Published Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with recent interest in the topic exploding over the last 10-15 years. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year. As of January 1, 2017 there are currently over 3,000 published tDCS studies on PubMed.gov, with nearly 700 (~23%) of them having been published in 2016 alone.

Below you will find a collection of the most recent scientific studies on tDCS. Each article includes data on where it was published, date published, contributing authors, as well as an abstract, or summary of the article.

 

  • Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson’s disease? A pilot study.
    Related ArticlesDoes transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson's disease? A pilot study. Hum Mov Sci. 2018 Feb 28;: Authors: Broeder S, Heremans E, Pinto Pereira M, Nackaerts E, Meesen R, Verheyden G, Nieuwboer A Abstract Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can boost motor performance in Parkinson's disease (PD) when it is applied at rest. However, the potential supplementary therapeutic effect of the concurrent application of tDCS during the training of motor tasks is largely unknown. The present study examined the effects of tDCS on upper ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Effects of transcranial direct current stimulation for treating depression: A modeling study.
    Related ArticlesEffects of transcranial direct current stimulation for treating depression: A modeling study. J Affect Disord. 2018 Feb 28;234:164-173 Authors: Csifcsák G, Boayue NM, Puonti O, Thielscher A, Mittner M Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) above the left dorsolateral prefrontal cortex (lDLPFC) has been widely used to improve symptoms of major depressive disorder (MDD). However, the effects of different stimulation protocols in the entire frontal lobe have not been investigated in a large sample including patient data. METHODS: We used 38 head models created from structural magnetic resonance imaging data of 19 healthy adults and 19 MDD ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Modulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study.
    Related ArticlesModulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study. PLoS One. 2018;13(3):e0194936 Authors: Sallard E, Mouthon M, De Pretto M, Spierer L Abstract Prefrontal anodal transcranial direct current stimulation (tDCS) has been proposed as a potential approach to improve inhibitory control performance. The functional consequences of tDCS during inhibition tasks remain, however, largely unresolved. We addressed this question by analyzing functional magnetic resonance imaging (fMRI) recorded while participants completed a Go/NoGo task after right-lateralized prefrontal anodal tDCS with a crossover, sham-controlled, double-blind experimental design. We replicated previous evidence for an absence of offline ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • tDCS; +21 new citations
    21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: tDCS These pubmed results were generated on 2018/03/29PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Prefrontal Modulation of Visual Processing and Sustained Attention in Aging, a Transcranial Direct Current Stimulation-Electroencephalogram Coregistration Approach.
    Prefrontal Modulation of Visual Processing and Sustained Attention in Aging, a Transcranial Direct Current Stimulation-Electroencephalogram Coregistration Approach. J Cogn Neurosci. 2018 Jul 13;:1-16 Authors: Brosnan MB, Arvaneh M, Harty S, Maguire T, O'Connell R, Robertson IH, Dockree PM Abstract The ability to sustain attention is integral to healthy cognition in aging. The right PFC (rPFC) is critical for maintaining high levels of attentional focus. Whether plasticity of this region can be harnessed to support sustained attention in older adults is unknown. We used transcranial direct current stimulation to increase cortical excitability of the rPFC, while monitoring behavioral and electrophysiological markers ... read more
    PubMed Transcranial Direct Current Stimulation
  • Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation.
    Related ArticlesRole of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation. Front Neurosci. 2018;12:427 Authors: Cocco S, Podda MV, Grassi C Abstract In the recent years numerous studies have provided encouraging results supporting the use of transcranial direct current stimulation (tDCS) as non-invasive brain stimulation technique to improve motor and cognitive functions in patients suffering from neurological and neuropsychiatric disorders as well as in healthy subjects. Among the multiple effects elicited by tDCS on cognitive functions, experimental evidence and clinical findings have highlighted the beneficial impact on long-term memory. Memory deficits occur during physiological aging as well ... read more
    PubMed Transcranial Direct Current Stimulation
  • Relevance of Dorsolateral and Frontotemporal Cortex on the Phonemic Verbal Fluency – A fNIRS-Study.
    Related ArticlesRelevance of Dorsolateral and Frontotemporal Cortex on the Phonemic Verbal Fluency - A fNIRS-Study. Neuroscience. 2017 Dec 26;367:169-177 Authors: Herrmann MJ, Horst AK, Löble S, Möll MT, Katzorke A, Polak T Abstract Non-invasive brain stimulation is widely used to investigate and manipulate specific brain functions to broaden knowledge about healthy people, and also to provide for a potential treatment option for people with various psychopathological disorders that do not adequately benefit from traditional treatments. Nevertheless, the underlying mechanisms have not been fully investigated yet. The aim of the present study was to investigate whether we could alter the ... read more
    PubMed Transcranial Direct Current Stimulation
  • Multi-Electrode Alpha tACS During Varying Background Tasks Fails to Modulate Subsequent Alpha Power.
    Multi-Electrode Alpha tACS During Varying Background Tasks Fails to Modulate Subsequent Alpha Power. Front Neurosci. 2018;12:428 Authors: Fekete T, Nikolaev AR, De Knijf F, Zharikova A, van Leeuwen C Abstract Transcranial alternating-current stimulation (tACS) for entraining alpha activity holds potential for influencing mental function, both in laboratory and clinical settings. While initial results of alpha entrainment are promising, questions remain regarding its translational potential-namely if tACS alpha entrainment is sufficiently robust to context and to what extent it can be upscaled to multi-electrode arrangements needed to direct currents into precise brain loci. We set out to explore these questions by ... read more
    PubMed Transcranial Direct Current Stimulation
  • Muscle length effect on corticospinal excitability during maximal concentric, isometric and eccentric contractions of the knee extensors.
    Related ArticlesMuscle length effect on corticospinal excitability during maximal concentric, isometric and eccentric contractions of the knee extensors. Exp Physiol. 2017 Nov 01;102(11):1513-1523 Authors: Doguet V, Nosaka K, Guével A, Thickbroom G, Ishimura K, Jubeau M Abstract NEW FINDINGS: What is the central question of this study? Does sensory input from peripheral mechanoreceptors determine the specific neural control of eccentric contractions? How corticospinal excitability (i.e. muscle responses to motor cortex stimulation) is affected by muscle length has never been investigated during eccentric contractions. What is the main finding and its importance? Muscle length does not influence corticospinal excitability during ... read more
    PubMed Transcranial Direct Current Stimulation
  • Oxiracetam or fastigial nucleus stimulation reduces cognitive injury at high altitude.
    Related ArticlesOxiracetam or fastigial nucleus stimulation reduces cognitive injury at high altitude. Brain Behav. 2017 Oct;7(10):e00762 Authors: Hu S, Shi J, Xiong W, Li W, Fang L, Feng H Abstract BACKGROUND: Cognitive impairment is common in people travelling to high altitude. Oxiracetam and electrical stimulation of cerebellar fastigial nucleus may have beneficial impacts. This study was to investigate the effects of preconditioning with Oxiracetam or fastigial nucleus stimulation (FNS) on cognitive decline following the ascension to high altitude. METHODS: The study was conducted on 60 male military voluntary members who were divided into control group, Oxiracetam group, and ... read more
    PubMed Transcranial Direct Current Stimulation
  • Clinical utility and tolerability of transcranial direct current stimulation in mild cognitive impairment.
    Related ArticlesClinical utility and tolerability of transcranial direct current stimulation in mild cognitive impairment. Asian J Psychiatr. 2017 Dec;30:135-140 Authors: Murugaraja V, Shivakumar V, Sivakumar PT, Sinha P, Venkatasubramanian G Abstract BACKGROUND: Neuromodulatory interventions like transcranial direct current stimulation (tDCS) is emerging as a potential therapeutic strategy to promote cognitive function in healthy and pathological aging. There is need for more studies evaluating the utility and tolerability of tDCS in Mild cognitive impairment (MCI). Since MCI is considered as the prodromal stage of dementia, it has emerged as the most important target for intervention in dementia. OBJECTIVE AND METHOD: ... read more
    PubMed Transcranial Direct Current Stimulation
  • Using tDCS as an Add-On Treatment Prior to FES Therapy in Improving Upper Limb Function in Severe Chronic Stroke Patients: A Randomized Controlled Study.
    Related ArticlesUsing tDCS as an Add-On Treatment Prior to FES Therapy in Improving Upper Limb Function in Severe Chronic Stroke Patients: A Randomized Controlled Study. Front Hum Neurosci. 2018;12:233 Authors: Shaheiwola N, Zhang B, Jia J, Zhang D Abstract Background: Upper limb function recovery is of vital importance for stroke patients. However, it is difficult to get ideal recovery, especially for patients with severe chronic stroke. As the first randomized controlled long-term trial combining bilateral transcranial direct current stimulation (tDCS) and functional electrical stimulation (FES) therapy, this study examined the efficacy of a novel protocol that included applying tDCS as ... read more
    PubMed Transcranial Direct Current Stimulation
  • Stimulation of the Prefrontal Cortex Reduces Intentions to Commit Aggression: A Randomized, Double-Blind, Placebo-Controlled, Stratified, Parallel-Group Trial.
    Stimulation of the Prefrontal Cortex Reduces Intentions to Commit Aggression: A Randomized, Double-Blind, Placebo-Controlled, Stratified, Parallel-Group Trial. J Neurosci. 2018 Jul 02;: Authors: Choy O, Raine A, Hamilton RH Abstract Although prefrontal brain impairments are one of the best-replicated brain imaging findings in relation to aggression, little is known about the causal role of this brain region. This study tests whether stimulating the dorsolateral prefrontal cortex (DLPFC) using transcranial direct current stimulation (tDCS) reduces the likelihood of engaging in aggressive acts, and the mechanism underlying this relationship. In a double-blind, stratified, placebo-controlled, randomized trial, 81 human adults (36 males, 45 ... read more
    PubMed Transcranial Direct Current Stimulation
  • Normal Electrical Activity of the Brain in Obsessive-Compulsive Patients After Anodal Stimulation of the Left Dorsolateral Prefrontal Cortex.
    Normal Electrical Activity of the Brain in Obsessive-Compulsive Patients After Anodal Stimulation of the Left Dorsolateral Prefrontal Cortex. Basic Clin Neurosci. 2018 Mar-Apr;9(2):135-146 Authors: Ghaffari H, Yoonessi A, Darvishi MJ, Ahmadi A Abstract Introduction: Transcranial Direct Current Stimulation (tDCS) has been used as a non-invasive method to increase the plasticity of brain. Growing evidence has shown several brain disorders such as depression, anxiety disorders, and chronic pain syndrome are improved following tDCS. In patients with Obsessive-Compulsive Disorder (OCD), increased brain rhythm activity particularly in the frontal lobe has been reported in several studies using Eectroencephalogram (EEG). To our knowledge, no ... read more
    PubMed Transcranial Direct Current Stimulation
  • Transcranial direct current stimulation versus user training on improving online myoelectric control for amputees.
    Related ArticlesTranscranial direct current stimulation versus user training on improving online myoelectric control for amputees. J Neural Eng. 2017 Aug;14(4):046019 Authors: Pan L, Zhang D, Jiang N, Sheng X, Zhu X Abstract OBJECTIVE: Transcranial direct current stimulation (tDCS) and user training (UT) are two types of methods to improve myoelectric control performance for amputees. In this study, we compared the independent effect between tDCS and UT, and investigated the combined effect of tDCS and UT. APPROACH: An online paradigm of simultaneous and proportional control (SPC) based on electromyography (EMG) was adopted. The proposed experiments were conducted on six naïve ... read more
    PubMed Transcranial Direct Current Stimulation
  • Sex Mediates the Effects of High-Definition Transcranial Direct Current Stimulation on “Mind-Reading”.
    Related ArticlesSex Mediates the Effects of High-Definition Transcranial Direct Current Stimulation on "Mind-Reading". Neuroscience. 2017 Dec 16;366:84-94 Authors: Martin AK, Huang J, Hunold A, Meinzer M Abstract Sex differences in social cognitive ability are well established, including measures of Theory of Mind (ToM). The aim of this study was to investigate if sex mediates the effects of high-definition transcranial direct current stimulation (HD-tDCS) administered to a key hub of the social brain (i.e., the dorsomedial prefrontal cortex, dmPFC) on the Reading the Mind in the Eyes Test (RMET). Forty healthy young adults (18-35 years) were randomly allocated to receive either ... read more
    PubMed Transcranial Direct Current Stimulation
  • The effects of anodal tDCS over the supplementary motor area on gait initiation in Parkinson’s disease with freezing of gait: a pilot study.
    Related ArticlesThe effects of anodal tDCS over the supplementary motor area on gait initiation in Parkinson's disease with freezing of gait: a pilot study. J Neurol. 2018 Jun 28;: Authors: Lu C, Amundsen Huffmaster SL, Tuite PJ, MacKinnon CD Abstract OBJECTIVE: We investigated if anodal transcranial direct current stimulation (A-tDCS), applied over the supplementary motor areas (SMAs), could improve gait initiation in Parkinson's disease (PD) with freezing of gait (FOG). METHODS: In this double-blinded cross-over pilot study, ten PD with FOG underwent two stimulation sessions: A-tDCS (1 mA, 10 min) and sham stimulation. Eight blocks of gait initiation were collected per session: ... read more
    PubMed Transcranial Direct Current Stimulation
  • Improving working memory in schizophrenia: Effects of 1 mA and 2 mA transcranial direct current stimulation to the left DLPFC.
    Related ArticlesImproving working memory in schizophrenia: Effects of 1 mA and 2 mA transcranial direct current stimulation to the left DLPFC. Schizophr Res. 2018 Jun 25;: Authors: Papazova I, Strube W, Becker B, Henning B, Schwippel T, Fallgatter AJ, Padberg F, Palm U, Falkai P, Plewnia C, Hasan A Abstract Deficits in various cognitive processes, such as working memory, are characteristic for schizophrenia, lowering patients' functioning and quality of life. Recent research suggests that transcranial direct stimulation (tDCS) applied to the dorsolateral prefrontal cortex (DLPFC) may be a potential therapeutic intervention for cognitive deficits in schizophrenia. Here, we examined the effects of ... read more
    PubMed Transcranial Direct Current Stimulation
  • One MRI-compatible tDCS session attenuates ventromedial cortical perfusion when exposed to verbal criticism: The role of perceived criticism.
    Related ArticlesOne MRI-compatible tDCS session attenuates ventromedial cortical perfusion when exposed to verbal criticism: The role of perceived criticism. Hum Brain Mapp. 2018 Jun 28;: Authors: Baeken C, Dedoncker J, Remue J, Wu GR, Vanderhasselt MA, De Witte S, Poppa T, Hooley JM, De Raedt R Abstract Transcranial direct current stimulation (tDCS) is a potential treatment strategy for mood and anxiety disorders, but how this application may influence emotional processes, and whether this is related to individual characteristics, is not well understood. It has been proposed that perceived criticism (PC) may represent a vulnerability factor for the development of such ... read more
    PubMed Transcranial Direct Current Stimulation
  • The effect of transcranial direct current stimulation (tDCS) on locomotion and balance in patients with chronic stroke: study protocol for a randomised controlled trial.
    Related ArticlesThe effect of transcranial direct current stimulation (tDCS) on locomotion and balance in patients with chronic stroke: study protocol for a randomised controlled trial. Trials. 2017 Oct 23;18(1):492 Authors: Geiger M, Supiot A, Zory R, Aegerter P, Pradon D, Roche N Abstract BACKGROUND: Following stroke, patients are often left with hemiparesis that reduces balance and gait capacity. A recent, non-invasive technique, transcranial direct current stimulation, can be used to modify cortical excitability when used in an anodal configuration. It also increases the excitability of spinal neuronal circuits involved in movement in healthy subjects. Many studies in patients ... read more
    PubMed Transcranial Direct Current Stimulation
  • Effects of neuromodulation on cognitive performance in individuals exhibiting addictive behaviour: a systematic review protocol.
    Related ArticlesEffects of neuromodulation on cognitive performance in individuals exhibiting addictive behaviour: a systematic review protocol. Syst Rev. 2018 Jun 26;7(1):90 Authors: Naish KR, Vedelago L, MacKillop J, Amlung M Abstract BACKGROUND: Individuals with substance use and addictive disorders often display greater risk-taking behaviour, higher impulsivity, and altered reward processing compared to individuals without these disorders. While it is not known whether cognitive biases precede or result from addictive behaviour, they likely influence addiction-related decision-making, and may facilitate pathological behaviour. There is evidence that cognitive functions-including those shown to be altered in substance use and addictive disorders-can be influenced by neuromodulation techniques ... read more
    PubMed Transcranial Direct Current Stimulation
  • Effects of single versus dual-site High-Definition transcranial direct current stimulation (HD-tDCS) on cortical reactivity and working memory performance in healthy subjects.
    Related ArticlesEffects of single versus dual-site High-Definition transcranial direct current stimulation (HD-tDCS) on cortical reactivity and working memory performance in healthy subjects. Brain Stimul. 2018 Jun 18;: Authors: Hill AT, Rogasch NC, Fitzgerald PB, Hoy KE Abstract BACKGROUND: Previous research has typically focussed on the neuromodulatory effects of direct currents applied over single regions of the cortex. However, complex processes such as working memory (WM) strongly rely on activations across a wider neural network and therefore might benefit from stimulation administered over multiple cortical targets. OBJECTIVE: We examined the neurobiological and cognitive effects of High-Definition transcranial direct current stimulation (HD-tDCS) ... read more
    PubMed Transcranial Direct Current Stimulation
  • Anodal transcranial direct current stimulation affects auditory cortex plasticity in normal-hearing and noise-exposed rats.
    Related ArticlesAnodal transcranial direct current stimulation affects auditory cortex plasticity in normal-hearing and noise-exposed rats. Brain Stimul. 2018 May 31;: Authors: Paciello F, Podda MV, Rolesi R, Cocco S, Petrosini L, Troiani D, Fetoni AR, Paludetti G, Grassi C Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive tool capable to modulate cortical functions by affecting neuronal excitability and synaptic plasticity. OBJECTIVE: Here we investigated the effects of anodal tDCS on auditory cortex (ACx) in normal-hearing rats and following a paradigm of noise-induced hearing loss (NIHL), that causes morphological alterations in ACx pyramidal neurons. METHODS: Male rats exposed to ... read more
    PubMed Transcranial Direct Current Stimulation
  • Augmentation of Fear Extinction by Transcranial Direct Current Stimulation (tDCS).
    Related ArticlesAugmentation of Fear Extinction by Transcranial Direct Current Stimulation (tDCS). Front Behav Neurosci. 2018;12:76 Authors: Dittert N, Hüttner S, Polak T, Herrmann MJ Abstract Although posttraumatic stress disorder (PTSD; DSM-V 309.82) and anxiety disorders (DSM-V 300.xx) are widely spread mental disorders, the effectiveness of their therapy is still unsatisfying. Non-invasive brain-stimulation techniques like transcranial direct current stimulation (tDCS) might be an option to improve extinction learning, which is a main functional factor of exposure-based therapy for anxiety disorders. To examine this hypothesis, we used a fear conditioning paradigm with female faces as conditioned stimuli (CS) and a 95-dB female ... read more
    PubMed Transcranial Direct Current Stimulation