Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • The clinical application of Transcranial Direct Current Stimulation in patients with cerebellar ataxia: a systematic review.
    Related ArticlesThe clinical application of Transcranial Direct Current Stimulation in patients with cerebellar ataxia: a systematic review. Int J Neurosci. 2020 Mar 31;:1-12 Authors: Orrù G, Cesari V, Conversano C, Gemignani A Abstract Aim: the aim of this review was to investigate the effects of transcranial direct current stimulation (tDCS) on motor function in patients with cerebellar ataxia.Materials and Methods: our systematic review has been performed by searching full-text articles on Pubmed and Scopus. Only studies investigating the motor effects of tDCS in patients with cerebellar ataxias were considered. A qualitative analysis of data was performed, as the methodology of ... read more
    7 hours ago
  • The Immediate Effects of Transcranial Direct Current Stimulation on Quadriceps Muscle Function in Individuals With a History of Anterior Cruciate Ligament Reconstruction: A Preliminary Investigation.
    Related ArticlesThe Immediate Effects of Transcranial Direct Current Stimulation on Quadriceps Muscle Function in Individuals With a History of Anterior Cruciate Ligament Reconstruction: A Preliminary Investigation. J Sport Rehabil. 2020 Mar 28;:1-10 Authors: Rush JL, Lepley LK, Davi S, Lepley AS Abstract CONTEXT: Altered quadriceps activation is common following anterior cruciate ligament reconstruction (ACLR), and can persist for years after surgery. These neural deficits are due, in part, to chronic central nervous system alterations. Transcranial direct current stimulation (tDCS) is a noninvasive modality, that is, believed to immediately increase motor neuron activity by stimulating the primary motor cortex, making it ... read more
    3 days ago
  • Transcranial Direct Current Stimulation of the Medial Prefrontal Cortex Has No Specific Effect on Self-referential Processes.
    Related ArticlesTranscranial Direct Current Stimulation of the Medial Prefrontal Cortex Has No Specific Effect on Self-referential Processes. Front Hum Neurosci. 2020;14:56 Authors: Mainz V, Britz S, Forster SD, Drüke B, Gauggel S Abstract The processing of self-referential information can be influenced by transcranial magnetic stimulation (TMS). The present randomized controlled study investigated whether similar effects can be elicited through the application of transcranial direct current stimulation (tDCS) regarding the "self-serving bias" (SSB) and the "mnemic neglect effect" (MNE). Seventy-five healthy males (M age = 25; SD = 4.3) were investigated in a between-groups design with random assignment by applying anodal, ... read more
    4 days ago
  • A Systematic Review of the Effectiveness of Non-Invasive Brain Stimulation Techniques to Reduce Violence Proneness by Interfering in Anger and Irritability.
    Related ArticlesA Systematic Review of the Effectiveness of Non-Invasive Brain Stimulation Techniques to Reduce Violence Proneness by Interfering in Anger and Irritability. J Clin Med. 2020 Mar 24;9(3): Authors: Romero-Martínez Á, Bressanutti S, Moya-Albiol L Abstract The field of neurocriminology has proposed several treatments (e.g., pharmacological, brain surgery, androgen-deprivation therapy, neurofeedback) to reduce violence proneness, but unfortunately, their effectiveness has been limited due to their side-effects. Therefore, it is necessary to explore alternative techniques to improve patients' behavioural regulation with minimal undesirable effects. In this regard, non-invasive brain stimulation techniques, which are based on applying changing magnetic fields or electric ... read more
    5 days ago
  • Owning Ethical Innovation: Claims about Commercial Wearable Brain Technologies.
    Related ArticlesOwning Ethical Innovation: Claims about Commercial Wearable Brain Technologies. Neuron. 2019 05 22;102(4):728-731 Authors: Coates McCall I, Lau C, Minielly N, Illes J Abstract The wearable neurotechnology market targets consumers with promises of cognitive benefit and personal wellness. Scientific evidence is essential to substantiate claims about utility, safety, and efficacy and for informed choice and public trust.PMID: 31121124 [PubMed - indexed for MEDLINE] ... read more
    1 week ago
  • Targeting cognition in schizophrenia trough transcranial direct current stimulation: A systematic review and perspective.
    Related ArticlesTargeting cognition in schizophrenia trough transcranial direct current stimulation: A systematic review and perspective. Schizophr Res. 2020 Mar 21;: Authors: Kostova R, Cecere R, Thut G, Uhlhaas PJ Abstract Cognitive deficits are a fundamental feature of schizophrenia for which currently no effective treatments exist. This paper examines the possibility to use transcranial direct current stimulation (tDCS) to target cognitive deficits in schizophrenia as evidence from studies in healthy participants suggests that tDCS may improve cognitive functions and associated neural processes. We carried out a systematic review with the following search terms: 'tDCS', 'electric brain stimulation', 'schizophrenia', 'cognitive', 'cognition' until ... read more
    1 week ago
  • Left parietal tACS at alpha frequency induces a shift of visuospatial attention.
    Related ArticlesLeft parietal tACS at alpha frequency induces a shift of visuospatial attention. PLoS One. 2019;14(11):e0217729 Authors: Schuhmann T, Kemmerer SK, Duecker F, de Graaf TA, Ten Oever S, De Weerd P, Sack AT Abstract BACKGROUND: Voluntary shifts of visuospatial attention are associated with a lateralization of parieto-occipital alpha power (7-13Hz), i.e. higher power in the hemisphere ipsilateral and lower power contralateral to the locus of attention. Recent noninvasive neuromodulation studies demonstrated that alpha power can be experimentally increased using transcranial alternating current stimulation (tACS). OBJECTIVE/HYPOTHESIS: We hypothesized that tACS at alpha frequency over the left parietal cortex ... read more
    1 week ago
  • Multisession transcranial direct current stimulation facilitates verbal learning and memory consolidation in young and older adults.
    Related ArticlesMultisession transcranial direct current stimulation facilitates verbal learning and memory consolidation in young and older adults. Brain Lang. 2020 Mar 18;205:104788 Authors: Perceval G, Martin AK, Copland DA, Laine M, Meinzer M Abstract This study investigated effects of multisession transcranial direct-current stimulation on learning and maintenance of novel memory content and scrutinised effects of baseline cognitive status and the role of multi-session tDCS on overnight memory consolidation. In a prospective, randomized, double-blind, parallel-group, sham-tDCS controlled design, 101 healthy young and older adults completed a five-day verbal associative learning paradigm while receiving multisession tDCS to the task-relevant left prefrontal cortex. ... read more
    2 weeks ago
  • Combining Transcranial Direct Current Stimulation and Transcutaneous Electrical Nerve Stimulation to Relieve Persistent Pain in a Patient Suffering from Complex Regional Pain Syndrome: A Case Report.
    Related ArticlesCombining Transcranial Direct Current Stimulation and Transcutaneous Electrical Nerve Stimulation to Relieve Persistent Pain in a Patient Suffering from Complex Regional Pain Syndrome: A Case Report. J Pain Res. 2020;13:467-473 Authors: Houde F, Harvey MP, Tremblay Labrecque PF, Lamarche F, Lefebvre A, Leonard G Abstract Purpose: Complex regional pain syndrome (CRPS) is a rare neuropathic pain condition characterized by sensory, motor and autonomic alterations. Previous investigations have shown that transcranial direct current stimulation (tDCS) and transcutaneous electrical nerve stimulation (TENS) can alleviate pain in various populations, and that a combination of these treatments could provide greater hypoalgesic effects. In ... read more
    2 weeks ago
  • Dissociable effects of tDCS polarity on latent decision processes are associated with individual differences in neurochemical concentrations and cortical morphology.
    Related ArticlesDissociable effects of tDCS polarity on latent decision processes are associated with individual differences in neurochemical concentrations and cortical morphology. Neuropsychologia. 2020 Mar 14;:107433 Authors: Filmer HL, Ballard T, Ehrhardt SE, Bollmann S, Shaw TB, Mattingley JB, Dux PE Abstract Applying a weak electrical current to the cortex has the potential to modulate neural functioning and behaviour. The most common stimulation technique, transcranial direct current stimulation (tDCS), has been used for causal investigations of brain and cognitive functioning, and to treat psychiatric conditions such as depression. However, the efficacy of tDCS in modulating behaviour varies across individuals. Moreover, despite ... read more
    2 weeks ago
  • Statistical power estimation in non-invasive brain stimulation studies and its clinical implications: An exploratory study of the meta-analyses.
    Related ArticlesStatistical power estimation in non-invasive brain stimulation studies and its clinical implications: An exploratory study of the meta-analyses. Asian J Psychiatr. 2019 Aug;44:29-34 Authors: Mitra S, Mehta UM, Binukumar B, Venkatasubramanian G, Thirthalli J Abstract BACKGROUND: Non-invasive brain stimulation (NIBS) techniques have emerged as a promising tool for understanding and treating psychiatric disorders, necessitating a caution in terms of interpreting research results. OBJECTIVE: This study aimed at systematically evaluating a representative sample of research conducted using NIBS interventions in neuro-psychiatric conditions, and assessing the power these studies achieved, given their sample sizes. METHODS: A database search was conducted ... read more
    2 weeks ago
  • Precision non-implantable neuromodulation therapies: a perspective for the depressed brain.
    Related ArticlesPrecision non-implantable neuromodulation therapies: a perspective for the depressed brain. Braz J Psychiatry. 2020 Mar 16;: Authors: Borrione L, Bellini H, Razza LB, Avila AG, Baeken C, Brem AK, Busatto G, Carvalho AF, Chekroud A, Daskalakis ZJ, Deng ZD, Downar J, Gattaz W, Loo C, Lotufo PA, Martin MDGM, McClintock SM, O'Shea J, Padberg F, Passos IC, Salum GA, Vanderhasselt MA, Fraguas R, Benseñor I, Valiengo L, Brunoni AR Abstract Current first-line treatments for major depressive disorder (MDD) include pharmacotherapy and cognitive-behavioral therapy. However, one-third of depressed patients do not achieve remission after multiple medication trials, and psychotherapy can ... read more
    2 weeks ago
  • Effects of concomitant neuromuscular electrical stimulation during repetitive transcranial magnetic stimulation before repetitive facilitation exercise on the hemiparetic hand.
    Related ArticlesEffects of concomitant neuromuscular electrical stimulation during repetitive transcranial magnetic stimulation before repetitive facilitation exercise on the hemiparetic hand. NeuroRehabilitation. 2019;45(3):323-329 Authors: Etoh S, Kawamura K, Tomonaga K, Miura S, Harada S, Noma T, Kikuno S, Ueno M, Miyata R, Shimodozono M Abstract BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) and Repetitive facilitative exercise (RFE) improves motor impairment after stroke. OBJECTIVE: To investigate whether neuromuscular electrical stimulation (NMES) can facilitate the effects of rTMS and RFE on the function of the hemiparetic hand in stroke patients. METHODS: This randomized double-blinded crossover study divided 20 patients with hemiparesis into two ... read more
    2 weeks ago
  • Noninvasive brain stimulation does not improve neuropathic pain in individuals with spinal cord injury: evidence from a meta-analysis of 11 randomized controlled trials.
    Related ArticlesNoninvasive brain stimulation does not improve neuropathic pain in individuals with spinal cord injury: evidence from a meta-analysis of 11 randomized controlled trials. Am J Phys Med Rehabil. 2020 Mar 13;: Authors: Yu B, Qiu H, Li J, Zhong C, Li J Abstract OBJECTIVE: To examine the effectiveness of noninvasive brain stimulation (NIBS) on neuropathic pain (NP) in individuals with spinal cord injury (SCI). METHODS: A meta-analysis on pain intensity, depression and anxiety levels was conducted to evaluate the effect of NIBS on NP in individuals with SCI. The authors searched Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE ... read more
    2 weeks ago
  • Online Theta Frequency Transcranial Alternating Current Stimulation for Cognitive Remediation in Schizophrenia: A Case Report and Review of Literature.
    Related ArticlesOnline Theta Frequency Transcranial Alternating Current Stimulation for Cognitive Remediation in Schizophrenia: A Case Report and Review of Literature. J ECT. 2019 Jun;35(2):139-143 Authors: Sreeraj VS, Shivakumar V, Sowmya S, Bose A, Nawani H, Narayanaswamy JC, Venkatasubramanian G Abstract Transcranial alternating current stimulation (tACS), a noninvasive brain stimulation technique that uses low-intensity alternating current, has been postulated to be a potential therapeutic option in treating the cognitive deficits in schizophrenia. Transcranial alternating current stimulation synchronizes the neural oscillations to the applied stimulation frequency in the stimulated cortical regions. In this report, we have reviewed the literature pertinent to ... read more
    2 weeks ago
  • Transcranial direct current stimulation (tDCS) as an intervention to improve empathic abilities and reduce violent behavior in forensic offenders: study protocol for a randomized controlled trial.
    Related ArticlesTranscranial direct current stimulation (tDCS) as an intervention to improve empathic abilities and reduce violent behavior in forensic offenders: study protocol for a randomized controlled trial. Trials. 2020 Mar 13;21(1):263 Authors: Sergiou CS, Woods AJ, Franken IHA, van Dongen JDM Abstract BACKGROUND: Recent studies show that changes in one of the brain areas related to empathic abilities (i.e. the ventromedial prefrontal cortex (vmPFC)) plays an important role in violent behavior in abusers of alcohol and cocaine. According to the models of James Blair, empathy is a potential inhibitor of violent behavior. Individuals with less empathic abilities may be less ... read more
    3 weeks ago
  • Effect of Transcranial Direct Current Stimulation Combined With Patient-Controlled Intravenous Morphine Analgesia on Analgesic Use and Post-Thoracotomy Pain. A Prospective, Randomized, Double-Blind, Sham-Controlled, Proof-of-Concept Clinical Trial.
    Related ArticlesEffect of Transcranial Direct Current Stimulation Combined With Patient-Controlled Intravenous Morphine Analgesia on Analgesic Use and Post-Thoracotomy Pain. A Prospective, Randomized, Double-Blind, Sham-Controlled, Proof-of-Concept Clinical Trial. Front Pharmacol. 2020;11:125 Authors: Stamenkovic DM, Mladenovic K, Rancic N, Cvijanovic V, Maric N, Neskovic V, Zeba S, Karanikolas M, Ilic TV Abstract Background: Transcranial direct current stimulation (tDCS) is used for various chronic pain conditions, but experience with tDCS for acute postoperative pain is limited. This study investigated the effect of tDCS vs. sham stimulation on postoperative morphine consumption and pain intensity after thoracotomy. Methods: This is a single-center, prospective, randomized, double-blind, ... read more
    3 weeks ago
  • Combined behavioral and electrophysiological evidence for a direct cortical effect of prefrontal tDCS on disorders of consciousness.
    Related ArticlesCombined behavioral and electrophysiological evidence for a direct cortical effect of prefrontal tDCS on disorders of consciousness. Sci Rep. 2020 Mar 09;10(1):4323 Authors: Hermann B, Raimondo F, Hirsch L, Huang Y, Denis-Valente M, Pérez P, Engemann D, Faugeras F, Weiss N, Demeret S, Rohaut B, Parra LC, Sitt JD, Naccache L Abstract Severe brain injuries can lead to long-lasting disorders of consciousness (DoC) such as vegetative state/unresponsive wakefulness syndrome (VS/UWS) or minimally conscious state (MCS). While behavioral assessment remains the gold standard to determine conscious state, EEG has proven to be a promising complementary tool to monitor the effect ... read more
    3 weeks ago
  • End-to-end semantic segmentation of personalized deep brain structures for non-invasive brain stimulation.
    Related ArticlesEnd-to-end semantic segmentation of personalized deep brain structures for non-invasive brain stimulation. Neural Netw. 2020 Feb 25;125:233-244 Authors: Rashed EA, Gomez-Tames J, Hirata A Abstract Electro-stimulation or modulation of deep brain regions is commonly used in clinical procedures for the treatment of several nervous system disorders. In particular, transcranial direct current stimulation (tDCS) is widely used as an affordable clinical application that is applied through electrodes attached to the scalp. However, it is difficult to determine the amount and distribution of the electric field (EF) in the different brain regions due to anatomical complexity and high inter-subject variability. Personalized ... read more
    3 weeks ago
  • The effect of transcranial direct current stimulation of pharyngeal motor cortex on swallowing function in patients with chronic dysphagia after stroke: A retrospective cohort study.
    Related ArticlesThe effect of transcranial direct current stimulation of pharyngeal motor cortex on swallowing function in patients with chronic dysphagia after stroke: A retrospective cohort study. Medicine (Baltimore). 2020 Mar;99(10):e19121 Authors: Li Y, Feng H, Li J, Wang H, Chen N, Yang J Abstract About 11% to 13% of patients with acute dysphagia induced by stroke remain chronic dysphagia 6 months after stroke which usually leads to many severe complications and poor quality of life.To investigate the effect of transcranial direct current stimulation (tDCS) on swallowing function in the patients with chronic dysphagia after stroke.26 post-stroke patients with chronic dysphagia ... read more
    3 weeks ago
  • Therapeutic Effects of Bilateral Anodal Transcranial Direct Current Stimulation on Prefrontal and Motor Cortical Areas in Children with Autism Spectrum Disorders: A Pilot Study.
    Related ArticlesTherapeutic Effects of Bilateral Anodal Transcranial Direct Current Stimulation on Prefrontal and Motor Cortical Areas in Children with Autism Spectrum Disorders: A Pilot Study. Autism Res. 2020 Mar 09;: Authors: Hadoush H, Nazzal M, Almasri NA, Khalil H, Alafeef M Abstract Dysfunctional frontal cortical areas associated with clinical features are observed in children with autism spectrum disorder (ASD). This study attempted to identify any potential therapeutic effects of bilateral anodal transcranial direct current stimulation (tDCS) applied over the left and right prefrontal and motor areas on the clinical characteristics of children with ASD. Fifty children with confirmed ASD medical ... read more
    3 weeks ago
  • Feasibility of Interferential and Pulsed Transcranial Electrical Stimulation for Neuromodulation at the Human Scale.
    Related ArticlesFeasibility of Interferential and Pulsed Transcranial Electrical Stimulation for Neuromodulation at the Human Scale. Neuromodulation. 2020 Mar 08;: Authors: Howell B, McIntyre CC Abstract OBJECTIVES: Transcranial electrical stimulation (tES) is a promising tool for modulating neural activity, but tES has poor penetrability and spatiotemporal resolution compared to invasive techniques like deep brain stimulation (DBS). Interferential strategies for alternating-current stimulation (IF-tACS) and pulsed/intersectional strategies for transcranial direct-current stimulation (IS-tDCS) address some of the limitations of tES, but the comparative advantages and disadvantages of these new techniques is not well understood. This study's objective was to evaluate the suprathreshold and subthreshold ... read more
    3 weeks ago
  • Effects of Transcranial Direct Current Stimulation (tDCS) and Approach Bias Modification (ABM) training on food cravings in people taking antipsychotic medication.
    Related ArticlesEffects of Transcranial Direct Current Stimulation (tDCS) and Approach Bias Modification (ABM) training on food cravings in people taking antipsychotic medication. Trials. 2020 Mar 06;21(1):245 Authors: Grycuk L, Gordon G, Gaughran F, Campbell IC, Schmidt U Abstract BACKGROUND: Antipsychotic drug-induced weight gain puts individuals with schizophrenia at increased cardiometabolic risk. As a potential intervention for this problem, we describe the theoretical background and a protocol for a feasibility randomised controlled trial (RCT) of approach bias modification (ABM) training combined with real versus sham (placebo) transcranial direct current stimulation (tDCS). The primary aim of this trial is to obtain information ... read more
    4 weeks ago
  • Noninvasive Brain Stimulation in Epilepsy.
    Related ArticlesNoninvasive Brain Stimulation in Epilepsy. J Clin Neurophysiol. 2020 Mar;37(2):118-130 Authors: VanHaerents S, Chang BS, Rotenberg A, Pascual-Leone A, Shafi MM Abstract Neurostimulation in epilepsy is a long standing established concept, and through experimental and clinical uses, our understanding of neurostimulation and neuromodulation has grown substantially. Noninvasive brain stimulation techniques use electromagnetic principles to noninvasively modulate brain activity in a spatiotemporally targeted manner. This review focused on the two predominant forms of noninvasive neurostimulation: transcranial magnetic stimulation (TMS) and transcranial direct current stimulation, and their current applications in the diagnosis and management of epilepsy. A number of small randomized ... read more
    4 weeks ago
  • Effects of low-frequency repetitive transcranial magnetic stimulation on depression- and anxiety-like behaviors in epileptic rats.
    Related ArticlesEffects of low-frequency repetitive transcranial magnetic stimulation on depression- and anxiety-like behaviors in epileptic rats. J Integr Neurosci. 2019 Sep 30;18(3):237-243 Authors: Wang S, Mao S, Yao B, Xiang D, Fang C Abstract Low-frequency repetitive transcranial magnetic stimulation (rTMS) has been considered as a treatment option for depression and anxiety. However, its role in epilepsy comorbid with depression and anxiety is unclear. Therefore, we evaluated whether low-frequency rTMS can alleviate depression- and anxiety-like behavior in epileptic rats. Forty-eight adult rats were allocated at random to four groups: Control, Pentylenetetrazol (PTZ), PTZ-rTMS and PTZ-Sham. The control group received intraperitoneal ... read more
    4 weeks ago