Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • Evidence Transcranial Direct Current Stimulation Can Improve Saccadic Eye Movement Control in Older Adults.
    Related ArticlesEvidence Transcranial Direct Current Stimulation Can Improve Saccadic Eye Movement Control in Older Adults. Vision (Basel). 2018 Dec 03;2(4): Authors: Chen PL, Stenling A, Machado L Abstract Objectives: Ageing is associated with declines in voluntary eye movement control, which negatively impact the performance of daily activities. Therapies treating saccadic eye movement control deficits are currently lacking. To address the need for an effective therapy to treat age-related deficits in saccadic eye movement control, the current study investigated whether saccadic behaviour in older adults can be improved by anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex using ... read more
    3 weeks ago
  • Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes.
    Related ArticlesBeyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes. J Neuroeng Rehabil. 2019 Nov 15;16(1):141 Authors: Morya E, Monte-Silva K, Bikson M, Esmaeilpour Z, Biazoli CE, Fonseca A, Bocci T, Farzan F, Chatterjee R, Hausdorff JM, da Silva Machado DG, Brunoni AR, Mezger E, Moscaleski LA, Pegado R, Sato JR, Caetano MS, Sá KN, Tanaka C, Li LM, Baptista AF, Okano AH Abstract Transcranial Direct Current Stimulation (tDCS) is a non-invasive technique used to modulate neural tissue. Neuromodulation apparently improves cognitive functions in several neurologic diseases treatment and sports performance. In this ... read more
    4 weeks ago
  • Correction to: Does transcranial direct current stimulation improve functional locomotion in people with Parkinson’s disease? A systematic review and meta-analysis.
    Related ArticlesCorrection to: Does transcranial direct current stimulation improve functional locomotion in people with Parkinson's disease? A systematic review and meta-analysis. J Neuroeng Rehabil. 2019 Nov 14;16(1):139 Authors: Lee HK, Ahn SJ, Shin YM, Kang N, Cauraugh JH Abstract In the original article [1], we mentioned that some study characteristics of the article by Dagan and colleagues [2] were unavailable.PMID: 31727089 [PubMed - in process] ... read more
    4 weeks ago
  • Noninvasive Brain Stimulation and Noninvasive Peripheral Stimulation for Neglect Syndrome Following Acquired Brain Injury.
    Related ArticlesNoninvasive Brain Stimulation and Noninvasive Peripheral Stimulation for Neglect Syndrome Following Acquired Brain Injury. Neuromodulation. 2019 Nov 14;: Authors: Lucente G, Valls-Sole J, Murillo N, Rothwell J, Coll J, Davalos A, Kumru H Abstract OBJECTIVE: Hemispatial neglect is a frequent condition usually following nondominant hemispheric brain injury. It strongly affects rehabilitation strategies and everyday life activities. It is associated with behavioral and cognitive disability with a strong impact on patient's life. METHODS: We reviewed the published literature on the use of noninvasive brain stimulation, including repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), and of noninvasive ... read more
    4 weeks ago
  • Probing the relevance of repeated cathodal tDCS over the primary motor cortex for prolongation of after-effects.
    Related ArticlesProbing the relevance of repeated cathodal tDCS over the primary motor cortex for prolongation of after-effects. J Physiol. 2019 Nov 12;: Authors: Samani MM, Agboada D, Kuo MF, Nitsche MA Abstract KEY POINTS: •To explore the capability of cathodal tDCS to induce late-phase LTD via repeated stimulation •Conventional (1mA for 15min) and intensified (3mA for 20min) protocols with short (20min) and long (24 h) intervals were tested •Late-phase plasticity was not induced by a single repetition of stimulation •Repetition reduced the efficacy of stimulation protocols with higher intensities ABSTRACT: Transcranial direct current stimulation (tDCS) has promising results in pilot ... read more
    4 weeks ago
  • Can transcranial direct current stimulation (tDCS) improve impulsivity in healthy and psychiatric adult populations? A systematic review.
    Related ArticlesCan transcranial direct current stimulation (tDCS) improve impulsivity in healthy and psychiatric adult populations? A systematic review. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Nov 09;:109814 Authors: Mayer J, Chopard G, Nicolier M, Gabriel D, Masse C, Giustiniani J, Vandel P, Haffen E, Bennabi D Abstract Impulsivity is a multidimensional phenomenon that remains hard to define. It compounds the core pathological construct of many neuropsychiatric illnesses, and despite its close relation to suicide risk, it currently has no specific treatment. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique whose application results in cognitive function improvement, both in healthy ... read more
    4 weeks ago
  • Can Anodal Transcranial Direct Current Stimulation Increase Steady-State Visual Evoked Potential Responses?
    Related ArticlesCan Anodal Transcranial Direct Current Stimulation Increase Steady-State Visual Evoked Potential Responses? J Korean Med Sci. 2019 Nov 11;34(43):e285 Authors: Kim DW, Kim E, Lee C, Im CH Abstract BACKGROUND: It has been frequently reported that non-negligible numbers of individuals have steady-state visual evoked potential (SSVEP) responses of low signal-to-noise-ratio (SNR) to specific stimulation frequencies, which makes detection of the SSVEP difficult especially in brain-computer interface applications. We investigated whether SSVEP can be modulated by anodal transcranial direct-current stimulation (tDCS) of the visual cortex. METHODS: Each participant participated in two 20-min experiments-an actual tDCS experiment and a sham tDCS ... read more
    1 month ago
  • Effects of Bihemispheric Transcranial Direct Current Stimulation on Upper Extremity Function in Stroke Patients: A randomized Double-Blind Sham-Controlled Study.
    Related ArticlesEffects of Bihemispheric Transcranial Direct Current Stimulation on Upper Extremity Function in Stroke Patients: A randomized Double-Blind Sham-Controlled Study. J Stroke Cerebrovasc Dis. 2019 Nov 04;:104454 Authors: Alisar DC, Ozen S, Sozay S Abstract BACKGROUND AND PURPOSE: Transcranial direct current stimulation (tDCS) is a treatment used in the rehabilitation of stroke patients aiming to improve functionality of the plegic upper extremity. Currently, tDCS is not routinely used in post stroke rehabilitation. The aim of this study was to establish the effects of bihemspheric tDCS combined with physical therapy (PT) and occupational therapy (OT) on upper extremity motor function. METHODS: ... read more
    1 month ago
  • Offline effects of transcranial direct current stimulation on reaction times of lower extremity movements in people after stroke: a pilot cross-over study.
    Related ArticlesOffline effects of transcranial direct current stimulation on reaction times of lower extremity movements in people after stroke: a pilot cross-over study. J Neuroeng Rehabil. 2019 Nov 07;16(1):136 Authors: Coppens MJM, Staring WHA, Nonnekes J, Geurts ACH, Weerdesteyn V Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that has shown promise for rehabilitation after stroke. Ipsilesional anodal tDCS (a-tDCS) over the motor cortex increases corticospinal excitability, while contralesional cathodal tDCS (c-tDCS) restores interhemispheric balance, both resulting in offline improved reaction times of delayed voluntary upper-extremity movements. We aimed to investigate whether tDCS would also ... read more
    1 month ago
  • Optimization of an optrode microdevice for infrared neural stimulation.
    Related ArticlesOptimization of an optrode microdevice for infrared neural stimulation. Appl Opt. 2019 May 10;58(14):3870-3876 Authors: Boros ÖC, Horváth ÁC, Beleznai S, Sepsi Ö, Csősz D, Fekete Z, Koppa P Abstract Infrared light is a promising candidate for the treatment of neurodegenerative diseases. Optimizing the device parameters to achieve the best optical and mechanical performance is essential for reliable in vivo operation. In this work, mechanical strength simulations and coupled optical and thermal model were used to determine optimal design parameters for maximizing overall device efficiency. Our analysis reveals that minimizing the number of integrated optical elements and optimizing the ... read more
    1 month ago
  • A comparison between threshold criterion and amplitude criterion in transcranial motor evoked potentials during surgery for supratentorial lesions.
    Related ArticlesA comparison between threshold criterion and amplitude criterion in transcranial motor evoked potentials during surgery for supratentorial lesions. J Neurosurg. 2018 09 07;131(3):740-749 Authors: Abboud T, Schwarz C, Westphal M, Martens T Abstract OBJECTIVE: The aim of this study was to compare sensitivity and specificity between the novel threshold and amplitude criteria for motor evoked potentials (MEPs) monitoring after transcranial electrical stimulation (TES) during surgery for supratentorial lesions in the same patient cohort. METHODS: One hundred twenty-six patients were included. All procedures were performed under general anesthesia. Craniotomies did not expose motor cortex, so that direct mapping was less ... read more
    1 month ago
  • Enhanced tES and tDCS computational models by meninges emulation.
    Related ArticlesEnhanced tES and tDCS computational models by meninges emulation. J Neural Eng. 2019 Nov 05;: Authors: Jiang J, Truong DQ, Esmaeilpour Z, Huang Y, Badran BW, Bikson M Abstract OBJECTIVE: Understanding how current reaches the brain during transcranial Electrical Stimulation (tES) underpins efforts to rationalize outcomes and optimize interventions. To this end, computational models of current flow relate applied dose to brain electric field. Conventional tES modeling considers distinct tissues like scalp, skull, cerebrospinal fluid (CSF), gray matter and white matter. The properties of highly conductive CSF are especially important. However, modeling the space between skull and brain as ... read more
    1 month ago
  • Direct current stimulation boosts hebbian plasticity in┬ávitro.
    Related ArticlesDirect current stimulation boosts hebbian plasticity in vitro. Brain Stimul. 2019 Oct 18;: Authors: Kronberg G, Rahman A, Sharma M, Bikson M, Parra LC Abstract BACKGROUND: There is evidence that transcranial direct current stimulation (tDCS) can improve learning performance. Arguably, this effect is related to long term potentiation (LTP), but the precise biophysical mechanisms remain unknown. HYPOTHESIS: We propose that direct current stimulation (DCS) causes small changes in postsynaptic membrane potential during ongoing endogenous synaptic activity. The altered voltage dynamics in the postsynaptic neuron then modify synaptic strength via the machinery of endogenous voltage-dependent Hebbian plasticity. This hypothesis predicts that ... read more
    1 month ago
  • The impact of targeted cathodal transcranial direct current stimulation on reward circuitry and affect in Bipolar Disorder.
    Related ArticlesThe impact of targeted cathodal transcranial direct current stimulation on reward circuitry and affect in Bipolar Disorder. Mol Psychiatry. 2019 Oct 29;: Authors: Bertocci MA, Chase HW, Graur S, Stiffler R, Edmiston EK, Coffman BA, Greenberg BD, Phillips ML Abstract Bipolar Disorder is costly and debilitating, and many treatments have side effects. Transcranial Direct Current Stimulation (tDCS) is a well-tolerated neuromodulation technique that may be a useful treatment for Bipolar Disorder if targeted to neural regions implicated in the disorder. One potential region is the left ventrolateral prefrontal cortex (vlPFC), which shows abnormally elevated activity during reward expectancy in ... read more
    1 month ago
  • Multi-Session Anodal Prefrontal Transcranial Direct Current Stimulation does not Improve Executive Functions among Older Adults.
    Related ArticlesMulti-Session Anodal Prefrontal Transcranial Direct Current Stimulation does not Improve Executive Functions among Older Adults. J Int Neuropsychol Soc. 2019 Oct 29;:1-10 Authors: Yu J, Lam CLM, Man ISC, Shao R, Lee TMC Abstract OBJECTIVE: Findings from single-session online studies highlighted the potential of using anodal prefrontal transcranial direct current stimulation (tDCS) to enhance executive functions (EF) in the context of aging. However, tDCS must be executed as a multi-session offline intervention to ascertain its viability in this context. Relatedly, findings from multi-session studies remained inconclusive. To this end, we examined the effects of multi-session anodal prefrontal tDCS on ... read more
    1 month ago
  • Interventional psychiatry in the management of behavioural and psychological symptoms of dementia: a qualitative review.
    Related ArticlesInterventional psychiatry in the management of behavioural and psychological symptoms of dementia: a qualitative review. Swiss Med Wkly. 2019 Oct 21;149:w20140 Authors: Swierkosz-Lenart K, Mall JF, von Gunten A Abstract INTRODUCTION: “Behavioural and psychological symptoms of dementia” (BPSD) refers to a heterogeneous group of clinical manifestations related to dementia, including apathy, depression, anxiety, delusions, hallucinations, sexual or social disinhibition, sleep-wake cycle disturbances, aggression, agitation and other behaviours considered inappropriate. Because of the complexity and heterogeneity of BPSD, as well as the fragility and multimorbidity of the elderly, pharmacological treatment appears to be limited in terms of safety and efficacy, ... read more
    1 month ago
  • Cervical trans-spinal direct current stimulation: a modelling-experimental approach.
    Related ArticlesCervical trans-spinal direct current stimulation: a modelling-experimental approach. J Neuroeng Rehabil. 2019 Oct 25;16(1):123 Authors: Fernandes SR, Pereira M, Salvador R, Miranda PC, de Carvalho M Abstract BACKGROUND: Trans-spinal direct current stimulation (tsDCS) is a non-invasive technique with promising neuromodulatory effects on spinal cord (SC) circuitry. Computational studies are essential to guide effective tsDCS protocols for specific clinical applications. This study aims to combine modelling and experimental studies to determine the electrode montage that maximizes electric field (E-field) delivery during cervical tsDCS. METHODS: Current and E-field distributions in the cervical SC were predicted for four electrode montages in a ... read more
    1 month ago
  • ROAST: An Open-Source, Fully-Automated, Realistic Volumetric-Approach-Based Simulator For TES.
    Related ArticlesROAST: An Open-Source, Fully-Automated, Realistic Volumetric-Approach-Based Simulator For TES. Conf Proc IEEE Eng Med Biol Soc. 2018 07;2018:3072-3075 Authors: Huang Y, Datta A, Bikson M, Parra LC Abstract Research in the area of transcranial electrical stimulation (TES) often relies on computational models of current flow in the brain. Models are built on magnetic resonance images (MRI) of the human head to capture detailed individual anatomy. To simulate current flow, MRIs have to be segmented, virtual electrodes have to be placed on the scalp, the volume is tessellated into a mesh, and the finite element model is solved numerically ... read more
    2 months ago
  • Neurostimulation methods in the treatment of chronic pain.
    Related ArticlesNeurostimulation methods in the treatment of chronic pain. J Neural Transm (Vienna). 2019 Oct 21;: Authors: Moisset X, Lanteri-Minet M, Fontaine D Abstract The goal of this narrative review was to give an up-to-date overview of the peripheral and central neurostimulation methods that can be used to treat chronic pain. Special focus has been given to three pain conditions: neuropathic pain, nociplastic pain and primary headaches. Both non-invasive and invasive techniques are briefly presented together with their pain relief potentials. For non-invasive stimulation techniques, data concerning transcutaneous electrical nerve stimulation (TENS), transcranial direct current stimulation (tDCS), repetitive transcranial magnetic ... read more
    2 months ago
  • The Effect of Cerebellar Transcranial Direct Current Stimulation on Motor Learning: A Systematic Review of Randomized Controlled Trials.
    Related ArticlesThe Effect of Cerebellar Transcranial Direct Current Stimulation on Motor Learning: A Systematic Review of Randomized Controlled Trials. Front Hum Neurosci. 2019;13:328 Authors: Kumari N, Taylor D, Signal N Abstract Background: Cerebellar transcranial direct current stimulation (ctDCS) appears to modulate motor performance in both adaptation and motor skill tasks; however, whether the gains are long-lasting is unclear. Objectives: This systematic review aims to evaluate the effect of ctDCS with respect to different time scales of motor learning. Methods: Ten electronic databases (CINAHL, MEDLINE, SPORT Discus, Scopus, Web of Science, Cochrane via OVID, Evidence-Based Reviews (EBM) via OVID, AMED: Allied ... read more
    2 months ago
  • Paradoxical, causal effects of sensory gain modulation on motor inhibitory control – a tDCS, EEG-source localization study.
    Related ArticlesParadoxical, causal effects of sensory gain modulation on motor inhibitory control - a tDCS, EEG-source localization study. Sci Rep. 2018 11 30;8(1):17486 Authors: Friedrich J, Beste C Abstract Response inhibition is a key component of executive functioning, but the role of perceptual processes has only recently been focused. Although the interrelation of incoming information and resulting behavioural (motor) effects is well-known to depend on gain control mechanisms, the causal role of sensory gain modulation for response inhibition is elusive. We investigate it using a somatosensory response inhibition (Go/Nogo) task and examine the effects of parietal (somatosensory) cathodal ... read more
    2 months ago
  • Anhedonia across borders: Transdiagnostic relevance of reward dysfunction for noninvasive brain stimulation endophenotypes.
    Related ArticlesAnhedonia across borders: Transdiagnostic relevance of reward dysfunction for noninvasive brain stimulation endophenotypes. CNS Neurosci Ther. 2019 Oct 22;: Authors: Spano MC, Lorusso M, Pettorruso M, Zoratto F, Di Giuda D, Martinotti G, di Giannantonio M Abstract INTRODUCTION: Anhedonia is a transdiagnostic psychopathological dimension, consisting in the impaired ability to experience pleasure. In order to further our understanding of its neural correlates and to explore its potential relevance as a predictor of treatment response, in this article we systematically reviewed studies involving anhedonia and neuromodulation interventions, across different disorders. METHODS: We included seven studies fulfilling inclusion/exclusion criteria and involving ... read more
    2 months ago
  • Effects of transcranial direct current stimulation on patients with disorders of consciousness after traumatic brain injury: study protocol for a randomized, double-blind controlled trial.
    Related ArticlesEffects of transcranial direct current stimulation on patients with disorders of consciousness after traumatic brain injury: study protocol for a randomized, double-blind controlled trial. Trials. 2019 Oct 17;20(1):596 Authors: Li S, Dong X, Sun W, Zhao N, Yu G, Shuai L Abstract BACKGROUND: Disorders of consciousness (DOC) after traumatic brain injury (TBI) raise the mortality of patients, restrict the rehabilitation of patients with TBI, and increase the physical and economic burden that TBI imposes on patients and their families. Thus, treatment to promote early awakening in DOC after TBI is of vital importance. Various treatments have been reported, but ... read more
    2 months ago
  • Effects of Transcranial Direct Current Stimulation on Apraxia of Speech and Cortical Activation in Patients With Stroke: A Randomized Sham-Controlled Study.
    Related ArticlesEffects of Transcranial Direct Current Stimulation on Apraxia of Speech and Cortical Activation in Patients With Stroke: A Randomized Sham-Controlled Study. Am J Speech Lang Pathol. 2019 Oct 17;:1-13 Authors: Wang J, Wu D, Cheng Y, Song W, Yuan Y, Zhang X, Zhang D, Zhang T, Wang Z, Tang J, Yin L Abstract Purpose The study aims to investigate, using anodal transcranial direct current stimulation (A-tDCS), over which site, the left lip region of primary motor cortex (M1) or the Broca's area, there would be better recovery from apraxia of speech (AoS) in patients with poststroke aphasia and to ... read more
    2 months ago
  • Improving emotion regulation of social exclusion in depression-prone individuals: a tDCS study targeting right VLPFC.
    Related ArticlesImproving emotion regulation of social exclusion in depression-prone individuals: a tDCS study targeting right VLPFC. Psychol Med. 2019 Oct 16;:1-12 Authors: He Z, Liu Z, Zhao J, Elliott R, Zhang D Abstract BACKGROUND: Growing evidence has indicated that right ventrolateral prefrontal cortex (RVLPFC) is critical in down-regulating emotional responses to social exclusion, and that depression is accompanied by social emotional dysregulation associated with reduced lateral prefrontal engagement. This study used anodal transcranial direct current stimulation (tDCS) to examine whether stimulating RVLPFC could improve emotional down-regulation of social exclusion in individuals with high depressive mood (DM). METHODS: A total of ... read more
    2 months ago