Published Research Studies on tDCS

Published Research Studies on tDCS

The scientific and academic research communities have been studying Transcranial Direct Current Stimulation (tDCS) for decades, with interest in the topic exploding over the last 10-15 years. The number of scientific studies conducted per year has increased every year since 2006. In 2007, 2008 and 2011, the number of published studies on tDCS doubled that of the previous year.

As of May 2019, there are over 4,200 research papers on tDCS available through PubMed alone! Below you will find a collection of the latest studies recently published on tDCS. Each study includes information on where the paper was published along with publication date, contributing authors, and an abstract or summary of the findings.

 

  • Gait-Synchronized Rhythmic Brain Stimulation Improves Poststroke Gait Disturbance.
    Related ArticlesGait-Synchronized Rhythmic Brain Stimulation Improves Poststroke Gait Disturbance. Stroke. 2019 Sep 10;:STROKEAHA119025354 Authors: Koganemaru S, Kitatani R, Fukushima-Maeda A, Mikami Y, Okita Y, Matsuhashi M, Ohata K, Kansaku K, Mima T Abstract Background and Purpose- Gait disturbance is one of serious impairments lowering activity of daily life in poststroke patients. The patients often show reduced hip and knee joint flexion and ankle dorsiflexion of the lower limbs during the swing phase of gait, which is partly controlled by the primary motor cortex (M1). In the present study, we investigated whether gait-synchronized rhythmic brain stimulation targeting swing phase-related M1 activity ... read more
    6 days ago
  • Traumatic axonal injury influences the cognitive effect of non-invasive brain stimulation.
    Traumatic axonal injury influences the cognitive effect of non-invasive brain stimulation. Brain. 2019 Aug 30;: Authors: Li LM, Violante IR, Zimmerman K, Leech R, Hampshire A, Patel M, Opitz A, McArthur D, Jolly A, Carmichael DW, Sharp DJ Abstract Non-invasive brain stimulation has been widely investigated as a potential treatment for a range of neurological and psychiatric conditions, including brain injury. However, the behavioural effects of brain stimulation are variable, for reasons that are poorly understood. This is a particular challenge for traumatic brain injury, where patterns of damage and their clinical effects are heterogeneous. Here we test the hypothesis ... read more
    6 days ago
  • Effectiveness of Cerebellar Circuitry Modulation in Schizophrenia: A Systematic Review.
    Effectiveness of Cerebellar Circuitry Modulation in Schizophrenia: A Systematic Review. J Nerv Ment Dis. 2019 Sep 09;: Authors: Escelsior A, Belvederi Murri M, Calcagno P, Cervetti A, Caruso R, Croce E, Grassi L, Amore M Abstract Structural and functional abnormalities of the cerebellum have been observed in schizophrenia since the first neuroimaging studies. More recently, the functions of the cerebellum have been extended beyond sensorimotor control to include participation in higher-level cognition and affective regulation. Consistently, the "cognitive dysmetria" theory posits that dysfunctions of cortical-subcortical-cerebellar circuitry may be crucial for the pathogenesis of different clinical features of schizophrenia. This conceptual ... read more
    6 days ago
  • Effects of Transcranial Direct Current Stimulation for Treatment of Primary Dysmenorrhea: Preliminary Results of a Randomized Sham-Controlled Trial.
    Related ArticlesEffects of Transcranial Direct Current Stimulation for Treatment of Primary Dysmenorrhea: Preliminary Results of a Randomized Sham-Controlled Trial. Pain Med. 2019 Sep 09;: Authors: Pegado R, Silva LK, da Silva Dantas H, Andrade Câmara H, Andrade Mescouto K, Silva-Filho EM, Lopes JM, Micussi MTABC, Correia GN Abstract OBJECTIVE: The aim of this trial was to investigate the effects of five consecutive sessions of anodal transcranial direct current stimulation (tDCS) over the motor cortex (M1) on pain, mood, and physical performance in patients with primary dysmenorrhea (PDM). DESIGN: This is a double-blind randomized controlled trial. SUBJECTS: Twenty-two participants with PDM ... read more
    7 days ago
  • Transcranial Direct Current Stimulation over the Left Dorsolateral Prefrontal Cortex Improves Inhibitory Control and Endurance Performance in Healthy Individuals.
    Related ArticlesTranscranial Direct Current Stimulation over the Left Dorsolateral Prefrontal Cortex Improves Inhibitory Control and Endurance Performance in Healthy Individuals. Neuroscience. 2019 Sep 04;: Authors: Angius L, Santarnecchi E, Pascual-Leone A, Marcora SM Abstract The dorsolateral prefrontal cortex (DLPFC) is a crucial brain region for inhibitory control, an executive function essential for behavioural self-regulation. Recently, inhibitory control has been shown to be important for endurance performance. Improvement in inhibitory control were found following transcranial direct current stimulation (tDCS) applied over the left DLPFC (L-DLPFC). This study examined the effect tDCS on both an inhibitory control and endurance performance in a ... read more
    1 week ago
  • Neurostimulation in Treating ADHD.
    Related ArticlesNeurostimulation in Treating ADHD. Psychiatr Danub. 2019 Sep;31(Suppl 3):265-275 Authors: Wong HC, Zaman R Abstract BACKGROUND: Neurostimulation techniques are potential methods of treating ADHD, involving stimulation of brain areas showing abnormal activity in ADHD. They are associated with benefits that last longer with fewer side effects. This literature review will evaluate the effectiveness of these methods. SUBJECTS AND METHODS: A literature search using scientific databases including PubMed and the Cochrane Library, using "ADHD" and "Attention Deficit Hyperactivity Disorder" combined with "Transcranial Magnetic Stimulation", "TMS", "Transcranial Direct Current Stimulation", "tDCS", "Vagus Nerve Stimulation", "VNS", "Trigeminal Nerve Stimulation", "TNS", "Deep Brain ... read more
    1 week ago
  • Reducing negative affect with anodal transcranial direct current stimulation increases memory performance in young-but not in elderly-individuals.
    Related ArticlesReducing negative affect with anodal transcranial direct current stimulation increases memory performance in young-but not in elderly-individuals. Brain Struct Funct. 2019 Sep 03;: Authors: Peter J, Neumann-Dunayevska E, Geugelin F, Ninosu N, Plewnia C, Klöppel S Abstract Affect can directly influence memory storage and retrieval, which offers the opportunity to improve memory performance by changing affective responses. A promising target is the left dorsolateral prefrontal cortex (dlPFC), as it is functionally involved in both affect and memory. This study explores whether anodal transcranial direct current stimulation (tDCS) to the left dlPFC improves memory retrieval through the reduction of negative ... read more
    2 weeks ago
  • Investigation into the effect of transcranial direct current stimulation on cardiac pacemakers.
    Related ArticlesInvestigation into the effect of transcranial direct current stimulation on cardiac pacemakers. Brain Stimul. 2019 Aug 17;: Authors: Roncero C, Mardigyan V, Service E, Singerman J, Whittaker KC, Friedman M, Chertkow H Abstract BACKGROUND: Studies investigating the therapeutic applications of transcranial direct current stimulation (tDCS) in the treatment of age-related neurodegenerative disease have been promising. However, exclusion criteria for these studies invariably disqualify patients implanted with internal cardiac pacemakers, citing safety concerns. Because the majority of cardiac pacemaker implantees are over 65, this criterion may limit candidacy for tDCS based research and/or treatment of age-related neurodegenerative disease. OBJECTIVE/HYPOTHESIS: We ... read more
    2 weeks ago
  • Prospects for transcranial temporal interference stimulation in humans: A computational study.
    Related ArticlesProspects for transcranial temporal interference stimulation in humans: A computational study. Neuroimage. 2019 Aug 29;:116124 Authors: Rampersad S, Roig-Solvas B, Yarossi M, Kulkarni PP, Santarnecchi E, Dorval AD, Brooks DH Abstract Transcranial alternating current stimulation (tACS) is a noninvasive method used to modulate activity of superficial brain regions. Deeper and more steerable stimulation could potentially be achieved using transcranial temporal interference stimulation (tTIS): two high-frequency alternating fields interact to produce a wave with an envelope frequency in the range thought to modulate neural activity. Promising initial results have been reported for experiments with mice. In this study we aim ... read more
    2 weeks ago
  • Motor stroke recovery after tDCS: a systematic review.
    Related ArticlesMotor stroke recovery after tDCS: a systematic review. Rev Neurosci. 2019 Aug 31;: Authors: Orrù G, Conversano C, Hitchcott PK, Gemignani A Abstract The purpose of the present study was to investigate the effects of transcranial direct current stimulation (tDCS) on motor recovery in adult patients with stroke, taking into account the parameters that could influence the motor recovery responses. The second aim was to identify the best tDCS parameters and recommendations available based on the enhanced motor recovery demonstrated by the analyzed studies. Our systematic review was performed by searching full-text articles published before February 18, 2019 in ... read more
    2 weeks ago
  • Beyond rehabilitation in MS: Insights from non-invasive brain stimulation.
    Related ArticlesBeyond rehabilitation in MS: Insights from non-invasive brain stimulation. Mult Scler. 2019 Sep;25(10):1363-1371 Authors: Leocani L, Chieffo R, Gentile A, Centonze D Abstract Although the number of disease-modifying treatments for people with multiple sclerosis (pwMS) has meaningfully increased in the past years, targeting repair or compensation for central nervous system damage associated with the disease process remains an important clinical goal. With this aim, neurorehabilitation is a powerful approach targeting central nervous system plasticity. Another driver of brain plasticity is non-invasive brain stimulation (NIBS), receiving recent attention in neurology, particularly for its potential synergy with neurorehabilitation and as add-on ... read more
    2 weeks ago
  • Effects of single-session cathodal transcranial direct current stimulation on tic symptoms in Tourette’s syndrome.
    Related ArticlesEffects of single-session cathodal transcranial direct current stimulation on tic symptoms in Tourette's syndrome. Exp Brain Res. 2019 Aug 28;: Authors: Dyke K, Jackson GM, Nixon E, Jackson SR Abstract Tourette syndrome is a neurodevelopmental disorder characterised by motor and phonic tics. For some, tics can be managed using medication and/or forms of behavioural therapy; however, adverse side effects and access to specialist resources can be barriers to treatment. In this sham-controlled brain stimulation study, we investigated the effects of transcranial direct current stimulation (tDCS) on the occurrence of tics and motor cortical excitability in individuals aged 16-33 years with ... read more
    3 weeks ago
  • Frequently overlooked realistic moral bioenhancement interventions.
    Related ArticlesFrequently overlooked realistic moral bioenhancement interventions. J Med Ethics. 2019 Aug 28;: Authors: Conan GM Abstract Many supporters of 'moral bioenhancement' (MBE), the use of biomedical interventions for moral improvement, have been criticised for having unrealistic proposals. The interventions they suggest have often been called infeasible and their implementation plans vague or unethical. I dispute these criticisms by showing that various interventions to implement MBE are practically and ethically feasible enough to warrant serious consideration. Such interventions include transcranial direct current stimulation over the medial and dorsolateral prefrontal cortex, as well as supplementation with lithium and omega-3. Considering their ... read more
    3 weeks ago
  • Anisotropic conductivity tensor by analyzing diffusion tensor for electrical brain stimulation (EBS).
    Related ArticlesAnisotropic conductivity tensor by analyzing diffusion tensor for electrical brain stimulation (EBS). Phys Med Biol. 2018 Dec 18;63(24):24NT04 Authors: Lee MB, Kim YH, Kim HJ, Kwon OI Abstract Electrical brain stimulation (EBS) is a promising medical treatment method for brain neurological disorders through the direct or indirect excitation by injecting an electric current. At present, it is difficult to directly measure the distribution of the electric current delivered by electrodes inside tissues. By applying low-frequency ([Formula: see text]1 kHz) external electrical brain stimulation (EBS), the low-frequency conductivity around the cells is uneven due to asymmetric cellular structures. We propose ... read more
    3 weeks ago
  • High-definition tDCS to the right temporoparietal junction modulates slow-wave resting state power and coherence in healthy adults.
    Related ArticlesHigh-definition tDCS to the right temporoparietal junction modulates slow-wave resting state power and coherence in healthy adults. J Neurophysiol. 2019 Aug 28;: Authors: Donaldson PH, Kirkovski M, Yang JS, Bekkali S, Enticott PG Abstract The right temporoparietal junction (rTPJ) is a multisensory integration hub that is increasingly utilised as a target of stimulation studies exploring its rich functional network roles and potential clinical applications. Whilst transcranial direct current stimulation (tDCS) is frequently employed in such studies, there is still relatively little known regarding its local and network neurophysiological effects, particularly at important non-motor sites such as the rTPJ. The ... read more
    3 weeks ago
  • Influence of neurovascular mechanisms on response to tDCS: an exploratory study.
    Related ArticlesInfluence of neurovascular mechanisms on response to tDCS: an exploratory study. Exp Brain Res. 2019 Aug 27;: Authors: Iyer PC, Rosenberg A, Baynard T, Madhavan S Abstract The beneficial effects of transcranial direct current stimulation (tDCS) for stroke rehabilitation are limited by the variability in changes in corticomotor excitability (CME) after tDCS. Neuronal activity is closely related to cerebral blood flow; however, the cerebral hemodynamics of neuromodulation in relation to neural effects have been less explored. In this study, we examined the effects of tDCS on cerebral blood velocity (CBv) in chronic stroke survivors using transcranial Doppler (TCD) ultrasound ... read more
    3 weeks ago
  • Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation.
    Related ArticlesTranscranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation. Mol Psychiatry. 2019 Aug 27;: Authors: Chase HW, Boudewyn MA, Carter CS, Phillips ML Abstract Transcranial direct current stimulation (tDCS) is a promising method for altering the function of neural systems, cognition, and behavior. Evidence is emerging that it can also influence psychiatric symptomatology, including major depression and schizophrenia. However, there are many open questions regarding how the method might have such an effect, and uncertainties surrounding its influence on neural activity, and human cognition and functioning. In the present critical review, we identify ... read more
    3 weeks ago
  • Postexercise blood pressure and autonomic responses after aerobic exercise following anodal tDCS applied over the medial prefrontal cortex.
    Related ArticlesPostexercise blood pressure and autonomic responses after aerobic exercise following anodal tDCS applied over the medial prefrontal cortex. Neurosci Lett. 2019 Aug 21;:134444 Authors: Farinatti P, Cordeiro R, Vogel M, Machado S, Monteiro W Abstract Transcranial direct current stimulation (tDCS) is acknowledged to modulate autonomic cardiac activity and hemodynamic responses at rest and during exercise. However, its potential to optimize postexercise hypotension (PEH) has not been investigated. This study investigated the effects of anodal tDCS applied over the medial prefrontal cortex (mPFC) upon blood pressure (BP) and heart rate variability (HRV) throughout 60 min following acute aerobic exercise. Fifteen young ... read more
    3 weeks ago
  • Transcranial direct current stimulation (tDCS) induces adrenergic receptor-dependent microglial morphological changes in mice.
    Related ArticlesTranscranial direct current stimulation (tDCS) induces adrenergic receptor-dependent microglial morphological changes in mice. eNeuro. 2019 Aug 23;: Authors: Mishima T, Nagai T, Yahagi K, Akther S, Oe Y, Monai H, Kohsaka S, Hirase H Abstract Transcranial direct current stimulation (tDCS) has been reported for its beneficial effects on memory formation and various brain disorders. While the electrophysiological readout of tDCS effects is subtle, astrocytes have been demonstrated to elicit Ca2+ elevations during tDCS in a rodent model. This study aimed to elucidate the effects of tDCS on another major glial cell type, microglia, by histology and in vivo imaging. ... read more
    3 weeks ago
  • Pre-stimulus Brain Activity Is Associated With State-Anxiety Changes During Single-Session Transcranial Direct Current Stimulation.
    Related ArticlesPre-stimulus Brain Activity Is Associated With State-Anxiety Changes During Single-Session Transcranial Direct Current Stimulation. Front Hum Neurosci. 2019;13:266 Authors: Nishida K, Koshikawa Y, Morishima Y, Yoshimura M, Katsura K, Ueda S, Ikeda S, Ishii R, Pascual-Marqui R, Kinoshita T Abstract Transcranial direct current stimulation is a promising neuromodulation method for treating depression. However, compared with pharmacological treatment, previous studies have reported that a relatively limited proportion of patients respond to tDCS treatment. In addition, the neurophysiological mechanisms underlying tDCS treatment remain unclear, making it difficult to identify response predictors for tDCS treatment based on neurophysiological function. Because treatment effects ... read more
    3 weeks ago
  • Comparison of transcranial electrical stimulation regimens for effects on inhibitory circuit activity in primary somatosensory cortex and tactile spatial discrimination performance.
    Related ArticlesComparison of transcranial electrical stimulation regimens for effects on inhibitory circuit activity in primary somatosensory cortex and tactile spatial discrimination performance. Behav Brain Res. 2019 Aug 20;:112168 Authors: Saito K, Otsuru N, Inukai Y, Miyaguchi S, Yokota H, Kojima S, Sasaki R, Onishi H Abstract Transcranial electrical stimulation (tES) can be used to modulate inhibitory circuits in primary somatosensory cortex, resulting in improved somatosensory function. However, efficacy may depend on the specific stimulus modality and patterns. For instance, transcranial alternating current stimulation (tACS), transcranial random noise stimulation (tRNS), and transcranial pulsed current stimulation (tPCS) were found to stably and ... read more
    3 weeks ago
  • Transcranial direct current stimulation for the treatment of generalized anxiety disorder: A randomized clinical trial.
    Related ArticlesTranscranial direct current stimulation for the treatment of generalized anxiety disorder: A randomized clinical trial. J Affect Disord. 2019 Aug 15;259:31-37 Authors: de Lima AL, Braga FMA, da Costa RMM, Gomes EP, Brunoni AR, Pegado R Abstract BACKGROUND: Generalized anxiety disorder (GAD) is a common condition with current treatments being only moderately effective. Non-invasive brain stimulation techniques might provide a novel approach for treating GAD. Transcranial direct current stimulation (tDCS) has shown promising efficacy and tolerability for major depression but has not been investigated for GAD yet. Thus, we investigated the effects of tDCS on patients with GAD. METHODS: ... read more
    4 weeks ago
  • Simulation Analyses of tDCS Montages for the Investigation of Dorsal and Ventral Pathways.
    Related ArticlesSimulation Analyses of tDCS Montages for the Investigation of Dorsal and Ventral Pathways. Sci Rep. 2019 Aug 21;9(1):12178 Authors: Bhattacharjee S, Kashyap R, Rapp B, Oishi K, Desmond JE, Chen SHA Abstract Modulating higher cognitive functions like reading with transcranial direct current stimulation (tDCS) can be challenging as reading involves regions in the dorsal and ventral cortical areas that lie in close proximity. If the two pathways are stimulated simultaneously, the function of dorsal pathway (predominantly used for graphophonological conversion) might interfere with the function of the ventral pathway (used for semantics), and vice-versa. To achieve functional specificity in ... read more
    4 weeks ago
  • Effect of Anodal tDCS on Articulatory Accuracy, Word Production, and Syllable Repetition in Subjects with Aphasia: A Crossover, Double-Blinded, Sham-Controlled Trial.
    Related ArticlesEffect of Anodal tDCS on Articulatory Accuracy, Word Production, and Syllable Repetition in Subjects with Aphasia: A Crossover, Double-Blinded, Sham-Controlled Trial. Neurol Ther. 2019 Aug 20;: Authors: Vila-Nova C, Lucena PH, Lucena R, Armani-Franceschi G, Campbell FQ Abstract INTRODUCTION: Transcranial direct-current stimulation (tDCS) has been used to modulate and induce changes in brain function and excitability. tDCS is a promising tool for the treatment of aphasia. OBJECTIVE: To evaluate whether tDCS improves articulatory accuracy and speech production in patients with aphasia after stroke. METHODS AND RESULTS: Twelve right-handed subjects participated in a double-blind, sham-controlled, crossover offline trial. We assessed ... read more
    4 weeks ago
  • Gamma Band Neural Stimulation in Humans and the Promise of a New Modality to Prevent and Treat Alzheimer’s Disease.
    Related ArticlesGamma Band Neural Stimulation in Humans and the Promise of a New Modality to Prevent and Treat Alzheimer's Disease. J Alzheimers Dis. 2018;65(2):363-392 Authors: McDermott B, Porter E, Hughes D, McGinley B, Lang M, O'Halloran M, Jones M Abstract Existing treatments for Alzheimer's disease (AD) have questionable efficacy with a need for research into new and more effective therapies to both treat and possibly prevent the condition. This review examines a novel therapeutic modality that shows promise for treating AD based on modulating neuronal activity in the gamma frequency band through external brain stimulation. The gamma frequency ... read more
    4 weeks ago