Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • Impact of Combined Transcranial Direct Current Stimulation and Speech-language Therapy on Spontaneous Speech in Aphasia: A Randomized Controlled Double-blind Study.
    Related ArticlesImpact of Combined Transcranial Direct Current Stimulation and Speech-language Therapy on Spontaneous Speech in Aphasia: A Randomized Controlled Double-blind Study. J Int Neuropsychol Soc. 2020 Jan;26(1):7-18 Authors: Guillouët E, Cogné M, Saverot E, Roche N, Pradat-Diehl P, Weill-Chounlamountry A, Ramel V, Taratte C, Lachasse AG, Haulot JA, Vaugier I, Barbot F, Azouvi P, Charveriat S Abstract OBJECTIVE: Aphasia recovery depends on neural reorganization, which can be enhanced by speech-language therapy and noninvasive brain stimulation. Several studies suggested that transcranial direct current stimulation (tDCS) associated with speech-language therapy may improve verbal performance evaluated by analytic tests, but none focused on ... read more
    18 hours ago
  • Is transcranial direct current stimulation (tDCS) effective for the treatment of pain in fibromyalgia? A systematic review and meta-analysis.
    Related ArticlesIs transcranial direct current stimulation (tDCS) effective for the treatment of pain in fibromyalgia? A systematic review and meta-analysis. J Pain. 2020 Jan 23;: Authors: Lloyd DM, Wittkopf PG, Arendsen LJ, Jones AKP Abstract BACKGROUND: Fibromyalgia is a debilitating condition characterized by chronic widespread pain. It is believed to be caused by dysfunction of the central nervous system (CNS) but current treatments are largely ineffective. Transcranial Direct Current Stimulation (tDCS), a neuromodulation technique that targets the CNS, may offer a new line of treatment. OBJECTIVE: To systematically review the most up-to-date literature and perform a meta-analysis of the effects ... read more
    2 days ago
  • Transcranial Direct Current Stimulation in Psychiatry: What Psychiatrists Need to Know.
    Related ArticlesTranscranial Direct Current Stimulation in Psychiatry: What Psychiatrists Need to Know. Focus (Am Psychiatr Publ). 2019 Jan;17(1):44-49 Authors: Zandvakili A, Berlow YA, Carpenter LL, Philip NS Abstract Transcranial direct current stimulation (tDCS) is emerging as a potential treatment for a host of neuropsychiatric disorders. Data appear to indicate that tDCS applied over frontal or prefrontal brain regions may reduce symptoms of major depression, yet results have been mixed. Early studies showed promise, but recent work failed to replicate earlier results. The decision whether to use tDCS is further affected by the complex regulatory environment; no tDCS devices are cleared ... read more
    4 days ago
  • A Critical Review and Synthesis of Clinical and Neurocognitive Effects of Noninvasive Neuromodulation Antidepressant Therapies.
    Related ArticlesA Critical Review and Synthesis of Clinical and Neurocognitive Effects of Noninvasive Neuromodulation Antidepressant Therapies. Focus (Am Psychiatr Publ). 2019 Jan;17(1):18-29 Authors: McClintock SM, Kallioniemi E, Martin DM, Kim JU, Weisenbach SL, Abbott CC Abstract There is a plethora of current and emerging antidepressant therapies in the psychiatric armamentarium for the treatment of major depressive disorder. Noninvasive neuromodulation therapies are one such therapeutic category; they typically involve the transcranial application of electrical or magnetic stimulation to modulate cortical and subcortical brain activity. Although electroconvulsive therapy (ECT) has been used since the 1930s, with the prevalence of major depressive disorder ... read more
    4 days ago
  • Anodal transcranial direct current stimulation and intermittent theta-burst stimulation improve deglutition and swallowing reproducibility in elderly patients with dysphagia.
    Related ArticlesAnodal transcranial direct current stimulation and intermittent theta-burst stimulation improve deglutition and swallowing reproducibility in elderly patients with dysphagia. Neurogastroenterol Motil. 2020 Jan 23;:e13791 Authors: Cosentino G, Tassorelli C, Prunetti P, Bertino G, De Icco R, Todisco M, Di Marco S, Brighina F, Schindler A, Rondanelli M, Fresia M, Mainardi L, Restivo DA, Priori A, Sandrini G, Alfonsi E Abstract BACKGROUND: Dysphagia in the elderly, known as presbydysphagia, has become a relevant public health problem in several countries. Swallowing disorders may be a consequence of different neurological disorders (secondary presbydysphagia) or the expression of the aging process itself (primary ... read more
    4 days ago
  • The comparative effects of unilateral and bilateral transcranial direct current stimulation on motor learning and motor performance: A systematic review of literature and meta-analysis.
    Related ArticlesThe comparative effects of unilateral and bilateral transcranial direct current stimulation on motor learning and motor performance: A systematic review of literature and meta-analysis. J Clin Neurosci. 2020 Jan 20;: Authors: Halakoo S, Ehsani F, Hosnian M, Zoghi M, Jaberzadeh S Abstract Application of unilateral tDCS (Uni-tDCS) vs. bilateral tDCS (Bi-tDCS) is another important factor that can affect the physiological results of tDCS intervention on motor learning and motor performance. According to the evidence, some studies indicated that motor performance or motor learning are facilitated in healthy individuals by application of the Bi-tDCS more than the Uni-tDCS. On the ... read more
    4 days ago
  • Cognitive changes after tDCS and escitalopram treatment in major depressive disorder: Results from the placebo-controlled ELECT-TDCS trial.
    Related ArticlesCognitive changes after tDCS and escitalopram treatment in major depressive disorder: Results from the placebo-controlled ELECT-TDCS trial. J Affect Disord. 2019 Dec 05;263:344-352 Authors: Moreno ML, Goerigk SA, Bertola L, Suemoto CK, Razza LB, Moffa AH, Veronezi BP, Tort L, Nogueira BS, Gattaz WF, Fraguas R, Padberg F, Lotufo PA, Benseñor IM, Brunoni AR Abstract BACKGROUND: Cognitive deficits in major depressive disorder (MDD) are associated with low quality of life and higher suicide risk. Antidepressant drugs have modest to null effects in improving such deficits. Therefore, we investigated the cognitive effects of transcranial direct current stimulation (tDCS), which is ... read more
    5 days ago
  • Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation.
    Related ArticlesUpdated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation. J Vis Exp. 2020 Jan 03;(155): Authors: Borges H, Dufau A, Paneri B, Woods AJ, Knotkova H, Bikson M Abstract Transcranial direct current stimulation (tDCS) is a noninvasive method of neuromodulation using low-intensity direct electrical currents. This method of brain stimulation presents several potential advantages compared to other techniques, as it is noninvasive, cost-effective, broadly deployable, and well-tolerated provided proper equipment and protocols are administered. Even though tDCS is apparently simple to perform, correct administration of the tDCS session, especially the electrode positioning and ... read more
    1 week ago
  • Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats.
    Related ArticlesNeuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats. Neural Plast. 2019;2019:4252943 Authors: Liu HH, He XK, Chen HY, Peng CW, Rotenberg A, Juan CH, Pei YC, Liu HL, Chiang YH, Wang JY, Feng XJ, Huang YZ, Hsieh TH Abstract Transcranial direct current stimulation (tDCS) is a noninvasive technique for modulating neural plasticity and is considered to have therapeutic potential in neurological disorders. For the purpose of translational neuroscience research, a suitable animal model can be ideal for providing a stable condition for identifying mechanisms that can help to explore therapeutic strategies. Here, we developed a ... read more
    2 weeks ago
  • Excitation Comparison between Multi-site Stimulation using Network-based tDCS and Focal Stimulation using High-definition tDCS.
    Related ArticlesExcitation Comparison between Multi-site Stimulation using Network-based tDCS and Focal Stimulation using High-definition tDCS. Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:6884-6887 Authors: Chen C, Fang Y, Wang X, Bao SC, Tang Z, Tong RK Abstract Transcranial direct current stimulation (tDCS) has been developed rapidly in recent years and derived various forms which serve as therapeutic tools for neurological disorders. However, differences of stimulation effect among these stimulation strategies have not been fully explored. In this pilot study, we compared the stimulation effect between High-definition tDCS (HD-tDCS) and Network-based tDCS (NB-tDCS) on a healthy subject. HD-tDCS mainly stimulated ... read more
    2 weeks ago
  • Influence of gender-related differences in transcranial direct current stimulation: A Computational Study.
    Related ArticlesInfluence of gender-related differences in transcranial direct current stimulation: A Computational Study. Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:5196-5199 Authors: Thomas C, Ghodratitoostani I, Delbem ACB, Ali A, Datta A Abstract Gender-related anatomical differences have been reported with respect to brain and cerebrospinal fluid. The cortical induced electric field (EF) in transcranial direct current stimulation (tDCS) depends both on the dose (electrode montage and applied current) and the individual anatomical details. Therefore in spite of fixed dose, one can expect gender-related differences to impact induced EF which in turn would influence tDCS outcome. The abundance of promise ... read more
    2 weeks ago
  • Assessing tDCS Placebo Effects on EEG and Cognitive Tasks.
    Related ArticlesAssessing tDCS Placebo Effects on EEG and Cognitive Tasks. Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:4509-4512 Authors: Petersen TH, Puthusserypady S Abstract Divergent thinking (DT) using transcranial direct current stimulation (tDCS) has previously been documented with promising results. This paper examines the placebo effect of tDCS. The reaction from a placebo group was tapped using electroencephalogram (EEG). Their performance was measured as a creativity score and compared to a control group. The experiments included multiplication problems and two DT tasks: Alternative Uses Tasks (AUT) and Instances Task (IT). Neither of the groups were sham stimulated during AUT, ... read more
    2 weeks ago
  • High-Definition Transcranial Direct Current Stimulation (HD-tDCS) enhances working memory training.
    Related ArticlesHigh-Definition Transcranial Direct Current Stimulation (HD-tDCS) enhances working memory training. Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:329-332 Authors: Wang N, Ming D, Ke Y, Du J, Liu W, Kong L, Zhao X, Liu S, Xu M, An X Abstract High-Definition transcranial direct current stimulation (HD-tDCS) is a noninvasive brain stimulation technique that can improve the performance of working memory (WM). However, the current researches have focused on the effects of stimulation, while ignored the process of stimulus and the neural mechanism. The targets of this study were to explore the effects of different stimulus categories (active or ... read more
    2 weeks ago
  • A review of transcranial direct current stimulation (tDCS) for the individualized treatment of depressive symptoms.
    Related ArticlesA review of transcranial direct current stimulation (tDCS) for the individualized treatment of depressive symptoms. Pers Med Psychiatry. 2019 Nov-Dec;17-18:17-22 Authors: Jog MV, Wang DJJ, Narr KL Abstract Transcranial direct current stimulation (tDCS) is a low intensity neuromodulation technique shown to elicit therapeutic effects in a number of neuropsychological conditions. Independent randomized sham-controlled trials and meta- and mega-analyses demonstrate that tDCS targeted to the left dorsolateral prefrontal cortex can produce a clinically meaningful response in patients with major depressive disorder (MDD), but effects are small to moderate in size. However, the heterogeneous presentation, and the neurobiology underlying particular features ... read more
    2 weeks ago
  • Brain age prediction in stroke patients: Highly reliable but limited sensitivity to cognitive performance and response to cognitive training.
    Related ArticlesBrain age prediction in stroke patients: Highly reliable but limited sensitivity to cognitive performance and response to cognitive training. Neuroimage Clin. 2019 Dec 30;25:102159 Authors: Richard G, Kolskår K, Ulrichsen KM, Kaufmann T, Alnæs D, Sanders AM, Dørum ES, Monereo Sánchez J, Petersen A, Ihle-Hansen H, Nordvik JE, Westlye LT Abstract Cognitive deficits are important predictors for outcome, independence and quality of life after stroke, but often remain unnoticed and unattended because other impairments are more evident. Computerized cognitive training (CCT) is among the candidate interventions that may alleviate cognitive difficulties, but the evidence supporting its feasibility and effectiveness ... read more
    2 weeks ago
  • A novel tDCS sham approach based on model-driven controlled shunting.
    Related ArticlesA novel tDCS sham approach based on model-driven controlled shunting. Brain Stimul. 2019 Nov 09;: Authors: Neri F, Mencarelli L, Menardi A, Giovannelli F, Rossi S, Sprugnoli G, Rossi A, Pascual-Leone A, Salvador R, Ruffini G, Santarnecchi E Abstract BACKGROUND: Transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique able to transiently modulate brain activity, is surging as one of the most promising therapeutic solutions in many neurological and psychiatric disorders. However, profound limitations exist in current placebo (sham) protocols that limit single- and double-blinding, especially in non-naïve subjects. OBJECTIVE: To ensure better blinding and strengthen reliability of ... read more
    2 weeks ago
  • Effectiveness and safety of repetitive transcranial magnetic stimulation (rTMS) on aphasia in cerebrovascular accident patients: Protocol of a systematic review and meta-analysis.
    Related ArticlesEffectiveness and safety of repetitive transcranial magnetic stimulation (rTMS) on aphasia in cerebrovascular accident patients: Protocol of a systematic review and meta-analysis. Medicine (Baltimore). 2019 Dec;98(52):e18561 Authors: Zheng Y, Zhong D, Huang Y, He M, Xiao Q, Jin R, Li J Abstract BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation approach, might be a promising technique in the management of aphasia after cerebrovascular accidents (CVA). This protocol of systematic review (SR) aims to investigate the effectiveness and safety of rTMS in patients with aphasia after CVA. METHODS: The following databases will be searched: PubMed, EMBASE, the ... read more
    2 weeks ago
  • Neurophysiology-Driven Parameter Selection in nTMS-Based DTI Tractography: A Multidimensional Mathematical Model.
    Related ArticlesNeurophysiology-Driven Parameter Selection in nTMS-Based DTI Tractography: A Multidimensional Mathematical Model. Front Neurosci. 2019;13:1373 Authors: Machetanz K, Trakolis L, Leão MT, Liebsch M, Mounts K, Bender B, Ernemann U, Gharabaghi A, Tatagiba M, Naros G Abstract Object: There is an increasing interest in preoperative diffusion tensor imaging-based fiber tracking (DTI-FT) to preserve function during surgeries in motor eloquent brain regions. However, DTI tractography is challenged by inherent presumptions during particular tracking steps [e.g., deterministic vs. probabilistic DTI, fractional anisotropy (FA) and fiber length (FL) thresholding] and the missing "ground truth" information. In the present study, we intended to establish ... read more
    3 weeks ago
  • Online polarity-dependent effects of cerebellar transcranial direct current stimulation on motor speed and fine manual dexterity. A randomized controlled trial.
    Online polarity-dependent effects of cerebellar transcranial direct current stimulation on motor speed and fine manual dexterity. A randomized controlled trial. Saudi Med J. 2020 Jan;41(1):18-24 Authors: Kinakool AN, Abualait TS Abstract OBJECTIVES: To investigate the role of cerebellar transcranial direct current stimulation (ctDCS) in modulating cerebellar functions in the motor domains of fine motor dexterity and motor speed. Methods: A single-blind, randomized sham-controlled study was conducted between January and July 2018 at the neuroscience laboratory of Imam Abdulrahman Bin Faisal University. A total of 63 healthy participants were assessed for eligibility. Sixty subjects met the criteria of the study and were ... read more
    3 weeks ago
  • Double-blind, randomized pilot clinical trial targeting alpha oscillations with transcranial alternating current stimulation (tACS) for the treatment of major depressive disorder (MDD).
    Related ArticlesDouble-blind, randomized pilot clinical trial targeting alpha oscillations with transcranial alternating current stimulation (tACS) for the treatment of major depressive disorder (MDD). Transl Psychiatry. 2019 03 05;9(1):106 Authors: Alexander ML, Alagapan S, Lugo CE, Mellin JM, Lustenberger C, Rubinow DR, Fröhlich F Abstract Major depressive disorder (MDD) is one of the most common psychiatric disorders, but pharmacological treatments are ineffective in a substantial fraction of patients and are accompanied by unwanted side effects. Here we evaluated the feasibility and efficacy of transcranial alternating current stimulation (tACS) at 10 Hz, which we hypothesized would improve clinical symptoms by renormalizing ... read more
    3 weeks ago
  • Effects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study.
    Effects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study. PLoS One. 2020;15(1):e0222620 Authors: Nwaroh C, Giuffre A, Cole L, Bell T, Carlson HL, MacMaster FP, Kirton A, Harris AD Abstract Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation that safely modulates brain excitability and has therapeutic potential for many conditions. Several studies have shown that anodal tDCS of the primary motor cortex (M1) facilitates motor learning and plasticity, but there is little information about the underlying mechanisms. Using magnetic resonance spectroscopy (MRS), it has been shown that tDCS can affect ... read more
    3 weeks ago
  • Cerebral Cortical Activity Following Non-invasive Cerebellar Stimulation-a Systematic Review of Combined TMS and EEG Studies.
    Cerebral Cortical Activity Following Non-invasive Cerebellar Stimulation-a Systematic Review of Combined TMS and EEG Studies. Cerebellum. 2020 Jan 06;: Authors: Fernandez L, Rogasch NC, Do M, Clark G, Major BP, Teo WP, Byrne LK, Enticott PG Abstract The cerebellum sends dense projections to both motor and non-motor regions of the cerebral cortex via the cerebellarthalamocortical tract. The integrity of this tract is crucial for healthy motor and cognitive function. This systematic review examines research using transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) to the cerebellum with combined cortical electroencephalography (EEG) to explore the temporal features of cerebellar-cortical ... read more
    3 weeks ago
  • Transcranial random noise stimulation for the acute treatment of depression: a randomized controlled trial.
    Related ArticlesTranscranial random noise stimulation for the acute treatment of depression: a randomized controlled trial. Int J Neuropsychopharmacol. 2020 Jan 03;: Authors: Nikolin S, Alonzo A, Martin D, Gálvez V, Buten S, Taylor R, Goldstein J, Oxley C, Hadzi-Pavlovic D, Loo CK Abstract BACKGROUND: Transcranial electrical stimulation has broad potential as a treatment for depression. Transcranial random noise stimulation (tRNS), which delivers randomly fluctuating current intensities, may have greater cortical excitatory effects compared to other forms of transcranial electrical stimulation. We therefore aimed to investigate the antidepressant efficacy of tRNS. METHODS: Depressed participants were randomly assigned by computer number generator ... read more
    4 weeks ago
  • Frontal Beta Transcranial Alternating Current Stimulation Improves Reversal Learning.
    Related ArticlesFrontal Beta Transcranial Alternating Current Stimulation Improves Reversal Learning. Cereb Cortex. 2020 Jan 02;: Authors: Wischnewski M, Joergensen ML, Compen B, Schutter DJLG Abstract Electroencephalogram (EEG) studies suggest an association between beta (13-30 Hz) power and reversal learning performance. In search for direct evidence concerning the involvement of beta oscillations in reversal learning, transcranial alternating current stimulation (tACS) was applied in a double-blind, sham-controlled and between-subjects design. Exogenous oscillatory currents were administered bilaterally to the frontal cortex at 20 Hz with an intensity of 1 mA peak-to-peak and the effects on reward-punishment based reversal learning were evaluated in hundred-and-eight healthy volunteers. Pre- ... read more
    4 weeks ago
  • Transcranial direct current stimulation in management of pain, mood, functionality, and quality of life in patients undergoing hemodialysis: a study protocol for a double-blind controlled randomized trial.
    Related ArticlesTranscranial direct current stimulation in management of pain, mood, functionality, and quality of life in patients undergoing hemodialysis: a study protocol for a double-blind controlled randomized trial. Trials. 2019 Dec 30;20(1):805 Authors: Quintiliano A, Oehmen T, Kirsztajn GM, Pegado R Abstract BACKGROUND: Persistent pain can lead to incapacitation requiring long-term pharmacological treatment. Up to 82% of chronic kidney disease (CKD) patients undergoing hemodialysis (HD) have chronic pain and most do not respond to usual medication. Advances in non-pharmacological treatments are necessary to promote pain relief without side effects and to restore functionality. Transcranial direct current stimulation (tDCS) promises to ... read more
    4 weeks ago