Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • Transcranial Direct Current Stimulation (tDCS) Induces Analgesia in Rats with Neuropathic Pain and Alcohol Abstinence.
    Related ArticlesTranscranial Direct Current Stimulation (tDCS) Induces Analgesia in Rats with Neuropathic Pain and Alcohol Abstinence. Neurochem Res. 2020 Aug 25;: Authors: Santos DS, Lopes BC, Medeiros LF, Assumpção JAF, de Souza A, Salvi AA, da Silva LS, Fregni F, Caumo W, Torres ILS Abstract Neuromodulatory techniques have been studied to treat drug addiction or compulsive eating as well as different chronic pain conditions, such as neuropathic and inflammatory pain in the clinical and preclinical settings. In this study, we aimed to investigate the effect of transcranial direct current stimulation (tDCS) on the association of alcohol withdrawal with neuropathic pain ... read more
    1 month ago
  • Efficacy and mechanisms of non-invasive brain stimulation to enhance exposure therapy: A review.
    Related ArticlesEfficacy and mechanisms of non-invasive brain stimulation to enhance exposure therapy: A review. Clin Psychol Rev. 2019 06;70:64-78 Authors: Nuñez M, Zinbarg RE, Mittal VA Abstract Though cognitive behavioral techniques are generally effective in the treatment of anxiety disorders, some people fail to benefit from exposure therapy or experience a return of fear after terminating exposure therapy. The burgeoning field of non-invasive brain stimulation provides a potential method of augmenting exposure therapy so that it is more effective. Successful exposure therapy is hypothesized to occur due to inhibition, and research suggests that brain stimulation ... read more
    1 month ago
  • The Efficacy and Safety of Transcranial Direct Current Stimulation for Cerebellar Ataxia: a Systematic Review and Meta-Analysis.
    Related ArticlesThe Efficacy and Safety of Transcranial Direct Current Stimulation for Cerebellar Ataxia: a Systematic Review and Meta-Analysis. Cerebellum. 2020 Aug 24;: Authors: Chen TX, Yang CY, Willson G, Lin CC, Kuo SH Abstract A promising new approach, transcranial direct current stimulation (tDCS) has recently been used as a therapeutic modality for cerebellar ataxia. However, the strength of the conclusions drawn from individual studies in the current literature may be constrained by the small sample size of each trial. Following a systematic literature retrieval of studies, meta-analyses were conducted by pooling the standardized mean differences (SMDs) using random-effects models to ... read more
    1 month ago
  • Realistic volumetric-approach to simulate transcranial electric stimulation-ROAST-a fully automated open-source pipeline.
    Related ArticlesRealistic volumetric-approach to simulate transcranial electric stimulation-ROAST-a fully automated open-source pipeline. J Neural Eng. 2019 07 30;16(5):056006 Authors: Huang Y, Datta A, Bikson M, Parra LC Abstract OBJECTIVE: Research in the area of transcranial electrical stimulation (TES) often relies on computational models of current flow in the brain. Models are built based on magnetic resonance images (MRI) of the human head to capture detailed individual anatomy. To simulate current flow on an individual, the subject's MRI is segmented, virtual electrodes are placed on this anatomical model, the volume is tessellated into a mesh, and a finite element ... read more
    1 month ago
  • A direct comparison of the electrophysiological effects of transcranial direct and alternating current stimulation in healthy subjects.
    A direct comparison of the electrophysiological effects of transcranial direct and alternating current stimulation in healthy subjects. Brain Res. 2020 Aug 17;:147065 Authors: Kim J, Jang KI, Roh D, Kim H, Kim DH Abstract OBJECTIVE: Despite the clinical effectiveness of transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), the comparability of these interventions in neurophysiological aspects have not been thoroughly investigated. Thus, we aimed to directly compare the electrophysiological effects of single-session tDCS and gamma-tACS in healthy subjects, matching the intervention protocol as closely as possible. METHODS: This was a randomized, double-blinded, and active-controlled study. Sixty healthy ... read more
    1 month ago
  • Transcutaneous spinal direct current stimulation increases corticospinal transmission and enhances voluntary motor output in humans.
    Related ArticlesTranscutaneous spinal direct current stimulation increases corticospinal transmission and enhances voluntary motor output in humans. Physiol Rep. 2020 Aug;8(16):e14531 Authors: Yamaguchi T, Beck MM, Therkildsen ER, Svane C, Forman C, Lorentzen J, Conway BA, Lundbye-Jensen J, Geertsen SS, Nielsen JB Abstract Optimization of motor performance is of importance in daily life, in relation to recovery following injury as well as for elite sports performance. The present study investigated whether transcutaneous spinal direct current stimulation (tsDCS) may enhance voluntary ballistic activation of ankle muscles and descending activation of spinal motor neurons in able-bodied adults. Forty-one adults (21 men; 24.0 ± 3.2 years) participated ... read more
    1 month ago
  • The effects of bi-anodal tDCS over the prefrontal cortex regions with extracephalic references placement on insight levels, cardio-respiratory and autonomic functions in schizophrenia patients and exploratory biomarker analyses for treatment response.
    The effects of bi-anodal tDCS over the prefrontal cortex regions with extracephalic references placement on insight levels, cardio-respiratory and autonomic functions in schizophrenia patients and exploratory biomarker analyses for treatment response. Int J Neuropsychopharmacol. 2020 Aug 18;: Authors: Chang CC, Kao YC, Chao CY, Tzeng NS, Chang HA Abstract BACKGROUND: We have previously shown the efficacy of bi-anodal transcranial direct current stimulation (tDCS) over the prefrontal cortex (PFC) regions with extracephalic references placement in improving negative symptoms in schizophrenia. In this ancillary investigation, the effects of this intervention on insight levels, other clinical outcomes, cardio-respiratory and autonomic functions were examined ... read more
    1 month ago
  • Cognitive Function Improvement in Mouse Model of Alzheimer’s Disease Following Transcranial Direct Current Stimulation.
    Cognitive Function Improvement in Mouse Model of Alzheimer's Disease Following Transcranial Direct Current Stimulation. Brain Sci. 2020 Aug 12;10(8): Authors: Kim WI, Han JY, Song MK, Park HK, Jo J Abstract Anodal transcranial direct current stimulation (tDCS) is a painless noninvasive method that reportedly improves cognitive function in Alzheimer's disease (AD) by stimulating the brain. However, its underlying mechanism remains unclear. Thus, the present study investigates the cognitive effects in a 5xFAD AD mouse model using electrophysiological and pathological methods. We used male 5xFAD C57BL/6J and male C57BL/6J wild-type mice; the dementia model was confirmed through DNA sequencing. The verified ... read more
    1 month ago
  • Effects of transcranial random noise stimulation combined with Graded Repetitive Arm Supplementary Program (GRASP) on motor rehabilitation of the upper limb in sub-acute ischemic stroke patients: a randomized pilot study.
    Related ArticlesEffects of transcranial random noise stimulation combined with Graded Repetitive Arm Supplementary Program (GRASP) on motor rehabilitation of the upper limb in sub-acute ischemic stroke patients: a randomized pilot study. J Neural Transm (Vienna). 2019 12;126(12):1701-1706 Authors: Arnao V, Riolo M, Carduccio F, Tuttolomondo A, D'Amelio M, Brighina F, Gangitano M, Salemi G, Ragonese P, Aridon P Abstract We evaluated the combined use of transcranial random noise stimulation (tRNS) with the Graded Repetitive Arm Supplementary Program (GRASP) in sub-acute ischemic stroke patients suffering from arm impairment. Eighteen ischemic stroke patients with upper limb disability were randomly assigned to ... read more
    1 month ago
  • Cortical priming strategies for gait training after stroke: a controlled, stratified trial.
    Related ArticlesCortical priming strategies for gait training after stroke: a controlled, stratified trial. J Neuroeng Rehabil. 2020 Aug 17;17(1):111 Authors: Madhavan S, Cleland BT, Sivaramakrishnan A, Freels S, Lim H, Testai FD, Corcos DM Abstract BACKGROUND: Stroke survivors experience chronic gait impairments, so rehabilitation has focused on restoring ambulatory capacity. High-intensity speed-based treadmill training (HISTT) is one form of walking rehabilitation that can improve walking, but its effectiveness has not been thoroughly investigated. Additionally, cortical priming with transcranial direct current stimulation (tDCS) and movement may enhance HISTT-induced improvements in walking, but there have been no systematic investigations. The objective of ... read more
    1 month ago
  • Transcranial direct current stimulation for post-stroke dysphagia: a systematic review and meta-analysis of randomized controlled trials.
    Transcranial direct current stimulation for post-stroke dysphagia: a systematic review and meta-analysis of randomized controlled trials. J Neurol. 2020 Aug 14;: Authors: Marchina S, Pisegna JM, Massaro JM, Langmore SE, McVey C, Wang J, Kumar S Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) has been investigated as a tool for dysphagia recovery after stroke in several single-center randomized controlled trials (RCT). OBJECTIVE: The aim of this investigation was to quantitatively evaluate the effect of tDCS on dysphagia recovery after a stroke utilizing a systematic review and meta-analysis. METHODS: Major databases were searched through October 2019 using a pre-defined set of ... read more
    1 month ago
  • The Effects of Transcranial Electrical Stimulation on Human Motor Functions: A Comprehensive Review of Functional Neuroimaging Studies.
    Related ArticlesThe Effects of Transcranial Electrical Stimulation on Human Motor Functions: A Comprehensive Review of Functional Neuroimaging Studies. Front Neurosci. 2020;14:744 Authors: Gao Y, Cavuoto L, Schwaitzberg S, Norfleet JE, Intes X, De S Abstract Transcranial electrical stimulation (tES) is a promising tool to enhance human motor skills. However, the underlying physiological mechanisms are not fully understood. On the other hand, neuroimaging modalities provide powerful tools to map some of the neurophysiological biomarkers associated with tES. Here, a comprehensive review was undertaken to summarize the neuroimaging evidence of how tES affects human motor skills. A literature search has been done ... read more
    1 month ago
  • Effects of Transcranial Electrical Stimulation on Human Auditory Processing and Behavior-A Review.
    Related ArticlesEffects of Transcranial Electrical Stimulation on Human Auditory Processing and Behavior-A Review. Brain Sci. 2020 Aug 08;10(8): Authors: Wang Y, Shi L, Dong G, Zhang Z, Chen R Abstract Transcranial electrical stimulation (tES) can adjust the membrane potential by applying a weak current on the scalp to change the related nerve activity. In recent years, tES has proven its value in studying the neural processes involved in human behavior. The study of central auditory processes focuses on the analysis of behavioral phenomena, including sound localization, auditory pattern recognition, and auditory discrimination. To our knowledge, studies on the application of ... read more
    2 months ago
  • Brain Stimulation for Improving Sleep and Memory.
    Related ArticlesBrain Stimulation for Improving Sleep and Memory. Sleep Med Clin. 2020 Mar;15(1):101-115 Authors: Malkani RG, Zee PC Abstract Given the critical role of sleep, particularly sleep slow oscillations, sleep spindles, and hippocampal sharp wave ripples, in memory consolidation, sleep enhancement represents a key opportunity to improve cognitive performance. Techniques such as transcranial electrical and magnetic stimulation and acoustic stimulation can enhance slow oscillations and sleep spindles and potentially improve memory. Targeted memory reactivation in sleep may enhance or stabilize memory consolidation. Each technique has technical considerations that may limit its broader clinical application. Therefore, neurostimulation to enhance sleep ... read more
    2 months ago
  • Ergogenic Effects of Bihemispheric Transcranial Direct Current Stimulation on Fitness: a Randomized Cross-over Trial.
    Ergogenic Effects of Bihemispheric Transcranial Direct Current Stimulation on Fitness: a Randomized Cross-over Trial. Int J Sports Med. 2020 Aug 11;: Authors: Codella R, Alongi R, Filipas L, Luzi L Abstract Several types of routines and methods have been experimented to gain neuromuscular advantages, in terms of exercise performance, in athletes and fitness enthusiasts. The aim of the present study was to evaluate the impact of biemispheric transcranial direct current stimulation on physical fitness indicators of healthy, physically active, men. In a randomized, single-blinded, crossover fashion, seventeen subjects (age: 30.9 ± 6.5 years, BMI: 24.8±3.1 kg/m2) underwent either stimulation or sham, ... read more
    2 months ago
  • Acute offline transcranial direct current stimulation does not change pain or anxiety produced by the cold pressor test.
    Acute offline transcranial direct current stimulation does not change pain or anxiety produced by the cold pressor test. Neurosci Lett. 2020 Aug 08;:135300 Authors: Brasil-Neto JP, Iannone A, Caixeta FV, Cavendish B, de Mello Cruz AP, Buratto LG Abstract Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has an antalgic effect on acute experimental pain in healthy volunteers. Many published studies have used online stimulation (i.e., tDCS performed during painful stimulation). On the other hand, daily tDCS sessions have been proposed as a therapy for chronic pain (offline tDCS). In such cases, the therapeutic potential depends on ... read more
    2 months ago
  • Visual motion perception improvements following direct current stimulation over V5 are dependent on initial performance.
    Visual motion perception improvements following direct current stimulation over V5 are dependent on initial performance. Exp Brain Res. 2020 Aug 09;: Authors: Wu D, Li C, Liu N, Xu P, Xiao W Abstract Transcranial direct current stimulation (tDCS) can improve visual perception. However, the effect of tDCS on visual perception is largely variable, possibly due to individual differences in initial performance. The goal of the present study was to evaluate the dependency of visual motion perception improvements on initial performance. Twenty-eight observers were randomly divided into two groups. Anodal tDCS and sham stimulation were separately applied to V5 (1.5 mA, 20 min), ... read more
    2 months ago
  • Ca2+ channel dynamics explain the nonlinear neuroplasticity induction by cathodal transcranial direct current stimulation over the primary motor cortex.
    Related ArticlesCa2+ channel dynamics explain the nonlinear neuroplasticity induction by cathodal transcranial direct current stimulation over the primary motor cortex. Eur Neuropsychopharmacol. 2020 Aug 04;: Authors: Mosayebi-Samani M, Melo L, Agboada D, Nitsche MA, Kuo MF Abstract Transcranial direct current stimulation (tDCS) induces polarity-dependent neuroplasticity: with conventional protocols, anodal tDCS results in excitability enhancement while cathodal stimulation reduces excitability. However, partially non-linear responses are observed with increased stimulation intensity and/or duration. Cathodal tDCS with 2 mA for 20 min reverses the excitability-diminishing plasticity induced by stimulation with 1 mA into excitation, while cathodal tDCS with 3 mA again results in excitability diminution. Since tDCS ... read more
    2 months ago
  • The Analgesic Effect of Transcranial Direct Current Stimulation (tDCS) combined with Physical Therapy on Common Musculoskeletal Conditions: A Systematic Review and Meta-Analysis.
    Related ArticlesThe Analgesic Effect of Transcranial Direct Current Stimulation (tDCS) combined with Physical Therapy on Common Musculoskeletal Conditions: A Systematic Review and Meta-Analysis. Princ Pract Clin Res. 2020 Jan-Apr;6(1):23-26 Authors: Teixeira PEP, Alawdah L, Alhassan HAA, Guidetti M, Priori A, Papatheodorou S, Fregni F Abstract BACKGROUND: The analgesic effects of transcranial Direct Current Stimulation (tDCS) combined with physical therapy remain unclear. OBJECTIVE: To systematically review available evidence comparing tDCS with any physical therapy modality (PTM) to PTM alone or PTM with sham tDCS on pain relief on common musculoskeletal (MSK) conditions, namely knee osteoarthritis (KOA), chronic low back pain (CLBP), ... read more
    2 months ago
  • Enhancing Memory for Relationship Actions by Transcranial Direct Current Stimulation of the Superior Temporal Sulcus.
    Related ArticlesEnhancing Memory for Relationship Actions by Transcranial Direct Current Stimulation of the Superior Temporal Sulcus. Brain Sci. 2020 Jul 29;10(8): Authors: Marrero H, Yagual SN, García-Marco E, Gámez E, Beltrán D, Díaz JM, Urrutia M Abstract We examine the effect of transcranial direct current stimulation (tDCS) of right superior temporal sulcus (rSTS) in memorization of approach/avoidance relationship-action sentences; for example, "Alejandro accepted/rejected Marta in his group." Sixty-five university students participated in a tDCS study, in which a between-subjects design was adopted. Sixty-four participants were also given the behavioral approach system (BAS) and behavioral inhibition system (BIS) scales. Participants were ... read more
    2 months ago
  • [The effect of transcranial direct current stimulation on dysfunction of bilateral posterior cingulate cortex after sleep deprivation: a preliminary study].
    Related Articles[The effect of transcranial direct current stimulation on dysfunction of bilateral posterior cingulate cortex after sleep deprivation: a preliminary study]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020 Mar;36(2):101-105 Authors: Meng QQ, Li JY, Guo DL, Shao YC, Zhang X Abstract Objective: To investigate the effects of transcranial direct current stimulation (tDCS) on the disturbance of brain network dysfunction after sleep deprivation (SD). Methods: The experimental design of self-control was used in the study. All 16 subjects received 2 times of 24 h SD with an interval of 3 weeks. After the first normal sleep, 24 h SD ... read more
    2 months ago
  • Probing the architecture of visual number sense with parietal tRNS.
    Related ArticlesProbing the architecture of visual number sense with parietal tRNS. Cortex. 2019 05;114:54-66 Authors: Karolis VR, Grinyaev M, Epure A, Tsoy V, Du Rietz E, Banissy MJ, Cappelletti M, Kovas Y Abstract Theoretical accounts of the visual number sense (VNS), i.e., an ability to discriminate approximate numerosities, remain controversial. A proposal that the VNS represents a process of numerosity extraction, leading to an abstract number representation in the brain, has been challenged by the view that the VNS is non-numerical in its essence and amounts to a weighted integration of continuous magnitude features that typically change with numerosity. ... read more
    2 months ago
  • Pulsed transcranial electric brain stimulation enhances speech comprehension.
    Pulsed transcranial electric brain stimulation enhances speech comprehension. Brain Stimul. 2020 Jul 28;: Authors: Ruhnau P, Rufener KS, Heinze HJ, Zaehle T Abstract BACKGROUND: One key mechanism thought to underlie speech processing is the alignment of cortical brain rhythms to the acoustic input, a mechanism termed entrainment. Recent work showed that transcranial electrical stimulation (tES) in speech relevant frequencies or adapted to the speech envelope can in fact enhance speech processing. However, it is unclear whether an oscillatory tES is necessary, or if transients in the stimulation (e.g., peaks in the tES signal) at relevant times are sufficient. OBJECTIVE: In ... read more
    2 months ago
  • Cathodal Cerebellar tDCS Combined with Visual Feedback Improves Balance Control.
    Related ArticlesCathodal Cerebellar tDCS Combined with Visual Feedback Improves Balance Control. Cerebellum. 2020 Jul 30;: Authors: Emadi Andani M, Villa-Sánchez B, Raneri F, Dametto S, Tinazzi M, Fiorio M Abstract Balance control is essential to maintain a stable body position and to prevent falls. The aim of this study was to determine whether balance control could be improved by using cerebellar transcranial direct current stimulation (tDCS) and visual feedback in a combined approach. A total of 90 healthy volunteers were randomly assigned to six groups defined by the delivery of tDCS (cathodal or anodal or sham) and the provision or ... read more
    2 months ago
  • An integrative clustering approach to tDCS individual response variability in cognitive performance: beyond a null effect on working memory.
    An integrative clustering approach to tDCS individual response variability in cognitive performance: beyond a null effect on working memory. Neuroscience. 2020 Jul 28;: Authors: Antonio LC, Rocío RF, Noa F, Eliseo IS, Miguel FD Abstract Despite the growing interest in the use of transcranial direct current stimulation (tDCS) for the modulation of human cognitive function, there are contradictory findings regarding the cognitive benefits of this technique. Inter-individual response variability to tDCS may play a significant role. We explored the effects of anodal versus sham tDCS over the left prefrontal cortex (LPFC) on working memory performance, taking into account the inter-individual ... read more
    2 months ago