Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • Effects of Bilateral Transcranial Direct Current Stimulation on Working Memory and Global Cognition in Older Patients with Remitted Major Depression: A Pilot Randomized Clinical Trial.
    Related ArticlesEffects of Bilateral Transcranial Direct Current Stimulation on Working Memory and Global Cognition in Older Patients with Remitted Major Depression: A Pilot Randomized Clinical Trial. Int J Geriatr Psychiatry. 2020 Jun 11;: Authors: Kumar S, Batist J, Ghazala Z, Zomorrodi RM, Brooks H, Goodman M, Blumberger DM, Daskalakis ZJ, Mulsant BH, Rajji TK Abstract OBJECTIVES: To assess the effects of a 10-day course of bilateral anodal transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) on working memory and global cognition in elderly participants with remitted major depressive disorder at 14 days (primary outcome) and 90 days (secondary outcome) ... read more
    3 weeks ago
  • Does neuromodulation transcranial direct current stimulation (tDCS) associated with peripheral stimulation through exercise to walk have an impact on falls in people with Parkinson’s disease?
    Related ArticlesDoes neuromodulation transcranial direct current stimulation (tDCS) associated with peripheral stimulation through exercise to walk have an impact on falls in people with Parkinson's disease? Med Hypotheses. 2020 Jun 04;144:109916 Authors: Arêas FZDS, Nakamura-Palacios EM, Boening A, Arêas GPT, Nascimento LR Abstract Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases in the world, with a high degree of disability. Among the various therapeutic possibilities, brain stimulation appears in a promising approach, with deep brain stimulation (DBS) being the best described and successful, yet it has the limitation of being invasive. In this context we present transcranial ... read more
    3 weeks ago
  • Contralesional Application of Transcranial Direct Current Stimulation on Functional Improvement in Ischemic Stroke Mice.
    Related ArticlesContralesional Application of Transcranial Direct Current Stimulation on Functional Improvement in Ischemic Stroke Mice. Stroke. 2020 Jun 10;:STROKEAHA120029221 Authors: Ahn SM, Jung DH, Lee HJ, Pak ME, Jung YJ, Shin YI, Shin HK, Choi BT Abstract BACKGROUND AND PURPOSE: The therapeutic use of transcranial direct current stimulation (tDCS), an adjuvant tool for stroke, induces long-term changes in cortical excitability, for example, the secretion of activity-dependent growth factors. We assessed the proper therapeutic configuration of high-definition tDCS (HD-tDCS) in the subacute stage of ischemic stroke and its underlying expression profiling of growth factors to propose a new method for ensuring ... read more
    3 weeks ago
  • Anodal transcranial direct current stimulation and intermittent theta-burst stimulation improve deglutition and swallowing reproducibility in elderly patients with dysphagia: A methodological issue to avoid misinterpretation.
    Related ArticlesAnodal transcranial direct current stimulation and intermittent theta-burst stimulation improve deglutition and swallowing reproducibility in elderly patients with dysphagia: A methodological issue to avoid misinterpretation. Neurogastroenterol Motil. 2020 Jun 09;:e13922 Authors: Sabour S PMID: 32515110 [PubMed - as supplied by publisher] ... read more
    3 weeks ago
  • Effect of transcranial direct-current stimulation on cognitive function in stroke patients: A systematic review and meta-analysis.
    Related ArticlesEffect of transcranial direct-current stimulation on cognitive function in stroke patients: A systematic review and meta-analysis. PLoS One. 2020;15(6):e0233903 Authors: Yan RB, Zhang XL, Li YH, Hou JM, Chen H, Liu HL Abstract OBJECTIVE: Transcranial direct-current stimulation (tDCS) is a noninvasive approach that can alter brain excitability. Several studies have shown the effectiveness of tDCS in improving language and movement function in stroke patients. However, the effect of tDCS on cognitive function after stroke remains uncertain. METHODS: We searched Medline, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), the China National Knowledge Infrastructure, the China Science and Technology ... read more
    3 weeks ago
  • Enhancing rehabilitation and functional recovery after brain and spinal cord trauma with electrical neuromodulation.
    Related ArticlesEnhancing rehabilitation and functional recovery after brain and spinal cord trauma with electrical neuromodulation. Curr Opin Neurol. 2019 12;32(6):828-835 Authors: Hofer AS, Schwab ME Abstract PURPOSE OF REVIEW: This review discusses recent advances in the rehabilitation of motor deficits after traumatic brain injury (TBI) and spinal cord injury (SCI) using neuromodulatory techniques. RECENT FINDINGS: Neurorehabilitation is currently the only treatment option for long-term improvement of motor functions that can be offered to patients with TBI or SCI. Major advances have been made in recent years in both preclinical and clinical rehabilitation. Activity-dependent plasticity of neuronal connections and circuits is ... read more
    4 weeks ago
  • Effects of 1 mA and 2 mA transcranial direct current stimulation on working memory performance in healthy participants.
    Related ArticlesEffects of 1 mA and 2 mA transcranial direct current stimulation on working memory performance in healthy participants. Conscious Cogn. 2020 Jun 02;83:102959 Authors: Papazova I, Strube W, Wienert A, Henning B, Schwippel T, Fallgatter AJ, Padberg F, Falkai P, Plewnia C, Hasan A Abstract Anodal transcranial current stimulation (tDCS) to the left dorsolateral prefrontal cortex (DLPFC) has been shown to enhance working memory (WM) in neuropsychiatric patients. In healthy populations, however, tDCS obtains inconclusive results, mostly due to heterogeneous study and stimulation protocols. Here, we approached these issues by investigating effects of tDCS intensity on simultaneous WM performance with three ... read more
    4 weeks ago
  • [Non-invasive brain and spinal cord stimulation for motor and functional recovery after a spinal cord injury].
    Related Articles[Non-invasive brain and spinal cord stimulation for motor and functional recovery after a spinal cord injury]. Rev Neurol. 2020 Jun 16;70(12):461-477 Authors: Kumru H, Flores A, Rodríguez-Cañón M, Soriano I, García L, Vidal-Samsó J Abstract INTRODUCTION: Spinal cord injury is a traumatic or non-traumatic event that causes an alteration of sensory, motor or autonomic functioning and ultimately affects the physical, psychological and social well-being of the person who suffers it. A comprehensive approach to spinal cord injury requires many health resources and can place a considerable financial burden on patients, their families and the community. AIM: To review the ... read more
    4 weeks ago
  • Modulation of Multiunit Spike Activity by Transcranial AC Stimulation (tACS) in the Rat Cerebellar Cortex.
    Related ArticlesModulation of Multiunit Spike Activity by Transcranial AC Stimulation (tACS) in the Rat Cerebellar Cortex. Conf Proc IEEE Eng Med Biol Soc. 2019 07;2019:5192-5195 Authors: Asan AS, Sahin M Abstract Transcranial electrical stimulation (tES) techniques have garnered significant interest due to their non-invasiveness and potential to offer a treatment option in a wide variety of brain disorders. Among several modulation techniques, transcranial alternating current stimulation (tACS) is favored for its ability to entrain the neural oscillations. The cerebellum is one of the targeted sites because of its involvement in motor and cognitive functions. However, animal studies are ... read more
    4 weeks ago
  • Effect of transcranial direct current stimulation on sports performance for two profiles of athletes (power and endurance) (COMPETE): a protocol for a randomised, crossover, double blind, controlled exploratory trial.
    Related ArticlesEffect of transcranial direct current stimulation on sports performance for two profiles of athletes (power and endurance) (COMPETE): a protocol for a randomised, crossover, double blind, controlled exploratory trial. Trials. 2020 Jun 03;21(1):461 Authors: Grandperrin Y, Grosprêtre S, Nicolier M, Gimenez P, Vidal C, Haffen E, Bennabi D Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) is promising for improving motor and cognitive performance. Nevertheless, its mechanisms of action are unclear and need to be better characterised according to the stimulated brain area and the type of exercise performed. METHODS/DESIGN: This is a double-blind crossover study, organised into two parts: ... read more
    4 weeks ago
  • Cognitive-Behavioral Therapy Versus Transcranial Direct Current Stimulation for Augmenting Selective Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder Patients.
    Related ArticlesCognitive-Behavioral Therapy Versus Transcranial Direct Current Stimulation for Augmenting Selective Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder Patients. Basic Clin Neurosci. 2020 Jan-Feb;11(1):111-120 Authors: Dadashi M, Yousefi Asl V, Morsali Y Abstract Introduction: Obsessive-Compulsive Disorder (OCD) belongs to the categories of psychiatric disorders with the potential to turn into a chronic condition without receiving the necessary treatments. The main feature of OCD is the frequent or intense obsession and compulsion that might induce great pain and suffering in patients. Moreover, as one of the most prevalent abnormalities, depression usually follows OCD. The present study aimed to compare the effects of ... read more
    1 month ago
  • Brain Stimulation to Modulate Food Intake and Eating Behavior.
    Related ArticlesBrain Stimulation to Modulate Food Intake and Eating Behavior. Curr Diab Rep. 2019 12 02;19(12):152 Authors: Dendy R, Stinson EJ, Guerithault N, Gluck ME Abstract PURPOSE OF REVIEW: Appetitive behaviors are mediated through homeostatic and reward signaling of brain circuits. There has been increasing interest in the use of neuromodulation techniques aimed at targeting brain regions such as the lateral prefrontal and subcortical regions associated with dysregulation of eating behaviors. RECENT FINDINGS: Invasive brain stimulation techniques have demonstrated promising results in treating severe and enduring anorexia nervosa and morbid obesity. In addition, non-invasive techniques have been shown to ... read more
    1 month ago
  • Incidence and linguistic quality of speech errors: a comparison of preoperative transcranial magnetic stimulation and intraoperative direct cortex stimulation.
    Related ArticlesIncidence and linguistic quality of speech errors: a comparison of preoperative transcranial magnetic stimulation and intraoperative direct cortex stimulation. J Neurosurg. 2020 May 29;:1-10 Authors: Bährend I, Muench MR, Schneider H, Moshourab R, Dreyer FR, Vajkoczy P, Picht T, Faust K Abstract OBJECTIVE: Given the interindividual variance of functional language anatomy, risk prediction based merely on anatomical data is insufficient in language area-related brain tumor surgery, suggesting the need for direct cortical and subcortical mapping during awake surgery. Reliable, noninvasive preoperative methods of language localization hold the potential for reducing the necessity for awake procedures and may improve patient ... read more
    1 month ago
  • Repeated transcranial direct current stimulation of dorsolateral-prefrontal cortex improves executive functions, cognitive reappraisal emotion regulation, and control over emotional processing in borderline personality disorder: A randomized, sham-controlled, parallel-group study.
    Related ArticlesRepeated transcranial direct current stimulation of dorsolateral-prefrontal cortex improves executive functions, cognitive reappraisal emotion regulation, and control over emotional processing in borderline personality disorder: A randomized, sham-controlled, parallel-group study. J Affect Disord. 2020 May 20;274:93-102 Authors: Molavi P, Aziziaram S, Basharpoor S, Atadokht A, Nitsche MA, Salehinejad MA Abstract BACKGROUND: Borderline personality disorder (BPD) is primarily characterized by deficient emotion regulation. Impaired cognitive control over negative emotions is central to emotion dysregulation in BPD. Respective executive dysfunctions are associated with hypoactivation of prefrontal regions, and consecutive alterations of fronto-limbic network functionality. Here, we investigated the effect of increasing activity ... read more
    1 month ago
  • Non-invasive brain stimulation modalities for the treatment and prevention of opioid use disorder: a systematic review of the literature.
    Related ArticlesNon-invasive brain stimulation modalities for the treatment and prevention of opioid use disorder: a systematic review of the literature. J Addict Dis. 2020 Apr-Jun;38(2):186-199 Authors: Young JR, Smani SA, Mischel NA, Kritzer MD, Appelbaum LG, Patkar AA Abstract The U.S. is currently facing an unprecedented epidemic of opioid-related deaths. Despite the efficacy of the current treatments for opioid use disorder (OUD), including psychosocial interventions and medication-assisted therapy (MAT), many patients remain treatment-resistant and at high risk for overdose. A potential augmentation strategy includes the use of non-invasive brain stimulation (NIBS) techniques, such as transcranial magnetic stimulation (TMS), transcranial direct ... read more
    1 month ago
  • Targeting Gamma-Related Pathophysiology in Autism Spectrum Disorder Using Transcranial Electrical Stimulation: Opportunities and Challenges.
    Related ArticlesTargeting Gamma-Related Pathophysiology in Autism Spectrum Disorder Using Transcranial Electrical Stimulation: Opportunities and Challenges. Autism Res. 2020 May 28;: Authors: Kayarian FB, Jannati A, Rotenberg A, Santarnecchi E Abstract A range of scalp electroencephalogram (EEG) abnormalities correlates with the core symptoms of autism spectrum disorder (ASD). Among these are alterations of brain oscillations in the gamma-frequency EEG band in adults and children with ASD, whose origin has been linked to dysfunctions of inhibitory interneuron signaling. While therapeutic interventions aimed to modulate gamma oscillations are being tested for neuropsychiatric disorders such as schizophrenia, Alzheimer's disease, and frontotemporal dementia, the prospects ... read more
    1 month ago
  • Non-invasive brain stimulation for posttraumatic stress disorder: a systematic review and meta-analysis.
    Related ArticlesNon-invasive brain stimulation for posttraumatic stress disorder: a systematic review and meta-analysis. Transl Psychiatry. 2020 May 28;10(1):168 Authors: Kan RLD, Zhang BBB, Zhang JJQ, Kranz GS Abstract Approximately 7-9% of people develop posttraumatic stress disorder in their lifetime, but standard pharmacological treatment or psychotherapy shows a considerable individual variation in their effectiveness. Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) hold promise for the treatment of posttraumatic stress disorder. The objective of this meta-analysis was to summarize the existing evidence on the therapeutic effects of these brain stimulation treatments on posttraumatic core symptoms. We systematically retrieved ... read more
    1 month ago
  • Effects of Transcranial Direct Current Stimulation on Visual Neuroplasticity in Schizophrenia.
    Related ArticlesEffects of Transcranial Direct Current Stimulation on Visual Neuroplasticity in Schizophrenia. Clin EEG Neurosci. 2020 May 28;:1550059420925697 Authors: Jahshan C, Wynn JK, Roach BJ, Mathalon DH, Green MF Abstract People with schizophrenia (SZ) exhibit visual processing abnormalities that affect their daily functioning and remediating these deficits might help to improve functioning. Transcranial direct current stimulation (tDCS) is a potential tool for perceptual enhancement for this purpose, though there are no reports of tDCS applied to visual cortex in SZ. In a within-subject, crossover design, we evaluated the effects of tDCS on visual processing in 27 SZ. All patients received ... read more
    1 month ago
  • The role of repetitive transcranial magnetic stimulation (rTMS) in the treatment of cognitive impairment in patients with Alzheimer’s disease: A systematic review and meta-analysis.
    Related ArticlesThe role of repetitive transcranial magnetic stimulation (rTMS) in the treatment of cognitive impairment in patients with Alzheimer's disease: A systematic review and meta-analysis. J Neurol Sci. 2019 Mar 15;398:184-191 Authors: Lin Y, Jiang WJ, Shan PY, Lu M, Wang T, Li RH, Zhang N, Ma L Abstract BACKGROUND: Although repetitive transcranial magnetic stimulation (rTMS) has been considered a potentially effective treatment for cognitive impairment in patients with Alzheimer's disease (AD), previous studies have produced inconsistent results. The objective of this meta-analysis was to evaluate the effects of rTMS on cognitive function in patients with AD. METHODS: PubMed, ... read more
    1 month ago
  • Transcranial Direct Current Stimulation to Facilitate Lower Limb Recovery Following Stroke: Current Evidence and Future Directions.
    Related ArticlesTranscranial Direct Current Stimulation to Facilitate Lower Limb Recovery Following Stroke: Current Evidence and Future Directions. Brain Sci. 2020 May 21;10(5): Authors: Gowan S, Hordacre B Abstract Stroke remains a global leading cause of disability. Novel treatment approaches are required to alleviate impairment and promote greater functional recovery. One potential candidate is transcranial direct current stimulation (tDCS), which is thought to non-invasively promote neuroplasticity within the human cortex by transiently altering the resting membrane potential of cortical neurons. To date, much work involving tDCS has focused on upper limb recovery following stroke. However, lower limb rehabilitation is important for ... read more
    1 month ago
  • A role for the right dorsolateral prefrontal cortex in enhancing regulation of both craving and negative emotions in internet gaming disorder: A randomized trial.
    A role for the right dorsolateral prefrontal cortex in enhancing regulation of both craving and negative emotions in internet gaming disorder: A randomized trial. Eur Neuropsychopharmacol. 2020 May 21;: Authors: Wu LL, Potenza MN, Zhou N, Kober H, Shi XH, Yip SW, Xu JH, Zhu L, Wang R, Liu GQ, Zhang JT Abstract Reward-seeking and relief from negative emotions are two central motivational drives underlying addictions. Impaired executive control over craving and negative emotions contributes to compulsive addictive behaviors. Neuroimaging evidence has implicated the prefrontal cortex (PFC) in regulating craving or emotions. This study aims at examining whether anodal transcranial ... read more
    1 month ago
  • Effect of anodal transcranial direct current stimulation at the right dorsolateral prefrontal cortex on the cognitive function in patients with mild cognitive impairment: a randomized double-blind controlled trial.
    Effect of anodal transcranial direct current stimulation at the right dorsolateral prefrontal cortex on the cognitive function in patients with mild cognitive impairment: a randomized double-blind controlled trial. Arch Phys Med Rehabil. 2020 May 10;: Authors: Stonsaovapak C, Hemrungroj S, Terachinda P, Piravej K Abstract OBJECTIVES: Study the effect of anodal transcranial direct stimulation (atDCS) of the right dorsolateral prefrontal cortex (DLPFC) on cognitive function and side effects in patients with mild cognitive impairment (MCI). STUDY DESIGN: Experimental double-blind randomized, sham-controlled trial SETTING: Department of Rehabilitation Medicine, Tertiary Hospital SUBJECTS: Volunteers with MCI METHODS: Participants (45) who met the inclusion ... read more
    1 month ago
  • Gait and Functional Mobility in Multiple Sclerosis: Immediate Effects of Transcranial Direct Current Stimulation (tDCS) Paired With Aerobic Exercise.
    Gait and Functional Mobility in Multiple Sclerosis: Immediate Effects of Transcranial Direct Current Stimulation (tDCS) Paired With Aerobic Exercise. Front Neurol. 2020;11:310 Authors: Pilloni G, Choi C, Coghe G, Cocco E, Krupp LB, Pau M, Charvet LE Abstract Walking impairments are a debilitating feature of multiple sclerosis (MS) because of the direct interference with daily activity. The management of motor symptoms in those with MS remains a therapeutic challenge. Transcranial direct current stimulation (tDCS) is a type of non-invasive brain stimulation that is emerging as a promising rehabilitative tool but requires further characterization to determine its optimal therapeutic use. In ... read more
    1 month ago
  • Locations for noninvasive brain stimulation in treating depressive disorders: A combination of meta-analysis and resting-state functional connectivity analysis.
    Related ArticlesLocations for noninvasive brain stimulation in treating depressive disorders: A combination of meta-analysis and resting-state functional connectivity analysis. Aust N Z J Psychiatry. 2020 May 18;:4867420920372 Authors: Zhang B, Liu J, Bao T, Wilson G, Park J, Zhao B, Kong J Abstract OBJECTIVE: Many noninvasive brain stimulation techniques have been applied to treat depressive disorders. However, the target brain region in most noninvasive brain stimulation studies is the dorsolateral prefrontal cortex. Exploring new stimulation locations may improve the efficacy of noninvasive brain stimulation for depressive disorders. We aimed to explore potential noninvasive brain stimulation locations for depressive disorders through ... read more
    2 months ago
  • Transcranial Direct Current Stimulation in ADHD: A Systematic Review of Efficacy, Safety, and Protocol-induced Electrical Field Modeling Results.
    Related ArticlesTranscranial Direct Current Stimulation in ADHD: A Systematic Review of Efficacy, Safety, and Protocol-induced Electrical Field Modeling Results. Neurosci Bull. 2020 May 16;: Authors: Salehinejad MA, Nejati V, Mosayebi-Samani M, Mohammadi A, Wischnewski M, Kuo MF, Avenanti A, Vicario CM, Nitsche MA Abstract Transcranial direct current stimulation (tDCS) is a promising method for altering cortical excitability with clinical implications. It has been increasingly used in neurodevelopmental disorders, especially attention-deficit hyperactivity disorder (ADHD), but its efficacy (based on effect size calculations), safety, and stimulation parameters have not been systematically examined. In this systematic review, we aimed to (1) explore the ... read more
    2 months ago