Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • Anisotropic conductivity tensor by analyzing diffusion tensor for electrical brain stimulation (EBS).
    Related ArticlesAnisotropic conductivity tensor by analyzing diffusion tensor for electrical brain stimulation (EBS). Phys Med Biol. 2018 Dec 18;63(24):24NT04 Authors: Lee MB, Kim YH, Kim HJ, Kwon OI Abstract Electrical brain stimulation (EBS) is a promising medical treatment method for brain neurological disorders through the direct or indirect excitation by injecting an electric current. At present, it is difficult to directly measure the distribution of the electric current delivered by electrodes inside tissues. By applying low-frequency ([Formula: see text]1 kHz) external electrical brain stimulation (EBS), the low-frequency conductivity around the cells is uneven due to asymmetric cellular structures. We propose ... read more
    1 month ago
  • High-definition tDCS to the right temporoparietal junction modulates slow-wave resting state power and coherence in healthy adults.
    Related ArticlesHigh-definition tDCS to the right temporoparietal junction modulates slow-wave resting state power and coherence in healthy adults. J Neurophysiol. 2019 Aug 28;: Authors: Donaldson PH, Kirkovski M, Yang JS, Bekkali S, Enticott PG Abstract The right temporoparietal junction (rTPJ) is a multisensory integration hub that is increasingly utilised as a target of stimulation studies exploring its rich functional network roles and potential clinical applications. Whilst transcranial direct current stimulation (tDCS) is frequently employed in such studies, there is still relatively little known regarding its local and network neurophysiological effects, particularly at important non-motor sites such as the rTPJ. The ... read more
    2 months ago
  • Influence of neurovascular mechanisms on response to tDCS: an exploratory study.
    Related ArticlesInfluence of neurovascular mechanisms on response to tDCS: an exploratory study. Exp Brain Res. 2019 Aug 27;: Authors: Iyer PC, Rosenberg A, Baynard T, Madhavan S Abstract The beneficial effects of transcranial direct current stimulation (tDCS) for stroke rehabilitation are limited by the variability in changes in corticomotor excitability (CME) after tDCS. Neuronal activity is closely related to cerebral blood flow; however, the cerebral hemodynamics of neuromodulation in relation to neural effects have been less explored. In this study, we examined the effects of tDCS on cerebral blood velocity (CBv) in chronic stroke survivors using transcranial Doppler (TCD) ultrasound ... read more
    2 months ago
  • Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation.
    Related ArticlesTranscranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation. Mol Psychiatry. 2019 Aug 27;: Authors: Chase HW, Boudewyn MA, Carter CS, Phillips ML Abstract Transcranial direct current stimulation (tDCS) is a promising method for altering the function of neural systems, cognition, and behavior. Evidence is emerging that it can also influence psychiatric symptomatology, including major depression and schizophrenia. However, there are many open questions regarding how the method might have such an effect, and uncertainties surrounding its influence on neural activity, and human cognition and functioning. In the present critical review, we identify ... read more
    2 months ago
  • Transcranial direct current stimulation (tDCS) induces adrenergic receptor-dependent microglial morphological changes in mice.
    Related ArticlesTranscranial direct current stimulation (tDCS) induces adrenergic receptor-dependent microglial morphological changes in mice. eNeuro. 2019 Aug 23;: Authors: Mishima T, Nagai T, Yahagi K, Akther S, Oe Y, Monai H, Kohsaka S, Hirase H Abstract Transcranial direct current stimulation (tDCS) has been reported for its beneficial effects on memory formation and various brain disorders. While the electrophysiological readout of tDCS effects is subtle, astrocytes have been demonstrated to elicit Ca2+ elevations during tDCS in a rodent model. This study aimed to elucidate the effects of tDCS on another major glial cell type, microglia, by histology and in vivo imaging. ... read more
    2 months ago
  • Postexercise blood pressure and autonomic responses after aerobic exercise following anodal tDCS applied over the medial prefrontal cortex.
    Related ArticlesPostexercise blood pressure and autonomic responses after aerobic exercise following anodal tDCS applied over the medial prefrontal cortex. Neurosci Lett. 2019 Aug 21;:134444 Authors: Farinatti P, Cordeiro R, Vogel M, Machado S, Monteiro W Abstract Transcranial direct current stimulation (tDCS) is acknowledged to modulate autonomic cardiac activity and hemodynamic responses at rest and during exercise. However, its potential to optimize postexercise hypotension (PEH) has not been investigated. This study investigated the effects of anodal tDCS applied over the medial prefrontal cortex (mPFC) upon blood pressure (BP) and heart rate variability (HRV) throughout 60 min following acute aerobic exercise. Fifteen young ... read more
    2 months ago
  • Comparison of transcranial electrical stimulation regimens for effects on inhibitory circuit activity in primary somatosensory cortex and tactile spatial discrimination performance.
    Related ArticlesComparison of transcranial electrical stimulation regimens for effects on inhibitory circuit activity in primary somatosensory cortex and tactile spatial discrimination performance. Behav Brain Res. 2019 Aug 20;:112168 Authors: Saito K, Otsuru N, Inukai Y, Miyaguchi S, Yokota H, Kojima S, Sasaki R, Onishi H Abstract Transcranial electrical stimulation (tES) can be used to modulate inhibitory circuits in primary somatosensory cortex, resulting in improved somatosensory function. However, efficacy may depend on the specific stimulus modality and patterns. For instance, transcranial alternating current stimulation (tACS), transcranial random noise stimulation (tRNS), and transcranial pulsed current stimulation (tPCS) were found to stably and ... read more
    2 months ago
  • Pre-stimulus Brain Activity Is Associated With State-Anxiety Changes During Single-Session Transcranial Direct Current Stimulation.
    Related ArticlesPre-stimulus Brain Activity Is Associated With State-Anxiety Changes During Single-Session Transcranial Direct Current Stimulation. Front Hum Neurosci. 2019;13:266 Authors: Nishida K, Koshikawa Y, Morishima Y, Yoshimura M, Katsura K, Ueda S, Ikeda S, Ishii R, Pascual-Marqui R, Kinoshita T Abstract Transcranial direct current stimulation is a promising neuromodulation method for treating depression. However, compared with pharmacological treatment, previous studies have reported that a relatively limited proportion of patients respond to tDCS treatment. In addition, the neurophysiological mechanisms underlying tDCS treatment remain unclear, making it difficult to identify response predictors for tDCS treatment based on neurophysiological function. Because treatment effects ... read more
    2 months ago
  • Transcranial direct current stimulation for the treatment of generalized anxiety disorder: A randomized clinical trial.
    Related ArticlesTranscranial direct current stimulation for the treatment of generalized anxiety disorder: A randomized clinical trial. J Affect Disord. 2019 Aug 15;259:31-37 Authors: de Lima AL, Braga FMA, da Costa RMM, Gomes EP, Brunoni AR, Pegado R Abstract BACKGROUND: Generalized anxiety disorder (GAD) is a common condition with current treatments being only moderately effective. Non-invasive brain stimulation techniques might provide a novel approach for treating GAD. Transcranial direct current stimulation (tDCS) has shown promising efficacy and tolerability for major depression but has not been investigated for GAD yet. Thus, we investigated the effects of tDCS on patients with GAD. METHODS: ... read more
    2 months ago
  • Simulation Analyses of tDCS Montages for the Investigation of Dorsal and Ventral Pathways.
    Related ArticlesSimulation Analyses of tDCS Montages for the Investigation of Dorsal and Ventral Pathways. Sci Rep. 2019 Aug 21;9(1):12178 Authors: Bhattacharjee S, Kashyap R, Rapp B, Oishi K, Desmond JE, Chen SHA Abstract Modulating higher cognitive functions like reading with transcranial direct current stimulation (tDCS) can be challenging as reading involves regions in the dorsal and ventral cortical areas that lie in close proximity. If the two pathways are stimulated simultaneously, the function of dorsal pathway (predominantly used for graphophonological conversion) might interfere with the function of the ventral pathway (used for semantics), and vice-versa. To achieve functional specificity in ... read more
    2 months ago
  • Effect of Anodal tDCS on Articulatory Accuracy, Word Production, and Syllable Repetition in Subjects with Aphasia: A Crossover, Double-Blinded, Sham-Controlled Trial.
    Related ArticlesEffect of Anodal tDCS on Articulatory Accuracy, Word Production, and Syllable Repetition in Subjects with Aphasia: A Crossover, Double-Blinded, Sham-Controlled Trial. Neurol Ther. 2019 Aug 20;: Authors: Vila-Nova C, Lucena PH, Lucena R, Armani-Franceschi G, Campbell FQ Abstract INTRODUCTION: Transcranial direct-current stimulation (tDCS) has been used to modulate and induce changes in brain function and excitability. tDCS is a promising tool for the treatment of aphasia. OBJECTIVE: To evaluate whether tDCS improves articulatory accuracy and speech production in patients with aphasia after stroke. METHODS AND RESULTS: Twelve right-handed subjects participated in a double-blind, sham-controlled, crossover offline trial. We assessed ... read more
    2 months ago
  • Gamma Band Neural Stimulation in Humans and the Promise of a New Modality to Prevent and Treat Alzheimer’s Disease.
    Related ArticlesGamma Band Neural Stimulation in Humans and the Promise of a New Modality to Prevent and Treat Alzheimer's Disease. J Alzheimers Dis. 2018;65(2):363-392 Authors: McDermott B, Porter E, Hughes D, McGinley B, Lang M, O'Halloran M, Jones M Abstract Existing treatments for Alzheimer's disease (AD) have questionable efficacy with a need for research into new and more effective therapies to both treat and possibly prevent the condition. This review examines a novel therapeutic modality that shows promise for treating AD based on modulating neuronal activity in the gamma frequency band through external brain stimulation. The gamma frequency ... read more
    2 months ago
  • A Pilot Double-Blind Randomized Controlled Trial of Cognitive Training Combined with Transcranial Direct Current Stimulation for Amnestic Mild Cognitive Impairment.
    Related ArticlesA Pilot Double-Blind Randomized Controlled Trial of Cognitive Training Combined with Transcranial Direct Current Stimulation for Amnestic Mild Cognitive Impairment. J Alzheimers Dis. 2019 Aug 12;-1(1):1 Authors: Martin DM, Mohan A, Alonzo A, Gates N, Gbadeyan O, Meinzer M, Sachdev P, Brodaty H, Loo C Abstract BACKGROUND: There is currently no effective intervention for improving memory in people at increased risk for dementia. Cognitive training (CT) has been promising, though effects are modest, particularly at follow-up. OBJECTIVE: To investigate whether adjunctive non-invasive brain stimulation (transcranial direct current stimulation, tDCS) could enhance the memory benefits of CT in amnestic mild ... read more
    2 months ago
  • A Case of Transcranial Direct-Current Stimulation for Childhood Stroke Hemiparesis: A Brief Report.
    Related ArticlesA Case of Transcranial Direct-Current Stimulation for Childhood Stroke Hemiparesis: A Brief Report. Dev Neurorehabil. 2019 Aug 19;:1-4 Authors: Ciechanski P, Carlson HL, Herrero M, Lane C, MacMaster FP, Kirton A Abstract Purpose: Survivors of childhood stroke incur lifelong physical disability. Treatment options are limited, however, models of motor reorganization after stroke are revealing cortical targets for neuromodulation. Transcranial direct-current stimulation (tDCS) enhances motor learning and may improve motor recovery in adult stroke, but remains uninvestigated in childhood-onset stroke. Here we documented the feasibility and safety of tDCS in an adolescent with chronic stroke-induced hemiparesis. Materials and methods: Over ... read more
    2 months ago
  • Effect of single-session transcranial direct current stimulation on cognition in Parkinson’s disease.
    Related ArticlesEffect of single-session transcranial direct current stimulation on cognition in Parkinson's disease. CNS Neurosci Ther. 2019 Aug 19;: Authors: Lau CI, Liu MN, Chang KC, Chang A, Bai CH, Tseng CS, Walsh V, Wang HC Abstract AIMS: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. METHODS: Ten nondemented ... read more
    2 months ago
  • Neural correlates of different behavioral response to transcranial direct current stimulation between patients in the unresponsive wakefulness syndrome and minimally conscious state.
    Related ArticlesNeural correlates of different behavioral response to transcranial direct current stimulation between patients in the unresponsive wakefulness syndrome and minimally conscious state. Neurol Sci. 2019 Aug 17;: Authors: Zhang Y, Lu J, Du J, Huo S, Li R, Song W Abstract In this study, we used event-related potential (ERP) and 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) to study the neural correlates of different behavioral response to transcranial direct current stimulation (tDCS) between patients in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS). Thirteen patients (eight in UWS and five in MCS) underwent 20 anodal tDCS sessions of the left dorsolateral ... read more
    2 months ago
  • Efficacy of combining home-based transcranial direct current stimulation with mindfulness-based meditation for pain in older adults with knee osteoarthritis: A randomized controlled pilot study.
    Related ArticlesEfficacy of combining home-based transcranial direct current stimulation with mindfulness-based meditation for pain in older adults with knee osteoarthritis: A randomized controlled pilot study. J Clin Neurosci. 2019 Aug 14;: Authors: Ahn H, Zhong C, Miao H, Chaoul A, Park L, Yen IH, Vila MA, Sorkpor S, Abdi S Abstract Transcranial direct current stimulation (tDCS) has been shown to be effective for reducing pain, and a growing body of literature shows the potential analgesic effects of mindfulness-based meditation (MBM). However, few studies have investigated the potential benefits associated with combining tDCS and MBM in older adults with knee osteoarthritis ... read more
    2 months ago
  • Electroencephalography and Functional Magnetic Resonance Imaging-Guided Simultaneous Transcranial Direct Current Stimulation and Repetitive Transcranial Magnetic Stimulation in a Patient With Minimally Conscious State.
    Related ArticlesElectroencephalography and Functional Magnetic Resonance Imaging-Guided Simultaneous Transcranial Direct Current Stimulation and Repetitive Transcranial Magnetic Stimulation in a Patient With Minimally Conscious State. Front Neurosci. 2019;13:746 Authors: Lin Y, Liu T, Huang Q, Su Y, Chen W, Gao D, Tian X, Huang T, Zhen Z, Han T, Ye H, Wang Y Abstract Objective: A minimally conscious state (MCS) is characterized by discernible behavioral evidence of consciousness that cannot be reproduced consistently. This condition is highly challenging to treat. Recent studies have demonstrated the potential therapeutic effect of non-invasive brain stimulation in patients with MCS. In one patient in an ... read more
    2 months ago
  • The efficacy of transcranial direct current stimulation and transcranial magnetic stimulation for chronic orofacial pain: A systematic review.
    Related ArticlesThe efficacy of transcranial direct current stimulation and transcranial magnetic stimulation for chronic orofacial pain: A systematic review. PLoS One. 2019;14(8):e0221110 Authors: Ferreira NR, Junqueira YN, Corrêa NB, Fonseca EO, Brito NBM, Menezes TA, Magini M, Fidalgo TKS, Ferreira DMTP, de Lima RL, Carvalho AC, DosSantos MF Abstract BACKGROUND: Transcranial Direct Current Stimulation (tDCS) and Transcranial Magnetic Stimulation (TMS) have been described as promising alternatives to treat different pain syndromes. This study evaluated the effects of TMS and tDCS in the treatment of chronic orofacial pain, through a systematic review. METHODS: An electronic search was performed in major databases: ... read more
    2 months ago
  • Auditory verbal hallucinations in schizophrenia: current perspectives in brain stimulation treatments.
    Related ArticlesAuditory verbal hallucinations in schizophrenia: current perspectives in brain stimulation treatments. Neuropsychiatr Dis Treat. 2019;15:2105-2117 Authors: Nathou C, Etard O, Dollfus S Abstract Purpose: This review reports the current perspectives of brain stimulation techniques in the treatment of auditory verbal hallucinations (AVH) in schizophrenia. Methods: A systematic search of the literature in the PubMed database revealed that the most studied techniques are noninvasive techniques (NIBS), including electroconvulsive therapy (ECT), transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS). Results: The results showed that ECT could have great clinical efficacy but is currently underused in practice perhaps due ... read more
    2 months ago
  • The modulation effect of non-invasive brain stimulation on cognitive function in patients with mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials.
    Related ArticlesThe modulation effect of non-invasive brain stimulation on cognitive function in patients with mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials. BMC Neurosci. 2019 Jan 03;20(1):2 Authors: Xu Y, Qiu Z, Zhu J, Liu J, Wu J, Tao J, Chen L Abstract BACKGROUND: To prevent and control dementia, many scholars have focused on the transition stage between normal ageing and dementia, mild cognitive impairment (MCI) which is a key interventional target for dementia. Studies have shown that non-invasive brain stimulation (NIBS) is beneficial to improve cognitive function of MCI patients. However, whether NIBS ... read more
    2 months ago
  • Using theoretical models from adult stroke recovery to improve use of noninvasive brain stimulation for children with congenital hemiparesis.
    Related ArticlesUsing theoretical models from adult stroke recovery to improve use of noninvasive brain stimulation for children with congenital hemiparesis. J Neurophysiol. 2017 09 01;118(3):1435-1438 Authors: Lin YL, Potter-Baker KA Abstract Noninvasive brain stimulation has been widely used for adults with stroke to improve upper limb motor function. A recent study by Kirton and colleagues (Kirton A, Ciechanski P, Zewdie E, Andersen J, Nettel-Aguirre A, Carlson H, Carsolio L, Herrero M, Quigley J, Mineyko A, Hodge J, Hill M. Neurology 88: 259-267, 2017) applied noninvasive brain stimulation to children with congenital hemiparesis but found no significant effect of ... read more
    2 months ago
  • [Neural mechanisms of visual feature binding].
    Related Articles[Neural mechanisms of visual feature binding]. Sheng Li Xue Bao. 2019 Feb 25;71(1):33-44 Authors: Zhang YY Abstract Integrating different visual features into a coherent object is a central challenge for the visual system, which is referred as the binding problem. Firstly, this review introduces the conception of the binding problem and the theoretical and empirical controversies regarding whether and how the binding processes are implemented in visual system. Although many neurons throughout the visual hierarchy are known to code multiple features, feature binding is recruited by visual system. Feature misbinding (or illusory conjunction) is probably the most striking evidence ... read more
    2 months ago
  • A novel promising therapeutic approach for patients with ataxic disorders?
    Related ArticlesA novel promising therapeutic approach for patients with ataxic disorders? Neurology. 2018 09 18;91(12):541-542 Authors: Fujioka S, Tsuboi Y, Friedman JH PMID: 30135252 [PubMed - indexed for MEDLINE] ... read more
    2 months ago
  • Single-arm, open-label, dose escalation phase I study to evaluate the safety and feasibility of transcranial direct current stimulation with electroencephalography biomarkers in paediatric disorders of consciousness: a study protocol.
    Related ArticlesSingle-arm, open-label, dose escalation phase I study to evaluate the safety and feasibility of transcranial direct current stimulation with electroencephalography biomarkers in paediatric disorders of consciousness: a study protocol. BMJ Open. 2019 Aug 10;9(8):e029967 Authors: Saleem GT, Ewen JB, Crasta JE, Slomine BS, Cantarero GL, Suskauer SJ Abstract INTRODUCTION: Children with disorders of consciousness (DOC) represent the highest end of the acquired brain injury (ABI) severity spectrum for survivors and experience a multitude of functional impairments. Current clinical management in DOC uses behavioural evaluation measures and interventions that fail to (1) describe the physiological consequences of ABI and (2) ... read more
    2 months ago