to develop health-economic studies. This would ultimately lead to official recognition of tDCS treatment for depression in France and pave the way for studying various scenarios of coverage by the French national health insurance system.

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Sleep Quality, Depression, and Quality of Life After Bilateral Anodal Transcranial Direct Current Stimulation in Patients with Parkinson’s Disease

Sleep Quality, Depression, and Quality of Life After Bilateral Anodal Transcranial Direct Current Stimulation in Patients with Parkinson’s Disease

Article Date: 2018-11-19 (Revised: 2019-02-15)
Authors: Hadoush H, Al-Sharman A, Khalil H, Banihani SA, Al-Jarrah M
PMID Link: 30449881


Journal Information
Title: Medical science monitor basic research
Abbreviation: Med Sci Monit Basic Res
Volume: 24
Issue:
Date: 2018-11-19
Citation: Med Sci Monit Basic Res 2018 Nov;24:198-205

Abstract

BACKGROUND Sleep dysfunctions impose a large burden on quality of life for patients with Parkinson’s disease (PD). Several studies on PD reported potential therapeutic effects of transcranial direct current stimulation (tDCS) on motor and non-motor functions, but not related to sleep quality. Therefore, the present study examined sleep quality, depression perception, and quality of life changes after bilateral anodal tDCS in patients with PD. MATERIAL AND METHODS Twenty-one patients (n=21) with PD underwent 10 sessions (20 min each, 5 per week) of bilateral anodal tDCS stimulation applied simultaneously over the left and right prefrontal and motor areas. The Pittsburgh Sleep Quality Index (PSQI) total score and sub-scores, Geriatric Depression Scale (GDS), and Health-related quality of life questionnaire (SF-36) were measured pre/post bilateral tDCS anodal stimulation. RESULTS PSQI total score (P=0.045), sleep latency sub-score (P=0.02), and GDS total score (P=0.016) significantly decreased, and physical and mental components scores of SF-36 (P=0.018 and P=0.001, respectively) significantly increased after bilateral anodal tDCS stimulation. The GDS score decrease was directly correlated with decrease in PSQI total score (P=0.01), sleep latency sub-score (P=0.002), and sleep disturbance sub-score (P=0.003). In addition, the GDS score decrease was inversely correlated with increasing mental component score of SF-36 (P=0.001), which was directly correlated with an increase in sleep efficiency sub-score (P=0.03) and the physical component score of SF-36 (P=0.0001). CONCLUSIONS Bilateral anodal tDCS stimulation showed potential therapeutic effects in patients with PD in terms of sleep quality and depression level improvement, which together improved mental and physical quality of life in patients with PD.

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Quantifying clinical improvements in patients with depression under the treatment of transcranial direct current stimulation using event related potentials

Quantifying clinical improvements in patients with depression under the treatment of transcranial direct current stimulation using event related potentials

Article Date: 2018-11-02 (Revised: 2018-11-30)
Authors: Shahsavar Y, Ghoshuni M, Talaei A
PMID Link: 30390213


Journal Information
Title: Australasian physical & engineering sciences in medicine
Abbreviation: Australas Phys Eng Sci Med
Volume: 41
Issue: 4
Date: 2018-12-01
Citation: Australas Phys Eng Sci Med 2018 Dec;41(4):973-983

Abstract

The main goal of this study was to assess the changes in brain activities of patients with severe depression by applying transcranial direct current stimulation (tDCS) using event related potentials (ERPs). Seven patients (four males, with the mean age 34.85 ± 4.25) were asked to fill out Beck’s depression questionnaires. EEG signals of subjects were recorded during Stroop test. This test entailed 360 stimulations, which included 120 congruent, 120 incongruent, and 120 neutral stimulations lasting for 12 min. Subsequently, the dorso lateral prefrontal cortex in patients’ left hemisphere was stimulated for six sessions using tDCS. At the end of tDCS treatment period, subjects filled out Beck’s depression questionnaires again and EEG signal recordings were repeated simultaneously with Stroop test. Wavelet coefficients of EEG frequency bands in every stimulation type were extracted from ERP components. The changes in Beck score before and after tDCS were estimated using neural network model. The ERP results showed that the latency period of N400 component after applying tDCS decreased significantly. Moreover, a significant correlation was observed between percentage changes of congruent and incongruent accuracy and the increase in the average energy of wavelet coefficients in alpha band in Pz electrode with p = 0.0128, r = 0.9060 and p = 0.0037, r = 0.95, respectively. Additionally, the results of neural network model revealed that the changes in Beck score were estimated with an average error of 0.0519. Consequently, the improvement of depressed patients treated with tDCS could be estimated with good accuracy using average energy of wavelet coefficients in alpha band.

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Treatment of major depression with a two-step tDCS protocol add-on to SSRI: Results from a naturalistic study

Treatment of major depression with a two-step tDCS protocol add-on to SSRI: Results from a naturalistic study

Article Date: 2018-10-03 (Revised: 2018-12-19)
Authors: Palm U, Goerigk S, Kirsch B, Bäumler L, Sarubin N, Hasan A, Brunoni AR, Padberg F
PMID Link: 30314900


Journal Information
Title: Brain stimulation
Abbreviation: Brain Stimul
Volume: 12
Issue: 1
Date: 2019-01-01
Citation: Brain Stimul 2019 Jan – Feb;12(1):195-197

Abstract

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Hypomania Induced by Bifrontal Transcranial Direct Current Stimulation in a Patient with Bipolar Depression

Hypomania Induced by Bifrontal Transcranial Direct Current Stimulation in a Patient with Bipolar Depression

Article Date: 2018-09-17 (Revised: 2018-11-14)
Authors: Chao PC, Chang CC, Chang HA
PMID Link: 30235920


Journal Information
Title: Psychiatry investigation
Abbreviation: Psychiatry Investig
Volume: 15
Issue: 9
Date: 2018-09-01
Citation: Psychiatry Investig 2018 Sep;15(9):914-915

Abstract

Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has been increasingly used to treat bipolar depression. Researchers recently noticed the risk of tDCS-emergent mania/hypomania in depressed patients and started to evaluate this risk by launching a meta-analysis. Here we present a female with bipolar II depression who rapidly developed hypomanic switching during bifrontal tDCS.

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Feasibility of Computerized Cognitive-Behavioral Therapy Combined With Bifrontal Transcranial Direct Current Stimulation for Treatment of Major Depression

Feasibility of Computerized Cognitive-Behavioral Therapy Combined With Bifrontal Transcranial Direct Current Stimulation for Treatment of Major Depression

Article Date: 2018-08-28 (Revised: 2018-08-28)
Authors: Welch ES, Weigand A, Hooker JE, Philip NS, Tyrka AR, Press DZ, Carpenter LL
PMID Link: 30153360


Journal Information
Title: Neuromodulation : journal of the International Neuromodulation Society
Abbreviation: Neuromodulation
Volume:
Issue:
Date: 2018-08-28
Citation: Neuromodulation 2018 Aug;

Abstract

BACKGROUND: Cognitive behavioral therapy (CBT) is effective in the treatment of major depressive disorder (MDD). Transcranial Direct Current Stimulation (tDCS) has demonstrated preliminary antidepressant effects and beneficial effects on cognitive function.

OBJECTIVE: We investigated the feasibility and acceptability of using tDCS to enhance the effects of computer-based CBT for treatment of MDD.

MATERIALS AND METHODS: In a randomized, double-blind, sham-controlled study, 14 patients with MDD on stable or no pharmacotherapy received active or sham bifrontal tDCS for four weeks with concurrent CBT.

RESULTS: Ten participants completed the protocol. Three withdrew from the study because of lack of efficacy or dislike of the eCBT program. One was discontinued from the protocol by the investigators. Treatment was well tolerated, and most side-effects were mild and consistent with prior tDCS research. Pooled data from both groups showed significant baseline to endpoint improvement in depression (p = 0.008). Overall percent change on the HAMD-21 was 28.98%. The study was underpowered to detect differences in tDCS treatment groups.

CONCLUSIONS: Combining tDCS with computer-based CBT is feasible for MDD. Further work is needed to evaluate potential synergistic effects of combined tDCS and CBT.

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Transcranial Direct Current Stimulation (tDCS) for Depression during Pregnancy: Scientific Evidence and What Is Being Said in the Media-A Systematic Review

Transcranial Direct Current Stimulation (tDCS) for Depression during Pregnancy: Scientific Evidence and What Is Being Said in the Media-A Systematic Review

Article Date: 2018-08-14 (Revised: 2018-11-14)
Authors: Kurzeck AK, Kirsch B, Weidinger E, Padberg F, Palm U
PMID Link: 30110930


Journal Information
Title: Brain sciences
Abbreviation: Brain Sci
Volume: 8
Issue: 8
Date: 2018-08-14
Citation: Brain Sci 2018 Aug;8(8)

Abstract

Major depression is the most frequent morbidity in pregnancy. The first-line therapies, psychopharmacologic treatment and psychotherapy, are either insufficient or may cause severe or teratogenic adverse events. As a result of its local limitation to the patient’s brain, transcranial direct current stimulation (tDCS) could potentially be an ideal treatment for pregnant women with depression. A literature search was conducted in medical databases, globally published newspapers, search engines, and clinical trial registers to collect all articles on tDCS for the treatment of depression during pregnancy. The aim of this review was to investigate the scientific evidence of tDCS use for depression during pregnancy and to compare these results with the textual and emotional perception in the media as interventions during pregnancy are under particular surveillance. We detected 13 medical articles dealing with tDCS for depression in pregnancy. Overall, the scientific evidence as well as articles in the media for tDCS in pregnancy are sparse, but promising. Further studies are required in this specifically vulnerable population of pregnant women to generate evidence. It is likely that public interest will increase when the results of a pilot study in Canada are published.

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