Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • Assessing neurophysiological changes associated with combined transcranial direct current stimulation and cognitive emotional training for treatment-resistant depression.
    Related ArticlesAssessing neurophysiological changes associated with combined transcranial direct current stimulation and cognitive emotional training for treatment-resistant depression. Eur J Neurosci. 2019 Dec 20;: Authors: Nikolin S, Martin D, Loo CK, Iacoviello BM, Boonstra TW Abstract Transcranial direct current stimulation (tDCS), a form of non-invasive brain stimulation, is a promising treatment for depression. Recent research suggests that tDCS efficacy can be augmented using concurrent cognitive emotional training (CET). However, the neurophysiological changes associated with this combined intervention remain to be elucidated. We therefore examined the effects of tDCS combined with CET using electroencephalography (EEG). A total of 20 participants with ... read more
    1 month ago
  • Effects of Non-Invasive Brain Stimulation on Clinical Pain Intensity and Experimental Pain Sensitivity Among Individuals with Central Post-Stroke Pain: A Systematic Review.
    Related ArticlesEffects of Non-Invasive Brain Stimulation on Clinical Pain Intensity and Experimental Pain Sensitivity Among Individuals with Central Post-Stroke Pain: A Systematic Review. J Pain Res. 2019;12:3319-3329 Authors: Ramger BC, Bader KA, Davies SP, Stewart DA, Ledbetter LS, Simon CB, Feld JA Abstract Purpose: Central post-stroke pain (CPSP) is a neuropathic disorder resulting in pain and disability. An emerging treatment for CPSP is non-invasive brain stimulation including direct current stimulation [tDCS] and repetitive transcranial magnetic stimulation [rTMS]. This systematic review analyzes the efficacy and quality of non-invasive brain stimulation intervention studies for CPSP. Methods: Studies were sought from three research ... read more
    1 month ago
  • Transcranial direct current stimulation facilitates category learning.
    Related ArticlesTranscranial direct current stimulation facilitates category learning. Brain Stimul. 2019 Nov 26;: Authors: Gibson BC, Mullins TS, Heinrich MD, Witkiewitz K, Yu AB, Hansberger JT, Clark VP Abstract BACKGROUND: After two decades of transcranial direct current stimulation (tDCS) research, it is still unclear which applications benefit most from which tDCS protocols. One prospect is the acceleration of learning, where previous work has demonstrated that anodal tDCS applied to the right ventrolateral prefrontal cortex (rVLPFC) is capable of doubling the rate of learning in a visual camouflaged threat detection and category learning task. GOALS: Questions remain as to the specific ... read more
    1 month ago
  • Anodal High-definition Transcranial Direct Current Stimulation over the Posterior Parietal Cortex Modulates Approximate Mental Arithmetic.
    Related ArticlesAnodal High-definition Transcranial Direct Current Stimulation over the Posterior Parietal Cortex Modulates Approximate Mental Arithmetic. J Cogn Neurosci. 2019 Dec 18;:1-15 Authors: Hartmann M, Singer S, Savic B, Müri RM, Mast FW Abstract The representation and processing of numerosity is a crucial cognitive capacity. Converging evidence points to the posterior parietal cortex (PPC) as primary "number" region. However, the exact role of the left and right PPC for different types of numerical and arithmetic tasks remains controversial. In this study, we used high-definition transcranial direct current stimulation (HD-tDCS) to further investigate the causal involvement of the PPC during approximative, ... read more
    1 month ago
  • Transcranial Direct Current Stimulation (tDCS) to Improve Gait in Multiple Sclerosis: A Timing Window Comparison.
    Related ArticlesTranscranial Direct Current Stimulation (tDCS) to Improve Gait in Multiple Sclerosis: A Timing Window Comparison. Front Hum Neurosci. 2019;13:420 Authors: Workman CD, Kamholz J, Rudroff T Abstract Unilateral weakness of the lower limb is a hallmark of multiple sclerosis (MS) and a significant contributor to the progressive worsening of walking ability. There are currently no effective rehabilitation strategies targeting strength asymmetries and/or gait impairments in people with MS (PwMS). Transcranial direct current stimulation (tDCS) has improved motor outcomes in various populations, but the effect of tDCS on gait in PwMS and the ideal timing window of tDCS application are ... read more
    1 month ago
  • Structural and functional brain biomarkers of clinical response to rTMS of medication-resistant auditory hallucinations in schizophrenia patients: study protocol for a randomized sham-controlled double-blind clinical trial.
    Related ArticlesStructural and functional brain biomarkers of clinical response to rTMS of medication-resistant auditory hallucinations in schizophrenia patients: study protocol for a randomized sham-controlled double-blind clinical trial. Trials. 2019 Apr 23;20(1):229 Authors: Thomas F, Bouaziz N, Gallea C, Schenin-King Andrianisaina P, Durand F, Bolloré O, Benadhira R, Isaac C, Braha-Zeitoun S, Moulier V, Valero-Cabré A, Januel D Abstract BACKGROUND: The potential of non-invasive repetitive transcranial magnetic stimulation (rTMS) to improve auditory verbal hallucinations (AVH) in schizophrenia patients has been increasingly explored over the past decade. Despite highly promising results, high inter-individual variability of clinical response and ineffective outcomes ... read more
    1 month ago
  • Transcranial electrical stimulation improves phoneme processing in developmental dyslexia.
    Related ArticlesTranscranial electrical stimulation improves phoneme processing in developmental dyslexia. Brain Stimul. 2019 Jul - Aug;12(4):930-937 Authors: Rufener KS, Krauel K, Meyer M, Heinze HJ, Zaehle T Abstract BACKGROUND: About 10% of the western population suffers from a specific disability in the acquisition of reading and writing skills, known as developmental dyslexia (DD). Even though DD starts in childhood it frequently continuous throughout lifetime. Impaired processing of acoustic features at the phonematic scale based on dysfunctional auditory temporal resolution is considered as one core deficit underlying DD. Recently, the efficacy of transcranial electrical stimulation (tES) to modulate auditory ... read more
    1 month ago
  • No effect of tDCS of the primary motor cortex on isometric exercise performance or perceived fatigue.
    Related ArticlesNo effect of tDCS of the primary motor cortex on isometric exercise performance or perceived fatigue. Eur J Neurosci. 2019 Dec 17;: Authors: Wrightson JG, Twomey R, Yeung ST, Millet GY Abstract Anodal transcranial direct current stimulation (tDCS) of the primary motor cortex has been reported to improve isometric exercise performance without changing corticospinal excitability. One possible cause for this may be the previous use of relatively high (2 mA) current intensities, which have inconsistent effects on corticospinal excitability. The present pre-registered study aimed to replicate previously reported ergogenic effects of 2 mA tDCS, and examine whether 1 mA anodal tDCS both ... read more
    1 month ago
  • Adverse Events Related to Transcranial Electric Stimulation for Motor-evoked Potential Monitoring in High-risk Spinal Surgery.
    Related ArticlesAdverse Events Related to Transcranial Electric Stimulation for Motor-evoked Potential Monitoring in High-risk Spinal Surgery. Spine (Phila Pa 1976). 2019 Oct 15;44(20):1435-1440 Authors: Yoshida G, Imagama S, Kawabata S, Yamada K, Kanchiku T, Fujiwara Y, Tadokoro N, Takahashi M, Wada K, Yamamoto N, Ushirozako H, Kobayashi K, Yasuda A, Ando M, Tani T, Matsuyama Y Abstract STUDY DESIGN: Prospective multicenter study. OBJECTIVE: The aim of this study was to study the incidence of nonneurologic adverse events related to transcranial electric stimulation (TES) for intraoperative spinal cord monitoring (IOM) with motor-evoked potentials (MEPs) (Tc(E)- MEPs) and determine the need ... read more
    1 month ago
  • Cognitive and language performance predicts effects of spelling intervention and tDCS in Primary Progressive Aphasia.
    Related ArticlesCognitive and language performance predicts effects of spelling intervention and tDCS in Primary Progressive Aphasia. Cortex. 2019 Nov 19;124:66-84 Authors: de Aguiar V, Zhao Y, Ficek BN, Webster K, Rofes A, Wendt H, Frangakis C, Caffo B, Hillis AE, Rapp B, Tsapkini K Abstract Predictors of treatment effects allow individual tailoring of treatment characteristics, thereby saving resources and optimizing outcomes. Electrical stimulation coupled with language intervention has shown promising results in improving language performance in individuals with Primary Progressive Aphasia (PPA). The current study aimed to identify language and cognitive variables associated with response to therapy consisting of language ... read more
    1 month ago
  • Neurocognitive correlates of self-esteem: from self-related attentional bias to involvement of the ventromedial prefrontal cortex.
    Related ArticlesNeurocognitive correlates of self-esteem: from self-related attentional bias to involvement of the ventromedial prefrontal cortex. Neurosci Res. 2019 Dec 12;: Authors: Salehinejad MA, Nejati V, Nitsche MA Abstract Despite growing interest in underlying cognitive mechanisms of self-esteem, its neurocognitive correlates are not fully-understood. Attention bias to self-related stimuli is an example of self-referential processing (SRP) and its association with self-esteem is not well-studied. Moreover, previous studies show that the medial prefrontal regions are involved in SRP which may suggest that it is involved in self-esteem too. We investigated the association between attention bias to self-related stimuli and its association ... read more
    1 month ago
  • A New Approach to Transcranial Direct Current Stimulation in Improving Cognitive Motor Learning and Hand Function with the Nintendo Switch in Stroke Survivors.
    Related ArticlesA New Approach to Transcranial Direct Current Stimulation in Improving Cognitive Motor Learning and Hand Function with the Nintendo Switch in Stroke Survivors. Med Sci Monit. 2019 Dec 14;25:9555-9562 Authors: Kim J, Lee M, Yim J Abstract BACKGROUND Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation (NIBS) technique designed to improve cognitive and physical function of stroke survivors. There are many studies being conducted in the search for an effective intervention of tDCS. This study focused on cognitive motor learning in relation to hand function of stroke survivors. MATERIAL AND METHODS We enrolled 30 subjects with cognitive ... read more
    1 month ago
  • Decreases in the Late Positive Potential to Alcohol Images Among Alcohol Treatment Seekers Following Mindfulness-Based Relapse Prevention.
    Related ArticlesDecreases in the Late Positive Potential to Alcohol Images Among Alcohol Treatment Seekers Following Mindfulness-Based Relapse Prevention. Alcohol Alcohol. 2019 Dec 11;: Authors: Brown DR, Jackson TCJ, Claus ED, Votaw VR, Stein ER, Robinson CSH, Wilson AD, Brandt E, Fratzke V, Clark VP, Witkiewitz K Abstract AIM: Heightened craving among individuals with alcohol use disorder (AUD) has been attributed to a hypersensitivity to alcohol cues in attentional brain networks. Active mindfulness training has been shown to help improve attentional control. Here, we examined alcohol cue-related hypersensitivity among individuals with AUD who received rolling group mindfulness-based relapse prevention (MBRP) in ... read more
    1 month ago
  • Stuttering Severity Modulates Effects of Non-invasive Brain Stimulation in Adults Who Stutter.
    Related ArticlesStuttering Severity Modulates Effects of Non-invasive Brain Stimulation in Adults Who Stutter. Front Hum Neurosci. 2019;13:411 Authors: Garnett EO, Chow HM, Choo AL, Chang SE Abstract Stuttering is a neurodevelopmental disorder that manifests as frequent disruptions in the flow of speech, affecting 1% of adults. Treatments are limited to behavioral interventions with variable success and high relapse rates, particularly in adults. However, even in severe cases, fluency can be temporarily induced during conditions in which the speaker synchronizes his speech with external rhythmic cues, such as when reading in unison (choral speech) or with a metronome. Non-invasive neuromodulation techniques ... read more
    1 month ago
  • Maximizing the Treatment Benefit of tDCS in Neurodegenerative Anomia.
    Related ArticlesMaximizing the Treatment Benefit of tDCS in Neurodegenerative Anomia. Front Neurosci. 2019;13:1231 Authors: Roncero C, Service E, De Caro M, Popov A, Thiel A, Probst S, Chertkow H Abstract We evaluated whether transcranial direct current stimulation (tDCS) in two different montages could improve picture naming abilities in participants with anomic Alzheimer Disease or Frontotemporal dementia. Methods: Utilizing a double-blind cross-over design, twelve participants were trained on picture naming over a series of 10 sessions with 30 min of anodal (2 mA) tDCS stimulation to either the left inferior parietotemporal region (P3), the left dorsolateral prefrontal cortex (F3), or sham ... read more
    1 month ago
  • Transcranial direct current stimulation (tDCS) over vmPFC modulates interactions between reward and emotion in delay discounting.
    Related ArticlesTranscranial direct current stimulation (tDCS) over vmPFC modulates interactions between reward and emotion in delay discounting. Sci Rep. 2019 Dec 10;9(1):18735 Authors: Manuel AL, Murray NWG, Piguet O Abstract Delay discounting requires computing trade-offs between immediate-small rewards and later-larger rewards. Negative and positive emotions shift decisions towards more or less impulsive responses, respectively. Models have conceptualized this trade-off by describing an interplay between "emotional" and "rational" processes, with the former involved during immediate choices and relying on the ventromedial prefrontal cortex (vmPFC), and the latter involved in long-term choices and relying on the dorsolateral prefrontal cortex (dlPFC). Whether stimulation ... read more
    1 month ago
  • Effect of multi-session prefrontal transcranial direct current stimulation on cognition in schizophrenia: A systematic review and meta-analysis.
    Related ArticlesEffect of multi-session prefrontal transcranial direct current stimulation on cognition in schizophrenia: A systematic review and meta-analysis. Schizophr Res. 2019 Dec 07;: Authors: Narita Z, Stickley A, DeVylder J, Yokoi Y, Inagawa T, Yamada Y, Maruo K, Koyanagi A, Oh H, Sawa A, Sumiyoshi T Abstract Patients with schizophrenia experience cognitive deficits that play a central role in predicting functional outcomes. In this study, we sought to evaluate the effect of transcranial direct current stimulation (tDCS) on cognition using meta-analysis. A search was performed from inception to 8 January 2019, to identify randomized controlled trials assessing the ability of ... read more
    1 month ago
  • The effect of single and repeated tDCS sessions on motor symptoms in Parkinson’s disease: a systematic review.
    Related ArticlesThe effect of single and repeated tDCS sessions on motor symptoms in Parkinson's disease: a systematic review. Arch Ital Biol. 2019 Sep 30;157(2-3):89-101 Authors: Orrù G, Baroni M, Cesari V, Conversano C, Hitchcott PK, Gemignani A Abstract OBJECTIVES: to update understanding of the effectiveness of transcranial direct current stimulation (tDCS) on motor dysfunction in Parkinson's disease, since the last review was published in 2016. METHODS: in order to identify suitable publications for inclusion, an online search of the Pubmed, Scopus and Cochrane databases was carried out. Searches of relevant full-text articles were performed through specific keywords. The final database ... read more
    1 month ago
  • The role of the cerebellum in degenerative ataxias and essential tremor: Insights from noninvasive modulation of cerebellar activity.
    Related ArticlesThe role of the cerebellum in degenerative ataxias and essential tremor: Insights from noninvasive modulation of cerebellar activity. Mov Disord. 2019 Dec 10;: Authors: Maas RPPWM, Helmich RCG, van de Warrenburg BPC Abstract Over the last three decades, measuring and modulating cerebellar activity and its connectivity with other brain regions has become an emerging research topic in clinical neuroscience. The most important connection is the cerebellothalamocortical pathway, which can be functionally interrogated using a paired-pulse transcranial magnetic stimulation paradigm. Cerebellar brain inhibition reflects the magnitude of suppression of motor cortex excitability after stimulating the contralateral cerebellar hemisphere and therefore ... read more
    1 month ago
  • Effectiveness of language training and non-invasive brain stimulation on oral and written naming performance in Primary Progressive Aphasia: A meta-analysis and systematic review.
    Related ArticlesEffectiveness of language training and non-invasive brain stimulation on oral and written naming performance in Primary Progressive Aphasia: A meta-analysis and systematic review. Neurosci Biobehav Rev. 2019 Dec 04;: Authors: Cotelli M, Manenti R, Ferrari C, Gobbi E, Macis A, Cappa SF Abstract The aim of this systematic review and meta-analysis is to examine the efficacy of language training, alone or in combination with non-invasive brain stimulation techniques, designed to improve oral and written naming abilities in Primary Progressive Aphasia (PPA), and to investigate whether gains can be maintained over time and generalize to untrained items. An electronic database ... read more
    2 months ago
  • Effects of transcranial direct current stimulation on cognition and symptoms in Chinese patients with schizophreniaâś°.
    Related ArticlesEffects of transcranial direct current stimulation on cognition and symptoms in Chinese patients with schizophrenia✰. Psychiatry Res. 2019 Nov 02;:112617 Authors: Smith RC, Md WL, Wang Y, Jiang J, Wang J, Szabo V, Faull R, Jin H, Davis JM, Li C Abstract There is preliminary evidence that transcranial direct current stimulation(tDCS) may improve symptoms and cognitive function in schizophrenia, but the generalizability of these results needs further investigation. We present a study of the effects of active vs. sham tDCS on cognition and symptoms in a sample of 45 Chinese patients with schizophrenia who showed significant cognitive deficits and ... read more
    2 months ago
  • Transcranial Direct Current Stimulation to Improve the Dysfunction of Descending Pain Modulatory System Related to Opioids in Chronic Non-cancer Pain: An Integrative Review of Neurobiology and Meta-Analysis.
    Related ArticlesTranscranial Direct Current Stimulation to Improve the Dysfunction of Descending Pain Modulatory System Related to Opioids in Chronic Non-cancer Pain: An Integrative Review of Neurobiology and Meta-Analysis. Front Neurosci. 2019;13:1218 Authors: Zortea M, Ramalho L, Alves RL, Alves CFDS, Braulio G, Torres ILDS, Fregni F, Caumo W Abstract Background: Opioid long-term therapy can produce tolerance, opioid-induced hyperalgesia (OIH), and it induces dysfunction in pain descending pain inhibitory system (DPIS). Objectives: This integrative review with meta-analysis aimed: (i) To discuss the potential mechanisms involved in analgesic tolerance and opioid-induced hyperalgesia (OIH). (ii) To examine how the opioid can affect the ... read more
    2 months ago
  • The Impact of Transcranial Direct Current Stimulation on Upper-Limb Motor Performance in Healthy Adults: A Systematic Review and Meta-Analysis.
    Related ArticlesThe Impact of Transcranial Direct Current Stimulation on Upper-Limb Motor Performance in Healthy Adults: A Systematic Review and Meta-Analysis. Front Neurosci. 2019;13:1213 Authors: Patel R, Ashcroft J, Patel A, Ashrafian H, Woods AJ, Singh H, Darzi A, Leff DR Abstract Background: Transcranial direct current stimulation (tDCS) has previously been reported to improve facets of upper limb motor performance such as accuracy and strength. However, the magnitude of motor performance improvement has not been reviewed by contemporaneous systematic review or meta-analysis of sham vs. active tDCS. Objective: To systematically review and meta-analyse the existing evidence regarding the benefits of tDCS ... read more
    2 months ago
  • Effects of transcranial direct current stimulation on heart rate variability: a systematic review protocol.
    Related ArticlesEffects of transcranial direct current stimulation on heart rate variability: a systematic review protocol. JBI Database System Rev Implement Rep. 2019 Nov 26;: Authors: Dias IA, Hazime FA, Lopes DA, Silva CSD, Baptista AF, Silva BAKD Abstract OBJECTIVE: This systematic review aims to synthesize the available evidence on the effects of transcranial direct current stimulation on heart rate modulation, indexed by heart rate variability parameters in healthy individuals and those with clinical disorders. INTRODUCTION: There is some evidence that altered heart rate variability (HRV) parameters are associated with different clinical disorders. For example, diminished parasympathetic activity has been explored ... read more
    2 months ago
  • Experimental-design specific changes in spontaneous EEG and during intermittent photic stimulation by High Definition transcranial Direct Current Stimulation.
    Related ArticlesExperimental-design specific changes in spontaneous EEG and during intermittent photic stimulation by High Definition transcranial Direct Current Stimulation. Neuroscience. 2019 Nov 27;: Authors: Lazarev VV, Gebodh N, Tamborino T, Bikson M, Caparelli-Daquer EM Abstract EEG as a biomarker of neuromodulation by High Definition transcranial Direct Current Stimulation (HD-tDCS) offers promise as both techniques are deployable and can be integrated into a single head-gear. The present research addresses experimental design for separating focal EEG effect of HD-tDCS in the '4-cathods x 1-anode' (4x1) montage over the left motor area (C3). We assessed change in offline EEG at the homologous central ... read more
    2 months ago