Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • Can Anodal Transcranial Direct Current Stimulation Increase Steady-State Visual Evoked Potential Responses?
    Related ArticlesCan Anodal Transcranial Direct Current Stimulation Increase Steady-State Visual Evoked Potential Responses? J Korean Med Sci. 2019 Nov 11;34(43):e285 Authors: Kim DW, Kim E, Lee C, Im CH Abstract BACKGROUND: It has been frequently reported that non-negligible numbers of individuals have steady-state visual evoked potential (SSVEP) responses of low signal-to-noise-ratio (SNR) to specific stimulation frequencies, which makes detection of the SSVEP difficult especially in brain-computer interface applications. We investigated whether SSVEP can be modulated by anodal transcranial direct-current stimulation (tDCS) of the visual cortex. METHODS: Each participant participated in two 20-min experiments-an actual tDCS experiment and a sham tDCS ... read more
    4 days ago
  • Effects of Bihemispheric Transcranial Direct Current Stimulation on Upper Extremity Function in Stroke Patients: A randomized Double-Blind Sham-Controlled Study.
    Related ArticlesEffects of Bihemispheric Transcranial Direct Current Stimulation on Upper Extremity Function in Stroke Patients: A randomized Double-Blind Sham-Controlled Study. J Stroke Cerebrovasc Dis. 2019 Nov 04;:104454 Authors: Alisar DC, Ozen S, Sozay S Abstract BACKGROUND AND PURPOSE: Transcranial direct current stimulation (tDCS) is a treatment used in the rehabilitation of stroke patients aiming to improve functionality of the plegic upper extremity. Currently, tDCS is not routinely used in post stroke rehabilitation. The aim of this study was to establish the effects of bihemspheric tDCS combined with physical therapy (PT) and occupational therapy (OT) on upper extremity motor function. METHODS: ... read more
    4 days ago
  • Offline effects of transcranial direct current stimulation on reaction times of lower extremity movements in people after stroke: a pilot cross-over study.
    Related ArticlesOffline effects of transcranial direct current stimulation on reaction times of lower extremity movements in people after stroke: a pilot cross-over study. J Neuroeng Rehabil. 2019 Nov 07;16(1):136 Authors: Coppens MJM, Staring WHA, Nonnekes J, Geurts ACH, Weerdesteyn V Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that has shown promise for rehabilitation after stroke. Ipsilesional anodal tDCS (a-tDCS) over the motor cortex increases corticospinal excitability, while contralesional cathodal tDCS (c-tDCS) restores interhemispheric balance, both resulting in offline improved reaction times of delayed voluntary upper-extremity movements. We aimed to investigate whether tDCS would also ... read more
    4 days ago
  • Optimization of an optrode microdevice for infrared neural stimulation.
    Related ArticlesOptimization of an optrode microdevice for infrared neural stimulation. Appl Opt. 2019 May 10;58(14):3870-3876 Authors: Boros ÖC, Horváth ÁC, Beleznai S, Sepsi Ö, Csősz D, Fekete Z, Koppa P Abstract Infrared light is a promising candidate for the treatment of neurodegenerative diseases. Optimizing the device parameters to achieve the best optical and mechanical performance is essential for reliable in vivo operation. In this work, mechanical strength simulations and coupled optical and thermal model were used to determine optimal design parameters for maximizing overall device efficiency. Our analysis reveals that minimizing the number of integrated optical elements and optimizing the ... read more
    4 days ago
  • A comparison between threshold criterion and amplitude criterion in transcranial motor evoked potentials during surgery for supratentorial lesions.
    Related ArticlesA comparison between threshold criterion and amplitude criterion in transcranial motor evoked potentials during surgery for supratentorial lesions. J Neurosurg. 2018 09 07;131(3):740-749 Authors: Abboud T, Schwarz C, Westphal M, Martens T Abstract OBJECTIVE: The aim of this study was to compare sensitivity and specificity between the novel threshold and amplitude criteria for motor evoked potentials (MEPs) monitoring after transcranial electrical stimulation (TES) during surgery for supratentorial lesions in the same patient cohort. METHODS: One hundred twenty-six patients were included. All procedures were performed under general anesthesia. Craniotomies did not expose motor cortex, so that direct mapping was less ... read more
    4 days ago
  • Enhanced tES and tDCS computational models by meninges emulation.
    Related ArticlesEnhanced tES and tDCS computational models by meninges emulation. J Neural Eng. 2019 Nov 05;: Authors: Jiang J, Truong DQ, Esmaeilpour Z, Huang Y, Badran BW, Bikson M Abstract OBJECTIVE: Understanding how current reaches the brain during transcranial Electrical Stimulation (tES) underpins efforts to rationalize outcomes and optimize interventions. To this end, computational models of current flow relate applied dose to brain electric field. Conventional tES modeling considers distinct tissues like scalp, skull, cerebrospinal fluid (CSF), gray matter and white matter. The properties of highly conductive CSF are especially important. However, modeling the space between skull and brain as ... read more
    6 days ago
  • Direct current stimulation boosts hebbian plasticity in┬ávitro.
    Related ArticlesDirect current stimulation boosts hebbian plasticity in vitro. Brain Stimul. 2019 Oct 18;: Authors: Kronberg G, Rahman A, Sharma M, Bikson M, Parra LC Abstract BACKGROUND: There is evidence that transcranial direct current stimulation (tDCS) can improve learning performance. Arguably, this effect is related to long term potentiation (LTP), but the precise biophysical mechanisms remain unknown. HYPOTHESIS: We propose that direct current stimulation (DCS) causes small changes in postsynaptic membrane potential during ongoing endogenous synaptic activity. The altered voltage dynamics in the postsynaptic neuron then modify synaptic strength via the machinery of endogenous voltage-dependent Hebbian plasticity. This hypothesis predicts that ... read more
    2 weeks ago
  • The impact of targeted cathodal transcranial direct current stimulation on reward circuitry and affect in Bipolar Disorder.
    Related ArticlesThe impact of targeted cathodal transcranial direct current stimulation on reward circuitry and affect in Bipolar Disorder. Mol Psychiatry. 2019 Oct 29;: Authors: Bertocci MA, Chase HW, Graur S, Stiffler R, Edmiston EK, Coffman BA, Greenberg BD, Phillips ML Abstract Bipolar Disorder is costly and debilitating, and many treatments have side effects. Transcranial Direct Current Stimulation (tDCS) is a well-tolerated neuromodulation technique that may be a useful treatment for Bipolar Disorder if targeted to neural regions implicated in the disorder. One potential region is the left ventrolateral prefrontal cortex (vlPFC), which shows abnormally elevated activity during reward expectancy in ... read more
    2 weeks ago
  • Multi-Session Anodal Prefrontal Transcranial Direct Current Stimulation does not Improve Executive Functions among Older Adults.
    Related ArticlesMulti-Session Anodal Prefrontal Transcranial Direct Current Stimulation does not Improve Executive Functions among Older Adults. J Int Neuropsychol Soc. 2019 Oct 29;:1-10 Authors: Yu J, Lam CLM, Man ISC, Shao R, Lee TMC Abstract OBJECTIVE: Findings from single-session online studies highlighted the potential of using anodal prefrontal transcranial direct current stimulation (tDCS) to enhance executive functions (EF) in the context of aging. However, tDCS must be executed as a multi-session offline intervention to ascertain its viability in this context. Relatedly, findings from multi-session studies remained inconclusive. To this end, we examined the effects of multi-session anodal prefrontal tDCS on ... read more
    2 weeks ago
  • Interventional psychiatry in the management of behavioural and psychological symptoms of dementia: a qualitative review.
    Related ArticlesInterventional psychiatry in the management of behavioural and psychological symptoms of dementia: a qualitative review. Swiss Med Wkly. 2019 Oct 21;149:w20140 Authors: Swierkosz-Lenart K, Mall JF, von Gunten A Abstract INTRODUCTION: “Behavioural and psychological symptoms of dementia” (BPSD) refers to a heterogeneous group of clinical manifestations related to dementia, including apathy, depression, anxiety, delusions, hallucinations, sexual or social disinhibition, sleep-wake cycle disturbances, aggression, agitation and other behaviours considered inappropriate. Because of the complexity and heterogeneity of BPSD, as well as the fragility and multimorbidity of the elderly, pharmacological treatment appears to be limited in terms of safety and efficacy, ... read more
    2 weeks ago
  • Cervical trans-spinal direct current stimulation: a modelling-experimental approach.
    Related ArticlesCervical trans-spinal direct current stimulation: a modelling-experimental approach. J Neuroeng Rehabil. 2019 Oct 25;16(1):123 Authors: Fernandes SR, Pereira M, Salvador R, Miranda PC, de Carvalho M Abstract BACKGROUND: Trans-spinal direct current stimulation (tsDCS) is a non-invasive technique with promising neuromodulatory effects on spinal cord (SC) circuitry. Computational studies are essential to guide effective tsDCS protocols for specific clinical applications. This study aims to combine modelling and experimental studies to determine the electrode montage that maximizes electric field (E-field) delivery during cervical tsDCS. METHODS: Current and E-field distributions in the cervical SC were predicted for four electrode montages in a ... read more
    2 weeks ago
  • ROAST: An Open-Source, Fully-Automated, Realistic Volumetric-Approach-Based Simulator For TES.
    Related ArticlesROAST: An Open-Source, Fully-Automated, Realistic Volumetric-Approach-Based Simulator For TES. Conf Proc IEEE Eng Med Biol Soc. 2018 07;2018:3072-3075 Authors: Huang Y, Datta A, Bikson M, Parra LC Abstract Research in the area of transcranial electrical stimulation (TES) often relies on computational models of current flow in the brain. Models are built on magnetic resonance images (MRI) of the human head to capture detailed individual anatomy. To simulate current flow, MRIs have to be segmented, virtual electrodes have to be placed on the scalp, the volume is tessellated into a mesh, and the finite element model is solved numerically ... read more
    3 weeks ago
  • Neurostimulation methods in the treatment of chronic pain.
    Related ArticlesNeurostimulation methods in the treatment of chronic pain. J Neural Transm (Vienna). 2019 Oct 21;: Authors: Moisset X, Lanteri-Minet M, Fontaine D Abstract The goal of this narrative review was to give an up-to-date overview of the peripheral and central neurostimulation methods that can be used to treat chronic pain. Special focus has been given to three pain conditions: neuropathic pain, nociplastic pain and primary headaches. Both non-invasive and invasive techniques are briefly presented together with their pain relief potentials. For non-invasive stimulation techniques, data concerning transcutaneous electrical nerve stimulation (TENS), transcranial direct current stimulation (tDCS), repetitive transcranial magnetic ... read more
    3 weeks ago
  • The Effect of Cerebellar Transcranial Direct Current Stimulation on Motor Learning: A Systematic Review of Randomized Controlled Trials.
    Related ArticlesThe Effect of Cerebellar Transcranial Direct Current Stimulation on Motor Learning: A Systematic Review of Randomized Controlled Trials. Front Hum Neurosci. 2019;13:328 Authors: Kumari N, Taylor D, Signal N Abstract Background: Cerebellar transcranial direct current stimulation (ctDCS) appears to modulate motor performance in both adaptation and motor skill tasks; however, whether the gains are long-lasting is unclear. Objectives: This systematic review aims to evaluate the effect of ctDCS with respect to different time scales of motor learning. Methods: Ten electronic databases (CINAHL, MEDLINE, SPORT Discus, Scopus, Web of Science, Cochrane via OVID, Evidence-Based Reviews (EBM) via OVID, AMED: Allied ... read more
    3 weeks ago
  • Paradoxical, causal effects of sensory gain modulation on motor inhibitory control – a tDCS, EEG-source localization study.
    Related ArticlesParadoxical, causal effects of sensory gain modulation on motor inhibitory control - a tDCS, EEG-source localization study. Sci Rep. 2018 11 30;8(1):17486 Authors: Friedrich J, Beste C Abstract Response inhibition is a key component of executive functioning, but the role of perceptual processes has only recently been focused. Although the interrelation of incoming information and resulting behavioural (motor) effects is well-known to depend on gain control mechanisms, the causal role of sensory gain modulation for response inhibition is elusive. We investigate it using a somatosensory response inhibition (Go/Nogo) task and examine the effects of parietal (somatosensory) cathodal ... read more
    3 weeks ago
  • Anhedonia across borders: Transdiagnostic relevance of reward dysfunction for noninvasive brain stimulation endophenotypes.
    Related ArticlesAnhedonia across borders: Transdiagnostic relevance of reward dysfunction for noninvasive brain stimulation endophenotypes. CNS Neurosci Ther. 2019 Oct 22;: Authors: Spano MC, Lorusso M, Pettorruso M, Zoratto F, Di Giuda D, Martinotti G, di Giannantonio M Abstract INTRODUCTION: Anhedonia is a transdiagnostic psychopathological dimension, consisting in the impaired ability to experience pleasure. In order to further our understanding of its neural correlates and to explore its potential relevance as a predictor of treatment response, in this article we systematically reviewed studies involving anhedonia and neuromodulation interventions, across different disorders. METHODS: We included seven studies fulfilling inclusion/exclusion criteria and involving ... read more
    3 weeks ago
  • Effects of transcranial direct current stimulation on patients with disorders of consciousness after traumatic brain injury: study protocol for a randomized, double-blind controlled trial.
    Related ArticlesEffects of transcranial direct current stimulation on patients with disorders of consciousness after traumatic brain injury: study protocol for a randomized, double-blind controlled trial. Trials. 2019 Oct 17;20(1):596 Authors: Li S, Dong X, Sun W, Zhao N, Yu G, Shuai L Abstract BACKGROUND: Disorders of consciousness (DOC) after traumatic brain injury (TBI) raise the mortality of patients, restrict the rehabilitation of patients with TBI, and increase the physical and economic burden that TBI imposes on patients and their families. Thus, treatment to promote early awakening in DOC after TBI is of vital importance. Various treatments have been reported, but ... read more
    4 weeks ago
  • Effects of Transcranial Direct Current Stimulation on Apraxia of Speech and Cortical Activation in Patients With Stroke: A Randomized Sham-Controlled Study.
    Related ArticlesEffects of Transcranial Direct Current Stimulation on Apraxia of Speech and Cortical Activation in Patients With Stroke: A Randomized Sham-Controlled Study. Am J Speech Lang Pathol. 2019 Oct 17;:1-13 Authors: Wang J, Wu D, Cheng Y, Song W, Yuan Y, Zhang X, Zhang D, Zhang T, Wang Z, Tang J, Yin L Abstract Purpose The study aims to investigate, using anodal transcranial direct current stimulation (A-tDCS), over which site, the left lip region of primary motor cortex (M1) or the Broca's area, there would be better recovery from apraxia of speech (AoS) in patients with poststroke aphasia and to ... read more
    4 weeks ago
  • Improving emotion regulation of social exclusion in depression-prone individuals: a tDCS study targeting right VLPFC.
    Related ArticlesImproving emotion regulation of social exclusion in depression-prone individuals: a tDCS study targeting right VLPFC. Psychol Med. 2019 Oct 16;:1-12 Authors: He Z, Liu Z, Zhao J, Elliott R, Zhang D Abstract BACKGROUND: Growing evidence has indicated that right ventrolateral prefrontal cortex (RVLPFC) is critical in down-regulating emotional responses to social exclusion, and that depression is accompanied by social emotional dysregulation associated with reduced lateral prefrontal engagement. This study used anodal transcranial direct current stimulation (tDCS) to examine whether stimulating RVLPFC could improve emotional down-regulation of social exclusion in individuals with high depressive mood (DM). METHODS: A total of ... read more
    4 weeks ago
  • Anodal Transcranial Direct Current Stimulation Over S1 Differentially Modulates Proprioceptive Accuracy in Young and Old Adults.
    Related ArticlesAnodal Transcranial Direct Current Stimulation Over S1 Differentially Modulates Proprioceptive Accuracy in Young and Old Adults. Front Aging Neurosci. 2019;11:264 Authors: Muffel T, Kirsch F, Shih PC, Kalloch B, Schaumberg S, Villringer A, Sehm B Abstract Background: Proprioception is a prerequisite for successful motor control but declines throughout the lifespan. Brain stimulation techniques such as anodal transcranial direct current stimulation (a-tDCS) are capable of enhancing sensorimotor performance across different tasks and age groups. Despite such growing evidence for a restorative potential of tDCS, its impact on proprioceptive accuracy has not been studied in detail yet. Objective: This study investigated ... read more
    4 weeks ago
  • Simulation of transcranial magnetic stimulation in head model with morphologically-realistic cortical neurons.
    Related ArticlesSimulation of transcranial magnetic stimulation in head model with morphologically-realistic cortical neurons. Brain Stimul. 2019 Oct 07;: Authors: Aberra AS, Wang B, Grill WM, Peterchev AV Abstract BACKGROUND: Transcranial magnetic stimulation (TMS) enables non-invasive modulation of brain activity with both clinical and research applications, but fundamental questions remain about the neural types and elements TMS activates and how stimulation parameters affect the neural response. OBJECTIVE: To develop a multi-scale computational model to quantify the effect of TMS parameters on the direct response of individual neurons. METHODS: We integrated morphologically-realistic neuronal models with TMS-induced electric fields computed in a finite ... read more
    4 weeks ago
  • Novel bifunctional cap for simultaneous electroencephalography and transcranial electrical stimulation.
    Related ArticlesNovel bifunctional cap for simultaneous electroencephalography and transcranial electrical stimulation. Sci Rep. 2018 05 08;8(1):7259 Authors: Wunder S, Hunold A, Fiedler P, Schlegelmilch F, Schellhorn K, Haueisen J Abstract Neuromodulation induced by transcranial electric stimulation (TES) exhibited promising potential for clinical practice. However, the underlying mechanisms remain subject of research. The combination of TES and electroencephalography (EEG) offers great potential for investigating these mechanisms and brain function in general, especially when performed simultaneously. In conventional applications, the combination of EEG and TES suffers from limitations on the electrode level (gel for electrode-skin interface) and the usability level ... read more
    4 weeks ago
  • Cost of focality in TDCS: Interindividual variability in electric fields.
    Related ArticlesCost of focality in TDCS: Interindividual variability in electric fields. Brain Stimul. 2019 Oct 02;: Authors: Mikkonen M, Laakso I, Tanaka S, Hirata A Abstract BACKGROUND: In transcranial direct current stimulation (TDCS), electric current is applied via two large electrodes to modulate brain activity. Computational models have shown that large electrodes produce diffuse electric fields (EFs) in the brain, which depends on individual head and brain anatomy. Recently, smaller electrodes as well as novel electrode arrangements, including high-definition TDCS (HD-TDCS) montages, have been introduced to improve the focality of EFs. Here, we investigated whether the EFs of focal montages ... read more
    1 month ago
  • Phase of beta-frequency tACS over primary motor cortex modulates corticospinal excitability.
    Related ArticlesPhase of beta-frequency tACS over primary motor cortex modulates corticospinal excitability. Cortex. 2018 06;103:142-152 Authors: Schilberg L, Engelen T, Ten Oever S, Schuhmann T, de Gelder B, de Graaf TA, Sack AT Abstract The assessment of corticospinal excitability by means of transcranial magnetic stimulation-induced motor evoked potentials is an established diagnostic tool in neurophysiology and a widely used procedure in fundamental brain research. However, concern about low reliability of these measures has grown recently. One possible cause of high variability of MEPs under identical acquisition conditions could be the influence of oscillatory neuronal activity on corticospinal excitability. Based ... read more
    1 month ago
  • Bite injuries caused by transcranial electrical stimulation motor-evoked potentials’ monitoring: incidence, associated factors, and clinical course.
    Related ArticlesBite injuries caused by transcranial electrical stimulation motor-evoked potentials' monitoring: incidence, associated factors, and clinical course. J Anesth. 2018 12;32(6):844-849 Authors: Yata S, Ida M, Shimotsuji H, Nakagawa Y, Ueda N, Takatani T, Shigematsu H, Motoyama Y, Nakase H, Kirita T, Kawaguchi M Abstract PURPOSE: The incidence of bite injuries associated with transcranial electrical stimulation motor-evoked potentials monitoring reportedly ranges from 0.13 to 0.19%. However, in clinical practice, bite injuries appear to occur more frequently than previously reported. Our aim was to identify the incidence of and perioperative risk factors associated with bite injuries caused by transcranial electrical ... read more
    1 month ago