Published Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with recent interest in the topic exploding over the last 10-15 years. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year. As of January 1, 2017 there are currently over 3,000 published tDCS studies on PubMed.gov, with nearly 700 (~23%) of them having been published in 2016 alone.

Below you will find a collection of the most recent scientific studies on tDCS. Each article includes data on where it was published, date published, contributing authors, as well as an abstract, or summary of the article.

 

  • Effects of transcranial direct current stimulation for treating depression: A modeling study.
    Related ArticlesEffects of transcranial direct current stimulation for treating depression: A modeling study. J Affect Disord. 2018 Feb 28;234:164-173 Authors: Csifcsák G, Boayue NM, Puonti O, Thielscher A, Mittner M Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) above the left dorsolateral prefrontal cortex (lDLPFC) has been widely used to improve symptoms of major depressive disorder (MDD). However, the effects of different stimulation protocols in the entire frontal lobe have not been investigated in a large sample including patient data. METHODS: We used 38 head models created from structural magnetic resonance imaging data of 19 healthy adults and 19 MDD ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Modulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study.
    Related ArticlesModulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study. PLoS One. 2018;13(3):e0194936 Authors: Sallard E, Mouthon M, De Pretto M, Spierer L Abstract Prefrontal anodal transcranial direct current stimulation (tDCS) has been proposed as a potential approach to improve inhibitory control performance. The functional consequences of tDCS during inhibition tasks remain, however, largely unresolved. We addressed this question by analyzing functional magnetic resonance imaging (fMRI) recorded while participants completed a Go/NoGo task after right-lateralized prefrontal anodal tDCS with a crossover, sham-controlled, double-blind experimental design. We replicated previous evidence for an absence of offline ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson’s disease? A pilot study.
    Related ArticlesDoes transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson's disease? A pilot study. Hum Mov Sci. 2018 Feb 28;: Authors: Broeder S, Heremans E, Pinto Pereira M, Nackaerts E, Meesen R, Verheyden G, Nieuwboer A Abstract Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can boost motor performance in Parkinson's disease (PD) when it is applied at rest. However, the potential supplementary therapeutic effect of the concurrent application of tDCS during the training of motor tasks is largely unknown. The present study examined the effects of tDCS on upper ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • tDCS; +21 new citations
    21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: tDCS These pubmed results were generated on 2018/03/29PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant major depression (TRMD) Veteran patients: study protocol for a randomized controlled trial.
    Related ArticlesRepetitive transcranial magnetic stimulation (rTMS) for treatment-resistant major depression (TRMD) Veteran patients: study protocol for a randomized controlled trial. Trials. 2017 Sep 02;18(1):409 Authors: Mi Z, Biswas K, Fairchild JK, Davis-Karim A, Phibbs CS, Forman SD, Thase M, Georgette G, Beale T, Pittman D, McNerney MW, Rosen A, Huang GD, George M, Noda A, Yesavage JA Abstract BACKGROUND: Evaluation of repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant major depression (TRMD) in Veterans offers unique clinical trial challenges. Here we describe a randomized, double-blinded, intent-to-treat, two-arm, superiority parallel design, a multicenter study funded by the Cooperative Studies Program ... read more
    PubMed Transcranial Direct Current Stimulation
  • The role of the inferior frontal gyrus in vicarious social touch: A transcranial direct current stimulation (tDCS) study.
    Related ArticlesThe role of the inferior frontal gyrus in vicarious social touch: A transcranial direct current stimulation (tDCS) study. Dev Cogn Neurosci. 2018 Apr 30;: Authors: Peled-Avron L, Glasner L, Gvirts HZ, Shamay-Tsoory SG Abstract The neural mechanisms facilitating the experience of vicarious social touch are largely unknown. The right inferior frontal gyrus (rIFG) has been suggested as part of a simulation observation-execution neural network that plays a key role in the perception of tactile stimuli. Considering that vicarious social touch involves vicarious sharing of emotions, we hypothesized that emotional empathy, i.e., the ability to feel what another individual ... read more
    PubMed Transcranial Direct Current Stimulation
  • Transcranial direct current stimulation produces long-lasting attenuation of cocaine-induced behavioral responses and gene regulation in corticostriatal circuits.
    Related ArticlesTranscranial direct current stimulation produces long-lasting attenuation of cocaine-induced behavioral responses and gene regulation in corticostriatal circuits. Addict Biol. 2017 Sep;22(5):1267-1278 Authors: Pedron S, Beverley J, Haffen E, Andrieu P, Steiner H, Van Waes V Abstract Transcranial direct current stimulation (tDCS) is a non-invasive method to modulate cortical excitability. This technique is a promising emerging tool to treat several neuropathologies, including addiction. We have previously shown in mice that repeated tDCS normalizes pathological behaviors associated with chronic nicotine exposure. Here, we evaluated, in adult female mice, the impact of tDCS on cocaine-induced behavior and gene regulation in corticostriatal ... read more
    PubMed Transcranial Direct Current Stimulation
  • Safety and feasibility of transcranial direct current stimulation (tDCS) combined with sensorimotor retraining in chronic low back pain: a protocol for a pilot randomised controlled trial.
    Related ArticlesSafety and feasibility of transcranial direct current stimulation (tDCS) combined with sensorimotor retraining in chronic low back pain: a protocol for a pilot randomised controlled trial. BMJ Open. 2017 Aug 21;7(8):e013080 Authors: Ouellette AL, Liston MB, Chang WJ, Walton DM, Wand BM, Schabrun SM Abstract INTRODUCTION: Chronic low back pain (LBP) is a common and costly health problem yet current treatments demonstrate at best, small effects. The concurrent application of treatments with synergistic clinical and mechanistic effects may improve outcomes in chronic LBP. This pilot trial aims to (1) determine the feasibility, safety and perceived patient response ... read more
    PubMed Transcranial Direct Current Stimulation
  • Automatic M1-SO Montage Headgear for Transcranial Direct Current Stimulation (TDCS) Suitable for Home and High-Throughput In-Clinic Applications.
    Related ArticlesAutomatic M1-SO Montage Headgear for Transcranial Direct Current Stimulation (TDCS) Suitable for Home and High-Throughput In-Clinic Applications. Neuromodulation. 2018 May 15;: Authors: Knotkova H, Riggs A, Berisha D, Borges H, Bernstein H, Patel V, Truong DQ, Unal G, Arce D, Datta A, Bikson M Abstract OBJECTIVES: Non-invasive transcranial direct current stimulation (tDCS) over the motor cortex is broadly investigated to modulate functional outcomes such as motor function, sleep characteristics, or pain. The most common montages that use two large electrodes (25-35 cm2 ) placed over the area of motor cortex and contralateral supraorbital region (M1-SO montages) require precise measurements, ... read more
    PubMed Transcranial Direct Current Stimulation
  • TMS evoked N100 reflects local GABA and glutamate balance.
    Related ArticlesTMS evoked N100 reflects local GABA and glutamate balance. Brain Stimul. 2018 May 04;: Authors: Du X, Rowland LM, Summerfelt A, Wijtenburg A, Chiappelli J, Wisner K, Kochunov P, Choa FS, Hong LE Abstract BACKGROUND: Animal studies suggest that synchronized electrical activities in the brain are regulated by the primary inhibitory and excitatory neurotransmitters gamma-aminobutyric acid (GABA) and glutamate, respectively. Identifying direct evidence that this same basic chemical-electrical neuroscience principle operates in the human brains is critical for translation of neuroscience to pathological research. OBJECTIVE/HYPOTHESIS: We hypothesize that the background neurochemical concentrations may affect the cortical excitability probed by ... read more
    PubMed Transcranial Direct Current Stimulation
  • Effect of single-session dual-tDCS before physical therapy on lower-limb performance in sub-acute stroke patients: a randomized sham-controlled crossover study.
    Related ArticlesEffect of single-session dual-tDCS before physical therapy on lower-limb performance in sub-acute stroke patients: a randomized sham-controlled crossover study. Ann Phys Rehabil Med. 2018 May 12;: Authors: Klomjai W, Aneksan B, Pheungphrarattanatrai A, Chantanachai T, Choowong N, Bunleukhet S, Auervitchayapat P, Nilanon Y, Hiengkaew V Abstract Anodal stimulation increases cortical excitably, whereas cathodal stimulation decreases cortical excitability. Dual transcranial direct current stimulation (tDCS; anodal over the lesioned hemisphere, cathodal over the non-lesioned hemisphere) was found to enhance motor learning. The corresponding tDCS-induced changes were reported to reduce the inhibition exerted by the unaffected hemisphere on the affected hemisphere and ... read more
    PubMed Transcranial Direct Current Stimulation
  • Efficacy and acceptability of non-invasive brain stimulation for the treatment of adult unipolar and bipolar depression: A systematic review and meta-analysis of randomised sham-controlled trials.
    Related ArticlesEfficacy and acceptability of non-invasive brain stimulation for the treatment of adult unipolar and bipolar depression: A systematic review and meta-analysis of randomised sham-controlled trials. Neurosci Biobehav Rev. 2018 May 12;: Authors: Mutz J, Edgcumbe DR, BrunoniMD AR, FuMD CHY Abstract We examined the efficacy and acceptability of non-invasive brain stimulation in adult unipolar and bipolar depression. Randomised sham-controlled trials of transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and theta-burst stimulation (TBS), without co-initiation of another treatment, were included. We analysed effects on response, remission, all-cause discontinuation rates and continuous depression severity measures. Fifty-six studies met our ... read more
    PubMed Transcranial Direct Current Stimulation
  • Anodal transcranial direct current stimulation over the right hemisphere improves auditory comprehension in a case of dementia.
    Related ArticlesAnodal transcranial direct current stimulation over the right hemisphere improves auditory comprehension in a case of dementia. NeuroRehabilitation. 2017;41(2):567-575 Authors: Costa V, Brighina F, Piccoli T, Realmuto S, Fierro B Abstract BACKGROUND: Noninvasive transcranial stimulation methods have been increasingly employed in order to improve cognitive performance in neurological patients. In previous studies with both stroke patients and healthy subjects, noninvasive stimulation of temporal-parietal regions and their homologue produced an improvement in linguistic tasks. OBJECTIVE: The aim of the current study was to evaluate if anodal transcranial direct current stimulation (tDCS) over Brodmann areas 39/40 (angular and supramarginal gyri) ... read more
    PubMed Transcranial Direct Current Stimulation
  • Anodal tDCS of the swallowing motor cortex for treatment of dysphagia in multiple sclerosis: a pilot open-label study.
    Related ArticlesAnodal tDCS of the swallowing motor cortex for treatment of dysphagia in multiple sclerosis: a pilot open-label study. Neurol Sci. 2018 May 13;: Authors: Cosentino G, Gargano R, Bonura G, Realmuto S, Tocco E, Ragonese P, Gangitano M, Alfonsi E, Fierro B, Brighina F, Salemi G Abstract Swallowing difficulties are a common symptom of multiple sclerosis (MS). The early detection and treatment of dysphagia is critical to prevent complications, including poor nutrition, dehydration, and lung infections. Recently, transcranial direct current stimulation (tDCS) has been proven to be effective in ameliorating swallowing problems in stroke patients. In this pilot study, ... read more
    PubMed Transcranial Direct Current Stimulation
  • The effect of transcranial direct current stimulation on psychotic symptoms of schizophrenia is associated with oxy-hemoglobin concentrations in the brain as measured by near-infrared spectroscopy: A pilot study.
    Related ArticlesThe effect of transcranial direct current stimulation on psychotic symptoms of schizophrenia is associated with oxy-hemoglobin concentrations in the brain as measured by near-infrared spectroscopy: A pilot study. J Psychiatr Res. 2018 May 08;103:5-9 Authors: Narita Z, Noda T, Setoyama S, Sueyoshi K, Inagawa T, Sumiyoshi T Abstract Transcranial direct current stimulation (tDCS) has been shown to be effective in treating some of the symptoms of schizophrenia. In the current study, we sought to determine whether oxy-hemoglobin ([oxy-Hb]), measured by near-infrared spectroscopy (NIRS), is associated with effects of transcranial direct current stimulation (tDCS) on psychotic symptoms of schizophrenia. Twenty-six ... read more
    PubMed Transcranial Direct Current Stimulation
  • High definition-transcranial direct current stimulation changes older adults’ subjective sleep and corresponding resting-state functional connectivity.
    Related ArticlesHigh definition-transcranial direct current stimulation changes older adults' subjective sleep and corresponding resting-state functional connectivity. Int J Psychophysiol. 2018 May 08;: Authors: Sheng J, Xie C, Fan DQ, Lei X, Yu J Abstract With advanced age, older adults show functional deterioration in sleep. Transcranial direct current stimulation (tDCS), a noninvasive brain stimulation, modulates individuals' behavioral performance in various cognitive domains. However, the modulation effect and neural mechanisms of tDCS on sleep, especially for the elderly population are not clear. Here, we aimed to investigate whether high-definition transcranial direct current stimulation (HD-tDCS) could modulate community-dwelling older adults' subjective sleep and ... read more
    PubMed Transcranial Direct Current Stimulation
  • Anodal Transcranial Direct Current Stimulation to Enhance Rehabilitation in Individuals With Rotator Cuff Tendinopathy: A Triple-Blind Randomized Control Trial.
    Related ArticlesAnodal Transcranial Direct Current Stimulation to Enhance Rehabilitation in Individuals With Rotator Cuff Tendinopathy: A Triple-Blind Randomized Control Trial. J Orthop Sports Phys Ther. 2018 May 10;:1-53 Authors: Fournier Belley A, Mercier C, Bastien M, Léonard G, Gaudreault N, Roy JS Abstract Study Design Triple-blind parallel-group randomized control trial. Background Anodal transcranial direct current stimulation (a-tDCS) has been shown to enhance the effects of sensorimotor training in neurological populations. For treatment of rotator cuff (RC) tendinopathy, sensorimotor training leads to reduce pain and increase function. Addition of a-tDCS during a rehabilitation program centered on sensorimotor training could improve treatment ... read more
    PubMed Transcranial Direct Current Stimulation
  • Non-invasive brain stimulation for fine motor improvement after stroke: a meta-analysis.
    Related ArticlesNon-invasive brain stimulation for fine motor improvement after stroke: a meta-analysis. Eur J Neurol. 2018 May 09;: Authors: O'Brien AT, Bertolucci F, Torrealba-Acosta G, Huerta R, Fregni F, Thibaut A Abstract The aim of this study was to determine whether non-invasive brain stimulation (NIBS) techniques improve fine motor performance in stroke. We searched PubMed, EMBASE, Web of Science, SciELO and OpenGrey for randomized clinical trials on NIBS for fine motor performance in stroke patients and healthy participants. We computed Hedges' g for active and sham groups, pooled data as random-effects models and performed sensitivity analysis on chronicity, montage, frequency ... read more
    PubMed Transcranial Direct Current Stimulation
  • A Preliminary Comparison of Motor Learning Across Different Non-invasive Brain Stimulation Paradigms Shows No Consistent Modulations.
    Related ArticlesA Preliminary Comparison of Motor Learning Across Different Non-invasive Brain Stimulation Paradigms Shows No Consistent Modulations. Front Neurosci. 2018;12:253 Authors: Lopez-Alonso V, Liew SL, Fernández Del Olmo M, Cheeran B, Sandrini M, Abe M, Cohen LG Abstract Non-invasive brain stimulation (NIBS) has been widely explored as a way to safely modulate brain activity and alter human performance for nearly three decades. Research using NIBS has grown exponentially within the last decade with promising results across a variety of clinical and healthy populations. However, recent work has shown high inter-individual variability and a lack of reproducibility of previous results. Here, ... read more
    PubMed Transcranial Direct Current Stimulation
  • Modulating Emotional Experience Using Electrical Stimulation of the Medial-Prefrontal Cortex: A Preliminary tDCS-fMRI Study.
    Modulating Emotional Experience Using Electrical Stimulation of the Medial-Prefrontal Cortex: A Preliminary tDCS-fMRI Study. Neuromodulation. 2018 May 09;: Authors: Abend R, Sar-El R, Gonen T, Jalon I, Vaisvaser S, Bar-Haim Y, Hendler T Abstract OBJECTIVES: Implicit regulation of emotions involves medial-prefrontal cortex (mPFC) regions exerting regulatory control over limbic structures. Diminished regulation relates to aberrant mPFC functionality and psychopathology. Establishing means of modulating mPFC functionality could benefit research on emotion and its dysregulation. Here, we tested the capacity of transcranial direct current stimulation (tDCS) targeting mPFC to modulate subjective emotional states by facilitating implicit emotion regulation. MATERIALS AND METHODS: Stimulation ... read more
    PubMed Transcranial Direct Current Stimulation
  • Anodal Transcranial Direct Current Stimulation Provokes Neuroplasticity in Repetitive Mild Traumatic Brain Injury in Rats.
    Related ArticlesAnodal Transcranial Direct Current Stimulation Provokes Neuroplasticity in Repetitive Mild Traumatic Brain Injury in Rats. Neural Plast. 2017;2017:1372946 Authors: Kim HJ, Han SJ Abstract Repetitive mild traumatic brain injury (rmTBI) provokes behavioral and cognitive changes. But the study about electrophysiologic findings and managements of rmTBI is limited. In this study, we investigate the effects of anodal transcranial direct current stimulation (tDCS) on rmTBI. Thirty-one Sprague Dawley rats were divided into the following groups: sham, rmTBI, and rmTBI treated by tDCS. Animals received closed head mTBI three consecutive times a day. Anodal tDCS was applied to the left ... read more
    PubMed Transcranial Direct Current Stimulation
  • Transcranial Direct Current Stimulation (tDCS): A Promising Treatment for Major Depressive Disorder?
    Related ArticlesTranscranial Direct Current Stimulation (tDCS): A Promising Treatment for Major Depressive Disorder? Brain Sci. 2018 May 06;8(5): Authors: Bennabi D, Haffen E Abstract Background: Transcranial direct current stimulation (tDCS) opens new perspectives in the treatment of major depressive disorder (MDD), because of its ability to modulate cortical excitability and induce long-lasting effects. The aim of this review is to summarize the current status of knowledge regarding tDCS application in MDD. Methods: In this review, we searched for articles published in PubMed/MEDLINE from the earliest available date to February 2018 that explored clinical and cognitive effects of tDCS in MDD. ... read more
    PubMed Transcranial Direct Current Stimulation