Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • Effects of treadmill training on gait of elders with Parkinson’s disease: a literature review.
    Related ArticlesEffects of treadmill training on gait of elders with Parkinson's disease: a literature review. Einstein (Sao Paulo). 2020;18:eRW5233 Authors: Luna NMS, Brech GC, Canonica A, Ernandes RC, Bocalini DS, Greve JMD, Alonso AC Abstract Parkinson's disease is the second most common neurodegenerative disorder in old age. Aging process for elders with Parkinson's disease can induce gait disturbances with more functional disabilities than for elders without the disease. Treadmill training as a therapy has resulted in notable effects on the gait of patients with Parkinson's disease and may be a resource for geriatric neurological rehabilitation. This review aimed to study ... read more
    20 hours ago
  • Transcranial direct current stimulation of dorsolateral prefrontal cortex improves dual-task gait performance in patients with Parkinson’s disease: A double blind, sham-controlled study.
    Related ArticlesTranscranial direct current stimulation of dorsolateral prefrontal cortex improves dual-task gait performance in patients with Parkinson's disease: A double blind, sham-controlled study. Gait Posture. 2020 Nov 16;84:11-16 Authors: Mishra RK, Thrasher AT Abstract BACKGROUND: Despite advances in pharmacological treatments and surgical processes, the problem of impaired dual-tasking persists in people with Parkinson's disease (PD). Recently, transcranial direct current stimulation (tDCS) applied to the dorsolateral prefrontal cortex (DLPFC) has shown the potential to improve dual-task walking. RESEARCH QUESTION: Can combining left DLPFC stimulation using tDCS with dual-task performance reduce the cost of dual-tasking in individuals with PD? METHODS: We conducted ... read more
    2 days ago
  • Women report more severe sensations from 2 mA and 4 mA transcranial direct current stimulation than men.
    Related ArticlesWomen report more severe sensations from 2 mA and 4 mA transcranial direct current stimulation than men. Eur J Neurosci. 2020 Dec 01;: Authors: Workman CD, Fietsam AC, Kamholz J, Rudroff T Abstract Interest in transcranial direct current stimulation (tDCS) to alter cortical excitability, facilitate neural plasticity, and improve performance is increasing. Subjects often report temporary stimulation-related sensations, which might distract from the task being performed or compromise blinding. tDCS is also prone to high outcome irregularity and one potential variability source is the biological sex of the subject. The purpose of this study was to re-analyze existing tolerability ... read more
    2 days ago
  • Systematic Review of the Impact of Transcranial Direct Current Stimulation on the Neuromechanical Management of Foot and Ankle Physical Performance in Healthy Adults.
    Related ArticlesSystematic Review of the Impact of Transcranial Direct Current Stimulation on the Neuromechanical Management of Foot and Ankle Physical Performance in Healthy Adults. Front Bioeng Biotechnol. 2020;8:587680 Authors: Xiao S, Wang B, Zhang X, Zhou J, Fu W Abstract Objective: This study aims to review existing literature regarding the effects of transcranial direct current stimulation (tDCS) on the physical performances of the foot and ankle of healthy adults and discuss the underlying neurophysiological mechanism through which cortical activities influence the neuromechanical management of the physical performances of the foot and ankle. Methods: This systematic review has followed the recommendations ... read more
    3 days ago
  • The Posterior Parietal Cortex Is Involved in Gait Adaptation: A Bilateral Transcranial Direct Current Stimulation Study.
    Related ArticlesThe Posterior Parietal Cortex Is Involved in Gait Adaptation: A Bilateral Transcranial Direct Current Stimulation Study. Front Hum Neurosci. 2020;14:581026 Authors: Young DR, Parikh PJ, Layne CS Abstract Gait is one of the fundamental behaviors we use to interact with the world. The functionality of the locomotor system is thus related to enriching interactions with our environment. The posterior parietal cortex (PPC) has been found to contribute to motor adaptation during both visuomotor and postural adaptation tasks. Additionally, structural or functional deficits of the PPC lead to impairments in gaits such as shortened steps and increased step width. Based ... read more
    3 days ago
  • Multi-session electrical neuromodulation effects on craving, relapse and cognitive functions in cocaine use disorder: A randomized, sham-controlled tDCS study.
    Related ArticlesMulti-session electrical neuromodulation effects on craving, relapse and cognitive functions in cocaine use disorder: A randomized, sham-controlled tDCS study. Drug Alcohol Depend. 2020 Nov 23;:108429 Authors: Verveer I, van der Veen FM, Shahbabaie A, Remmerswaal D, Franken IHA Abstract BACKGROUND: The use of transcranial Direct Current Stimulation (tDCS) has previously shown promising results for reducing craving in cocaine use disorder. In this study we further explored the potential of tDCS as add-on intervention in the treatment of cocaine use disorder. METHODS: In a randomized, placebo-controlled, between subject study, we applied tDCS bilaterally with the anodal electrode targeting the right ... read more
    3 days ago
  • Anodal transcranial direct current stimulation over the posterior parietal cortex enhances three-dimensional mental rotation ability.
    Related ArticlesAnodal transcranial direct current stimulation over the posterior parietal cortex enhances three-dimensional mental rotation ability. Neurosci Res. 2020 Nov 26;: Authors: Zhu R, Wang Z, You X Abstract Prior neuroimaging and neurophysiological studies have found that the right posterior parietal cortex (PPC) plays an important role in mental rotation ability. Transcranial direct-current stimulation (tDCS) has been shown the potential to enhance cognitive ability by delivering a low current to the brain cortex of interest, via electrodes on the scalp. Here, we tested whether stimulating the PPC with tDCS can improve three-dimensional mental rotation performance and narrow gender difference. The ... read more
    4 days ago
  • Additive Analgesic Effect of Transcranial Direct Current Stimulation Together with Mirror Therapy for the Treatment of Phantom Pain.
    Related ArticlesAdditive Analgesic Effect of Transcranial Direct Current Stimulation Together with Mirror Therapy for the Treatment of Phantom Pain. Pain Med. 2020 Nov 29;: Authors: Segal N, Pud D, Amir H, Ratmansky M, Kuperman P, Honigman L, Treister R Abstract OBJECTIVE: Current analgesic treatments for phantom pain are not optimal. One well-accepted yet limited nonpharmacological option is mirror therapy, which is thought to counterbalance abnormal plasticity. Transcranial direct current stimulation (tDCS) is an emerging approach believed to affect the membrane potential and activity threshold of cortical neurons. tDCS analgesic effectiveness, however, is mild and short, rendering it a noneffective stand-alone ... read more
    4 days ago
  • Cerebellar neuromodulation improves naming in post-stroke aphasia.
    Related ArticlesCerebellar neuromodulation improves naming in post-stroke aphasia. Brain Commun. 2020;2(2):fcaa179 Authors: Sebastian R, Kim JH, Brenowitz R, Tippett DC, Desmond JE, Celnik PA, Hillis AE Abstract Transcranial direct current stimulation has been shown to increase the efficiency of language therapy in chronic aphasia; however, to date, an optimal stimulation site has not been identified. We investigated whether neuromodulation of the right cerebellum can improve naming skills in chronic aphasia. Using a randomized, double-blind, sham-controlled, within-subject crossover study design, participants received anodal cerebellar stimulation (n = 12) or cathodal cerebellar stimulation (n = 12) + computerized aphasia therapy then sham + computerized aphasia therapy, ... read more
    7 days ago
  • tRNS effects on visual contrast detection.
    Related ArticlestRNS effects on visual contrast detection. Neurosci Lett. 2020 01 19;717:134696 Authors: Battaglini L, Contemori G, Penzo S, Maniglia M Abstract In recent years, transcranial electrical stimulation (tES) has been used to improve cognitive and perceptual abilities and to boost learning. In the visual domain, transcranial random noise stimulation (tRNS), a type of tES in which electric current is randomly alternating in between two electrodes at high frequency, has shown potential in inducing long lasting perceptual improvements when coupled with tasks such as contrast detection. However, its cortical mechanisms and online effects have not been fully understood yet, ... read more
    1 week ago
  • COMBINED TRANSCRANIAL DIRECT CURRENT STIMULATION AND PSYCHOLOGICAL INTERVENTIONS: STATE OF THE ART AND PROMISING PERSPECTIVES FOR CLINICAL PSYCHOLOGY.
    Related ArticlesCOMBINED TRANSCRANIAL DIRECT CURRENT STIMULATION AND PSYCHOLOGICAL INTERVENTIONS: STATE OF THE ART AND PROMISING PERSPECTIVES FOR CLINICAL PSYCHOLOGY. Biol Psychol. 2020 Nov 21;:107991 Authors: Dedoncker J, Baeken C, De Raedt R, Vanderhasselt MA Abstract Recent literature shows great heterogeneity in the reported efficacy of transcranial direct current stimulation (tDCS) as a stand-alone psychiatric treatment. Aiming to increase its efficacy, tDCS has been combined with psychological interventions. Our state-of-the-art overview of such combined treatment trials indicates, however, that these usually do not elicit synergistic clinical effects. We therefore explored more basic mechanisms related to the brain state-dependency of tDCS. Importantly, ... read more
    1 week ago
  • Clinicians’ views on neuromodulation as a treatment for eating disorders: A qualitative study.
    Related ArticlesClinicians' views on neuromodulation as a treatment for eating disorders: A qualitative study. Neuropsychiatr. 2020 Nov 24;: Authors: Dalton B, Dornik J, McClelland J, Bartholdy S, Kekic M, Campbell IC, Schmidt U Abstract BACKGROUND: Neuromodulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS) and deep brain stimulation (DBS), are emerging as promising treatment options in eating disorders (EDs). To date, the views of ED clinicians regarding these interventions have not been explored. METHODS: Eighteen clinicians were recruited from a specialist ED Service in London, UK. Following a short educational presentation on rTMS, tDCS and DBS, they completed a semi-structured ... read more
    1 week ago
  • Prediction of Recovery and Outcome Using Motor Evoked Potentials and Brain Derived Neurotrophic Factor in Subacute Stroke.
    Related ArticlesPrediction of Recovery and Outcome Using Motor Evoked Potentials and Brain Derived Neurotrophic Factor in Subacute Stroke. J Stroke Cerebrovasc Dis. 2020 Nov;29(11):105202 Authors: Bembenek JP, Kurczych K, Kłysz B, Cudna A, Antczak J, Członkowska A Abstract INTRODUCTION AND OBJECTIVES: Motor evoked potentials (MEPs) have been postulated to be useful in predicting recovery in patients with motor impairment. We aimed to investigate whether MEPs elicited by transcranial magnetic stimulation (TMS), serum brain derived neurotrophic factor (BDNF) and its genotype have prognostic value on stroke recovery in patients with hand paresis due to stroke. METHODS: This was an observational ... read more
    1 week ago
  • Target specific effects of direct current stimulation in schizo-obsessive disorder: A case report.
    Related ArticlesTarget specific effects of direct current stimulation in schizo-obsessive disorder: A case report. Brain Stimul. 2020 May - Jun;13(3):858-860 Authors: Thimmashetty VH, Parlikar R, Selvaraj S, Sreeraj VS, Shivakumar V, Narayanaswamy JC, Venkatasubramanian G Abstract Transcranial direct current stimulation (tDCS) is a type of non-invasive brain stimulation technique that is explored as an add-on treatment for the alleviation of symptoms across the diverse symptom domains in neuropsychiatric disorders. In psychiatry, data is emerging on the effects of tDCS as an add-on treatment in schizophrenia as well as obsessive-compulsive disorder (OCD). But despite high prevalence, the effectiveness of ... read more
    1 week ago
  • Consequences Of Prefrontal TDCS On Inhibitory Control And Reactive Aggression.
    Related ArticlesConsequences Of Prefrontal TDCS On Inhibitory Control And Reactive Aggression. Soc Cogn Affect Neurosci. 2020 Nov 23;: Authors: Weidler C, Habel U, Wallheinke P, Wagels L, Hofhansel L, Ling S, Blendy JA, Clemens B Abstract Increased aggression and impulsivity represent a key component of several psychiatric disorders, including substance use disorder, which is often associated with deficient prefrontal brain activation. Thus, innovative tools to increase cognitive control are highly warranted. The current study investigates the potential of transcranial direct current stimulation (tDCS), a tool to modulate cortical activation, to increase cognitive control in individuals with a high potential for ... read more
    1 week ago
  • Efficacy and neurophysiological predictors of treatment response of adjunct bifrontal transcranial direct current stimulation (tDCS) in treating unipolar and bipolar depression.
    Related ArticlesEfficacy and neurophysiological predictors of treatment response of adjunct bifrontal transcranial direct current stimulation (tDCS) in treating unipolar and bipolar depression. J Affect Disord. 2020 Nov 11;280(Pt A):295-304 Authors: Lin YY, Chang CC, Huang CC, Tzeng NS, Kao YC, Chang HA Abstract BACKGROUND: Although add-on transcranial direct current stimulation (tDCS) is a promising intervention for treating unipolar (UD) and bipolar depression (BD), its moderate antidepressant efficacy urges research into biomarkers for predicting therapeutic response and achieving highly targeted applications. METHODS: This open-label trial enrolled UD (N=58) and BD (N=22) patients who had failed 1 or more trials of adequate ... read more
    2 weeks ago
  • tDCS and motor training in individuals with central nervous system disease: A systematic review.
    Related ArticlestDCS and motor training in individuals with central nervous system disease: A systematic review. J Bodyw Mov Ther. 2020 Oct;24(4):442-451 Authors: Santos LV, Lopes JBP, Duarte NAC, Castro CRAP, Grecco LAC, Oliveira CS Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) is a promising tool for patients with neurological disorders, as it increases cortical excitability, motor learning and functionality. The studies up to date have focused on the tDCS parameters while the effects of the motor training have not yet been fully addressed. The purpose of this study is to present a systematic review of all studies related to tDCS ... read more
    2 weeks ago
  • Reliability, sensitivity, and predictive value of fMRI during multiple object tracking as a marker of cognitive training gain in combination with tDCS in stroke survivors.
    Related ArticlesReliability, sensitivity, and predictive value of fMRI during multiple object tracking as a marker of cognitive training gain in combination with tDCS in stroke survivors. Hum Brain Mapp. 2020 Nov 20;: Authors: Kolskår KK, Richard G, Alnaes D, Dørum ES, Sanders AM, Ulrichsen KM, Sánchez JM, Ihle-Hansen H, Nordvik JE, Westlye LT Abstract Computerized cognitive training (CCT) combined with transcranial direct current stimulation (tDCS) has showed some promise in alleviating cognitive impairments in patients with brain disorders, but the robustness and possible mechanisms are unclear. In this prospective double-blind randomized clinical trial, we investigated the feasibility and effectiveness of ... read more
    2 weeks ago
  • Transcranial direct current stimulation (tDCS) over the auditory cortex modulates GABA and glutamate: a 7 T MR-spectroscopy study.
    Related ArticlesTranscranial direct current stimulation (tDCS) over the auditory cortex modulates GABA and glutamate: a 7 T MR-spectroscopy study. Sci Rep. 2020 Nov 18;10(1):20111 Authors: Heimrath K, Brechmann A, Blobel-Lüer R, Stadler J, Budinger E, Zaehle T Abstract Transcranial direct current stimulation (tDCS) is one of the most prominent non-invasive electrical brain stimulation method to alter neuronal activity as well as behavioral processes in cognitive and perceptual domains. However, the exact mode of action of tDCS-related cortical alterations is still unclear as the results of tDCS studies often do not comply with the somatic doctrine assuming that anodal tDCS enhances while ... read more
    2 weeks ago
  • HD-tDCS as a neurorehabilitation technique for a case of post-anoxic leukoencephalopathy.
    Related ArticlesHD-tDCS as a neurorehabilitation technique for a case of post-anoxic leukoencephalopathy. Neuropsychol Rehabil. 2020 Nov 18;:1-21 Authors: Garcia S, Hampstead BM Abstract Post-anoxic leukoencephalopathy is a rare event that causes global demyelination secondary to anoxic injury. Given the nature and extent of the damage, cognitive and functional deficits are typically chronic even after standard therapies. Here, we describe a novel treatment approach that used high definition transcranial direct-current stimulation (HD-tDCS) with a 62-year-old male who was 5 years post-anoxic leukoencephalopathy secondary to an accidental drug overdose. HD-tDCS was administered over the left lateral prefrontal cortex across 29 daily sessions ... read more
    2 weeks ago
  • TcMEP threshold change is superior to A-train detection when predicting facial nerve outcome in CPA tumour surgery.
    Related ArticlesTcMEP threshold change is superior to A-train detection when predicting facial nerve outcome in CPA tumour surgery. Acta Neurochir (Wien). 2020 05;162(5):1197-1203 Authors: Hendriks T, Kunst HPM, Huppelschoten M, Doorduin J, Ter Laan M Abstract OBJECT: Surgery of tumours in the cerebellopontine angle (CPA) can lead to loss of facial nerve function. Different methods of intra-operative nerve monitoring (IOM) (including free-running EMG, direct nerve stimulation and transcranial motor evoked potentials (TcMEP)) have been used to predict facial nerve outcome during surgery. Recent research has shown TcMEP threshold increase and the occurrence of A-trains on the EMG to ... read more
    2 weeks ago
  • Effect of Transcranial Alternating Current Stimulation for the Treatment of Chronic Insomnia: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Clinical Trial.
    Related ArticlesEffect of Transcranial Alternating Current Stimulation for the Treatment of Chronic Insomnia: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Clinical Trial. Psychother Psychosom. 2020;89(1):38-47 Authors: Wang HX, Wang L, Zhang WR, Xue Q, Peng M, Sun ZC, Li LP, Wang K, Yang XT, Jia Y, Zhou QL, Xu ZX, Li N, Dong K, Zhang Q, Song HQ, Zhan SQ, Min BQ, Fan CQ, Zhou AH, Guo XH, Li HB, Liang LR, Yin L, Si TM, Huang J, Yan TY, Cosci F, Kamiya A, Lu J, Wang YP Abstract BACKGROUND: Not all adults with chronic insomnia respond to the recommended therapeutic ... read more
    2 weeks ago
  • Transforming treatments for schizophrenia: Virtual reality, brain stimulation and social cognition.
    Related ArticlesTransforming treatments for schizophrenia: Virtual reality, brain stimulation and social cognition. Psychiatry Res. 2020 06;288:112974 Authors: Gainsford K, Fitzgibbon B, Fitzgerald PB, Hoy KE Abstract Schizophrenia is characterised by delusions, hallucinations, anhedonia and apathy; while impairments in social cognition are often less recognised. Poor social cognition can lead to difficulties in obtaining and maintaining employment, academic progression, interpersonal relationships, and community functioning. Current interventions are highly intensive, require significant resources and have only modest effects on functional outcomes. Virtual reality (VR) and non-invasive brain stimulation (NIBS) may have a role in addressing these limitations. VR allows treatments that ... read more
    2 weeks ago
  • Combined effects of tDCS over the left DLPFC and gaze-contingent training on attention mechanisms of emotion regulation in low-resilient individuals.
    Related ArticlesCombined effects of tDCS over the left DLPFC and gaze-contingent training on attention mechanisms of emotion regulation in low-resilient individuals. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Nov 12;:110177 Authors: Sanchez-Lopez A, De Raedt R, Puttevils L, Koster EHW, Baeken C, Vanderhasselt MA Abstract Low resilience is characterized by impairments in attention and emotion regulation mechanisms that depend on prefrontal cortical activity. The aim of this study was to test whether transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) can augment the effectiveness of a new computerized mouse-based (gaze)contingent training (MCAT) to improve attention and emotion regulation ... read more
    2 weeks ago
  • High definition transcranial direct current stimulation modulates abnormal neurophysiological activity in post-stroke aphasia.
    Related ArticlesHigh definition transcranial direct current stimulation modulates abnormal neurophysiological activity in post-stroke aphasia. Sci Rep. 2020 Nov 12;10(1):19625 Authors: Shah-Basak PP, Sivaratnam G, Teti S, Francois-Nienaber A, Yossofzai M, Armstrong S, Nayar S, Jokel R, Meltzer J Abstract Recent findings indicate that measures derived from resting-state magnetoencephalography (rsMEG) are sensitive to cortical dysfunction in post-stroke aphasia. Spectral power and multiscale entropy (MSE) measures show that left-hemispheric areas surrounding the stroke lesion (perilesional) exhibit pathological oscillatory slowing and alterations in signal complexity. In the current study, we tested whether individually-targeted high-definition transcranial direct current stimulation (HD-tDCS) can reduce MEG abnormalities ... read more
    2 weeks ago