Published Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with recent interest in the topic exploding over the last 10-15 years. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year. As of January 1, 2017 there are currently over 3,000 published tDCS studies on PubMed.gov, with nearly 700 (~23%) of them having been published in 2016 alone.

Below you will find a collection of the most recent scientific studies on tDCS. Each article includes data on where it was published, date published, contributing authors, as well as an abstract, or summary of the article.

 

  • Modulating regional motor cortical excitability with non-invasive brain stimulation results in neurochemical changes in bilateral motor cortices.
    Related ArticlesModulating regional motor cortical excitability with non-invasive brain stimulation results in neurochemical changes in bilateral motor cortices. J Neurosci. 2018 Jul 20;: Authors: Bachtiar V, Johnstone A, Berrington A, Lemke C, Johansen-Berg H, Emir U, Stagg C Abstract Learning a novel motor skill is dependent both on regional changes within the primary motor cortex (M1) contralateral to the active hand, and also on modulation between and within anatomically-distant but functionally-connected brain regions. Inter-regional changes are particularly important in functional recovery after stroke, where critical plastic changes underpinning behavioural improvements are observed in both ipsilesional and contralesional M1s. It ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
  • Effect of transcranial direct current stimulation associated with hypocaloric diet on weight loss and metabolic profile in overweight or obesity: study protocol for a double-blind, randomized controlled clinical trial.
    Related ArticlesEffect of transcranial direct current stimulation associated with hypocaloric diet on weight loss and metabolic profile in overweight or obesity: study protocol for a double-blind, randomized controlled clinical trial. Trials. 2018 Jul 16;19(1):386 Authors: Araujo C, Fitz RC, Nogara DA, Schestatsky P, Gerchman F Abstract BACKGROUND: Dietary interventions have limited success in promoting sustainable weight loss; new treatments allowing better compliance with hypocaloric diets should be developed. The aim of this trial is to describe the effects of a protocol combining repetitive active transcranial direct current stimulation (tDCS) with a hypocaloric diet on weight loss and food ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
  • Improved conceptual generation and selection with transcranial direct current stimulation in older adults.
    Related ArticlesImproved conceptual generation and selection with transcranial direct current stimulation in older adults. J Clin Exp Neuropsychol. 2018 Jul 17;:1-15 Authors: Madden DL, Sale MV, Robinson GA Abstract INTRODUCTION: Normal aging is associated with deficits in various aspects of spoken language production, including idea generation and selection, and involves activity in frontal brain areas including left inferior frontal cortex (LIFG). These conceptual preparation processes, largely involving executive control, precede formulation and articulation stages and are critical for language production. Noninvasive brain stimulation (e.g., transcranial direct current stimulation, tDCS) has proven beneficial for age-related fluency and naming deficits, but this ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
  • Multi-session anodal tDCS enhances the effects of postural training on balance and postural stability in older adults with high fall risk: Primary motor cortex versus cerebellar stimulation.
    Related ArticlesMulti-session anodal tDCS enhances the effects of postural training on balance and postural stability in older adults with high fall risk: Primary motor cortex versus cerebellar stimulation. Brain Stimul. 2018 Jul 14;: Authors: Yosephi MH, Ehsani F, Zoghi M, Jaberzadeh S Abstract BACKGROUND: Postural control impairment is a key target for rehabilitation of older adults with high fall risk. OBJECTIVE: To investigate whether anodal transcranial direct current stimulation (a-tDCS) over primary motor cortex (M1) or cerebellum can enhance the positive effects of postural training on balance and postural stability in older adults with high fall risk. METHOD: In ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
  • Compromised tDCS-induced facilitation of motor consolidation in patients with multiple sclerosis.
    Related ArticlesCompromised tDCS-induced facilitation of motor consolidation in patients with multiple sclerosis. J Neurol. 2018 Aug 06;: Authors: Rumpf JJ, Dietrich S, Stoppe M, Fricke C, Weise D, Then Bergh F, Classen J Abstract OBJECTIVE: To investigate whether consolidation after motor learning can be facilitated by offline (post-training) transcranial direct current stimulation (tDCS) in patients with multiple sclerosis (MS). METHODS: In this cross-sectional double-blind interventional study, effects of tDCS on motor consolidation were examined in 14 patients with relapsing remitting MS [median Expanded Disability Status Scale score 2.0 (range 1-4)] and 14 age- and sex-matched healthy controls. tDCS with ... read more
    Promising Scientific Studies on Transcranial Direct Current Stimulation
  • Effect of Modulating Activity of DLPFC and Gender on Search Behavior: A tDCS Experiment.
    Related ArticlesEffect of Modulating Activity of DLPFC and Gender on Search Behavior: A tDCS Experiment. Front Hum Neurosci. 2018;12:325 Authors: Yang X, Lin Y, Gao M, Jin X Abstract Studies of search behavior have shown that individuals stop searching earlier and accept a lower point than predicted by the optimal, risk-neutral stopping rule. This behavior may be related to individual risk preferences. Studies have also found correlativity between risk preferences and the dorsolateral prefrontal cortex (DLPFC). As risk attitude plays a crucial role in search behavior, we studied whether modulating the activity of DLPFC, by using a transcranial direct current ... read more
  • Effects of transcranial direct current stimulation for treating depression: A modeling study.
    Related ArticlesEffects of transcranial direct current stimulation for treating depression: A modeling study. J Affect Disord. 2018 07;234:164-173 Authors: Csifcsák G, Boayue NM, Puonti O, Thielscher A, Mittner M Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) above the left dorsolateral prefrontal cortex (lDLPFC) has been widely used to improve symptoms of major depressive disorder (MDD). However, the effects of different stimulation protocols in the entire frontal lobe have not been investigated in a large sample including patient data. METHODS: We used 38 head models created from structural magnetic resonance imaging data of 19 healthy adults and 19 MDD patients ... read more
  • Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation.
    Related ArticlesOptogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation. Nat Commun. 2017 10 30;8(1):1187 Authors: Wahl AS, Büchler U, Brändli A, Brattoli B, Musall S, Kasper H, Ineichen BV, Helmchen F, Ommer B, Schwab ME Abstract Current neuromodulatory strategies to enhance motor recovery after stroke often target large brain areas non-specifically and without sufficient understanding of their interaction with internal repair mechanisms. Here we developed a novel therapeutic approach by specifically activating corticospinal circuitry using optogenetics after large strokes in rats. Similar to a neuronal growth-promoting immunotherapy, optogenetic stimulation together with ... read more
  • Effectiveness of a single session of dual-transcranial direct current stimulation in combination with upper limb robotic-assisted rehabilitation in chronic stroke patients: a randomized, double-blind, cross-over study.
    Related ArticlesEffectiveness of a single session of dual-transcranial direct current stimulation in combination with upper limb robotic-assisted rehabilitation in chronic stroke patients: a randomized, double-blind, cross-over study. Int J Rehabil Res. 2018 Jun;41(2):138-145 Authors: Dehem S, Gilliaux M, Lejeune T, Delaunois E, Mbonda P, Vandermeeren Y, Detrembleur C, Stoquart G Abstract The impact of transcranial direct current stimulation (tDCS) is controversial in the neurorehabilitation literature. It has been suggested that tDCS should be combined with other therapy to improve their efficacy. To assess the effectiveness of a single session of upper limb robotic-assisted therapy (RAT) combined with real or ... read more
  • Transcranial direct current stimulation: a study on naming performance in aphasic individuals.
    Transcranial direct current stimulation: a study on naming performance in aphasic individuals. Codas. 2018 Aug 30;30(5):e20170242 Authors: Silva FRD, Mac-Kay APMG, Chao JC, Santos MDD, Gagliadi RJ Abstract PURPOSE: Compare the results in naming tasks of after-stroke aphasic individuals divided into active and placebo groups pre- and post-transcranial direct current stimulation. METHODS: A double-blind, randomized, controlled study conducted with 14 individuals. Patients underwent five 20-min sessions with stimulation of 2mA's on consecutive days. The cathode was placed over the Broca's homologous area and the anode was placed over the supraorbital region of the left hemisphere. Boston and Snodgrass naming tasks ... read more
  • Studying Implicit Social Cognition with Noninvasive Brain Stimulation.
    Related ArticlesStudying Implicit Social Cognition with Noninvasive Brain Stimulation. Trends Cogn Sci. 2018 Sep 01;: Authors: Marini M, Banaji MR, Pascual-Leone A Abstract Given that globalization has brought different sociocultural groups together on an unprecedented scale, understanding the neurobiology underlying intergroup social behavior has never been more urgent. Social and cognitive scientists are increasingly using noninvasive brain-stimulation techniques (NBS) to explore the neural mechanisms underlying implicit attitudes and stereotyping. NBS methods, such as transcranial magnetic stimulation (TMS) and transcranial direct-current stimulation (tDCS), can interfere with ongoing brain activity in targeted brain areas and distributed networks, and thus offer unique insights ... read more
  • Increases in Microvascular Perfusion and Tissue Oxygenation via Vasodilatation After Anodal Transcranial Direct Current Stimulation in the Healthy and Traumatized Mouse Brain.
    Related ArticlesIncreases in Microvascular Perfusion and Tissue Oxygenation via Vasodilatation After Anodal Transcranial Direct Current Stimulation in the Healthy and Traumatized Mouse Brain. Adv Exp Med Biol. 2018;1072:27-31 Authors: Bragina OA, Lara DA, Nemoto EM, Shuttleworth CW, Semyachkina-Glushkovskaya OV, Bragin DE Abstract Traumatic brain injury (TBI), causing neurological deficit in 70% of survivors, still lacks a clinically proven effective therapy. Transcranial direct current stimulation (tDCS) has emerged as a promising electroceutical therapeutic intervention possibly suitable for TBI; however, due to limited animal studies the mechanisms and optimal parameters are unknown. Using a mouse model of TBI we evaluated the acute ... read more
  • Pre-treatment attentional processing speed and antidepressant response to transcranial direct current stimulation: Results from an international randomized controlled trial.
    Pre-treatment attentional processing speed and antidepressant response to transcranial direct current stimulation: Results from an international randomized controlled trial. Brain Stimul. 2018 Aug 23;: Authors: Martin DM, McClintock SM, Aaronson ST, Alonzo A, Husain MM, Lisanby SH, McDonald WM, Mohan A, Nikolin S, O'Reardon J, Weickert CS, Loo CK Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) has promising antidepressant effects, however, clinical trials have shown variable efficacy. Pre-treatment neurocognitive functioning has previously been identified as an inter-individual predictor of tDCS antidepressant efficacy. OBJECTIVE: In this international multicentre, sham-controlled study, we investigated this relationship while also assessing the influence of clinical ... read more
  • Clinical pilot study of transcranial direct current stimulation combined with Cognitive Emotional Training for medication resistant depression.
    Related ArticlesClinical pilot study of transcranial direct current stimulation combined with Cognitive Emotional Training for medication resistant depression. J Affect Disord. 2018 05;232:89-95 Authors: Martin DM, Teng JZ, Lo TY, Alonzo A, Goh T, Iacoviello BM, Hoch MM, Loo CK Abstract BACKGROUND: While the clinical results from transcranial direct current stimulation (tDCS) for the treatment of depression have been promising, antidepressant effects in patients with medication resistance have been suboptimal. There is therefore a need to further optimise tDCS for medication resistant patients. In this clinical pilot study we examined the feasibility, safety, and clinical efficacy of combining tDCS ... read more
  • Low-intensity ultrasound neuromodulation: An overview of mechanisms and emerging human applications.
    Related ArticlesLow-intensity ultrasound neuromodulation: An overview of mechanisms and emerging human applications. Brain Stimul. 2018 Aug 23;: Authors: Fomenko A, Neudorfer C, Dallapiazza RF, Kalia SK, Lozano AM Abstract BACKGROUND: There is an emerging need for noninvasive neuromodulation techniques to improve patient outcomes while minimizing adverse events and morbidity. Low-intensity focused ultrasound (LIFUS) is gaining traction as a non-surgical experimental approach of modulating brain activity. Several LIFUS sonication parameters have been found to potentiate neural firing, suppress cortical and epileptic discharges, and alter behavior when delivered to cortical and subcortical mammalian brain regions. OBJECTIVE: This review introduces the elements of ... read more
  • Anodal tDCS over the primary motor cortex improves motor imagery benefits on postural control: A pilot study.
    Related ArticlesAnodal tDCS over the primary motor cortex improves motor imagery benefits on postural control: A pilot study. Sci Rep. 2017 03 28;7(1):480 Authors: Saruco E, Di Rienzo F, Nunez-Nagy S, Rubio-Gonzalez MA, Jackson PL, Collet C, Saimpont A, Guillot A Abstract Performing everyday actions requires fine postural control, which is a major focus of functional rehabilitation programs. Among the various range of training methods likely to improve balance and postural stability, motor imagery practice (MIP) yielded promising results. Transcranial direct current stimulation (tDCS) applied over the primary motor cortex was also found to potentiate the benefits of ... read more
  • Transcranial electrical stimulation for human enhancement and the risk of inequality: Prohibition or compensation?
    Transcranial electrical stimulation for human enhancement and the risk of inequality: Prohibition or compensation? Bioethics. 2018 Aug 29;: Authors: Lavazza A Abstract Non-invasive brain stimulation is used to modulate brain excitation and inhibition and to improve cognitive functioning. The effectiveness of the enhancement due to transcranial direct current stimulation (tDCS) is still controversial, but the technique seems to have large potential for improvement and more specific applications. In particular, it has recently been used by athletes, both beginners and professionals. This paper analyses the ethical issues related to tDCS enhancement, which depend on its specific features: ease of use, immediate effect, ... read more
  • 1H MR spectroscopy of the motor cortex immediately following transcranial direct current stimulation at 7 Tesla.
    1H MR spectroscopy of the motor cortex immediately following transcranial direct current stimulation at 7 Tesla. PLoS One. 2018;13(8):e0198053 Authors: Ryan K, Wawrzyn K, Gati JS, Chronik BA, Wong D, Duggal N, Bartha R Abstract Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation that may modulate cortical excitability, metabolite concentration, and human behaviour. The supplementary motor area (SMA) has been largely ignored as a potential target for tDCS neurorehabilitation but is an important region in motor compensation after brain injury with strong efferent connections to the primary motor cortex (M1). The objective of this work was ... read more
  • Noninvasive brain stimulation of the parietal lobe for improving neurologic, neuropsychologic, and neuropsychiatric deficits.
    Related ArticlesNoninvasive brain stimulation of the parietal lobe for improving neurologic, neuropsychologic, and neuropsychiatric deficits. Handb Clin Neurol. 2018;151:427-446 Authors: Bolognini N, Miniussi C Abstract Transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) are noninvasive brain stimulation (NIBS) tools that are now widely used in neuroscientific research in humans. The fact that both TMS and tES are able to modulate brain plasticity and, in turn, affect behavior is opening up new horizons in the treatment of brain circuit and plasticity disorders. In the present chapter, we will first provide the reader with a brief background on the basic ... read more
  • Feasibility of Computerized Cognitive-Behavioral Therapy Combined With Bifrontal Transcranial Direct Current Stimulation for Treatment of Major Depression.
    Feasibility of Computerized Cognitive-Behavioral Therapy Combined With Bifrontal Transcranial Direct Current Stimulation for Treatment of Major Depression. Neuromodulation. 2018 Aug 28;: Authors: Welch ES, Weigand A, Hooker JE, Philip NS, Tyrka AR, Press DZ, Carpenter LL Abstract BACKGROUND: Cognitive behavioral therapy (CBT) is effective in the treatment of major depressive disorder (MDD). Transcranial Direct Current Stimulation (tDCS) has demonstrated preliminary antidepressant effects and beneficial effects on cognitive function. OBJECTIVE: We investigated the feasibility and acceptability of using tDCS to enhance the effects of computer-based CBT for treatment of MDD. MATERIALS AND METHODS: In a randomized, double-blind, sham-controlled study, 14 patients ... read more
  • [Non-invasive brain stimulation techniques in psychiatric disorders: influential factors and combination of interventions].
    Related Articles[Non-invasive brain stimulation techniques in psychiatric disorders: influential factors and combination of interventions]. Tijdschr Psychiatr. 2017;59(10):594-599 Authors: Vanderhasselt M-, Dedoncker J, Arns M, Baeken C Abstract BACKGROUND: The causal influence of cortico-subcortical connectivity by means of brain stimulation seems to be an effective biological treatment in psychiatric patients. AIM: To review the working mechanisms and moderating factors of two non-invasive brain stimulation techniques (NIBS), namely repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). METHOD: We reviewed the current literature on the use of nibs in neuropsychiatric disorders. RESULTS: First of all, stimulation parameters (location of the ... read more
  • [Clinical effects of non-invasive neuromodulation techniques in substance use disorder: an overview].
    Related Articles[Clinical effects of non-invasive neuromodulation techniques in substance use disorder: an overview]. Tijdschr Psychiatr. 2017;59(10):643-649 Authors: Herremans SC, Baeken C Abstract BACKGROUND: Substance dependence is a chronic disorder that is difficult to treat. Non-invasive stimulation techniques may have beneficial effects on the course of the illness. AIM: To provide an overview of studies that evaluate the clinical effects that transcranial magnetic stimulation (tMS) and transcranial direct current stimulation (tDCS) have on patients with substance use disorders. METHOD: We performed an extensive search of the literature, using PubMed. RESULTS: Most studies showed that both tMS and tDCS have a beneficial ... read more
  • [Minimally invasive brain stimulation for unipolar depression].
    Related Articles[Minimally invasive brain stimulation for unipolar depression]. Tijdschr Psychiatr. 2017;59(10):600-604 Authors: van Eijndhoven P, Tendolkar I, van Eijndhoven P, Tendolkar I, Schutter DJLG Abstract BACKGROUND: Unipolar depression is one of the most prevalent psychiatric disorders and has a high impact at individual and societal level. Commonly used treatments such as antidepressants and psychotherapy are often not effective. AIM: To determine the efficacy of repetitive transcranial magnetic stimulation (rTMS) and direct current stimulation (tDCS) as minimally invasive forms of treatment for unipolar depression. METHOD: We searched the literature. RESULTS: rTMS is effective in treating unipolar depression and is comparable to ... read more
  • Optimizing Electrode Montages of Transcranial Direct Current Stimulation for Attentional Bias Modification in Early Abstinent Methamphetamine Users.
    Optimizing Electrode Montages of Transcranial Direct Current Stimulation for Attentional Bias Modification in Early Abstinent Methamphetamine Users. Front Pharmacol. 2018;9:907 Authors: Shahbabaie A, Hatami J, Farhoudian A, Ekhtiari H, Khatibi A, Nitsche MA Abstract Introduction: Chronic use of most psychoactive drugs may lead to substance dependence and drug addiction. Drug addiction is a chronically relapsing disorder, and current pharmacological and behavioral therapies are not fully efficient. Attentional bias (AB) is hypothesized to have a causal contribution to substance abuse, addiction development and, maintenance. Transcranial direct current stimulation (tDCS) has been of increasing interest in the past few years as a ... read more
  • Guide to Enhancing Swallowing Initiation: Insights from Findings in Healthy Subjects and Dysphagic Patients.
    Guide to Enhancing Swallowing Initiation: Insights from Findings in Healthy Subjects and Dysphagic Patients. Curr Phys Med Rehabil Rep. 2018;6(3):178-185 Authors: Yamamura K, Kurose M, Okamoto K Abstract Purpose of Review: Difficulty in initiating swallowing is one of the main symptoms of oropharyngeal dysphagia. Therefore, enhancing swallowing initiation is an important approach for the treatment of oropharyngeal dysphagia. This review aims to introduce recent approaches to enhancing swallowing and to discuss their therapeutic potential. Recent Findings: Both central interventions such as non-invasive brain stimulation and peripheral interventions such as electrical stimulation to peripheral tissues are conducted to enhance swallowing. Recent ... read more