Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • Effects of Transcranial Direct Current Stimulation Over the Dorsolateral Prefrontal Cortex (PFC) on Cognitive-Motor Dual Control Skills.
    Related ArticlesEffects of Transcranial Direct Current Stimulation Over the Dorsolateral Prefrontal Cortex (PFC) on Cognitive-Motor Dual Control Skills. Percept Mot Skills. 2020 Jul 13;:31512520935695 Authors: Lee J, Dong S, Jeong J, Yoon B Abstract This randomized crossover study investigated whether anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefontal cortex (dlPFC) modulates memory-guided finger isometric maintenance during single motor and dual cognitive-motor tasks, based on electroencephalogram (EEG) signals. Twenty-three healthy participants (14 female; M age = 29.130 years, SD = 10.918) underwent both sham and 2-mA stimulation sessions over the dlPFC for 20 minutes, with a minimum washout period of seven days. We ... read more
    1 day ago
  • Transcranial Random Noise Stimulation is More Effective than Transcranial Direct Current Stimulation for Enhancing Working Memory in Healthy Individuals: Behavioural and Electrophysiological Evidence.
    Related ArticlesTranscranial Random Noise Stimulation is More Effective than Transcranial Direct Current Stimulation for Enhancing Working Memory in Healthy Individuals: Behavioural and Electrophysiological Evidence. Brain Stimul. 2020 Jul 10;: Authors: Murphy OW, Hoy KE, Wong D, Bailey NW, Fitzgerald PB, Segrave RA Abstract BACKGROUND: Transcranial direct current stimulation (tDCS) has been shown to improve working memory (WM) performance in healthy individuals, however effects tend to be modest and variable. Transcranial random noise stimulation (tRNS) can be delivered with a direct-current offset (DC-offset) to induce equal or even greater effects on cortical excitability than tDCS. To-date, no research has directly compared ... read more
    2 days ago
  • Advances in the Use of Neuromodulation for Neurogenic Dysphagia: Mechanisms and Therapeutic Application of Pharyngeal Electrical Stimulation, Transcranial Magnetic Stimulation, and Transcranial Direct Current Stimulation.
    Related ArticlesAdvances in the Use of Neuromodulation for Neurogenic Dysphagia: Mechanisms and Therapeutic Application of Pharyngeal Electrical Stimulation, Transcranial Magnetic Stimulation, and Transcranial Direct Current Stimulation. Am J Speech Lang Pathol. 2020 Jul 10;29(2S):1044-1064 Authors: Sasegbon A, Cheng I, Zhang M, Hamdy S Abstract Purpose The swallowing motor system and, specifically, its cortical substrates appear to have certain unique properties that make it highly susceptible to brain plasticity, both driven and following injury. Furthermore, neurogenic dysphagia is a common complication of brain disease, associated with poor outcomes, and yet treatment options remain limited. Therefore, translating the physiology of neurostimulation into ... read more
    4 days ago
  • Transcranial Direct Current Stimulation and Cognition in Neuropsychiatric Disorders: Systematic Review of the Evidence and Future Directions.
    Related ArticlesTranscranial Direct Current Stimulation and Cognition in Neuropsychiatric Disorders: Systematic Review of the Evidence and Future Directions. Neuroscientist. 2020 Jul 09;:1073858420936167 Authors: Ciullo V, Spalletta G, Caltagirone C, Banaj N, Vecchio D, Piras F, Piras F Abstract Transcranial direct current stimulation (tDCS) has been implemented in neuropsychiatric disorders characterized by cognitive impairment. However, methodological heterogeneity challenges conclusive remarks. Through a critical analysis of previous conflicting findings and in the light of current neurobiological models of pathophysiology, we qualitatively assessed the effects of tDCS in neuropsychiatric disorders that share neurobiological underpinnings, as to evaluate whether stimulation can improve cognitive deficits ... read more
    6 days ago
  • Association of Central Noninvasive Brain Stimulation Interventions With Efficacy and Safety in Tinnitus Management: A Meta-analysis.
    Related ArticlesAssociation of Central Noninvasive Brain Stimulation Interventions With Efficacy and Safety in Tinnitus Management: A Meta-analysis. JAMA Otolaryngol Head Neck Surg. 2020 Jul 09;: Authors: Chen JJ, Zeng BS, Wu CN, Stubbs B, Carvalho AF, Brunoni AR, Su KP, Tu YK, Wu YC, Chen TY, Lin PY, Liang CS, Hsu CW, Hsu SP, Kuo HC, Chen YW, Tseng PT, Li CT Abstract Importance: Tinnitus has a prevalence of 10% to 25% and is frequently associated with numerous complications, such as neuropsychiatric disease. Traditional treatments have failed to meet the needs of patients with tinnitus. Noninvasive brain stimulation (NIBS) can ... read more
    6 days ago
  • Transcranial direct current stimulation (tDCS) for improving aphasia after stroke: a systematic review with network meta-analysis of randomized controlled trials.
    Related ArticlesTranscranial direct current stimulation (tDCS) for improving aphasia after stroke: a systematic review with network meta-analysis of randomized controlled trials. J Neuroeng Rehabil. 2020 Jul 08;17(1):88 Authors: Elsner B, Kugler J, Mehrholz J Abstract BACKGROUND: Transcranial Direct Current Stimulation (tDCS) is an emerging approach for improving aphasia after stroke. However, it remains unclear what type of tDCS stimulation is most effective. Our aim was to give an overview of the evidence network regarding the efficacy and safety of tDCS and to estimate the effectiveness of the different stimulation types. METHODS: This is a systematic review of randomized controlled trials ... read more
    6 days ago
  • Gamma transcranial alternating current stimulation in patients with negative symptoms in schizophrenia: A case series.
    Related ArticlesGamma transcranial alternating current stimulation in patients with negative symptoms in schizophrenia: A case series. Neurophysiol Clin. 2020 Jul 03;: Authors: Haller N, Hasan A, Padberg F, Brunelin J, da Costa Lane Valiengo L, Palm U Abstract Non-invasive transcranial brain stimulation therapies, such as transcranial direct current stimulation, have been found to improve negative symptoms in schizophrenia. Another new technique is transcranial alternating current stimulation (tACS). Here we report a series of three patient treated with twice-daily 10min prefrontal 40Hz tACS stimulation over ten days. Patients showed an improvement in the Positive and Negative Syndrome Scale, Scale for the ... read more
    1 week ago
  • Spino-cerebellar tDCS modulates N100 components of the P300 event related potential.
    Related ArticlesSpino-cerebellar tDCS modulates N100 components of the P300 event related potential. Neuropsychologia. 2019 12;135:107231 Authors: Ruggiero F, Ferrucci R, Bocci T, Nigro M, Vergari M, Marceglia S, Barbieri S, Priori A Abstract OBJECTIVE: To evaluate the role of the cerebellum and spinal cord in cognitive processes, we assessed changes in event-related potentials (ERPs), before and after different combinations of spinal and cerebellar direct current stimulation (tDCS) in healthy subjects. METHOD: We enrolled 37 volunteers (11 males and 26 females, aged 20-50 years), who were subsequently randomly assigned to one of four stimulation conditions: i) anodal cerebellar tDCS, with ... read more
    1 week ago
  • Review of Transcranial Magnetic Stimulation in Epilepsy.
    Related ArticlesReview of Transcranial Magnetic Stimulation in Epilepsy. Clin Ther. 2020 Jul 02;: Authors: Tsuboyama M, Kaye HL, Rotenberg A Abstract PURPOSE: Despite the availability of numerous pharmacologic and nonpharmacologic antiseizure therapies, a fraction of patients with epilepsy remain refractory to current treatment options, underscoring the need for novel drugs and neuromodulatory therapies. Transcranial magnetic stimulation (TMS), coupled with either electromyography or electroencephalography, enables rapid measurement of the cortical excitation/inhibition ratio, which is pathologically shifted toward excess excitability in patients with epilepsy. In this review, we summarize: (1) TMS protocols that have been deployed to identify promising compounds in the ... read more
    1 week ago
  • Direct cortical stimulation with cylindrical depth electrodes in the interhemispheric fissure for leg motor evoked potential monitoring.
    Related ArticlesDirect cortical stimulation with cylindrical depth electrodes in the interhemispheric fissure for leg motor evoked potential monitoring. Clin Neurophysiol. 2020 01;131(1):127-132 Authors: Brage L, Pérez-Lorensu PJ, Plata-Bello J, Saponaro-González Á, Pérez-Orribo L, García-Conde M, Febles-García P, Roldán-Delgado H, García-Marín V Abstract OBJECTIVE: To evaluate cylindrical depth electrodes in the interhemispheric fissure as an alternative to subdural strip electrodes for direct cortical stimulation (DCS) leg motor evoked potential (MEP) monitoring. METHODS: A cylindrical depth electrode was positioned in the interhemispheric fissure of 37 patients who underwent supratentorial brain surgery. Leg sensory and motor cortices were localized by highest tibial ... read more
    1 week ago
  • Neuromodulation for the Treatment of Epilepsy: a Review of Current Approaches and Future Directions.
    Related ArticlesNeuromodulation for the Treatment of Epilepsy: a Review of Current Approaches and Future Directions. Clin Ther. 2020 Jun 30;: Authors: Davis P, Gaitanis J Abstract PURPOSE: Neuromodulation holds great promise for the treatment of drug-resistant epilepsy. This article reviews the most common types of neuromodulation as well as potential future applications of preclinical techniques such as optogenetics. This review serves as a reference for treating neurologists on the latest science behind such treatment approaches. METHODS: This narrative review briefly describes the preclinical and clinical history of each technique, with a special emphasis on, wherever possible, strong clinical evidence and ... read more
    1 week ago
  • Transcranial magnetic stimulation and gait disturbances in Parkinson’s disease: A systematic review.
    Related ArticlesTranscranial magnetic stimulation and gait disturbances in Parkinson's disease: A systematic review. Neurophysiol Clin. 2020 Jun 30;: Authors: Nardone R, Versace V, Brigo F, Golaszewski S, Carnicelli L, Saltuari L, Trinka E, Sebastianelli L Abstract Transcranial magnetic stimulation (TMS) may offer a reliable means of characterizing important pathophysiologic aspects of motor impairments in Parkinson's disease (PD). Moreover, high-frequency repetitive TMS (rTMS), especially if delivered bilaterally over motor cortical regions, can have beneficial effects on parkinsonian motor symptoms. However, only a few studies have investigated the effects of rTMS on freezing of gait (FOG) and other gait disturbances in PD. ... read more
    1 week ago
  • Change in core symptoms of borderline personality disorder by tDCS: A pilot study.
    Change in core symptoms of borderline personality disorder by tDCS: A pilot study. Psychiatry Res. 2020 Jun 28;291:113261 Authors: Lisoni J, Miotto P, Barlati S, Calza S, Crescini A, Deste G, Sacchetti E, Vita A Abstract Borderline personality disorder (BPD) recognizes several psychopathological dimensions related to prefrontal cortex impairments. Transcranial Direct Current Stimulation (tDCS) targeting the right prefrontal dorsolateral cortex (DLPFC) positively influence cognitive functions related to impulsivity in healthy subjects. A randomized double-blind study was designed to investigate whether tDCS could modulate core dimensions (impulsivity, aggression, affective dysregulation) of BPD. Also effects on decision making process and substances craving ... read more
    1 week ago
  • Unskilled shooters improve both accuracy and grouping shot having as reference skilled shooters cortical area: An EEG and tDCS study.
    Related ArticlesUnskilled shooters improve both accuracy and grouping shot having as reference skilled shooters cortical area: An EEG and tDCS study. Physiol Behav. 2020 Jun 26;:113036 Authors: Rocha K, Marinho V, Magalhães F, Carvalho V, Fernandes T, Ayres M, Crespo E, Velasques B, Ribeiro P, Cagy M, Bastos VH, Gupta DS, Teixeira S Abstract Transcranial direct current stimulation (tDCS) has been used as a non-invasive method for enhanced motor and cognitive abilities. However, no previous study has investigated if the tDCS application in unskilled shooters on cortical sites, selected based on the cortical activity of skilled shooters, improves the accuracy ... read more
    2 weeks ago
  • Anodal Transcranial Direct Current Stimulation Can Improve Spatial Learning and Memory and Attenuate Aβ42 Burden at the Early Stage of Alzheimer’s Disease in APP/PS1 Transgenic Mice.
    Related ArticlesAnodal Transcranial Direct Current Stimulation Can Improve Spatial Learning and Memory and Attenuate Aβ42 Burden at the Early Stage of Alzheimer's Disease in APP/PS1 Transgenic Mice. Front Aging Neurosci. 2020;12:134 Authors: Luo Y, Yang W, Li N, Yang X, Zhu B, Wang C, Hou W, Wang X, Wen H, Tian X Abstract Alzheimer's disease (AD) is an irreversible progressive neurodegenerative disease. Intervention in the early stage of AD is a new path for AD treatment that is being explored. The behavioral and pathological effects of anodal transcranial direct current stimulation (AtDCS) at the early stage of AD in ... read more
    2 weeks ago
  • Using prefrontal transcranial direct current stimulation (tDCS) to enhance proactive cognitive control in schizophrenia.
    Related ArticlesUsing prefrontal transcranial direct current stimulation (tDCS) to enhance proactive cognitive control in schizophrenia. Neuropsychopharmacology. 2020 Jun 30;: Authors: Boudewyn M, Scangos K, Ranganath C, Carter CS Abstract The goal of this study was to use transcranial direct current stimulation (tDCS) to examine the role of the prefrontal cortex (PFC) in neural oscillatory activity associated with proactive cognitive control in schizophrenia. To do so, we tested the impact of PFC-targeted tDCS on behavioral and electrophysiological markers of proactive cognitive control engagement in individuals with schizophrenia. Using a within-participants, double-blinded, sham-controlled crossover design, we recorded EEG while participants with schizophrenia ... read more
    2 weeks ago
  • Invasive versus non-invasive mapping of the motor cortex.
    Related ArticlesInvasive versus non-invasive mapping of the motor cortex. Hum Brain Mapp. 2020 Jun 26;: Authors: Weiss Lucas C, Nettekoven C, Neuschmelting V, Oros-Peusquens AM, Stoffels G, Viswanathan S, Rehme AK, Faymonville AM, Shah NJ, Langen KJ, Goldbrunner R, Grefkes C Abstract Precise and comprehensive mapping of somatotopic representations in the motor cortex is clinically essential to achieve maximum resection of brain tumours whilst preserving motor function, especially since the current gold standard, that is, intraoperative direct cortical stimulation (DCS), holds limitations linked to the intraoperative setting such as time constraints or anatomical restrictions. Non-invasive techniques are increasingly relevant with ... read more
    3 weeks ago
  • Study of the Functional Brain Connectivity and Lower-Limb Motor Imagery Performance After Transcranial Direct Current Stimulation.
    Related ArticlesStudy of the Functional Brain Connectivity and Lower-Limb Motor Imagery Performance After Transcranial Direct Current Stimulation. Int J Neural Syst. 2020 Jun 26;:2050038 Authors: Ortiz M, Iáñez E, Gaxiola-Tirado JA, Gutiérrez D, Azorín JM Abstract The use of transcranial direct current stimulation (tDCS) has been related to the improvement of motor and learning tasks. The current research studies the effects of an asymmetric tDCS setup over brain connectivity, when the subject is performing a motor imagery (MI) task during five consecutive days. A brain-computer interface (BCI) based on electroencephalography is simulated in offline analysis to study the effect that ... read more
    3 weeks ago
  • The Effects of an Ocular Direct Electrical Stimulation on Pattern-Reversal Electroretinogram.
    Related ArticlesThe Effects of an Ocular Direct Electrical Stimulation on Pattern-Reversal Electroretinogram. Front Neurosci. 2020;14:588 Authors: Blum MC, Hunold A, Solf B, Klee S Abstract Studies on transcranial current stimulation have shown that a direct current stimulation of the occipital cortex can influence the amplitude size of a visual evoked potential (VEP). The current direction (cathodal or anodal) determines whether the VEP amplitudes increase or decrease. The aim of this study was to design a new experimental setup that will enable a simultaneous ocular direct current stimulation and electroretinogram (ERG) recording which will broaden our understanding of current stimulation effects ... read more
    3 weeks ago
  • Brain Metabolite Changes After Anodal Transcranial Direct Current Stimulation in Autism Spectrum Disorder.
    Related ArticlesBrain Metabolite Changes After Anodal Transcranial Direct Current Stimulation in Autism Spectrum Disorder. Front Mol Neurosci. 2020;13:70 Authors: Auvichayapat N, Patjanasoontorn N, Phuttharak W, Suphakunpinyo C, Keeratitanont K, Tunkamnerdthai O, Aneksan B, Klomjai W, Boonphongsathian W, Sinkueakunkit A, Punjaruk W, Tiamkao S, Auvichayapat P Abstract Objectives: Previous research has provided evidence that transcranial direct current stimulation (tDCS) can reduce severity of autism spectrum disorder (ASD); however, the exact mechanism of this effect is still unknown. Magnetic resonance spectroscopy has demonstrated low levels of brain metabolites in the anterior cingulate cortex (ACC), amygdala, and left dorsolateral prefrontal cortex (DLPFC) in ... read more
    3 weeks ago
  • Non-invasive Transcranial Electrical Stimulation in Movement Disorders.
    Related ArticlesNon-invasive Transcranial Electrical Stimulation in Movement Disorders. Front Neurosci. 2020;14:522 Authors: Ganguly J, Murgai A, Sharma S, Aur D, Jog M Abstract Dysfunction within large-scale brain networks as the basis for movement disorders is an accepted hypothesis. The treatment options for restoring network function are limited. Non-invasive brain stimulation techniques such as repetitive transcranial magnetic stimulation are now being studied to modify the network. Transcranial electrical stimulation (tES) is also a portable, cost-effective, and non-invasive way of network modulation. Transcranial direct current stimulation and transcranial alternating current stimulation have been studied in Parkinson's disease, dystonia, tremor, and ataxia. Transcranial ... read more
    3 weeks ago
  • Non-Invasive Neuromodulation for Tinnitus.
    Related ArticlesNon-Invasive Neuromodulation for Tinnitus. J Audiol Otol. 2020 Jun 25;: Authors: Langguth B Abstract Tinnitus is a prevalent disorder that has no cure currently. Within the last two decades, neuroscientific research has facilitated a better understanding of the pathophysiological mechanisms that underlie the generation and maintenance of tinnitus, and the brain and nerves have been identified as potential targets for its treatment using non-invasive brain stimulation methods. This article reviews studies on tinnitus patients using transcranial magnetic stimulation, transcranial electrical stimulation, such as transcranial direct current stimulation, alternating current stimulation, transcranial random noise stimulation as well as transcutaneous vagus ... read more
    3 weeks ago
  • Suboptimal Engagement of High-Level Cortical Regions Predicts Random-Noise-Related Gains in Sustained Attention.
    Related ArticlesSuboptimal Engagement of High-Level Cortical Regions Predicts Random-Noise-Related Gains in Sustained Attention. Psychol Sci. 2019 09;30(9):1318-1332 Authors: Harty S, Cohen Kadosh R Abstract Interindividual variability in outcomes across individuals poses great challenges for the application of noninvasive brain stimulation in psychological research. Here, we examined how the effects of high-frequency transcranial random-noise stimulation (tRNS) on sustained attention varied as a function of a well-studied electrocortical marker: spontaneous theta:beta ratio. Seventy-two participants received sham, 1-mA, and 2-mA tRNS in a double-blind, crossover manner while they performed a sustained-attention task. Receiving 1-mA tRNS was associated with improved sustained attention, whereas ... read more
    3 weeks ago
  • Effects of transcranial direct current stimulation of left and right inferior frontal gyrus on creative divergent thinking are moderated by changes in inhibition control.
    Related ArticlesEffects of transcranial direct current stimulation of left and right inferior frontal gyrus on creative divergent thinking are moderated by changes in inhibition control. Brain Struct Funct. 2020 Jun 17;: Authors: Khalil R, Karim AA, Kondinska A, Godde B Abstract Divergent thinking (DT) as one component of creativity is the ability to search for multiple solutions to a single problem and is reliably tested with the Alternative Uses Task (AUT). DT depends on activity in the inferior frontal gyrus (IFG), a prefrontal region that has also been associated with inhibitory control (IC). Experimentally manipulating IC through transcranial direct current ... read more
    4 weeks ago
  • “A systematic review of non-invasive neurostimulation for the treatment of depression during pregnancy”.
    Related Articles"A systematic review of non-invasive neurostimulation for the treatment of depression during pregnancy". J Affect Disord. 2020 Jul 01;272:259-268 Authors: Konstantinou GN, Vigod SN, Mehta S, Daskalakis ZJ, Blumberger DM Abstract BACKGROUND: Antidepressant use in pregnancy is associated with high levels of decision-making difficulty for patients, and psychotherapy may not be effective for severe symptoms. Alternative treatment options are needed. We conducted a systematic review of the clinical effects and tolerability of non-invasive neurostimulation: repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), trigeminal nerve stimulation (TNS), and transcutaneous vagus nerve stimulation (tVNS) ... read more
    4 weeks ago