Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • Non-invasive brain stimulation combined with exercise in chronic pain: a systematic review and meta-analysis.
    Related ArticlesNon-invasive brain stimulation combined with exercise in chronic pain: a systematic review and meta-analysis. Expert Rev Neurother. 2020 Mar 04;: Authors: Cardenas-Rojas A, Pacheco-Barrios K, Giannoni-Luza S, Rivera-Torrejon O, Fregni F Abstract Background: The use of non-invasive brain stimulation (NIBS) combined with exercise could produce synergistic effects on chronic pain conditions. This study aims to evaluate the efficacy and safety of NIBS combined with exercise to treat chronic pain as well as to describe the parameters used to date in this combination.Methods: The search was carried out in Medline, Central, Scopus, Embase, and Pedro until November 2019. Randomized clinical ... read more
    4 weeks ago
  • Endocrine and immune effects of non-convulsive neurostimulation in depression: A systematic review.
    Related ArticlesEndocrine and immune effects of non-convulsive neurostimulation in depression: A systematic review. Brain Behav Immun. 2020 Feb 29;: Authors: Perrin AJ, Pariante CM Abstract BACKGROUND: Non-convulsive neurostimulation is a rapidly-developing alternative to traditional treatment approaches in depression. Modalities such as repetitive Transcranial Magnetic Stimulation (rTMS), transcranial Direct Current Stimulation (tDCS), Vagal Nerve Stimulation (VNS) and Deep Brain Stimulation (DBS) are now recognized as potential treatments. How non-convulsive neurostimulation interventions impact the neurohormonal and neuroimmune changes that accompany depression remains relatively unknown. If this type of intervention can drive endocrine, immune, as well symptom changes in depression, non-convulsive neurostimulation may ... read more
    4 weeks ago
  • Transcranial focal electrical stimulation via concentric ring electrodes in freely moving cats: Antiepileptogenic and postictal effects.
    Related ArticlesTranscranial focal electrical stimulation via concentric ring electrodes in freely moving cats: Antiepileptogenic and postictal effects. Exp Neurol. 2019 10;320:113012 Authors: Valdés-Cruz A, Villasana-Salazar B, Williams B, Martínez-Vargas D, Magdaleno-Madrigal VM, Almazán-Alvarado S, Besio WG Abstract Transcranial focal electrical stimulation (TFS) via tripolar concentric ring electrodes (TCRE), tripolar TFS, is proposed to treat pharmacoresistant epilepsy. We determined the effect of tripolar TFS on electrical amygdaloid kindling (AK) in freely moving cats. Fifteen cats were bilaterally implanted with electrodes in the amygdala (AM) and prefrontal cortex and assigned to three groups: the control group, which only received AK; the ... read more
    4 weeks ago
  • Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats.
    Related ArticlesTranscranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats. Exp Neurol. 2020 Feb 28;:113264 Authors: Wu YJ, Chien ME, Huang CH, Chiang CC, Lin CC, Huang CW, Durand DM, Hsu KS Abstract Status epilepticus (SE) is a state of prolonged and repeated seizures that can lead to permanent brain damage or life-threatening conditions. Transcranial direct current stimulation (tDCS) non-invasively provides a polarity-specific electric current to modulate brain excitability. Little is known about the therapeutic potential of tDCS in SE. Here, we aim to determine the tDCS effects on seizure severity, EEG and post-SE consequences in ... read more
    1 month ago
  • Effects of Anodal tDCS on Arithmetic Performance and Electrophysiological Activity.
    Related ArticlesEffects of Anodal tDCS on Arithmetic Performance and Electrophysiological Activity. Front Hum Neurosci. 2020;14:17 Authors: Mosbacher JA, Brunner C, Nitsche MA, Grabner RH Abstract Arithmetic abilities are among the most important school-taught skills and form the basis for higher mathematical competencies. At the same time, their acquisition and application can be challenging. Hence, there is broad interest in methods to improve arithmetic abilities. One promising method is transcranial direct current stimulation (tDCS). In the present study, we compared two anodal tDCS protocols in their efficacy to improve arithmetic performance and working memory. In addition, we investigated stimulation-related electrophysiological changes. ... read more
    1 month ago
  • Effects of Transcranial Stimulation With Direct and Alternating Current on Resting-State Functional Connectivity: An Exploratory Study Simultaneously Combining Stimulation and Multiband Functional Magnetic Resonance Imaging.
    Related ArticlesEffects of Transcranial Stimulation With Direct and Alternating Current on Resting-State Functional Connectivity: An Exploratory Study Simultaneously Combining Stimulation and Multiband Functional Magnetic Resonance Imaging. Front Hum Neurosci. 2019;13:474 Authors: Mondino M, Ghumman S, Gane C, Renauld E, Whittingstall K, Fecteau S Abstract Background: Transcranial stimulation with direct (tDCS) and alternating current (tACS) has increasingly gained interest in various fields, from cognitive neuroscience to clinical investigations. Transcranial current stimulation used alone may modulate brain activity that consequently influences behaviors, without providing information on potentially induced brain activity changes. The combination of transcranial current stimulation and functional magnetic resonance imaging ... read more
    1 month ago
  • The effect of transcranial direct current stimulation on balance in healthy young and older adults: A systematic review of the literature.
    Related ArticlesThe effect of transcranial direct current stimulation on balance in healthy young and older adults: A systematic review of the literature. Neurophysiol Clin. 2020 Feb 26;: Authors: Baharlouei H, Saba MA, Shaterzadeh Yazdi MJ, Jaberzadeh S Abstract Various studies have investigated the effect of noninvasive brain stimulation methods such as transcranial direct stimulation (tDCS) on postural control in healthy young and older adults. However, the use of different treatment protocols and outcome measures makes it difficult to interpret the research results. This systematic review provides a comprehensive overview of the current literature on the effect of tDCS on postural ... read more
    1 month ago
  • Transcranial Direct Current Stimulation Over the Prefrontal Cortex in Depression Modulates Cortical Excitability in Emotion Regulation Regions as Measured by Concurrent Functional Magnetic Resonance Imaging: An Exploratory Study.
    Related ArticlesTranscranial Direct Current Stimulation Over the Prefrontal Cortex in Depression Modulates Cortical Excitability in Emotion Regulation Regions as Measured by Concurrent Functional Magnetic Resonance Imaging: An Exploratory Study. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Dec 17;: Authors: Chrysikou EG, Wing EK, van Dam WO Abstract BACKGROUND: A well-established impaired top-down network for effortful emotion regulation (ER) in major depressive disorder (MDD) includes the dorsal and ventromedial prefrontal cortex (PFC) and the amygdala. Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulation method that has been used successfully to induce mood changes in MDD. Despite reliable findings, little is known ... read more
    1 month ago
  • A systematic review and meta-analysis on the effects of transcranial direct current stimulation in depressive episodes.
    Related ArticlesA systematic review and meta-analysis on the effects of transcranial direct current stimulation in depressive episodes. Depress Anxiety. 2020 Feb 26;: Authors: Razza LB, Palumbo P, Moffa AH, Carvalho AF, Solmi M, Loo CK, Brunoni AR Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) has shown mixed results for depression treatment. OBJECTIVE: To perform a systematic review and meta-analysis of trials using tDCS to improve depressive symptoms. METHODS: A systematic review was performed from the first date available to January 06, 2020 in PubMed, EMBASE, Cochrane Library, and additional sources. We included randomized, sham-controlled clinical trials (RCTs) enrolling participants with ... read more
    1 month ago
  • Non-invasive brain stimulation in stroke: Do the electrical currents have the potential to enhance neuroplasticity?
    Related ArticlesNon-invasive brain stimulation in stroke: Do the electrical currents have the potential to enhance neuroplasticity? Neurol India. 2019 Mar-Apr;67(2):424-426 Authors: Arya KN PMID: 31085853 [PubMed - indexed for MEDLINE] ... read more
    1 month ago
  • Efficiently searching through large tACS parameter spaces using closed-loop Bayesian optimization.
    Related ArticlesEfficiently searching through large tACS parameter spaces using closed-loop Bayesian optimization. Brain Stimul. 2019 Nov - Dec;12(6):1484-1489 Authors: Lorenz R, Simmons LE, Monti RP, Arthur JL, Limal S, Laakso I, Leech R, Violante IR Abstract BACKGROUND: Selecting optimal stimulation parameters from numerous possibilities is a major obstacle for assessing the efficacy of non-invasive brain stimulation. OBJECTIVE: We demonstrate that Bayesian optimization can rapidly search through large parameter spaces and identify subject-level stimulation parameters in real-time. METHODS: To validate the method, Bayesian optimization was employed using participants' binary judgements about the intensity of phosphenes elicited through tACS. ... read more
    1 month ago
  • Working memory performance with online-tDCS in schizophrenia: A randomized, double-blinded, sham-controlled, partial cross-over proof-of-concept study.
    Related ArticlesWorking memory performance with online-tDCS in schizophrenia: A randomized, double-blinded, sham-controlled, partial cross-over proof-of-concept study. Asian J Psychiatr. 2020 Feb 11;50:101946 Authors: Sreeraj VS, Bose A, Chhabra H, Shivakumar V, Agarwal SM, Narayanaswamy JC, Rao NP, Kesavan M, Varambally S, Venkatasubramanian G Abstract Combining cognitive retraining with transcranial direct current stimulation (tDCS) has been hypothesized to improve cognitive deficits in schizophrenia. The effect of combining a neuropsychological/psychophysiological task with tDCS, called "online-tDCS" for cognitive enhancement in schizophrenia is not rigorously assessed. In this proof-of-concept study, we aimed at evaluating the effect of a single session online-tDCS on working memory(WM) ... read more
    1 month ago
  • Transcranial electric stimulation optimizes the balance of visual attention across space.
    Related ArticlesTranscranial electric stimulation optimizes the balance of visual attention across space. Clin Neurophysiol. 2020 Jan 31;131(4):912-920 Authors: Andres M, Masson N, Larigaldie N, Bonato M, Vandermeeren Y, Dormal V Abstract OBJECTIVE: Transcranial direct current stimulation (tDCS) provides a way to modulate spatial attention by enhancing the ratio of neural activity between the left and right hemispheres, with a potential benefit for the rehabilitation of visual neglect. METHODS: We tested the effect of bilateral tDCS in healthy individuals performing a visual detection task. This protocol consists in the positioning of the anode and cathode on mirror positions over the left ... read more
    1 month ago
  • Vision modulation, plasticity and restoration using non-invasive brain stimulation – An IFCN-sponsored review.
    Related ArticlesVision modulation, plasticity and restoration using non-invasive brain stimulation - An IFCN-sponsored review. Clin Neurophysiol. 2020 Feb 03;131(4):887-911 Authors: Sabel BA, Thut G, Haueisen J, Henrich-Noack P, Herrmann CS, Hunold A, Kammer T, Matteo B, Sergeeva EG, Waleszczyk W, Antal A Abstract The visual system has one of the most complex structures of all sensory systems and is perhaps the most important sense for everyday life. Its functional organization was extensively studied for decades in animal and humans, for example by correlating circumscribed anatomical lesions in patients with the resulting visual dysfunction. During the past two decades, significant achievements ... read more
    1 month ago
  • Transcranial direct-current stimulation combined with attention increases cortical excitability and improves motor learning in healthy volunteers.
    Related ArticlesTranscranial direct-current stimulation combined with attention increases cortical excitability and improves motor learning in healthy volunteers. J Neuroeng Rehabil. 2020 Feb 19;17(1):23 Authors: Yamaguchi T, Moriya K, Tanabe S, Kondo K, Otaka Y, Tanaka S Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that has the potential to induce motor cortical plasticity in humans. It is well known that motor cortical plasticity plays an essential role in motor learning and recovery in patients with stroke and neurodegenerative disorders. However, it remains unclear how cognitive function influences motor cortical plasticity induced by tDCS. The present ... read more
    1 month ago
  • Altered corticomotor latencies but normal motor neuroplasticity in concussed athletes.
    Related ArticlesAltered corticomotor latencies but normal motor neuroplasticity in concussed athletes. J Neurophysiol. 2020 Feb 19;: Authors: Stokes W, Choynowki J, St Pierre M, Anaya MA, Statton MA, Celnik PA, Cantarero G Abstract Persistent cognitive, affective, and motor symptoms have been associated with sports-related concussions including several neurophysiological changes in the primary motor cortex. In particular, previous research has provided some evidence of altered latencies of the corticomotor pathway and altered motor neuroplasticity. However, to date no studies have assessed these neurophysiological metrics in a common group of athletes across different phases of injury and recovery. Here corticomotor latencies and ... read more
    1 month ago
  • The Effects of Transcranial Direct Current Stimulation of Dorsolateral Prefrontal Cortex on Reduction of Craving in Daily and Social Smokers.
    Related ArticlesThe Effects of Transcranial Direct Current Stimulation of Dorsolateral Prefrontal Cortex on Reduction of Craving in Daily and Social Smokers. Iran J Psychiatry. 2019 Oct;14(4):291-296 Authors: Hajloo N, Pouresmali A, Alizadeh Goradel J, Mowlaie M Abstract Objective: Tobacco smoking is an addictive behavior with many psychological side effects, and many smokers are unable to quit it. Despite various treatments for smoking cessation, there is an urgent need to develop and utilize a noninvasive technique with high efficacy. This study aimed to determine the effects of transcranial direct current stimulation (tDCS) of dorsolateral prefrontal cortex (DLPFC) on reduction of craving ... read more
    1 month ago
  • Effectiveness of anodal transcranial direct current stimulation to improve muscle strength and motor functionality after incomplete spinal cord injury: a systematic review and meta-analysis.
    Related ArticlesEffectiveness of anodal transcranial direct current stimulation to improve muscle strength and motor functionality after incomplete spinal cord injury: a systematic review and meta-analysis. Spinal Cord. 2020 Feb 17;: Authors: de Araújo AVL, Ribeiro FPG, Massetti T, Potter-Baker KA, Cortes M, Plow EB, da Silva TD, Tonks J, Anghinah R, Magalhães FH, Fregni F, de Mello Monteiro CB Abstract STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVES: We aimed to investigate the effects of anodal transcranial direct current stimulation (tDCS) against sham on muscle strength and motor functionality after incomplete spinal cord injury (iSCI). SETTING: University of São Paulo, Brazil. ... read more
    1 month ago
  • A Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder.
    Related ArticlesA Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder. Neuromodulation. 2020 Feb 14;: Authors: Ward HB, Mosquera MJ, Suzuki J, Mariano TY Abstract BACKGROUND: There is a great public health need to identify novel treatment strategies for opioid use disorder (OUD) in order to reduce relapse and overdose. Noninvasive brain stimulation (NIBS) has demonstrated preliminary effectiveness for substance use, but little is known about its use in OUD. Neuromodulation may represent a potential adjunctive treatment modality for OUD, so we conducted a systematic review to understand the state of the current research in this field. METHODS: We ... read more
    2 months ago
  • Deep Cerebellar Transcranial Direct Current Stimulation of the Dentate Nucleus to Facilitate Standing Balance in Chronic Stroke Survivors-A Pilot Study.
    Related ArticlesDeep Cerebellar Transcranial Direct Current Stimulation of the Dentate Nucleus to Facilitate Standing Balance in Chronic Stroke Survivors-A Pilot Study. Brain Sci. 2020 Feb 10;10(2): Authors: Rezaee Z, Kaura S, Solanki D, Dash A, Srivastava MVP, Lahiri U, Dutta A Abstract OBJECTIVE: Cerebrovascular accidents are the second leading cause of death and the third leading cause of disability worldwide. We hypothesized that cerebellar transcranial direct current stimulation (ctDCS) of the dentate nuclei and the lower-limb representations in the cerebellum can improve functional reach during standing balance in chronic (>6 months' post-stroke) stroke survivors. MATERIALS AND METHODS: Magnetic resonance imaging ... read more
    2 months ago
  • A multiple modulation synthesis method with high spatial resolution for noninvasive neurostimulation.
    Related ArticlesA multiple modulation synthesis method with high spatial resolution for noninvasive neurostimulation. PLoS One. 2019;14(6):e0218293 Authors: Xiao Q, Zhong Z, Lai X, Qin H Abstract Noninvasive neurostimulation plays a pivotal role in the direct control of neural circuits and the modulation of neuronal function. However, it is difficult to balance both spatial resolution and penetration depth when stimulating deep neurons. Here, we designed a multiple (time-division, frequency and polarity) modulation synthesis (MMS) method for noninvasively stimulating deep neurons with low-frequency envelopes. Compared to conventional transcranial electrical stimulation, we demonstrated that it can stimulate deep neurons at the ... read more
    2 months ago
  • Polarity- and Intensity-Independent Modulation of Timing During Delay Eyeblink Conditioning Using Cerebellar Transcranial Direct Current Stimulation.
    Related ArticlesPolarity- and Intensity-Independent Modulation of Timing During Delay Eyeblink Conditioning Using Cerebellar Transcranial Direct Current Stimulation. Cerebellum. 2020 Feb 08;: Authors: Mitroi J, Burroughs LP, Moussa-Tooks AB, Bolbecker AR, Lundin NB, O'Donnell BF, Hetrick WP Abstract Delay eyeblink conditioning (dEBC) is widely used to assess cerebellar-dependent associative motor learning, including precise timing processes. Transcranial direct current stimulation (tDCS), noninvasive brain stimulation used to indirectly excite and inhibit select brain regions, may be a promising tool for understanding how functional integrity of the cerebellum influences dEBC behavior. The aim of this study was to assess whether tDCS-induced inhibition (cathodal) and ... read more
    2 months ago
  • Can we boost attention and inhibition in binge drinking? Electrophysiological impact of neurocognitive stimulation.
    Related ArticlesCan we boost attention and inhibition in binge drinking? Electrophysiological impact of neurocognitive stimulation. Psychopharmacology (Berl). 2020 Feb 08;: Authors: Dormal V, Lannoy S, Bollen Z, D'Hondt F, Maurage P Abstract RATIONALE: Binge drinking (i.e. excessive episodic alcohol consumption) among young adults has been associated with deleterious consequences, notably at the cognitive and brain levels. These behavioural impairments and brain alterations have a direct impact on psychological and interpersonal functioning, but they might also be involved in the transition towards severe alcohol use disorders. Development of effective rehabilitation programs to reduce these negative effects as they emerge thus constitutes ... read more
    2 months ago
  • No Immediate Effects of Transcranial Direct Current Stimulation at Various Intensities on Cerebral Blood Flow in People with Multiple Sclerosis.
    Related ArticlesNo Immediate Effects of Transcranial Direct Current Stimulation at Various Intensities on Cerebral Blood Flow in People with Multiple Sclerosis. Brain Sci. 2020 Feb 04;10(2): Authors: Workman CD, Ponto LLB, Kamholz J, Rudroff T Abstract Animal and transcranial magnetic stimulation motors have evoked potential studies suggesting that the currently used transcranial direct current stimulation (tDCS) intensities produce measurable physiological changes. However, the validity, mechanisms, and general efficacy of this stimulation modality are currently being scrutinized. The purpose of this pilot study was to investigate the effects of dorsolateral prefrontal cortex tDCS on cerebral blood flow. A sample of three ... read more
    2 months ago
  • Transcranial direct current stimulation (tDCS) elicits stimulus-specific enhancement of cortical plasticity.
    Related ArticlesTranscranial direct current stimulation (tDCS) elicits stimulus-specific enhancement of cortical plasticity. Neuroimage. 2020 Feb 04;:116598 Authors: Boroda E, Sponheim SR, Fiecas M, Lim KO Abstract BACKGROUND: Deficits in plasticity underlie many severe psychiatric disorders. Transcranial direct current stimulation (tDCS) is a promising method for modulating plasticity. However, given its non-focal nature, there are open questions as to how targeting and outcome specificity can best be achieved. OBJECTIVE: Understanding how tDCS interacts with concurrent brain activity is necessary for the rational advancement of tDCS. In the present study, we use an event-related potential (ERP) paradigm to assess the stimulus-specific effects ... read more
    2 months ago