Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • Anti-repulsive guidance molecule-a antibody treatment and repetitive transcranial magnetic stimulation have synergistic effects on motor recovery after spinal cord injury.
    Related ArticlesAnti-repulsive guidance molecule-a antibody treatment and repetitive transcranial magnetic stimulation have synergistic effects on motor recovery after spinal cord injury. Neurosci Lett. 2019 09 14;709:134329 Authors: Nakanishi T, Fujita Y, Tanaka T, Yamashita T Abstract Damaged axons in the adult central nervous system (CNS) fail to regenerate spontaneously due to several intrinsic and extrinsic factors that inhibit axon elongation. An extrinsic inhibitory factor, repulsive guidance molecule-a (RGMa), is upregulated around spinal cord lesion sites. Inhibition of RGMa using an antibody promotes axon sprouting, regeneration, and motor recovery after spinal cord injury (SCI) in rodents and primates. Repetitive transcranial ... read more
    2 hours ago
  • The effects of transcranial direct current stimulation (tDCS) on clinical symptoms in schizophrenia: A systematic review and meta-analysis.
    Related ArticlesThe effects of transcranial direct current stimulation (tDCS) on clinical symptoms in schizophrenia: A systematic review and meta-analysis. Asian J Psychiatr. 2020 Sep 05;53:102392 Authors: Cheng PWC, Louie LLC, Wong YL, Wong SMC, Leung WY, Michael AN, Chan WC Abstract OBJECTIVE: This systematic review and meta-analysis aims to examine the effects of transcranial direct current stimulation (tDCS) on clinical symptoms in schizophrenia. METHODS: A literature search was performed for articles published in English using the following databases: MEDLINE, EMBASE, PsycINFO, INSPEC, the Cumulative Index to Nursing & Allied Health Literature Plus (CINAHL Plus), AMED, Cochrane Central Register of Controlled ... read more
    3 days ago
  • A feasibility study of application and potential effects of a single session transcranial Direct Current Stimulation (tDCS) on competitive anxiety, mood state, salivary levels of cortisol and alpha amylase in elite athletes under a real-world competition.
    Related ArticlesA feasibility study of application and potential effects of a single session transcranial Direct Current Stimulation (tDCS) on competitive anxiety, mood state, salivary levels of cortisol and alpha amylase in elite athletes under a real-world competition. Physiol Behav. 2020 Sep 18;:113173 Authors: Mehrsafar AH, Rosa MAS, Zadeh AM, Gazerani P Abstract OBJECTIVE: To examine feasibility and potential effects of a single session tDCS over the dorsolateral prefrontal cortex (DLPFC) on competitive anxiety, mood state, and autonomic and endocrine stress responses in elite archer athletes under a real world competition. METHODS: Twelve male elite archers volunteered to participate in this ... read more
    3 days ago
  • Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD.
    Related ArticlesTherapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD. Elife. 2020 Sep 21;9: Authors: Jung DH, Ahn SM, Pak ME, Lee HJ, Jung YJ, Kim K, Shin YI, Shin HK, Choi BT Abstract Most therapeutic candidates for treating attention deficit hyperactivity disorder (ADHD) have focused on modulating the dopaminergic neurotransmission system with neurotrophic factors. Regulation of this system by transcranial direct current stimulation (tDCS) could contribute to the recovery of cognitive symptoms observed in patients with ADHD. Here, male spontaneously hypertensive (SHR) rats were subjected to consecutive high-definition tDCS (HD-tDCS) (20 min, 50 μA, ... read more
    3 days ago
  • Transcending the brain: is there a cost to hacking the nervous system?
    Related ArticlesTranscending the brain: is there a cost to hacking the nervous system? Brain Commun. 2019;1(1):fcz015 Authors: Khan S, Aziz T Abstract Great advancements have recently been made to understand the brain and the potential that we can extract out of it. Much of this has been centred on modifying electrical activity of the nervous system for improved physical and cognitive performance in those with clinical impairment. However, there is a risk of going beyond purely physiological performance improvements and striving for human enhancement beyond traditional human limits. Simple ethical guidelines and legal doctrine must be examined to keep ahead ... read more
    3 days ago
  • Age-related differences of motor cortex plasticity in adults: a transcranial direct current stimulation study.
    Related ArticlesAge-related differences of motor cortex plasticity in adults: a transcranial direct current stimulation study. Brain Stimul. 2020 Sep 16;: Authors: Ghasemian-Shirvan E, Farnad L, Mosayebi-Samani M, Verstraelen S, Meesen RLJ, Kuo MF, Nitsche MA Abstract BACKGROUND: Cognitive, and motor performance are reduced in aging, especially with respect to acquisition of new knowledge, which is associated with a neural plasticity decline. Animal models show a reduction of long-term potentiation, but not long-term depression, in higher age. Findings in humans are more heterogeneous, with some studies showing respective deficits, but others not, or mixed results, for plasticity induced by non-invasive brain ... read more
    5 days ago
  • Transcranial Direct Current Stimulation (tDCS) Improves Back-Squat Performance in Intermediate Resistance-Training Men.
    Related ArticlesTranscranial Direct Current Stimulation (tDCS) Improves Back-Squat Performance in Intermediate Resistance-Training Men. Res Q Exerc Sport. 2020 Sep 15;:1-9 Authors: Vieira LAF, Lattari E, de Jesus Abreu MA, Rodrigues GM, Viana B, Machado S, Oliveira BRR, Maranhão Neto GA Abstract Purpose: The purpose of this study was to evaluate the effects of anodal tDCS applied over the dorsolateral prefrontal cortex (DLPFC) on muscle endurance in the back-squat exercise. Methods: Eleven healthy males, intermediate in resistance training (RT), aged between 18 and 31 years (25.5 ± 4.4 years) were recruited. In the initial visits (1st and 2nd visits), participants performed a 1RM test ... read more
    1 week ago
  • Treatments for Self-Injurious Thoughts and Behaviors in Youth: Progress and Challenges.
    Treatments for Self-Injurious Thoughts and Behaviors in Youth: Progress and Challenges. Evid Based Pract Child Adolesc Ment Health. 2020;5(3):354-364 Authors: Bettis AH, Liu RT, Walsh BW, Klonsky ED Abstract Self-injurious thoughts and behaviors (SITBs) remain a common clinical problem in youth. This article reviews the state of knowledge regarding psychosocial treatments for SITBs in youth. Broadly speaking, psychosocial treatments that incorporate parents/family and that emphasize skills development (including emotion regulation and interpersonal skills) appear to produce the best outcomes. We also describe several challenges to the implementation of evidence-based psychotherapy, as well as potential solutions to these challenges, and provide ... read more
    1 week ago
  • Transcranial direct current stimulation accelerates the onset of exercise-induced hypoalgesia: a randomised controlled study.
    Transcranial direct current stimulation accelerates the onset of exercise-induced hypoalgesia: a randomised controlled study. J Pain. 2020 Sep 11;: Authors: Borovskis J, Cavaleri R, Blackstock F, Summers SJ Abstract Exercise-induced hypoalgesia (EIH) describes acute reductions in pain that occur following exercise. Current evidence suggests that the magnitude of EIH is small-to-moderate at best, warranting exploration of novel avenues to bolster these effects. Transcranial direct current stimulation (tDCS) has been shown to relieve pain and represents a promising intervention that may enhance EIH. This study aimed to determine whether anodal tDCS of the primary motor cortex (M1) can augment EIH in ... read more
    1 week ago
  • Entrainment of Cerebellar Purkinje Cells with Directional AC Electric Fields in Anesthetized Rats.
    Entrainment of Cerebellar Purkinje Cells with Directional AC Electric Fields in Anesthetized Rats. Brain Stimul. 2020 Sep 09;: Authors: Asan AS, Lang EJ, Sahin M Abstract BACKGROUND: Transcranial electrical stimulation (tES) shows promise to treat neurological disorders. Knowledge of how the orthogonal components of the electric field (E-field) alter neuronal activity is required for strategic placement of transcranial electrodes. Yet, essentially no information exists on this relationship for mammalian cerebellum in vivo, despite the cerebellum being a target for clinical tES studies. OBJECTIVE: /Hypothesis: To characterize how cerebellar Purkinje cell (PC) activity varies with the intensity, frequency, and direction of ... read more
    2 weeks ago
  • Beneficial effects of cerebellar tDCS on motor learning are associated with altered putamen-cerebellar connectivity: a simultaneous tDCS-fMRI study.
    Beneficial effects of cerebellar tDCS on motor learning are associated with altered putamen-cerebellar connectivity: a simultaneous tDCS-fMRI study. Neuroimage. 2020 Sep 09;:117363 Authors: Liebrand M, Karabanov A, Antonenko D, Flöel A, Siebner HR, Classen J, Krämer UM, Tzvi E Abstract Non-invasive transcranial stimulation of cerebellum and primary motor cortex (M1) has been shown to enhance motor learning. However, the mechanisms by which stimulation improves learning remain largely unknown. Here, we sought to shed light on the neural correlates of transcranial direct current stimulation (tDCS) during motor learning by simultaneously recording functional magnetic resonance imaging (fMRI). We found that right cerebellar ... read more
    2 weeks ago
  • A Review on the Role of the Neuroscience of Flow States in the Modern World.
    A Review on the Role of the Neuroscience of Flow States in the Modern World. Behav Sci (Basel). 2020 Sep 09;10(9): Authors: Gold J, Ciorciari J Abstract Flow states have been shown to help people reach peak performance, yet this elusive state is not easily attained. The review describes the current state of literature on flow by addressing the environmental influences as well as the cognitive and neurocognitive elements that underlie the experience. In particular, the research focusses on the transition of cognitive control from an explicit to an implicit process. This is further expanded upon to look at the ... read more
    2 weeks ago
  • Randomized clinical trial comparing of transcranial direct current stimulation (tDCS) and transcutaneous electrical nerve stimulation (TENS) in knee osteoarthritis.
    Randomized clinical trial comparing of transcranial direct current stimulation (tDCS) and transcutaneous electrical nerve stimulation (TENS) in knee osteoarthritis. Neurophysiol Clin. 2020 Sep 07;: Authors: Sajadi S, Karimi M, Forogh B, Raissi GR, Zarnegar F, Ahadi T Abstract BACKGROUND: Due to the limitations of pharmacological and surgical management of knee osteoarthritis (OA), several non-pharmacologic approaches including transcutaneous electrical nerve stimulation (TENS) and transcranial direct current stimulation (tDCS) have been introduced, with promising results. OBJECTIVE: We aimed to investigate and compare the therapeutic effects of TENS and tDCS for the treatment of patients with knee OA. METHODS: In this double-blinded randomized ... read more
    2 weeks ago
  • Therapeutic Effects of Diagonal-Transcranial Direct Current Stimulation on Functional Recovery in Acute Stroke: A Pilot Study.
    Therapeutic Effects of Diagonal-Transcranial Direct Current Stimulation on Functional Recovery in Acute Stroke: A Pilot Study. J Stroke Cerebrovasc Dis. 2020 Oct;29(10):105107 Authors: Shibata T, Urata A, Kawahara K, Furuya K, Ishikuro K, Hattori N, Kuroda S Abstract BACKGROUND: Peak neurologic recovery from acute stroke occurs within the first 3 months, and continues at a slower pace for 6 months. OBJECTIVE/HYPOTHESIS: The aim of this pilot study is to clarify the safety and feasibility of multiple diagonal-transcranial direct current stimulation (d-tDCS) sessions up to 3 months with electrodes placed diagonally over the lesional dorsolateral prefrontal cortex and contralesional primary motor ... read more
    2 weeks ago
  • Corrigendum: Does Transcranial Direct Current Stimulation (tDCS) Improve Disgust Regulation Through Imagery Rescripting?
    Corrigendum: Does Transcranial Direct Current Stimulation (tDCS) Improve Disgust Regulation Through Imagery Rescripting? Front Hum Neurosci. 2020;14:263 Authors: Fink J, Exner C Abstract [This corrects the article DOI: 10.3389/fnhum.2019.00192.].PMID: 32903601 [PubMed - as supplied by publisher] ... read more
    2 weeks ago
  • Functional Near-Infrared Spectroscopy to Assess Central Pain Responses in a Nonpharmacologic Treatment Trial of Osteoarthritis.
    Related ArticlesFunctional Near-Infrared Spectroscopy to Assess Central Pain Responses in a Nonpharmacologic Treatment Trial of Osteoarthritis. J Neuroimaging. 2020 Sep 08;: Authors: Pollonini L, Montero-Hernandez S, Park L, Miao H, Mathis K, Ahn H Abstract BACKGROUND AND PURPOSE: Knee osteoarthritis (OA) is a common source of pain in older adults. Although OA-induced pain can be relieved with analgesics and anti-inflammatory drugs, the current opioid epidemic is fostering the exploration of nonpharmacologic strategies for pain mitigation. Amongs these, transcranial direct current stimulation (tDCS) and mindfulness-based meditation (MBM) hold potential for pain-relief efficacy due to their neuromodulatory effects of the central nervous ... read more
    2 weeks ago
  • Transcranial direct current stimulation: a novel approach in the treatment of vascular depression.
    Related ArticlesTranscranial direct current stimulation: a novel approach in the treatment of vascular depression. Brain Stimul. 2020 Sep 04;: Authors: Zanardi R, Poletti S, Prestifilippo D, Attanasio F, Barbini B, Colombo C Abstract BACKGROUND: Despite the impact of depression in terms of personal suffering and socioeconomic burden, most currently available treatment options are often ineffective. A particularly difficult-to-treat depressive disorder characteristic of the elderly is vascular depression, a late-life depressive syndrome related to a variety of potential vascular mechanisms. Transcranial Direct Current Stimulation (tDCS), a non-invasive and effective somatic approach to depression, has also been shown positive effect on cognitive ... read more
    2 weeks ago
  • Tolerance of transcranial direct current stimulation in psychiatric disorders: An analysis of 2000+ sessions.
    Related ArticlesTolerance of transcranial direct current stimulation in psychiatric disorders: An analysis of 2000+ sessions. Psychiatry Res. 2020 02;284:112744 Authors: Chhabra H, Bose A, Shivakumar V, Agarwal SM, Sreeraj VS, Shenoy S, Hazari N, Dinakaran D, Parlikar R, Koparde V, Ramesh V, Biswal J, Murugaraja V, Gowda SM, Chand PK, Sivakumar PT, Kalmady SV, Narayanaswamy JC, Murthy P, Girimaji SC, Venkatasubramanian G Abstract Transcranial direct current stimulation (tDCS), a non-invasive, neuromodulatory technique, is being increasingly applied to several psychiatric disorders. In this study, we describe the side-effect profile of repeated tDCS sessions (N = 2005) that were administered to 171 patients ... read more
    2 weeks ago
  • Using non-invasive transcranial direct current stimulation for neglect and associated attentional deficits following stroke.
    Related ArticlesUsing non-invasive transcranial direct current stimulation for neglect and associated attentional deficits following stroke. Neuropsychol Rehabil. 2020 Sep 07;:1-32 Authors: Olgiati E, Malhotra PA Abstract Neglect is a disabling neuropsychological syndrome that is frequently observed following right-hemispheric stroke. Affected individuals often present with multiple attentional deficits, ranging from reduced orienting towards contralesional space to a generalized impairment in maintaining attention over time. Although a degree of spontaneous recovery occurs in most patients, in some individuals this condition can be treatment-resistant with prominent ongoing non-spatial deficits. Further, there is a large inter-individual variability in response to different therapeutic approaches. Given ... read more
    2 weeks ago
  • Network-level mechanisms underlying effects of transcranial direct current stimulation (tDCS) on visuomotor learning.
    Related ArticlesNetwork-level mechanisms underlying effects of transcranial direct current stimulation (tDCS) on visuomotor learning. Neuroimage. 2020 Sep 01;:117311 Authors: Sehatpour P, Donde C, Hoptman MJ, Kreither J, Adair D, Dias E, Vail B, Rohrig S, Silipo G, Lopez-Calderon J, Martinez A, Javitt DC Abstract Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation approach in which low level currents are administered over the scalp to influence underlying brain function. Prevailing theories of tDCS focus on modulation of excitation-inhibition balance at the local stimulation location. However, network level effects are reported as well, and appear to depend upon differential underlying ... read more
    3 weeks ago
  • Methods and strategies of tDCS for the treatment of pain: current status and future directions.
    Related ArticlesMethods and strategies of tDCS for the treatment of pain: current status and future directions. Expert Rev Med Devices. 2020 Aug 26;: Authors: Pacheco-Barrios K, Cardenas-Rojas A, Thibaut A, Costa B, Ferreira I, Caumo W, Fregni F Abstract INTRODUCTION: Transcranial Direct Current Stimulation (tDCS) is a non-invasive neuromodulation technique which has been widely studied for the treatment of chronic pain. It is considered a promising and safe alternative pain therapy. Different targets have been tested, each having their own particular mechanisms for modulating pain perception. AREAS COVERED: We discuss the current state of the art of tDCS to manage ... read more
    4 weeks ago
  • Neurostimulation and Reach-to-Grasp Function Recovery Following Acquired Brain Injury: Insight From Pre-clinical Rodent Models and Human Applications.
    Related ArticlesNeurostimulation and Reach-to-Grasp Function Recovery Following Acquired Brain Injury: Insight From Pre-clinical Rodent Models and Human Applications. Front Neurol. 2020;11:835 Authors: Latchoumane CV, Barany DA, Karumbaiah L, Singh T Abstract Reach-to-grasp is an evolutionarily conserved motor function that is adversely impacted following stroke and traumatic brain injury (TBI). Non-invasive brain stimulation (NIBS) methods, such as transcranial magnetic stimulation and transcranial direct current stimulation, are promising tools that could enhance functional recovery of reach-to-grasp post-brain injury. Though the rodent literature provides a causal understanding of post-injury recovery mechanisms, it has had a limited impact on NIBS protocols in human research. ... read more
    4 weeks ago
  • Epileptic Seizure Detection and Experimental Treatment: A Review.
    Related ArticlesEpileptic Seizure Detection and Experimental Treatment: A Review. Front Neurol. 2020;11:701 Authors: Kim T, Nguyen P, Pham N, Bui N, Truong H, Ha S, Vu T Abstract One-fourths of the patients have medication-resistant seizures and require seizure detection and treatment continuously to cope with sudden seizures. Seizures can be detected by monitoring the brain and muscle activities, heart rate, oxygen level, artificial sounds, or visual signatures through EEG, EMG, ECG, motion, or audio/video recording on the human head and body. In this article, we first discuss recent advances in seizure sensing, signal processing, time- or frequency-domain analysis, and classification ... read more
    4 weeks ago
  • Effect of non-invasive brain stimulation on neuropathic pain following spinal cord injury: A systematic review and meta-analysis.
    Related ArticlesEffect of non-invasive brain stimulation on neuropathic pain following spinal cord injury: A systematic review and meta-analysis. Medicine (Baltimore). 2020 Aug 21;99(34):e21507 Authors: Shen Z, Li Z, Ke J, He C, Liu Z, Zhang D, Zhang Z, Li A, Yang S, Li X, Li R, Zhao K, Ruan Q, Du H, Guo L, Yin F Abstract BACKGROUND: In recent years, some studies indicated that repetitive transcranial magnetic stimulation (rTMS) could relieve neuropathic pain (NP) following a spinal cord injury (SCI), whereas some studies showed no pain relief effect. In addition, some studies showed the analgesic effect of transcranial direct ... read more
    4 weeks ago
  • Transcranial Direct Current Stimulation (tDCS) Induces Analgesia in Rats with Neuropathic Pain and Alcohol Abstinence.
    Related ArticlesTranscranial Direct Current Stimulation (tDCS) Induces Analgesia in Rats with Neuropathic Pain and Alcohol Abstinence. Neurochem Res. 2020 Aug 25;: Authors: Santos DS, Lopes BC, Medeiros LF, Assumpção JAF, de Souza A, Salvi AA, da Silva LS, Fregni F, Caumo W, Torres ILS Abstract Neuromodulatory techniques have been studied to treat drug addiction or compulsive eating as well as different chronic pain conditions, such as neuropathic and inflammatory pain in the clinical and preclinical settings. In this study, we aimed to investigate the effect of transcranial direct current stimulation (tDCS) on the association of alcohol withdrawal with neuropathic pain ... read more
    1 month ago