Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • [The effect of transcranial direct current stimulation on dysfunction of bilateral posterior cingulate cortex after sleep deprivation: a preliminary study].
    Related Articles[The effect of transcranial direct current stimulation on dysfunction of bilateral posterior cingulate cortex after sleep deprivation: a preliminary study]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020 Mar;36(2):101-105 Authors: Meng QQ, Li JY, Guo DL, Shao YC, Zhang X Abstract Objective: To investigate the effects of transcranial direct current stimulation (tDCS) on the disturbance of brain network dysfunction after sleep deprivation (SD). Methods: The experimental design of self-control was used in the study. All 16 subjects received 2 times of 24 h SD with an interval of 3 weeks. After the first normal sleep, 24 h SD ... read more
    2 hours ago
  • Probing the architecture of visual number sense with parietal tRNS.
    Related ArticlesProbing the architecture of visual number sense with parietal tRNS. Cortex. 2019 05;114:54-66 Authors: Karolis VR, Grinyaev M, Epure A, Tsoy V, Du Rietz E, Banissy MJ, Cappelletti M, Kovas Y Abstract Theoretical accounts of the visual number sense (VNS), i.e., an ability to discriminate approximate numerosities, remain controversial. A proposal that the VNS represents a process of numerosity extraction, leading to an abstract number representation in the brain, has been challenged by the view that the VNS is non-numerical in its essence and amounts to a weighted integration of continuous magnitude features that typically change with numerosity. ... read more
    2 hours ago
  • Pulsed transcranial electric brain stimulation enhances speech comprehension.
    Pulsed transcranial electric brain stimulation enhances speech comprehension. Brain Stimul. 2020 Jul 28;: Authors: Ruhnau P, Rufener KS, Heinze HJ, Zaehle T Abstract BACKGROUND: One key mechanism thought to underlie speech processing is the alignment of cortical brain rhythms to the acoustic input, a mechanism termed entrainment. Recent work showed that transcranial electrical stimulation (tES) in speech relevant frequencies or adapted to the speech envelope can in fact enhance speech processing. However, it is unclear whether an oscillatory tES is necessary, or if transients in the stimulation (e.g., peaks in the tES signal) at relevant times are sufficient. OBJECTIVE: In ... read more
    3 days ago
  • Cathodal Cerebellar tDCS Combined with Visual Feedback Improves Balance Control.
    Related ArticlesCathodal Cerebellar tDCS Combined with Visual Feedback Improves Balance Control. Cerebellum. 2020 Jul 30;: Authors: Emadi Andani M, Villa-Sánchez B, Raneri F, Dametto S, Tinazzi M, Fiorio M Abstract Balance control is essential to maintain a stable body position and to prevent falls. The aim of this study was to determine whether balance control could be improved by using cerebellar transcranial direct current stimulation (tDCS) and visual feedback in a combined approach. A total of 90 healthy volunteers were randomly assigned to six groups defined by the delivery of tDCS (cathodal or anodal or sham) and the provision or ... read more
    3 days ago
  • An integrative clustering approach to tDCS individual response variability in cognitive performance: beyond a null effect on working memory.
    An integrative clustering approach to tDCS individual response variability in cognitive performance: beyond a null effect on working memory. Neuroscience. 2020 Jul 28;: Authors: Antonio LC, Rocío RF, Noa F, Eliseo IS, Miguel FD Abstract Despite the growing interest in the use of transcranial direct current stimulation (tDCS) for the modulation of human cognitive function, there are contradictory findings regarding the cognitive benefits of this technique. Inter-individual response variability to tDCS may play a significant role. We explored the effects of anodal versus sham tDCS over the left prefrontal cortex (LPFC) on working memory performance, taking into account the inter-individual ... read more
    4 days ago
  • The Downsides of Cognitive Enhancement.
    Related ArticlesThe Downsides of Cognitive Enhancement. Neuroscientist. 2020 Jul 30;:1073858420945971 Authors: Colzato LS, Hommel B, Beste C Abstract Cognitive enhancement is becoming progressively popular as a subject of scientific investigation and by the public, although possible adverse effects are not sufficiently understood. We call for cognitive enhancement to build on more specific, mechanistic theories given that a-theoretical approaches to cognitive enhancement are both a cause and a consequence of a strong, if not exclusive focus on the benefits of procedures suited to enhance human cognition. We focus on downsides of cognitive enhancement and suggest that every attempt to enhance human ... read more
    4 days ago
  • What Do We Know about Transcranial Direct Current Stimulation for Major Depression?
    Related ArticlesWhat Do We Know about Transcranial Direct Current Stimulation for Major Depression? Brain Sci. 2020 Jul 25;10(8): Authors: Buchanan DM, Robaey P, D'Angiulli A Abstract The interest in using non-invasive brain stimulation (NIBS) for the treatment of major depression (MD), including treatment resistant depression, is growing rapidly. The paper by Bennabi and Haffen (Brain Sci. 2018, 8) was an important step towards the formal acceptance of transcranial direct current stimulation (tDCS) as a possible form of therapy. Their review demonstrated favourable support for the beneficial effects of tDCS for MD, coupled with necessary practical considerations, such as its relatively ... read more
    5 days ago
  • Stimulating the sleeping brain: Current approaches to modulating memory-related sleep physiology.
    Related ArticlesStimulating the sleeping brain: Current approaches to modulating memory-related sleep physiology. J Neurosci Methods. 2019 03 15;316:125-136 Authors: Cellini N, Mednick SC Abstract BACKGROUND: One of the most audacious proposals throughout the history of psychology was the potential ability to learn while we sleep. The idea penetrated culture via sci-fi movies and inspired the invention of devices that claimed to teach foreign languages, facts, and even quit smoking by simply listening to audiocassettes or other devices during sleep. However, the promises from this endeavor didn't stand up to experimental scrutiny, and the dream was shunned from the scientific ... read more
    6 days ago
  • Evidence-based guidelines and secondary meta-analysis for the use of transcranial direct current stimulation (tDCS) in neurological and psychiatric disorders.
    Related ArticlesEvidence-based guidelines and secondary meta-analysis for the use of transcranial direct current stimulation (tDCS) in neurological and psychiatric disorders. Int J Neuropsychopharmacol. 2020 Jul 26;: Authors: Fregni F, El-Hagrassy MM, Pacheco-Barrios K, Carvalho S, Leite J, Simis M, Brunelin J, Nakamura-Palacios EM, Marangolo P, Venkatasubramanian G, San-Juan D, Caumo W, Bikson M, Brunoni AR, Neuromodulation Center Working Group Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) has shown promising clinical results, leading to increased demand for an evidence-based review on its clinical effects. OBJECTIVE: We convened a team of tDCS experts to conduct a systematic review of clinical trials with ... read more
    1 week ago
  • High-Frequency Repetitive Transcranial Magnetic Stimulation Could Improve Impaired Working Memory Induced by Sleep Deprivation.
    Related ArticlesHigh-Frequency Repetitive Transcranial Magnetic Stimulation Could Improve Impaired Working Memory Induced by Sleep Deprivation. Neural Plast. 2019;2019:7030286 Authors: Guo Z, Jiang Z, Jiang B, McClure MA, Mu Q Abstract Objective: To investigate whether and how the working memory impairment induced by sleep deprivation (SD) could be recovered by using repetitive transcranial magnetic stimulation (rTMS), as well as to clarify the corresponding brain activity changes. Methods: Seventeen healthy adults received one session of 5.0 Hz rTMS over the left dorsolateral prefrontal cortex (DLPFC) following 24 hours of SD. Resting state functional magnetic resonance imaging (fMRI) and working memory test ... read more
    1 week ago
  • Application of tRNS to improve multiple sclerosis fatigue: a pilot, single-blind, sham-controlled study.
    Related ArticlesApplication of tRNS to improve multiple sclerosis fatigue: a pilot, single-blind, sham-controlled study. J Neural Transm (Vienna). 2019 06;126(6):795-799 Authors: Salemi G, Vazzoler G, Ragonese P, Bianchi A, Cosentino G, Croce G, Gangitano M, Portera E, Realmuto S, Fierro B, Brighina F Abstract We evaluated the effects of transcranial random noise stimulation (tRNS) on fatigue in 17 subjects with relapsing-remitting multiple sclerosis with low physical disability. Two different patient groups underwent real or sham stimulation for 10 days, targeting the primary motor cortex of the dominant side or contralateral to the most compromised limb. In the 'real group', beneficial ... read more
    1 week ago
  • Neuromodulation of Gamma-Range Auditory Steady-State Responses: A Scoping Review of Brain Stimulation Studies.
    Related ArticlesNeuromodulation of Gamma-Range Auditory Steady-State Responses: A Scoping Review of Brain Stimulation Studies. Front Syst Neurosci. 2020;14:41 Authors: Griskova-Bulanova I, Sveistyte K, Bjekic J Abstract Neural oscillations represent a fundamental mechanism that enables coordinated action during normal brain functioning. Auditory steady-state responses (ASSRs) are used to test the ability to generate gamma-range activity. Different non-invasive brain stimulation (NIBS) techniques have the potential to modulate neural activation patterns that are aberrant in a variety of neuropsychiatric disorders. Here, we summarize the current state of knowledge on how different methods of NIBS (transcranial altering current stimulation-tACS, transcranial direct current stimulation-tDCS, transcranial ... read more
    1 week ago
  • Electrophysiological Effects of Transcranial Direct Current Stimulation on Neural Activity in the Rat Motor Cortex.
    Related ArticlesElectrophysiological Effects of Transcranial Direct Current Stimulation on Neural Activity in the Rat Motor Cortex. Front Neurosci. 2020;14:495 Authors: Tanaka T, Isomura Y, Kobayashi K, Hanakawa T, Tanaka S, Honda M Abstract Transcranial direct current stimulation (tDCS) is a non-invasive technique that modulates the neuronal membrane potential. We have previously documented a sustainable increase in extracellular dopamine levels in the rat striatum of cathodal tDCS, suggesting that cathodal tDCS enhances the neuronal excitability of the cortex. In the present study, we investigated changes in neuronal activity in the cerebral cortex induced by tDCS at the point beneath the stimulus ... read more
    1 week ago
  • Reply to: “Anodal transcranial direct current stimulation and intermittent theta burst stimulation improve deglutition and swallowing reproducibility in elderly patients with dysphagia: A methodological issue to avoid misinterpretation”.
    Related ArticlesReply to: "Anodal transcranial direct current stimulation and intermittent theta burst stimulation improve deglutition and swallowing reproducibility in elderly patients with dysphagia: A methodological issue to avoid misinterpretation". Neurogastroenterol Motil. 2020 Aug;32(8):e13933 Authors: Cosentino G, Todisco M, Alfonsi E PMID: 32697019 [PubMed - in process] ... read more
    2 weeks ago
  • Effects of add-on transcranial direct current stimulation on pain in Korean patients with fibromyalgia.
    Related ArticlesEffects of add-on transcranial direct current stimulation on pain in Korean patients with fibromyalgia. Sci Rep. 2020 Jul 21;10(1):12114 Authors: Kang JH, Choi SE, Park DJ, Xu H, Lee JK, Lee SS Abstract Despite promising preliminary results of transcranial direct current stimulation (tDCS) treatment in patients with fibromyalgia (FM), several issues need to be addressed, including its limited efficacy, low response rate, and poor tolerability. We investigated the efficacy and safety of tDCS as an add-on treatment for chronic pain in Korean patients with FM. This study enrolled 46 patients who were refractory to pain medications from May 2016 ... read more
    2 weeks ago
  • Structural controllability predicts functional patterns and brain stimulation benefits associated with working memory.
    Related ArticlesStructural controllability predicts functional patterns and brain stimulation benefits associated with working memory. J Neurosci. 2020 Jul 20;: Authors: Beynel L, Deng L, Crowell CA, Dannhauer M, Palmer H, Hilbig S, Peterchev AV, Luber B, Lisanby SH, Cabeza R, Appelbaum LG, Davis SW Abstract The brain is an inherently dynamic system, and much work has focused on the ability to modify neural activity through both local perturbations and changes in the function of global network ensembles. Network controllability is a recent concept in network neuroscience that purports to predict the influence of individual cortical sites on global network states ... read more
    2 weeks ago
  • Cognitive control training and transcranial direct current stimulation: a systematic approach to optimisation.
    Cognitive control training and transcranial direct current stimulation: a systematic approach to optimisation. Brain Stimul. 2020 Jul 17;: Authors: Weller S, Nitsche MA, Plewnia C Abstract BACKGROUND: Cognitive control (CC) is an important prerequisite for goal-directed behaviour and efficient information processing. Impaired CC is associated with reduced prefrontal cortex activity and various mental disorders, but may be effectively tackled by transcranial direct current stimulation (tDCS)-enhanced training. However, study data are inconsistent as efficacy depends on stimulation parameters whose implementations vary widely between studies. OBJECTIVE: We systematically tested various tDCS parameter effects (anodal/cathodal polarity, 1/2 mA stimulation intensity, left/right prefrontal cortex ... read more
    2 weeks ago
  • Failure of tDCS to modulate motor excitability and speech motor learning.
    Failure of tDCS to modulate motor excitability and speech motor learning. Neuropsychologia. 2020 Jul 17;:107568 Authors: Wiltshire CEE, Watkins KE Abstract Transcranial direct current stimulation (tDCS) modulates cortical excitability in a polarity-specific way and, when used in combination with a behavioural task, it can alter performance. TDCS has the potential, therefore, for use as an adjunct to therapies designed to treat disorders affecting speech, including, but not limited to acquired aphasias and developmental stuttering. For this reason, it is important to conduct studies evaluating its effectiveness and the parameters optimal for stimulation. Here, we aimed to evaluate the effects of ... read more
    2 weeks ago
  • Impact of network-targeted multichannel transcranial direct current stimulation on intrinsic and network-to-network functional connectivity.
    Related ArticlesImpact of network-targeted multichannel transcranial direct current stimulation on intrinsic and network-to-network functional connectivity. J Neurosci Res. 2020 Jul 20;: Authors: Mencarelli L, Menardi A, Neri F, Monti L, Ruffini G, Salvador R, Pascual-Leone A, Momi D, Sprugnoli G, Rossi A, Rossi S, Santarnecchi E Abstract Dynamics within and between functional resting-state networks have a crucial role in determining both healthy and pathological brain functioning in humans. The possibility to noninvasively interact and selectively modulate the activity of networks would open to relevant applications in neuroscience. Here we tested a novel approach for multichannel, network-targeted transcranial direct current stimulation ... read more
    2 weeks ago
  • Feasibility of single and combined with other treatments using transcranial direct current stimulation for chronic stroke: A pilot study.
    Related ArticlesFeasibility of single and combined with other treatments using transcranial direct current stimulation for chronic stroke: A pilot study. SAGE Open Med. 2020;8:2050312120940546 Authors: Hyakutake K, Morishita T, Saita K, Ogata T, Uehara Y, Shiota E, Inoue T Abstract Objectives: This pilot study aimed to investigate the safety and efficacy of transcranial direct current stimulation (tDCS) for chronic stroke in adult and pediatric patients. We also aimed to verify the efficacy of botulinum toxin A and peripheral neuromuscular electrical stimulation combined therapy involving bilateral tDCS in adult patients with chronic stroke. Methods: We conducted a pilot study applying an ... read more
    2 weeks ago
  • Neither cathodal nor anodal transcranial direct current stimulation on the left dorsolateral prefrontal cortex alone or applied during moderate aerobic exercise modulates executive function.
    Neither cathodal nor anodal transcranial direct current stimulation on the left dorsolateral prefrontal cortex alone or applied during moderate aerobic exercise modulates executive function. Neuroscience. 2020 Jul 16;: Authors: Thomas F, Pixa NH, Berger A, Cheng MY, Doppelmayr M, Steinberg F Abstract There is converging evidence that both aerobic exercise (AE) and transcranial direct current stimulation (tDCS) can acutely modulate executive functions (EF). In addition, recent studies have proposed the beneficial effects of applying tDCS during AE on physical performance. This study aimed to investigate whether tDCS applied during an AE session additionally or differently effects EF. Therefore, five experiments ... read more
    2 weeks ago
  • Cerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial.
    Related ArticlesCerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial. Sci Rep. 2020 Jul 16;10(1):11853 Authors: Kumari N, Taylor D, Rashid U, Vandal AC, Smith PF, Signal N Abstract This study aimed to examine the effect of repeated anodal cerebellar transcranial direct current stimulation (ctDCS) on learning a split-belt treadmill task. Thirty healthy individuals randomly received three consecutive sessions of active or sham anodal ctDCS during split-belt treadmill training. Motor performance and strides to steady-state performance were evaluated before (baseline), during (adaptation), and after (de-adaptation) the intervention. The outcomes were measured one week ... read more
    2 weeks ago
  • Anodal Transcranial Direct Current Stimulation Enhances Retention of Visuomotor Stepping Skills in Healthy Adults.
    Related ArticlesAnodal Transcranial Direct Current Stimulation Enhances Retention of Visuomotor Stepping Skills in Healthy Adults. Front Hum Neurosci. 2020;14:251 Authors: Tseng SC, Chang SH, Hoerth KM, Nguyen AA, Perales D Abstract Transcranial direct current stimulation (tDCS) paired with exercise training can enhance learning and retention of hand tasks; however, there have been few investigations of the effects of tDCS on leg skill improvements. The purpose of this study was to investigate whether tDCS paired with visuomotor step training can promote skill learning and retention. We hypothesized that pairing step training with anodal tDCS would improve skill learning and retention, evidenced ... read more
    2 weeks ago
  • Non-invasive Brain Stimulation of the Posterior Parietal Cortex Alters Postural Adaptation.
    Related ArticlesNon-invasive Brain Stimulation of the Posterior Parietal Cortex Alters Postural Adaptation. Front Hum Neurosci. 2020;14:248 Authors: Young DR, Parikh PJ, Layne CS Abstract Effective central sensory integration of visual, vestibular, and proprioceptive information is required to promote adaptability in response to changes in the environment during postural control. Patients with a lesion in the posterior parietal cortex (PPC) have an impaired ability to form an internal representation of body position, an important factor for postural control and adaptation. Suppression of PPC excitability has also been shown to decrease postural stability in some contexts. As of yet, it is unknown ... read more
    2 weeks ago
  • Randomized Controlled Study Evaluating Efficiency of Low Intensity Transcranial Direct Current Stimulation (tDCS) for Dyspnea Relief in Mechanically Ventilated COVID-19 Patients in ICU: The tDCS-DYSP-COVID Protocol.
    Related ArticlesRandomized Controlled Study Evaluating Efficiency of Low Intensity Transcranial Direct Current Stimulation (tDCS) for Dyspnea Relief in Mechanically Ventilated COVID-19 Patients in ICU: The tDCS-DYSP-COVID Protocol. Front Med (Lausanne). 2020;7:372 Authors: Azabou E, Bao G, Heming N, Bounab R, Moine P, Chevallier S, Chevret S, Resche-Rigon M, Siami S, Sharshar T, Lofaso F, Annane D Abstract The severe respiratory distress syndrome linked to the new coronavirus disease (COVID-19) includes unbearable dyspneic suffering which contributes to the deterioration of the prognosis of patients in intensive care unit (ICU). Patients are put on mechanical ventilation to reduce respiratory suffering and preserve ... read more
    3 weeks ago