Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • Transcranial Direct Current Stimulation and Mirror Therapy for Neuropathic Pain After Brachial Plexus Avulsion: A Randomized, Double-Blind, Controlled Pilot Study.
    Related ArticlesTranscranial Direct Current Stimulation and Mirror Therapy for Neuropathic Pain After Brachial Plexus Avulsion: A Randomized, Double-Blind, Controlled Pilot Study. Front Neurol. 2020;11:568261 Authors: Ferreira CM, de Carvalho CD, Gomes R, Bonifácio de Assis ED, Andrade SM Abstract Introduction: Although transcranial direct current stimulation (tDCS) and mirror therapy (MT) have benefits in combating chronic pain, there is still no evidence of the effects of the simultaneous application of these techniques in patients with neuropathic pain. This study aims to assess the efficacy of tDCS paired with MT in neuropathic pain after brachial plexus injury. Methods: In a sham controlled, ... read more
    3 weeks ago
  • Effects of Transcranial Direct Current Stimulation on Motor Function in Children 8-12 Years With Developmental Coordination Disorder: A Randomized Controlled Trial.
    Related ArticlesEffects of Transcranial Direct Current Stimulation on Motor Function in Children 8-12 Years With Developmental Coordination Disorder: A Randomized Controlled Trial. Front Hum Neurosci. 2020;14:608131 Authors: Grohs MN, Craig BT, Kirton A, Dewey D Abstract Background and objectives: Developmental coordination disorder (DCD) is a neurodevelopmental motor disorder occurring in 5-6% of school-aged children. It is suggested that children with DCD show deficits in motor learning. Transcranial direct current stimulation (tDCS) enhances motor learning in adults and children but is unstudied in DCD. We aimed to investigate if tDCS, paired with motor skill training, facilitates motor learning in a pediatric ... read more
    3 weeks ago
  • Effects of transcranial direct current stimulation on addictive behavior and brain glucose metabolism in problematic online gamers.
    Related ArticlesEffects of transcranial direct current stimulation on addictive behavior and brain glucose metabolism in problematic online gamers. J Behav Addict. 2020 Dec 23;: Authors: Jeong H, Oh JK, Choi EK, Im JJ, Yoon S, Knotkova H, Bikson M, Song IU, Lee SH, Chung YA Abstract Background and aims: Some online gamers may encounter difficulties in controlling their gaming behavior. Previous studies have demonstrated beneficial effects of transcranial direct current stimulation (tDCS) on various kinds of addiction. This study investigated the effects of tDCS on addictive behavior and regional cerebral metabolic rate of glucose (rCMRglu) in problematic online gamers. Methods: ... read more
    3 weeks ago
  • Distinct trajectories of response to prefrontal tDCS in major depression: results from a 3-arm randomized controlled trial.
    Related ArticlesDistinct trajectories of response to prefrontal tDCS in major depression: results from a 3-arm randomized controlled trial. Neuropsychopharmacology. 2020 Dec 21;: Authors: Goerigk SA, Padberg F, Bühner M, Sarubin N, Kaster TS, Daskalakis ZJ, Blumberger DM, Borrione L, Razza LB, Brunoni AR Abstract Transcranial direct current stimulation (tDCS) is a safe, effective treatment for major depressive disorder (MDD). While antidepressant effects are heterogeneous, no studies have investigated trajectories of tDCS response. We characterized distinct improvement trajectories and associated baseline characteristics for patients treated with prefrontal tDCS, an active pharmacotherapy (escitalopram), and placebo. This is a secondary analysis of a ... read more
    1 month ago
  • The effect of tDCS applied to the dorsolateral prefrontal cortex on cycling performance and the modulation of exercise induced pain.
    Related ArticlesThe effect of tDCS applied to the dorsolateral prefrontal cortex on cycling performance and the modulation of exercise induced pain. Neurosci Lett. 2020 Dec 19;:135584 Authors: Judge M, Hopker J, Mauger AR Abstract Transcranial direct current stimulation (tDCS) is a neuromodulatory tool purported to enhance endurance performance through reducing fatigue related perceptions, including exercise-induced pain (EIP). We examined whether tDCS of the left DLPFC (1) can reduce EIP during a fixed intensity cycling trial (FI), (2) can improve cycling time trial (TT) performance, and (3) whether this was affected by a bilateral or an extracephalic montage. This investigation was ... read more
    1 month ago
  • Cerebellar Direct Current Stimulation (ctDCS) in the Treatment of Huntington’s Disease: A Pilot Study and a Short Review of the Literature.
    Related ArticlesCerebellar Direct Current Stimulation (ctDCS) in the Treatment of Huntington's Disease: A Pilot Study and a Short Review of the Literature. Front Neurol. 2020;11:614717 Authors: Bocci T, Baloscio D, Ferrucci R, Sartucci F, Priori A Abstract Introduction: In recent years, a growing body of literature has investigated the use of non-invasive brain stimulation (NIBS) techniques as a putative treatment in Huntington's Disease (HD). Our aim was to evaluate the effects of cerebellar transcranial Direct Current Simulation (ctDCS) on the motor outcome in patients affected by HD, encompassing at the same time the current knowledge about the effects of NIBS ... read more
    1 month ago
  • Clinical Feasibility of Combining Transcranial Direct Current Stimulation with Standard Aphasia Therapy.
    Related ArticlesClinical Feasibility of Combining Transcranial Direct Current Stimulation with Standard Aphasia Therapy. Ann Indian Acad Neurol. 2020 Sep;23(Suppl 2):S102-S108 Authors: Duncan ES, Nakkawita SG Abstract Background: Transcranial direct current stimulation (tDCS) is a safe, portable, and inexpensive form of noninvasive brain stimulation that appears to augment the effects of concurrent therapy. However, several methodological issues in existing studies distance tDCS from current clinical practice. In this study, we offered (and administered) tDCS to individuals seeking typical behavioral aphasia therapy on an outpatient basis. Methods: We approached clients (n = 10) planning to receive standard aphasia therapy at a university ... read more
    1 month ago
  • A Review of Biological Interventions in Chronic Aphasia.
    Related ArticlesA Review of Biological Interventions in Chronic Aphasia. Ann Indian Acad Neurol. 2020 Sep;23(Suppl 2):S82-S94 Authors: Duncan ES, Pradeep AA, Small SL Abstract Aphasia is a common and debilitating condition following stroke. While the gold standard for aphasia treatment is behavioral speech-language therapy, benefits remain modest in chronic stages of recovery. This limitation motivates the pursuit of novel interventions for chronic aphasia. Here, we review biological approaches that have been used (or proposed for use, in the case of regenerative and genetic therapies) to treat chronic aphasia. These techniques aim to ameliorate the deficits of aphasia by directly manipulating ... read more
    1 month ago
  • Improving consolidation by applying anodal transcranial direct current stimulation at primary motor cortex during repetitive practice.
    Related ArticlesImproving consolidation by applying anodal transcranial direct current stimulation at primary motor cortex during repetitive practice. Neurobiol Learn Mem. 2020 Dec 18;:107365 Authors: Kim T, Kim H, Wright DL Abstract Engagement of primary motor cortex (M1) is important for successful consolidation of motor skills. Recruitment of M1 has been reported to be more extensive during interleaved compared to repetitive practice and this differential recruitment has been proposed to contribute to the long-term retention benefit associated with interleaved practice. The present study administered anodal direct current stimulation (tDCS) during repetitive practice in an attempt to increase M1 activity throughout repetitive ... read more
    1 month ago
  • Neuromodulation in post-stroke aphasia treatment.
    Related ArticlesNeuromodulation in post-stroke aphasia treatment. Curr Phys Med Rehabil Rep. 2020 Jun;8(2):44-56 Authors: Breining BL, Sebastian R Abstract Purpose of Review: This paper aims to review non-invasive brain stimulation (NIBS) methods to augment speech and language therapy (SLT) for patients with post-stroke aphasia. Recent Findings: In the past five years there have been more than 30 published studies assessing the effect of transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) for improving aphasia in people who have had a stroke. Different approaches to NIBS treatment have been used in post-stroke aphasia treatment including different stimulation locations, stimulation ... read more
    1 month ago
  • Transcranial Direct Current Stimulation for Fatigue in Patients with Sjogren’s Syndrome: a Randomized, Double-blind Pilot Study.
    Related ArticlesTranscranial Direct Current Stimulation for Fatigue in Patients with Sjogren's Syndrome: a Randomized, Double-blind Pilot Study. Brain Stimul. 2020 Dec 16;: Authors: Pinto ACPN, Piva SR, Vieira AGDS, Gomes SGCN, Rocha APD, Tavares DRB, Santana MVA, Carlesso CDR, Andriolo A, Santos FC, Fregni F, Trevisani VFM Abstract BACKGROUND: Transcranial direct-current stimulation (tDCS) has shown promise to decrease fatigue. However, it has never been examined in primary Sjogren Syndrome (pSS). OBJECTIVE: To assess the effect of a tDCS protocol on fatigue in patients with pSS. METHODS: This is a parallel, double-blind pilot study (NCT04119128). Women aged 18-65 years, with pSS, ... read more
    1 month ago
  • Vestibular rehabilitation therapy in combination with transcranial direct current stimulation (tDCS) for treatment of chronic vestibular dysfunction in the elderly: a double-blind randomized controlled trial.
    Related ArticlesVestibular rehabilitation therapy in combination with transcranial direct current stimulation (tDCS) for treatment of chronic vestibular dysfunction in the elderly: a double-blind randomized controlled trial. Braz J Otorhinolaryngol. 2020 Nov 29;: Authors: Saki N, Bayat A, Nikakhlagh S, Mirmomeni G Abstract INTRODUCTION: Dizziness and imbalance are common dysfunctions in the elderly. Vestibular rehabilitation therapy is an effective method to alleviate chronic dizziness in patients with vestibular dysfunction. Transcranial direct current stimulation has reportedly improved balance function in patients with vestibular dysfunction. OBJECTIVE: This study was conducted to investigate the therapeutic efficacy of vestibular rehabilitation combined with transcranial direct current ... read more
    1 month ago
  • Modulation of Repeated Anodal HD-tDCS on Attention in Healthy Young Adults.
    Related ArticlesModulation of Repeated Anodal HD-tDCS on Attention in Healthy Young Adults. Front Psychol. 2020;11:564447 Authors: Lu H, Liu Q, Guo Z, Zhou G, Zhang Y, Zhu X, Wu S Abstract High-definition transcranial direct current stimulation (HD-tDCS) is a valid brain stimulation technology to optimize cognitive function. Recent evidence indicates that single anodal tDCS session enhances attention; however, the variation in attention produced by repeated anodal HD-tDCS over a longer period of time has not been explored. We examined the modulation of attention function in healthy young participants (39 young adults) who received repeated HD-tDCS sustained for 4 weeks. The ... read more
    1 month ago
  • Non-invasive Brain and Spinal Stimulation for Pain and Related Symptoms in Multiple Sclerosis: A Systematic Review.
    Related ArticlesNon-invasive Brain and Spinal Stimulation for Pain and Related Symptoms in Multiple Sclerosis: A Systematic Review. Front Neurosci. 2020;14:547069 Authors: Zucchella C, Mantovani E, De Icco R, Tassorelli C, Sandrini G, Tamburin S Abstract Background: Neuropathic and nociceptive pain frequently affect patients with multiple sclerosis (MS), with a prevalence close to 90% and significant impact on general health and quality of life. Pharmacological strategies are widely used to treat pain in MS, but their effectiveness and side-effects are controversial. Among non-pharmacological treatments for pain, non-invasive brain and spinal stimulation (NIBSS) has shown promising preliminary results in MS. Objective: Systematic ... read more
    1 month ago
  • Cerebellar Transcranial Direct Current Stimulation for Motor Learning in People with Chronic Stroke: A Pilot Randomized Controlled Trial.
    Related ArticlesCerebellar Transcranial Direct Current Stimulation for Motor Learning in People with Chronic Stroke: A Pilot Randomized Controlled Trial. Brain Sci. 2020 Dec 14;10(12): Authors: Kumari N, Taylor D, Olsen S, Rashid U, Signal N Abstract Cerebellar transcranial direct current stimulation (ctDCS) is a non-invasive brain stimulation technique that alters neural plasticity through weak, continuous, direct currents delivered to the cerebellum. This study aimed to evaluate the feasibility of conducting a randomized controlled trial (RCT) delivering three consecutive days of ctDCS during split-belt treadmill training (SBTT) in people with chronic stroke. Using a double-blinded, parallel-group RCT design, eligible participants were ... read more
    1 month ago
  • Transcranial Direct Current Stimulation to Enhance Cognitive Impairment in Parkinson’s Disease: A Systematic Review and Meta-Analysis.
    Related ArticlesTranscranial Direct Current Stimulation to Enhance Cognitive Impairment in Parkinson's Disease: A Systematic Review and Meta-Analysis. Front Neurol. 2020;11:597955 Authors: Suarez-García DMA, Grisales-Cárdenas JS, Zimerman M, Cardona JF Abstract Cognitive deficits are increasingly being recognized as a common trait in Parkinson's disease (PD). Recently, transcranial direct current stimulation (tDCS) has been shown to exert positive effects as an adjunctive therapy on motor and non-motor symptoms in PD. This systematic review and meta-analysis aims to provide an overview of reported evidence on the efficacy of tDCS interventions in the treatment of cognitive impairments in PD. A systematic literature review was ... read more
    1 month ago
  • Verum versus sham tDCS in the treatment of stroke-induced apraxia: study protocol of the randomized controlled trial RAdiCS -“Rehabilitating (stroke-induced) Apraxia with direct Current Stimulation”.
    Related ArticlesVerum versus sham tDCS in the treatment of stroke-induced apraxia: study protocol of the randomized controlled trial RAdiCS -"Rehabilitating (stroke-induced) Apraxia with direct Current Stimulation". Neurol Res Pract. 2020;2:7 Authors: Kleineberg NN, Richter MK, Becker I, Weiss PH, Fink GR Abstract Introduction: Stroke is the leading cause of acquired disability in western societies. (Motor) cognitive deficits like apraxia significantly contribute to disability after stroke, harming activities of daily living and rehabilitation outcome. To date, efficient therapeutic options for apraxia remain sparse. Thus, randomized controlled trials (RCTs) are warranted. Methods: Based on promising results of a pilot study, the on-going ... read more
    1 month ago
  • BrainWave Nets: Are Sparse Dynamic Models Susceptible to Brain Manipulation Experimentation?
    Related ArticlesBrainWave Nets: Are Sparse Dynamic Models Susceptible to Brain Manipulation Experimentation? Front Syst Neurosci. 2020;14:527757 Authors: Nascimento DC, Pinto-Orellana MA, Leite JP, Edwards DJ, Louzada F, Santos TEG Abstract Sparse time series models have shown promise in estimating contemporaneous and ongoing brain connectivity. This paper was motivated by a neuroscience experiment using EEG signals as the outcome of our established interventional protocol, a new method in neurorehabilitation toward developing a treatment for visual verticality disorder in post-stroke patients. To analyze the [complex outcome measure (EEG)] that reflects neural-network functioning and processing in more specific ways regarding traditional analyses, we ... read more
    1 month ago
  • Lack of cerebellar tDCS effects on learning of a complex whole body dynamic balance task in middle-aged (50-65 years) adults.
    Related ArticlesLack of cerebellar tDCS effects on learning of a complex whole body dynamic balance task in middle-aged (50-65 years) adults. Neurol Res Pract. 2020;2:38 Authors: Rauscher M, Yavari F, Batsikadze G, Ludolph N, Ilg W, Nitsche MA, Timmann D, Steiner KM Abstract Background: Cerebellar transcranial direct current stimulation (tDCS) is widely considered as a promising non-invasive tool to foster motor performance and learning in health and disease. The results of previous studies, however, are inconsistent. Our group failed to provide evidence for an effect of cerebellar tDCS on learning of a complex whole body dynamic balance task in young and ... read more
    1 month ago
  • White Matter Integrity Predicts Electrical Stimulation (tDCS) and Language Therapy Effects in Primary Progressive Aphasia.
    Related ArticlesWhite Matter Integrity Predicts Electrical Stimulation (tDCS) and Language Therapy Effects in Primary Progressive Aphasia. Neurorehabil Neural Repair. 2021 Jan;35(1):44-57 Authors: Zhao Y, Ficek B, Webster K, Frangakis C, Caffo B, Hillis AE, Faria A, Tsapkini K Abstract BACKGROUND: Transcranial direct current stimulation (tDCS), in conjunction with language therapy, improves language therapy outcomes in primary progressive aphasia (PPA). However, no studies show whether white matter integrity predicts language therapy or tDCS effects in PPA. OBJECTIVE: We aimed to determine whether white matter integrity, measured by diffusion tensor imaging (DTI), predicts written naming/spelling language therapy effects (letter accuracy on trained ... read more
    1 month ago
  • Effect of add-on transcranial alternating current stimulation (tACS) on persistent delusions in schizophrenia.
    Related ArticlesEffect of add-on transcranial alternating current stimulation (tACS) on persistent delusions in schizophrenia. Psychiatry Res. 2020 08;290:113106 Authors: Sreeraj VS, Suhas S, Parlikar R, Selvaraj S, Dinakaran D, Shivakumar V, Narayanaswamy JC, Venkatasubramanian G Abstract The utility of non-invasive brain stimulation techniques to alleviate resistant delusions in schizophrenia is an under-researched area. In this study, we report the effectiveness of alpha transcranial alternating current stimulation (tACS) targeting the medial prefrontal cortex in ameliorating persistent delusions. Twelve Schizophrenia patients (N=12) with persistent delusions received add-on treatment with a twice-daily 20-minutes session of 10-Hz tACS. Significant reduction in severity of ... read more
    1 month ago
  • [Research Progress and Application Prospect of Nerve Rehabilitation by Transcranial Electrical and Magnetic Stimulation].
    Related Articles[Research Progress and Application Prospect of Nerve Rehabilitation by Transcranial Electrical and Magnetic Stimulation]. Zhongguo Yi Liao Qi Xie Za Zhi. 2020 Dec 08;44(6):513-519 Authors: He F, He B, Wang Z, Chen L, Ming D Abstract Accidents or diseases may cause impairment or even loss of human motor function, among which stroke is a disease which is most likely to cause disability and seriously endangers social health. During recent years, as a new nerve regulation technology, non-invasive brain stimulation technology can achieve the application of nerve stimulation to the brain, induce and promote neuroplasticity and improve the excitability of ... read more
    1 month ago
  • Electric Field Strength From Prefrontal Transcranial Direct Current Stimulation Determines Degree of Working Memory Response: A Potential Application of Reverse-Calculation Modeling?
    Related ArticlesElectric Field Strength From Prefrontal Transcranial Direct Current Stimulation Determines Degree of Working Memory Response: A Potential Application of Reverse-Calculation Modeling? Neuromodulation. 2020 Dec 14;: Authors: Caulfield KA, Indahlastari A, Nissim NR, Lopez JW, Fleischmann HH, Woods AJ, George MS Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) for working memory is an enticing treatment, but there is mixed evidence to date. OBJECTIVES: We tested the effects of electric field strength from uniform 2 mA dosing on working memory change from prestimulation to poststimulation. Second, we statistically evaluated a reverse-calculation method of individualizing tDCS dose and its effect on normalizing ... read more
    1 month ago
  • Entraining neurons via noninvasive electric stimulation improves cognition.
    Related ArticlesEntraining neurons via noninvasive electric stimulation improves cognition. PLoS Biol. 2020 10;18(10):e3000931 Authors: van der Plas M, Hanslmayr S Abstract Transcranial Alternating Current Stimulation (tACS) is a method that injects rhythmic currents into the human brain via electrodes attached to the scalp of a participant. This technique allows researchers to control naturally occurring brain rhythms and study their causal relevance for cognition. Recent findings, however, cast doubts on the effectiveness of tACS to stimulate the brain and its mode of action. Two new studies by Vieira and colleagues and Marchesotti and colleagues reported in the current issue ... read more
    1 month ago
  • The left prefrontal cortex supports inhibitory processing during semantic memory retrieval.
    Related ArticlesThe left prefrontal cortex supports inhibitory processing during semantic memory retrieval. Cortex. 2020 Nov 20;134:296-306 Authors: Marko M, Riečanský I Abstract Semantic control refers to a set of neural and cognitive mechanisms that govern semantic processing and retrieval. Neuroimaging studies have indicated that controlled semantic processing engages the left prefrontal cortex (PFC), yet the functional role of the prefrontal activity in semantic control is poorly understood and was therefore addressed in the present study. We used a double-blind randomized controlled experiment, in which participants from three distinct groups received anodal transcranial direct current stimulation (tDCS) over left lateral PFC ... read more
    1 month ago