Published Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with recent interest in the topic exploding over the last 10-15 years. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year. As of January 1, 2017 there are currently over 3,000 published tDCS studies on PubMed.gov, with nearly 700 (~23%) of them having been published in 2016 alone.

Below you will find a collection of the most recent scientific studies on tDCS. Each article includes data on where it was published, date published, contributing authors, as well as an abstract, or summary of the article.

 

  • Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability.
    Related ArticlesRemotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability. J Vis Exp. 2017 Oct 07;(128): Authors: Shaw MT, Kasschau M, Dobbs B, Pawlak N, Pau W, Sherman K, Bikson M, Datta A, Charvet LE Abstract The remotely supervised tDCS (RS-tDCS) protocol enables participation from home through guided and monitored self-administration of tDCS treatment while maintaining clinical standards. The current consensus regarding the efficacy of tDCS is that multiple treatment sessions are needed to observe targeted behavioral reductions in symptom burden. However, the requirement for patients to travel to clinic daily for stimulation sessions presents a major ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Stimulating thought: a functional MRI study of transcranial direct current stimulation in schizophrenia.
    Related ArticlesStimulating thought: a functional MRI study of transcranial direct current stimulation in schizophrenia. Brain. 2017 Sep 01;140(9):2490-2497 Authors: Orlov ND, O'Daly O, Tracy DK, Daniju Y, Hodsoll J, Valdearenas L, Rothwell J, Shergill SS Abstract Individuals with schizophrenia typically suffer a range of cognitive deficits, including prominent deficits in working memory and executive function. These difficulties are strongly predictive of functional outcomes, but there is a paucity of effective therapeutic interventions targeting these deficits. Transcranial direct current stimulation is a novel neuromodulatory technique with emerging evidence of potential pro-cognitive effects; however, there is limited understanding of its mechanism. This ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Neuronal and behavioral effects of multi-day brain stimulation and memory training.
    Related ArticlesNeuronal and behavioral effects of multi-day brain stimulation and memory training. Neurobiol Aging. 2017 Sep 28;: Authors: Antonenko D, Külzow N, Sousa A, Prehn K, Grittner U, Flöel A Abstract Strategies for memory enhancement, especially for the older population, are of great scientific and public interest. Here, we aimed at investigating neuronal and behavioral effects of transcranial direct current stimulation (tDCS) paired with memory training. Young and older adults were trained on an object-location-memory task on 3 consecutive days with either anodal or sham tDCS. Recall performance was assessed immediately after training, 1 day and 1 month later, as well as ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Neuromodulation directed at the prefrontal cortex of subjects with obesity reduces snack food intake and hunger in a randomized trial.
    Related ArticlesNeuromodulation directed at the prefrontal cortex of subjects with obesity reduces snack food intake and hunger in a randomized trial. Am J Clin Nutr. 2017 Oct 18;: Authors: Heinitz S, Reinhardt M, Piaggi P, Weise CM, Diaz E, Stinson EJ, Venti C, Votruba SB, Wassermann EM, Alonso-Alonso M, Krakoff J, Gluck ME Abstract Background: Obesity is associated with reduced activation in the left dorsolateral prefrontal cortex (DLPFC), a region of the brain that plays a key role in the support of self-regulatory aspects of eating behavior and inhibitory control. Transcranial direct current stimulation (tDCS) is a noninvasive technique used ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Transcranial direct current stimulation of the rLPFC shifts normative judgments in voluntary cooperation.
    Related ArticlesTranscranial direct current stimulation of the rLPFC shifts normative judgments in voluntary cooperation. Neurosci Lett. 2017 Oct 13;: Authors: Liu X, Li J, Wang G, Yin X, Li S, Fu X Abstract Normative judgment is a key capacity for human social norm compliance. Previous studies have revealed that the right lateral prefrontal cortex (rLPFC) is closely related to social norm compliance and that it has proven stimulation effects on behavior in voluntary and sanction-induced norm compliance, but not normative judgments. Nearly all these studies have been based on sanction-induced coordination cooperation, and a number of them have found ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Transcranial brain stimulation for the treatment of tinnitus: Positive lessons from a negative trial.
    Related ArticlesTranscranial brain stimulation for the treatment of tinnitus: Positive lessons from a negative trial. Brain Stimul. 2017 Oct 05;: Authors: Plewnia C PMID: 29037789 [PubMed - as supplied by publisher] ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Possible Facilitative Effects of Repeated Anodal Transcranial Direct Current Stimulation on Functional Outcome 1 Month Later in Schizophrenia: An Open Trial.
    Related ArticlesPossible Facilitative Effects of Repeated Anodal Transcranial Direct Current Stimulation on Functional Outcome 1 Month Later in Schizophrenia: An Open Trial. Front Psychiatry. 2017;8:184 Authors: Narita Z, Inagawa T, Sueyoshi K, Lin C, Sumiyoshi T Abstract Recent research on neuromodulation techniques, such as transcranial direct current stimulation (tDCS), for the treatment of schizophrenia has mainly focused on psychotic symptoms. We aimed to determine whether repetitive tDCS is efficacious in improving determinants of outcome, such as cognitive function, daily living skills, and depressive mood in patients with schizophrenia. Twenty-eight patients underwent tDCS (2 mA × 20 min) two times per day for ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Plasticity induced by non-invasive transcranial brain stimulation: A position paper.
    Related ArticlesPlasticity induced by non-invasive transcranial brain stimulation: A position paper. Clin Neurophysiol. 2017 Sep 28;128(11):2318-2329 Authors: Huang YZ, Lu MK, Antal A, Classen J, Nitsche M, Ziemann U, Ridding M, Hamada M, Ugawa Y, Jaberzadeh S, Suppa A, Paulus W, Rothwell J Abstract Several techniques and protocols of non-invasive transcranial brain stimulation (NIBS), including transcranial magnetic and electrical stimuli, have been developed in the past decades. Non-invasive transcranial brain stimulation may modulate cortical excitability outlasting the period of non-invasive transcranial brain stimulation itself from several minutes to more than one hour. Quite a few lines of evidence, including ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Non-pharmacological interventions for spasticity in adults: an overview of systematic reviews.
    Related ArticlesNon-pharmacological interventions for spasticity in adults: an overview of systematic reviews. Ann Phys Rehabil Med. 2017 Oct 14;: Authors: Khan F, Amatya B, Bensmail D, Yelnik A Abstract OBJECTIVES: Spasticity causes significant long-term disability-burden, requiring comprehensive management. This review evaluates evidence from published systematic reviews of clinical trials for effectiveness of non-pharmacological interventions for improved spasticity outcomes. METHODS: Data sources: A literature search was conducted using medical and health science electronic (MEDLINE, EMBASE, CINAHL, PubMed, and the Cochrane Library) databases for published systematic reviews up to 15(th) June 2017. DATA EXTRACTION AND SYNTHESIS: Two reviewers applied inclusion criteria ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Task demands, tDCS intensity, and the COMT val(158)met polymorphism impact tDCS-linked working memory training gains.
    Related ArticlesTask demands, tDCS intensity, and the COMT val(158)met polymorphism impact tDCS-linked working memory training gains. Sci Rep. 2017 Oct 18;7(1):13463 Authors: Stephens JA, Jones KT, Berryhill ME Abstract Working memory (WM) training paired with transcranial direct current stimulation (tDCS) can improve executive function in older adults. The unclear mechanism of tDCS likely depends on tDCS intensity, and task relevant genetic factors (e.g., for WM: COMT val(158)met, DAT, BDNF val(66)met). Higher tDCS intensity does not always lead to greater cognitive gains, and genetic polymorphisms may modulate tDCS-linked WM improvements. To evaluate these factors, 137 healthy older adults provided DNA ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Modulating hemispheric lateralization by brain stimulation yields gain in mental and physical activity.
    Related ArticlesModulating hemispheric lateralization by brain stimulation yields gain in mental and physical activity. Sci Rep. 2017 Oct 18;7(1):13430 Authors: Zich C, Harty S, Kranczioch C, Mansfield KL, Sella F, Debener S, Cohen Kadosh R Abstract Imagery plays an important role in our life. Motor imagery is the mental simulation of a motor act without overt motor output. Previous studies have documented the effect of motor imagery practice. However, its translational potential for patients as well as for athletes, musicians and other groups, depends largely on the transfer from mental practice to overt physical performance. We used bilateral transcranial ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Using transcranial direct current stimulation to treat symptoms in mild cognitive impairment and Alzheimer’s disease.
    Related ArticlesUsing transcranial direct current stimulation to treat symptoms in mild cognitive impairment and Alzheimer's disease. Neurodegener Dis Manag. 2017 Oct 18;: Authors: Liu CS, Rau A, Gallagher D, Rajji TK, Lanctôt KL, Herrmann N Abstract Transcranial direct current stimulation (tDCS) has recently been investigated as a potential nonpharmacological treatment for individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD). A comprehensive literature search was performed on tDCS studies published until March 2017 using MEDLINE, Embase and PsychINFO databases. 12 articles with a total of 202 MCI or AD participants were included. Although ten of the 12 studies demonstrated ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Transcranial Direct Current Stimulation Facilitates Associative Learning and Alters Functional Connectivity in the Primate Brain.
    Related ArticlesTranscranial Direct Current Stimulation Facilitates Associative Learning and Alters Functional Connectivity in the Primate Brain. Curr Biol. 2017 Oct 11;: Authors: Krause MR, Zanos TP, Csorba BA, Pilly PK, Choe J, Phillips ME, Datta A, Pack CC Abstract There has been growing interest in transcranial direct current stimulation (tDCS), a non-invasive technique purported to modulate neural activity via weak, externally applied electric fields. Although some promising preliminary data have been reported for applications ranging from stroke rehabilitation to cognitive enhancement, little is known about how tDCS affects the human brain, and some studies have concluded that it may ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Sex mediates the effects of high-definition transcranial direct current stimulation on “mind-reading”.
    Related ArticlesSex mediates the effects of high-definition transcranial direct current stimulation on "mind-reading". Neuroscience. 2017 Oct 11;: Authors: Martin AK, Huang J, Hunold A, Meinzer M Abstract Sex differences in social cognitive ability are well established, including measures of Theory of Mind (ToM). The aim of this study was to investigate if sex mediates the effects of high definition transcranial direct current stimulation (HD-tDCS) administered to a key hub of the social brain (i.e., the dorsomedial prefrontal cortex, dmPFC) on the Reading the Mind in the Eyes Test (RMET). 40 healthy young adults (18-35 years) were randomly allocated to ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Modulating what is and what could have been: The effect of transcranial direct current stimulation on the evaluation of attained and unattained decision outcomes.
    Related ArticlesModulating what is and what could have been: The effect of transcranial direct current stimulation on the evaluation of attained and unattained decision outcomes. Cogn Affect Behav Neurosci. 2017 Oct 10;: Authors: van 't Wout M, Silverman H Abstract The affective evaluation of decision outcomes, whether attained (e.g., disappointment) or based on the conscious realization that a decision made differently would have led to a better or worse outcome (e.g., regret), greatly influence future decisions. Prior research has demonstrated a role of the medial and orbitofrontal cortex (M/OFC) in decision valuation and the experience of regret and relief. ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Hypericum perforatum extract modulates cortical plasticity in humans.
    Related ArticlesHypericum perforatum extract modulates cortical plasticity in humans. Psychopharmacology (Berl). 2017 Oct 10;: Authors: Concerto C, Boo H, Hu C, Sandilya P, Krish A, Chusid E, Coira D, Aguglia E, Battaglia F Abstract BACKGROUND: Hypericum perforatum (HYP) extract is one of the most commonly used complementary alternative medicines (CAMs) for the treatment of mild-to-moderate depression. Non-invasive brain stimulation protocols can be used to investigate the effect of psychoactive substances on the human brain. In this study, we explored the effect of a single dose of HYP extract (WS 5570) intake on corticospinal excitability and plasticity in humans. METHODS: ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Combination of a Short Cognitive Training and tDCS to Enhance Visuospatial Skills: A Comparison Between Online and Offline Neuromodulation.
    Related ArticlesCombination of a Short Cognitive Training and tDCS to Enhance Visuospatial Skills: A Comparison Between Online and Offline Neuromodulation. Brain Res. 2017 Oct 07;: Authors: Oldrati V, Colombo B, Antonietti A Abstract Visuospatial skills can be enhanced thanks to specific intervention programs, but the additional benefits of neuromodulation on these skills have not been fully investigated yet, although transcranial direct current stimulation (tDCS) has demonstrated to boost the effects of cognitive trainings. When combining cognitive intervention with neuromodulation, the time-window of tDCS application in relation to task execution has to be taken into account since it has been ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Effect of transcranial direct current stimulation combined with cognitive training on cognitive functioning in older adults with HIV: A pilot study.
    Related ArticlesEffect of transcranial direct current stimulation combined with cognitive training on cognitive functioning in older adults with HIV: A pilot study. Appl Neuropsychol Adult. 2017 Oct 11;:1-12 Authors: Fazeli PL, Woods AJ, Pope CN, Vance DE, Ball KK Abstract The objective of this study was to examine combination speed of processing (SOP) cognitive remediation therapy (CRT) and transcranial direct stimulation (tDCS) as neurorehabilitation in older HIV+ adults. Thirty-three HIV+ adults aged 50+ completed neurocognitive testing and were randomized to either active (n = 17) or sham (n = 16) tDCS. Both conditions received 10 1-hour sessions of SOP CRT, with either active ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Using tDCS priming to improve brain function: Can metaplasticity provide the key to boosting outcomes?
    Related ArticlesUsing tDCS priming to improve brain function: Can metaplasticity provide the key to boosting outcomes? Neurosci Biobehav Rev. 2017 Oct 08;: Authors: Hurley R, Machado L Abstract Transcranial direct current stimulation (tDCS) has been trialled by many researchers attempting to improve brain function. Outcomes have been quite variable with seemingly similar protocols yielding either inconsistent or insufficiently robust improvements for clinical translation. A potentially fruitful avenue for increasing benefits conferred by tDCS stems from findings from motor and visual cortex studies that indicate tDCS priming prior to a subsequent period of stimulation (tDCS or transcranial magnetic stimulation) can ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Transcranial direct current stimulation in stroke rehabilitation: ready to move to randomized clinical trials and clinical practice? The issue of safety guidelines.
    Related ArticlesTranscranial direct current stimulation in stroke rehabilitation: ready to move to randomized clinical trials and clinical practice? The issue of safety guidelines. Eur J Neurol. 2017 Nov;24(11):e78 Authors: Bolognini N, Souza Carneiro MI, Russo C, Vallar G PMID: 29024357 [PubMed - in process] ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Integrated treatment modality of cathodal-transcranial direct current stimulation with peripheral sensory stimulation affords neuroprotection in a rat stroke model.
    Related ArticlesIntegrated treatment modality of cathodal-transcranial direct current stimulation with peripheral sensory stimulation affords neuroprotection in a rat stroke model. Neurophotonics. 2017 Oct;4(4):045002 Authors: Liu YH, Chan SJ, Pan HC, Bandla A, King NKK, Wong PTH, Chen YY, Ng WH, Thakor NV, Liao LD Abstract Cathodal-transcranial direct current stimulation induces therapeutic effects in animal ischemia models by preventing the expansion of ischemic injury during the hyperacute phase of ischemia. However, its efficacy is limited by an accompanying decrease in cerebral blood flow. On the other hand, peripheral sensory stimulation can increase blood flow to specific brain areas resulting in rescue ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Enhancing Neuroplasticity to Augment Cognitive Remediation in Schizophrenia.
    Related ArticlesEnhancing Neuroplasticity to Augment Cognitive Remediation in Schizophrenia. Front Psychiatry. 2017;8:191 Authors: Jahshan C, Rassovsky Y, Green MF Abstract There is a burgeoning need for innovative treatment strategies to improve the cognitive deficits in schizophrenia. Cognitive remediation (CR) is effective at the group level, but the variability in treatment response is large. Given that CR may depend on intact neuroplasticity to produce cognitive gains, it is reasonable to combine it with strategies that harness patients' neuroplastic potential. In this review, we discuss two non-pharmacological approaches that can enhance neuroplasticity and possibly augment the effects of CR in ... read more
    Scientific Studies on Transcranial Direct Current Stimulation
  • Anodal tDCS applied during multitasking training leads to transferable performance gains.
    Related ArticlesAnodal tDCS applied during multitasking training leads to transferable performance gains. Sci Rep. 2017 Oct 11;7(1):12988 Authors: Filmer HL, Lyons M, Mattingley JB, Dux PE Abstract Cognitive training can lead to performance improvements that are specific to the tasks trained. Recent research has suggested that transcranial direct current stimulation (tDCS) applied during training of a simple response-selection paradigm can broaden performance benefits to an untrained task. Here we assessed the impact of combined tDCS and training on multitasking, stimulus-response mapping specificity, response-inhibition, and spatial attention performance in a cohort of healthy adults. Participants trained over four days ... read more
    Scientific Studies on Transcranial Direct Current Stimulation